dbPTM

UB2D1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UB2D1_HUMAN
UniProt AC	P51668
Protein Name	Ubiquitin-conjugating enzyme E2 D1
Gene Name	UBE2D1
Organism	Homo sapiens (Human).
Sequence Length	147
Subcellular Localization	Cytoplasm .
Protein Description	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. [PubMed: 22496338 In vitro catalyzes 'Lys-48'-linked polyubiquitination]
Protein Sequence	MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MALKRIQKELSDLQR CHHHHHHHHHHHHHH	59.25	-
11	Phosphorylation	KRIQKELSDLQRDPP HHHHHHHHHHHHCCC	37.05	27499020
74	Phosphorylation	IAFTTKIYHPNINSN EEEEEEECCCCCCCC	16.87	28152594
80	Phosphorylation	IYHPNINSNGSICLD ECCCCCCCCCEEHHH	38.48	24076635
83	Phosphorylation	PNINSNGSICLDILR CCCCCCCEEHHHHHH	17.87	25849741
144	Acetylation	HAREWTQKYAM---- HHHHHHHHHCC----	27.83	25953088
144	Ubiquitination	HAREWTQKYAM---- HHHHHHHHHCC----	27.83	21906983
145	Phosphorylation	AREWTQKYAM----- HHHHHHHHCC-----	9.70	20736484

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MPG	P29372	PMID:21296087
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UB2D1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UB2D1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI39_HUMAN	TRIM39	physical	16189514
RN126_HUMAN	RNF126	physical	16189514
UBE3A_HUMAN	UBE3A	physical	10066826
RSP5_YEAST	RSP5	physical	10066826
DDX58_HUMAN	DDX58	physical	17719635
STAM2_HUMAN	STAM2	physical	17588522
EPS15_HUMAN	EPS15	physical	17588522
DPOLM_HUMAN	POLM	physical	17588522
DPOLL_HUMAN	POLL	physical	17588522
HDAC6_HUMAN	HDAC6	physical	17588522
UBS3B_HUMAN	UBASH3B	physical	17588522
UFM1_HUMAN	UFM1	physical	19690564
AMFR_HUMAN	AMFR	physical	19690564
MUL1_HUMAN	MUL1	physical	19690564
CAPS2_HUMAN	CADPS2	physical	19690564
DTX1_HUMAN	DTX1	physical	19690564
UBE4A_HUMAN	UBE4A	physical	19690564
RN103_HUMAN	RNF103	physical	19690564
RN181_HUMAN	RNF181	physical	19690564
M3K1_HUMAN	MAP3K1	physical	19690564
MIB1_HUMAN	MIB1	physical	19690564
PJA2_HUMAN	PJA2	physical	19690564
RFWD3_HUMAN	RFWD3	physical	19690564
RNF11_HUMAN	RNF11	physical	19690564
RN111_HUMAN	RNF111	physical	19690564
RNF13_HUMAN	RNF13	physical	19690564
GOLI_HUMAN	RNF130	physical	19690564
RN150_HUMAN	RNF150	physical	19690564
RN165_HUMAN	RNF165	physical	19690564
RN167_HUMAN	RNF167	physical	19690564
RNF25_HUMAN	RNF25	physical	19690564
RNF43_HUMAN	RNF43	physical	19690564
RNF4_HUMAN	RNF4	physical	19690564
TOPRS_HUMAN	TOPORS	physical	19690564
RN115_HUMAN	RNF115	physical	19690564
ZNRF1_HUMAN	ZNRF1	physical	19690564
ZNRF2_HUMAN	ZNRF2	physical	19690564
ZNRF4_HUMAN	ZNRF4	physical	19690564
XIAP_HUMAN	XIAP	physical	19549727
RN125_HUMAN	RNF125	physical	19549727
RN126_HUMAN	RNF126	physical	19549727
RNF37_HUMAN	UBOX5	physical	19549727
RNF5_HUMAN	RNF5	physical	19549727
DTX3_HUMAN	DTX3	physical	19549727
RNF14_HUMAN	RNF14	physical	19549727
ZNRF1_HUMAN	ZNRF1	physical	19549727
RN114_HUMAN	RNF114	physical	19549727
RNF11_HUMAN	RNF11	physical	19549727
TRIM8_HUMAN	TRIM8	physical	19549727
DTX3L_HUMAN	DTX3L	physical	19549727
DZIP3_HUMAN	DZIP3	physical	19549727
TRI18_HUMAN	MID1	physical	19549727
MKRN3_HUMAN	MKRN3	physical	19549727
TRI39_HUMAN	TRIM39	physical	19549727
TRI27_HUMAN	TRIM27	physical	19549727
RNF10_HUMAN	RNF10	physical	19549727
RN111_HUMAN	RNF111	physical	19549727
RN166_HUMAN	RNF166	physical	19549727
RN185_HUMAN	RNF185	physical	19549727
RING2_HUMAN	RNF2	physical	19549727
RNF25_HUMAN	RNF25	physical	19549727
TRI43_HUMAN	TRIM43	physical	19549727
TRAF6_HUMAN	TRAF6	physical	19549727
BIRC8_HUMAN	BIRC8	physical	19549727
BFAR_HUMAN	BFAR	physical	19549727
RNF4_HUMAN	RNF4	physical	19549727
TRAF7_HUMAN	TRAF7	physical	19549727
RING1_HUMAN	RING1	physical	19549727
RNF12_HUMAN	RLIM	physical	19549727
LRSM1_HUMAN	LRSAM1	physical	19549727
AMFR_HUMAN	AMFR	physical	19549727
SIAH1_HUMAN	SIAH1	physical	19549727
CHFR_HUMAN	CHFR	physical	19549727
ARI2_HUMAN	ARIH2	physical	19549727
MGRN1_HUMAN	MGRN1	physical	19549727
TRI55_HUMAN	TRIM55	physical	19549727
RFWD3_HUMAN	RFWD3	physical	19549727
RNF38_HUMAN	RNF38	physical	19549727
RBX2_HUMAN	RNF7	physical	19549727
TRI17_HUMAN	TRIM17	physical	19549727
TRIM2_HUMAN	TRIM2	physical	19549727
TRI25_HUMAN	TRIM25	physical	19549727
TRI26_HUMAN	TRIM26	physical	19549727
TRI31_HUMAN	TRIM31	physical	19549727
TRI35_HUMAN	TRIM35	physical	19549727
TRIM5_HUMAN	TRIM5	physical	19549727
MDM2_HUMAN	MDM2	physical	17301054
STA5A_MOUSE	Stat5a	physical	16569768
FOS_HUMAN	FOS	physical	8524278
TRIM1_HUMAN	MID2	physical	21143188
TRI10_HUMAN	TRIM10	physical	21143188
TRI11_HUMAN	TRIM11	physical	21143188
TRI18_HUMAN	MID1	physical	21143188
TRI27_HUMAN	TRIM27	physical	21143188
TRI50_HUMAN	TRIM50	physical	21143188
TRI37_HUMAN	TRIM37	physical	21143188
BRCA1_HUMAN	BRCA1	physical	16403807
HIF1A_HUMAN	HIF1A	physical	15611064
TF65_HUMAN	RELA	physical	14690596
TBL1X_HUMAN	TBL1X	physical	14980219
UB2D1_HUMAN	UBE2D1	physical	9362508
UB2D2_HUMAN	UBE2D2	physical	22939629
UFM1_HUMAN	UFM1	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
USP9X_HUMAN	USP9X	physical	22939629
UTRO_HUMAN	UTRN	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
UBE3C_HUMAN	UBE3C	physical	22939629
UBXN7_HUMAN	UBXN7	physical	22939629
UBP34_HUMAN	USP34	physical	22939629
ANCHR_HUMAN	ZFYVE19	physical	22939629
UBL7_HUMAN	UBL7	physical	22939629
UBE4B_HUMAN	UBE4B	physical	22939629
WDR4_HUMAN	WDR4	physical	22939629
UBE2B_HUMAN	UBE2B	physical	22939629
UBQL1_HUMAN	UBQLN1	physical	22939629
UNK_HUMAN	UNK	physical	22939629
UBR5_HUMAN	UBR5	physical	22939629
UPP1_HUMAN	UPP1	physical	22939629
YAP1_HUMAN	YAP1	physical	22939629
WDR1_HUMAN	WDR1	physical	22939629
NBN_HUMAN	NBN	physical	23115235
IKBA_HUMAN	NFKBIA	physical	9362451
SMUF2_HUMAN	SMURF2	physical	24709419
UBE3C_HUMAN	UBE3C	physical	11278995
UBR1_HUMAN	UBR1	physical	11278995
USP9X_HUMAN	USP9X	physical	11278995
CAND1_HUMAN	CAND1	physical	11278995
CAND2_HUMAN	CAND2	physical	11278995
UB2D1_HUMAN	UBE2D1	physical	20061386
RNF26_HUMAN	RNF26	physical	19549727
MKRN3_HUMAN	MKRN3	physical	25416956
RNF14_HUMAN	RNF14	physical	25416956
TRIM1_HUMAN	MID2	physical	25416956
MKRN2_HUMAN	MKRN2	physical	25416956
RN115_HUMAN	RNF115	physical	25416956
RN111_HUMAN	RNF111	physical	25416956
RN126_HUMAN	RNF126	physical	25416956
TRI39_HUMAN	TRIM39	physical	25416956
DTX2_HUMAN	DTX2	physical	25416956
UBE3A_HUMAN	UBE3A	physical	8576257
RSP5_YEAST	RSP5	physical	8576257
TRI25_HUMAN	TRIM25	physical	22350887
RN125_HUMAN	RNF125	physical	21571784
RN114_HUMAN	RNF114	physical	21571784
MDM2_HUMAN	MDM2	physical	15280377
UBE3A_HUMAN	UBE3A	physical	14517261
UBC_HUMAN	UBC	physical	21095585
MDM2_HUMAN	MDM2	physical	25624478
FA12_HUMAN	F12	physical	18838541
TF_HUMAN	F3	physical	27599717
RN114_HUMAN	RNF114	physical	28625874
NQO1_HUMAN	NQO1	physical	27733512
LRSM1_HUMAN	LRSAM1	physical	28335037
VIE1_HCMVM	UL123	physical	28750047

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UB2D1_HUMAN

Related Literatures of Post-Translational Modification