RNF37_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF37_HUMAN
• UniProt AC: O94941
• Protein Name: RING finger protein 37 {ECO:0000305}
• Gene Name: UBOX5 {ECO:0000312|HGNC:HGNC:17777}
• Organism: Homo sapiens (Human).
• Sequence Length: 541
• Subcellular Localization: Nucleus . Enriched in nuclear bodies.
• Protein Description: May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates..
• Protein Sequence: MVINLCLPQFRPRIHCNKISADGYEVENLISEDLTKRSHGFRTEYFIKPPVYVTVSFPFNVEICRINIDLTAGGGQNVTGLEMYTSASSSRVSWNTPQCRTLGPAEPSVPDKEAFTLVGKVLLKNQSQVVFSHRGFKARPPFGAMEATLPSPAVVAQELWNKGALSLSHVAHLRICITHVTGGGIPCIKRLEVWGQPAKTCSQEVIDSILLVTSENLPQDVALQAPALPMESDCDPGDQPESQQAPSSLQKLAEIIQDVPEEFLDPITLEIMPCPMLLPSGKVIDQSTLEKCNRSEATWGRVPSDPFTGVAFTPHSQPLPHPSLKARIDHFLLQHSIPGCHLLGRAQTALAVIPSSIVLPSQKRKIEQAEHVPDSNFGVNASCFSATSPLVLPTTSEHTAKKMKATNEPSLTHMDCSTGPLSHEQKLSQSLEIALASTLGSMPSFTARLTRGQLQHLGTRGSNTSWRPGTGSEQPGSILGPECASCKRVFSPYFKKEPVYQLPCGHLLCRPCLGEKQRSLPMTCTACQRPVASQDVLRVHF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	RIHCNKISADGYEVE CEECCEECCCCCEEH	23.16	-
24	Phosphorylation	NKISADGYEVENLIS CEECCCCCEEHHHHC	19.83	27174698
31	Phosphorylation	YEVENLISEDLTKRS CEEHHHHCCCHHHCC	28.37	27174698
35	Phosphorylation	NLISEDLTKRSHGFR HHHCCCHHHCCCCCC	36.41	27174698
36	Ubiquitination	LISEDLTKRSHGFRT HHCCCHHHCCCCCCC	60.23	22817900
38	Phosphorylation	SEDLTKRSHGFRTEY CCCHHHCCCCCCCEE	29.53	27174698
101	Phosphorylation	WNTPQCRTLGPAEPS CCCCCCCCCCCCCCC	43.63	22210691
280	Phosphorylation	PCPMLLPSGKVIDQS CCCCCCCCCCEECHH	51.74	24719451
291	Ubiquitination	IDQSTLEKCNRSEAT ECHHHHHHCCCCCCC	39.66	29967540
304	Phosphorylation	ATWGRVPSDPFTGVA CCCCCCCCCCCCCCE	55.87	-
363	Ubiquitination	SIVLPSQKRKIEQAE HHCCHHHHCCHHHCC	61.06	21906983
365	Ubiquitination	VLPSQKRKIEQAEHV CCHHHHCCHHHCCCC	58.59	22817900
385	Phosphorylation	GVNASCFSATSPLVL CCCCHHHCCCCCEEC	34.66	25627689
388	Phosphorylation	ASCFSATSPLVLPTT CHHHCCCCCEECCCC	18.89	25627689
437	Phosphorylation	SLEIALASTLGSMPS HHHHHHHHHHCCCCH	25.64	-
441	Phosphorylation	ALASTLGSMPSFTAR HHHHHHCCCCHHHHE	30.54	-
446	Phosphorylation	LGSMPSFTARLTRGQ HCCCCHHHHEECHHC	18.40	-
451	Methylation	SFTARLTRGQLQHLG HHHHEECHHCHHHCC	35.14	24129315
451	Asymmetric dimethylarginine	SFTARLTRGQLQHLG HHHHEECHHCHHHCC	35.14	-
491	Phosphorylation	ASCKRVFSPYFKKEP HCCCCCCCCCCCCCC	18.81	28555341
496	Ubiquitination	VFSPYFKKEPVYQLP CCCCCCCCCCEEECC	58.30	-
519	Phosphorylation	CLGEKQRSLPMTCTA CCCCCCCCCCCCCCC	34.04	27080861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RNF37_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF37_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF37_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UB2L3_HUMAN	UBE2L3	physical	11274149
RNF37_HUMAN	UBOX5	physical	11435423
UB2D3_HUMAN	UBE2D3	physical	11435423

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.