RN166_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN166_HUMAN
• UniProt AC: Q96A37
• Protein Name: RING finger protein 166
• Gene Name: RNF166
• Organism: Homo sapiens (Human).
• Sequence Length: 237
• Protein Sequence: MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLSEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	MFRSLVASAQQRQPP HHHHHHHHHHHHCCC	21.09	26471730
20	Ubiquitination	QRQPPAGPAGGDSGL HHCCCCCCCCCCCCH	29.82	32015554
48	Ubiquitination	HRPVAIGSCGHTFCG CCCEEECCCCCEECC	15.71	32015554
58 (in isoform 2)	Ubiquitination	-	5.76	21890473
58	Ubiquitination	HTFCGECLQPCLQVP CEECCHHHHHHCCCC	5.76	21890473
83	Ubiquitination	FDPKKVDKATHVEKQ CCHHHCCCCHHHHHH	59.16	23000965
86	Ubiquitination	KKVDKATHVEKQLSS HHCCCCHHHHHHHHC	30.51	21890473
89	Ubiquitination	DKATHVEKQLSSYKA CCCHHHHHHHHCCCC	56.29	23000965
95	Ubiquitination	EKQLSSYKAPCRGCN HHHHHCCCCCCCCCC	48.04	23000965
104	Acetylation	PCRGCNKKVTLAKMR CCCCCCCCCCHHHHH	26.85	7427419
115	Phosphorylation	AKMRVHISSCLKVQE HHHHHHHHHHHHHHH	10.50	27794612
116	Phosphorylation	KMRVHISSCLKVQEQ HHHHHHHHHHHHHHH	23.90	27794612
119	Acetylation	VHISSCLKVQEQMAN HHHHHHHHHHHHHHC	46.31	7427429
129	Ubiquitination	EQMANCPKFVPVVPT HHHHCCCCEEEECCC	62.28	32015554
137	Phosphorylation	FVPVVPTSQPIPSNI EEEECCCCCCCCCCC	28.08	-
167	Ubiquitination	LDQQELVKHCVESHR CCHHHHHHHHHHHCC	43.86	22817900
167 (in isoform 1)	Ubiquitination	-	43.86	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN166_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN166_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN166_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MKRN3_HUMAN	MKRN3	physical	22493164
TRIM9_HUMAN	TRIM9	physical	22493164
TRI39_HUMAN	TRIM39	physical	22493164
RNF41_HUMAN	RNF41	physical	22493164
CENPF_HUMAN	CENPF	physical	26186194
PARP1_HUMAN	PARP1	physical	26186194
DNLI1_HUMAN	LIG1	physical	26186194
HLTF_HUMAN	HLTF	physical	26186194
NUP98_HUMAN	NUP98	physical	26186194
TNKS2_HUMAN	TNKS2	physical	26186194
TNKS1_HUMAN	TNKS	physical	26186194
AMOL1_HUMAN	AMOTL1	physical	26186194
AMOT_HUMAN	AMOT	physical	26186194
ZO1_HUMAN	TJP1	physical	26186194
INADL_HUMAN	INADL	physical	26186194
MPDZ_HUMAN	MPDZ	physical	26186194
HERC2_HUMAN	HERC2	physical	26186194
ACY1_HUMAN	ACY1	physical	26186194
SSA27_HUMAN	SSSCA1	physical	26186194
XRCC1_HUMAN	XRCC1	physical	26186194
NUP58_HUMAN	NUPL1	physical	26186194
GMDS_HUMAN	GMDS	physical	26186194
CHD1L_HUMAN	CHD1L	physical	26186194
MERL_HUMAN	NF2	physical	26186194
KIF1A_HUMAN	KIF1A	physical	26186194
TFCP2_HUMAN	TFCP2	physical	26186194
NUP54_HUMAN	NUP54	physical	26186194
NUP53_HUMAN	NUP35	physical	26186194
NEUL4_HUMAN	NEURL4	physical	26186194
VPS11_HUMAN	VPS11	physical	26186194
HECD2_HUMAN	HECTD2	physical	26186194
TRAF3_HUMAN	TRAF3	physical	26456228
TRAF6_HUMAN	TRAF6	physical	26456228
MAVS_HUMAN	MAVS	physical	26456228
SQSTM_HUMAN	SQSTM1	physical	27880896
DNLI1_HUMAN	LIG1	physical	28514442
TNKS2_HUMAN	TNKS2	physical	28514442
TNKS1_HUMAN	TNKS	physical	28514442
MPDZ_HUMAN	MPDZ	physical	28514442
MERL_HUMAN	NF2	physical	28514442
KIF1A_HUMAN	KIF1A	physical	28514442
XRCC1_HUMAN	XRCC1	physical	28514442
HECD2_HUMAN	HECTD2	physical	28514442
ZO1_HUMAN	TJP1	physical	28514442
CHD1L_HUMAN	CHD1L	physical	28514442
INADL_HUMAN	INADL	physical	28514442
CENPF_HUMAN	CENPF	physical	28514442
HERC2_HUMAN	HERC2	physical	28514442
DNLI3_HUMAN	LIG3	physical	28514442
NUP58_HUMAN	NUPL1	physical	28514442
PARP1_HUMAN	PARP1	physical	28514442
AMOL1_HUMAN	AMOTL1	physical	28514442
AMOT_HUMAN	AMOT	physical	28514442
NUP54_HUMAN	NUP54	physical	28514442
RN114_HUMAN	RNF114	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.