INADL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INADL_HUMAN
• UniProt AC: Q8NI35
• Protein Name: InaD-like protein
• Gene Name: PATJ {ECO:0000303|PubMed:22006950, ECO:0000312|HGNC:HGNC:28881}
• Organism: Homo sapiens (Human).
• Sequence Length: 1801
• Subcellular Localization: Cell junction, tight junction . Apical cell membrane ; Peripheral membrane protein . Cytoplasm, perinuclear region . Cell membrane ; Peripheral membrane protein . Localized in the paranodal region of myelinating Schwann cells (By similarity). Membran
• Protein Description: Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries. [PubMed: 22006950]
• Protein Sequence: MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAWEMHEFLTPRLQEMDEEREILVDEEYELYQDPSPSMELYPLSHIQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTVYSQEAQPYGYCPENVMKENFVMESLPSVPSTEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDLPVVAQRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPTAEHHPEDTEEQLQMTAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	KLQEKGDTSQNEKLS HHHHHCCCCHHHHHH	40.66	24719451
30	Phosphorylation	LQEKGDTSQNEKLSM HHHHCCCCHHHHHHH	35.43	24719451
36	Phosphorylation	TSQNEKLSMFYETLK CCHHHHHHHHHHHHH	20.22	28122231
39	Phosphorylation	NEKLSMFYETLKSPL HHHHHHHHHHHHCHH	10.20	28122231
39 (in isoform 2)	Phosphorylation	-	10.20	27642862
41	Phosphorylation	KLSMFYETLKSPLFN HHHHHHHHHHCHHHH	28.27	24719451
44	Phosphorylation	MFYETLKSPLFNQIL HHHHHHHCHHHHHHH	29.92	28348404
52	Phosphorylation	PLFNQILTLQQSIKQ HHHHHHHHHHHHHHH	24.93	21060948
56	Phosphorylation	QILTLQQSIKQLKGQ HHHHHHHHHHHHHHH	20.84	21060948
69	Phosphorylation	GQLNHIPSDCSANFD HHHCCCCCCCCCCCC	51.12	28348404
111	Phosphorylation	VSGLFPWTPKLGNED CCCCCCCCCCCCCCC	15.70	28348404
209	Phosphorylation	AIALLQQTTGSLRLI HHHHHHHCCCCEEEE	21.84	28348404
210	Phosphorylation	IALLQQTTGSLRLIV HHHHHHCCCCEEEEE	22.04	28348404
212	Phosphorylation	LLQQTTGSLRLIVAR HHHHCCCCEEEEEEC	14.28	28348404
231	Phosphorylation	TKSSTSSSLNDTTLP CCCCCCCCCCCCCCC	30.84	22468782
333	Phosphorylation	RDPAGDISVTPPAPA ECCCCCCCCCCCCCC	25.36	29255136
335	Phosphorylation	PAGDISVTPPAPAAL CCCCCCCCCCCCCCC	19.43	29255136
348	Phosphorylation	ALPVALPTVASKGPG CCCCCCCCCCCCCCC	29.56	23312004
351	Phosphorylation	VALPTVASKGPGSDS CCCCCCCCCCCCCCC	33.53	23312004
356	Phosphorylation	VASKGPGSDSSLFET CCCCCCCCCCCHHEE	37.14	28348404
358	Phosphorylation	SKGPGSDSSLFETYN CCCCCCCCCHHEEEE	30.55	28348404
359	Phosphorylation	KGPGSDSSLFETYNV CCCCCCCCHHEEEEE	41.91	28348404
375	Phosphorylation	LVRKDGQSLGIRIVG EEECCCCEEEEEEEE	33.81	20873877
393	Phosphorylation	TSHTGEASGIYVKSI CCCCCCCCEEEEEEE	22.78	28152594
396	Phosphorylation	TGEASGIYVKSIIPG CCCCCEEEEEEECCC	12.83	28152594
454	Phosphorylation	LTLVRRKTSSSTSPL EEEEEECCCCCCCCC	31.84	30266825
455	Phosphorylation	TLVRRKTSSSTSPLE EEEEECCCCCCCCCC	25.90	30266825
456	Phosphorylation	LVRRKTSSSTSPLEP EEEECCCCCCCCCCC	42.75	30266825
457	Phosphorylation	VRRKTSSSTSPLEPP EEECCCCCCCCCCCC	32.44	30266825
458	Phosphorylation	RRKTSSSTSPLEPPS EECCCCCCCCCCCCC	35.99	30266825
459	Phosphorylation	RKTSSSTSPLEPPSD ECCCCCCCCCCCCCC	29.45	30266825
465	Phosphorylation	TSPLEPPSDRGTVVE CCCCCCCCCCCCCCC	51.13	28985074
504	Phosphorylation	EIKERIDTLKNDNIQ HHHHHHHHHHHCCHH	36.94	23312004
522	O-linked_Glycosylation	KLEKVPDSPENELKS HHCCCCCCHHHHHHH	28.22	30379171
522	Phosphorylation	KLEKVPDSPENELKS HHCCCCCCHHHHHHH	28.22	30266825
622	Phosphorylation	KSRREAVSFLKEVPP CCHHHHHHHHHHCCC	31.73	24719451
645	Phosphorylation	RLFDDEASVDEPRRT HHCCCCCCCCCCCCC	28.22	19664994
652	Phosphorylation	SVDEPRRTETSLPET CCCCCCCCCCCCCCC	44.91	28348404
654	Phosphorylation	DEPRRTETSLPETEV CCCCCCCCCCCCCCC	34.64	25159151
655	Phosphorylation	EPRRTETSLPETEVD CCCCCCCCCCCCCCC	35.38	25159151
659	Phosphorylation	TETSLPETEVDHNMD CCCCCCCCCCCCCCC	39.09	30266825
669	Phosphorylation	DHNMDVNTEEDDDGE CCCCCCCCCCCCCCC	40.37	30266825
681	Phosphorylation	DGELALWSPEVKIVE CCCEEEECCCEEEEE	16.42	30266825
699	Phosphorylation	DCKGLGFSILDYQDP CCCCCCCEEEECCCC	22.05	20068231
703	Phosphorylation	LGFSILDYQDPLDPT CCCEEEECCCCCCCC	16.03	-
728	Phosphorylation	ADGVAERSGGLLPGD HHCHHHHCCCCCCCC	28.81	24719451
739	Phosphorylation	LPGDRLVSVNEYCLD CCCCEEEECCHHCCC	24.66	24719451
748	Phosphorylation	NEYCLDNTSLAEAVE CHHCCCCCCHHHHHH	25.45	24719451
781	Phosphorylation	VEDNEEESCYILHSS CCCCCCCCEEEEECC	18.59	25627689
783	Phosphorylation	DNEEESCYILHSSSN CCCCCCEEEEECCCC	18.79	25159151
788	Phosphorylation	SCYILHSSSNEDKTE CEEEEECCCCCCCCE	26.83	25627689
805	Phosphorylation	GTIHDINSSLILEAP EEEEECCCCEEEECC	27.19	25627689
806	Phosphorylation	TIHDINSSLILEAPK EEEECCCCEEEECCC	18.23	25159151
820	Phosphorylation	KGFRDEPYFKEELVD CCCCCCCCCCHHHCC	25.82	25159151
820 (in isoform 2)	Phosphorylation	-	25.82	27642862
822	Ubiquitination	FRDEPYFKEELVDEP CCCCCCCCHHHCCCC	44.42	-
822 (in isoform 2)	Ubiquitination	-	44.42	-
836	Phosphorylation	PFLDLGKSFHSQQKE CCHHHHHHHHHHHHH	26.79	29449344
839	Phosphorylation	DLGKSFHSQQKEIEQ HHHHHHHHHHHHHHH	32.09	29449344
847	Phosphorylation	QQKEIEQSKEAWEMH HHHHHHHHHHHHHHH	21.48	27251275
858	Phosphorylation	WEMHEFLTPRLQEMD HHHHHHHHHHHHHCH	16.22	28985074
879	Phosphorylation	VDEEYELYQDPSPSM ECCCHHHHCCCCCCC	10.03	20736484
929	Phosphorylation	QEARTGRTVYSQEAQ CHHHCCCEEEECCCC	25.74	21945579
929 (in isoform 2)	Phosphorylation	-	25.74	27642862
931	Phosphorylation	ARTGRTVYSQEAQPY HHCCCEEEECCCCCC	12.20	21945579
932	Phosphorylation	RTGRTVYSQEAQPYG HCCCEEEECCCCCCC	19.74	21945579
932 (in isoform 2)	Phosphorylation	-	19.74	27642862
938	Phosphorylation	YSQEAQPYGYCPENV EECCCCCCCCCCHHH	14.51	21945579
938 (in isoform 2)	Phosphorylation	-	14.51	27642862
940	Phosphorylation	QEAQPYGYCPENVMK CCCCCCCCCCHHHHH	10.05	21945579
940 (in isoform 2)	Phosphorylation	-	10.05	27642862
954	Phosphorylation	KENFVMESLPSVPST HHCCCEECCCCCCCC	27.73	24275569
957	Phosphorylation	FVMESLPSVPSTEGN CCEECCCCCCCCCCC	52.53	28348404
960	Phosphorylation	ESLPSVPSTEGNSQQ ECCCCCCCCCCCCCC	36.61	28348404
978	Phosphorylation	DDLENLNSLAKTSLD CCHHHHHHHHHHHCC	32.63	28857561
982	Phosphorylation	NLNSLAKTSLDLGMI HHHHHHHHHCCCCCC	28.99	28348404
983	Phosphorylation	LNSLAKTSLDLGMIP HHHHHHHHCCCCCCC	21.12	28348404
1017	Phosphorylation	EQEDLPLYQHQATRV CCCCCCCHHHHHHHH	11.29	21945579
1017 (in isoform 2)	Phosphorylation	-	11.29	27642862
1022	Phosphorylation	PLYQHQATRVISKAS CCHHHHHHHHHHHHH	20.92	24719451
1026	Phosphorylation	HQATRVISKASAYTG HHHHHHHHHHHHHHC	21.22	28188228
1027	Methylation	QATRVISKASAYTGM HHHHHHHHHHHHHCC	34.92	72630007
1027	Ubiquitination	QATRVISKASAYTGM HHHHHHHHHHHHHCC	34.92	-
1029	Phosphorylation	TRVISKASAYTGMLS HHHHHHHHHHHCCCC	26.08	28188228
1031	Phosphorylation	VISKASAYTGMLSSR HHHHHHHHHCCCCCC	11.00	21945579
1031 (in isoform 2)	Phosphorylation	-	11.00	27642862
1032	Phosphorylation	ISKASAYTGMLSSRY HHHHHHHHCCCCCCC	18.81	21945579
1039	Phosphorylation	TGMLSSRYATDTCEL HCCCCCCCCCCCCCC	18.79	-
1078	Phosphorylation	IFREPNVSLGISIVG EECCCCCEEEEEEEC	27.76	-
1088	Phosphorylation	ISIVGGQTVIKRLKN EEEECCHHHHHHCCC	27.72	-
1111	Phosphorylation	IKQVLEDSPAGKTNA EEHHHCCCCCCCCCC	13.79	25159151
1160	Phosphorylation	VFIVQSLSSTPRVIP EEEEECCCCCCCCCC	37.10	28348404
1161	Phosphorylation	FIVQSLSSTPRVIPN EEEECCCCCCCCCCC	47.96	28348404
1162	Phosphorylation	IVQSLSSTPRVIPNV EEECCCCCCCCCCCC	16.25	27050516
1177	Phosphorylation	HNKANKITGNQNQDT CCCHHHCCCCCCHHH	31.52	28985074
1206	Acetylation	MKLPPPYKALTDDSD CCCCCCCCCCCCCCC	42.57	26051181
1209	Phosphorylation	PPPYKALTDDSDENE CCCCCCCCCCCCCCH	42.49	25159151
1212	Phosphorylation	YKALTDDSDENEEED CCCCCCCCCCCHHHC	50.03	25159151
1222	Phosphorylation	NEEEDAFTDQKIRQR CHHHCCCCHHHHHHH	38.96	24732914
1225	Ubiquitination	EDAFTDQKIRQRYAD HCCCCHHHHHHHHHC	42.54	-
1225 (in isoform 2)	Ubiquitination	-	42.54	-
1252	Phosphorylation	DKNGLGLSLAGNKDR CCCCCCCCCCCCCCC	17.86	21406692
1299	Phosphorylation	NQILYGRSHQNASAI CEEEECCCCCCCCHH	25.68	29691806
1304	Phosphorylation	GRSHQNASAIIKTAP CCCCCCCCHHEECCC	27.79	29691806
1359	Phosphorylation	ISSEEDGSVEVGIKQ CCCCCCCCEEEEEEE	27.68	25332170
1370	Phosphorylation	GIKQLPESESFKLAV EEEECCCCHHHHHHH	36.28	28348404
1372	Phosphorylation	KQLPESESFKLAVSQ EECCCCHHHHHHHHH	36.64	21815630
1457 (in isoform 4)	Phosphorylation	-	32.91	22210691
1468 (in isoform 4)	Phosphorylation	-	12.79	22210691
1469 (in isoform 4)	Phosphorylation	-	55.95	22210691
1496	Phosphorylation	NGVDLRNSSHEEAIT CCEECCCCCHHHHHH	27.00	23312004
1497	Phosphorylation	GVDLRNSSHEEAITA CEECCCCCHHHHHHH	38.17	23312004
1498 (in isoform 2)	Phosphorylation	-	36.42	27642862
1503	Phosphorylation	SSHEEAITALRQTPQ CCHHHHHHHHHCCCC	27.04	30266825
1508	Phosphorylation	AITALRQTPQKVRLV HHHHHHCCCCEEEEE	22.66	30266825
1542	Methylation	DLQKKAGRGLGLSIV CHHHHCCCCCCCEEE	41.86	115480339
1555	Phosphorylation	IVGKRNGSGVFISDI EEEECCCCCEEEHHH	35.02	28857561
1560	Phosphorylation	NGSGVFISDIVKGGA CCCCEEEHHHHCCCC	15.15	-
1592	Phosphorylation	GEDMRNASQETVATI HHHHCCCCHHHHHHH	31.90	27050516
1595	Phosphorylation	MRNASQETVATILKC HCCCCHHHHHHHHHH	14.06	23312004
1618	Phosphorylation	IGRLRAGSWTSARTT ECCCCCCCEEECCCC	26.62	26657352
1620	Phosphorylation	RLRAGSWTSARTTSQ CCCCCCEEECCCCCC	17.76	28102081
1621	Phosphorylation	LRAGSWTSARTTSQN CCCCCEEECCCCCCC	14.97	28102081
1661	Phosphorylation	LVGTKRVSDPSQKNS HHCCCCCCCHHHCCC	48.08	28985074
1664	Phosphorylation	TKRVSDPSQKNSGTD CCCCCCHHHCCCCCC	59.79	28176443
1668	Phosphorylation	SDPSQKNSGTDMEPR CCHHHCCCCCCCCCC	50.54	21712546
1684	Phosphorylation	VEINRELSDALGISI CCCCHHHHHHHCCEE	18.98	21082442
1697	Phosphorylation	SIAGGRGSPLGDIPV EECCCCCCCCCCHHH	18.65	28348404
1739	Phosphorylation	GQPLDGLSHADVVNL CEECCCCCHHHHHHH	23.35	28842319

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INADL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INADL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INADL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PARD3_HUMAN	PARD3	physical	17235357

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522; SER-645; THR-1209AND SER-1212, AND MASS SPECTROMETRY.
PubMed: 18669648

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522, AND MASSSPECTROMETRY.
PubMed: 19007248