ACY1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACY1_HUMAN
• UniProt AC: Q03154
• Protein Name: Aminoacylase-1
• Gene Name: ACY1
• Organism: Homo sapiens (Human).
• Sequence Length: 408
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate)..
• Protein Sequence: MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSKGPEEE ------CCCCCCCCC	38.86	28857561
3	Phosphorylation	-----MTSKGPEEEH -----CCCCCCCCCC	34.03	28857561
4	Ubiquitination	----MTSKGPEEEHP ----CCCCCCCCCCC	70.13	-
28	Ubiquitination	RIRTVQPKPDYGAAV EEEECCCCCCCCCHH	33.17	-
100	Ubiquitination	HDPFEAFKDSEGYIY CCHHHHHCCCCCCEE	68.35	-
107	Phosphorylation	KDSEGYIYARGAQDM CCCCCCEEEECCCCC	5.03	28674419
115	Ubiquitination	ARGAQDMKCVSIQYL EECCCCCEEEEHHHH	39.51	-
129	Ubiquitination	LEAVRRLKVEGHRFP HHHHHHHCCCCCCCC	36.11	-
201	Phosphorylation	WWVRVTSTGRPGHAS CEEEEECCCCCCCHH	28.04	24425749
218	Ubiquitination	MEDTAAEKLHKVVNS CHHHHHHHHHHHHHH	51.68	-
221	Ubiquitination	TAAEKLHKVVNSILA HHHHHHHHHHHHHHH	59.31	-
225	Phosphorylation	KLHKVVNSILAFREK HHHHHHHHHHHHHHH	13.84	28857561
239	Phosphorylation	KEWQRLQSNPHLKEG HHHHHHHCCCCCCCC	57.85	28857561
244	Ubiquitination	LQSNPHLKEGSVTSV HHCCCCCCCCCEEEE	57.93	2190698
292	Phosphorylation	AFEEQLQSWCQAAGE HHHHHHHHHHHHHCC	38.11	28258704
320	Phosphorylation	QVTPTDDSNPWWAAF CCCCCCCCCHHHHHH	47.83	28857561
332	Ubiquitination	AAFSRVCKDMNLTLE HHHHHHHHHCCCCCC	58.09	-
334	Ubiquitination	FSRVCKDMNLTLEPE HHHHHHHCCCCCCCC	2.43	21906983
337	Phosphorylation	VCKDMNLTLEPEIMP HHHHCCCCCCCCCCC	24.87	20068231
347	Phosphorylation	PEIMPAATDNRYIRA CCCCCCCCCCCEEEE	35.59	20068231
363	Phosphorylation	GVPALGFSPMNRTPV CCCCCCCCCCCCCCE	22.80	28674419
368	Phosphorylation	GFSPMNRTPVLLHDH CCCCCCCCCEECCCC	16.85	26853621
386	Methylation	LHEAVFLRGVDIYTR HHHHHHHCCHHHHHH	31.46	-
406	Phosphorylation	ASVPALPSDS----- HCCCCCCCCC-----	51.87	28857561
408	Phosphorylation	VPALPSDS------- CCCCCCCC-------	46.59	73401223

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACY1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACY1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACY1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTC1_HUMAN	TTC1	physical	16189514
ACY1_HUMAN	ACY1	physical	16189514
A4_HUMAN	APP	physical	21832049
NPM_HUMAN	NPM1	physical	21988832
8ODP_HUMAN	NUDT1	physical	25416956
BPNT1_HUMAN	BPNT1	physical	26344197
ACY1_HUMAN	ACY1	physical	21516116
TRI33_HUMAN	TRIM33	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 609924: Aminoacylase-1 deficiency (ACY1D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB06151: Acetylcysteine
• DB00128: L-Aspartic Acid