RNF41_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF41_HUMAN
• UniProt AC: Q9H4P4
• Protein Name: E3 ubiquitin-protein ligase NRDP1
• Gene Name: RNF41
• Organism: Homo sapiens (Human).
• Sequence Length: 317
• Protein Description: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. [PubMed: 24949970]
• Protein Sequence: MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	Ubiquitination	LDNLMSHLSDCEHNP HHHHHHHHHCCCCCC	3.47	21890473
106	S-nitrosylation	LMSHLSDCEHNPKRP HHHHHHCCCCCCCCC	5.28	24105792
134	S-nitrosylation	DELPNHNCIKHLRSV CCCCCCHHHHHHHHH	3.22	24105792
136	Ubiquitination	LPNHNCIKHLRSVVQ CCCCHHHHHHHHHHH	38.49	-
154	Ubiquitination	TRIAELEKTSAEHKH HHHHHHHHHHHHHHH	61.48	-
167	Acetylation	KHQLAEQKRDIQLLK HHHHHHHHHHHHHHH	43.47	30591977
167	Ubiquitination	KHQLAEQKRDIQLLK HHHHHHHHHHHHHHH	43.47	-
174	Ubiquitination	KRDIQLLKAYMRAIR HHHHHHHHHHHHHHH	46.17	21890473
238	S-nitrosylation	RSLVESGCPASIVNE HHHHHCCCCHHHHHH	3.37	24105792
254	Phosphorylation	IENAHERSWPQGLAT HHHHHHCCCCCHHHH	39.87	-
264	Phosphorylation	QGLATLETRQMNRRY CHHHHHHHHHHHHHH	29.34	24850871

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
254	S	Phosphorylation	Kinase	MARK2	Q7KZI7	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	RNF41	Q9H4P4	PMID:15314180

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF41_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF41_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP8_HUMAN	USP8	physical	15314180
BIRC6_HUMAN	BIRC6	physical	15314180
ERBB3_HUMAN	ERBB3	physical	11867753
ERBB4_HUMAN	ERBB4	physical	11867753
PRKN_HUMAN	PARK2	physical	18541373
ERBB3_HUMAN	ERBB3	physical	12411582
PRKN_HUMAN	PARK2	physical	15632191
ERBB3_HUMAN	ERBB3	physical	21576364
BIRC6_HUMAN	BIRC6	physical	14765125
ERBB3_HUMAN	ERBB3	physical	17384230
LEPR_HUMAN	LEPR	physical	21378310
UB2D3_HUMAN	UBE2D3	physical	18541373
UB2D3_HUMAN	UBE2D3	physical	14765125
A4_HUMAN	APP	physical	21832049
RNF41_HUMAN	RNF41	physical	22493164
MARK2_HUMAN	MARK2	physical	24259665
RNF41_HUMAN	RNF41	physical	25416956
AR6P4_HUMAN	ARL6IP4	physical	25416956
CA109_HUMAN	C1orf109	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
ISCA2_HUMAN	ISCA2	physical	25416956
ASB6_HUMAN	ASB6	physical	25416956
RFC4_HUMAN	RFC4	physical	21516116
KIFC3_HUMAN	KIFC3	physical	26496610
NPAT_HUMAN	NPAT	physical	26496610
P4HA1_HUMAN	P4HA1	physical	26496610
SF01_HUMAN	SF1	physical	26496610
EVI5_HUMAN	EVI5	physical	26496610
LGAT1_HUMAN	LPGAT1	physical	26496610
N4BP3_HUMAN	N4BP3	physical	26496610
MTCL1_HUMAN	MTCL1	physical	26496610
CL16A_HUMAN	CLEC16A	physical	26496610
CLAP1_HUMAN	CLASP1	physical	26496610
C1GLC_HUMAN	C1GALT1C1	physical	26496610
ITSN2_HUMAN	ITSN2	physical	26496610
RAIN_HUMAN	RASIP1	physical	26496610
RFWD3_HUMAN	RFWD3	physical	26496610
REN3A_HUMAN	UPF3A	physical	26496610
NAV1_HUMAN	NAV1	physical	26496610
SOGA1_HUMAN	SOGA1	physical	26496610
ZAP70_HUMAN	ZAP70	physical	26390156
UBS3B_HUMAN	UBASH3B	physical	26390156
UBS3A_HUMAN	UBASH3A	physical	26390156
CD3Z_HUMAN	CD247	physical	26390156
VE2_HPV16	E2	physical	26963794
VANG1_HUMAN	VANGL1	physical	27648936
DVL2_HUMAN	DVL2	physical	27648936
ERBB4_HUMAN	ERBB4	physical	27648936
IRS4_HUMAN	IRS4	physical	28973533
UBP8_HUMAN	USP8	physical	28973533
VPS52_HUMAN	VPS52	physical	28973533
VPS52_HUMAN	VPS52	physical	28542518
KDM3B_HUMAN	KDM3B	physical	28542518
HOME2_HUMAN	HOMER2	physical	28542518
ASB6_HUMAN	ASB6	physical	28542518
RNF41_HUMAN	RNF41	physical	28542518
RTN4_HUMAN	RTN4	physical	27353365

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.