VPS52_HUMAN - dbPTM
VPS52_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS52_HUMAN
UniProt AC Q8N1B4
Protein Name Vacuolar protein sorting-associated protein 52 homolog
Gene Name VPS52
Organism Homo sapiens (Human).
Sequence Length 723
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein. Endosome membrane
Peripheral membrane protein. Recycling endosome . Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endos
Protein Description Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. [PubMed: 15878329]
Protein Sequence MAAAATMAAAARELVLRAGTSDMEEEEGPLAGGPGLQEPLQLGELDITSDEFILDEVDVHIQANLEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDYIQESENIASLHNQITACDAVLERMEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAKAAAVREQEARGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQTALLKYRFFYQFLLGNERATAKEIRDEYVETLSKIYLSYYRSYLGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKPSLRSRNTIFTLGTRGSVISPTELEAPILVPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFVVSGPAAHDLFHAVMGRTLSMTLKHLDSYLADCYDAIAVFLCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSINQTIPNERTMQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEFIEELLSPPFGGLVAFVKEAEALIERGQAERLRGEEARVTQLIRGFGSSWKSSVESLSQDVMRSFTNFRNGTSIIQGALTQLIQLYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHKPNF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAAATMAA
------CHHHHHHHH		13.0522223895
6Phosphorylation--MAAAATMAAAARE
--CHHHHHHHHHHHH		11.5623684312
7Sulfoxidation-MAAAATMAAAAREL
-CHHHHHHHHHHHHH		1.7328465586
80UbiquitinationALKTGVDLRHYSKQV
HHHHCCCHHHHHHHH		3.19-
80UbiquitinationALKTGVDLRHYSKQV
HHHHCCCHHHHHHHH		3.19-
85UbiquitinationVDLRHYSKQVELELQ
CCHHHHHHHHHHHHH		51.72-
97UbiquitinationELQQIEQKSIRDYIQ
HHHHHHHHHHHHHHH		34.7521906983
126UbiquitinationCDAVLERMEQMLGAF
HHHHHHHHHHHHHHH		2.83-
131PhosphorylationERMEQMLGAFQSDLS
HHHHHHHHHHHHHHH		21.00-
151PhosphorylationIRTLQEQSGAMNIRL
HHHHHHHHCCCCHHH		27.97-
154SulfoxidationLQEQSGAMNIRLRNR
HHHHHCCCCHHHHCH		4.9621406390
193UbiquitinationLEAPVTEPRFLEQLQ
HHCCCCCHHHHHHHH		23.98-
205UbiquitinationQLQELDAKAAAVREQ
HHHHHHHHHHHHHHH		37.92-
205UbiquitinationQLQELDAKAAAVREQ
HHHHHHHHHHHHHHH		37.9221906983
212PhosphorylationKAAAVREQEARGTAA
HHHHHHHHHHHCCHH		38.80-
230PhosphorylationVRGVLDRLRVKAVTK
HHHHHHHHHHHHHHH		8.03-
254PhosphorylationYSFRKPMTNYQIPQT
HHCCCCCCCCCCCHH		39.0229507054
256PhosphorylationFRKPMTNYQIPQTAL
CCCCCCCCCCCHHHH		9.9218491316
261PhosphorylationTNYQIPQTALLKYRF
CCCCCCHHHHHHHHH		17.5829507054
296PhosphorylationVETLSKIYLSYYRSY
HHHHHHHHHHHHHHH		8.04-
300PhosphorylationSKIYLSYYRSYLGRL
HHHHHHHHHHHHHHH		6.95-
303PhosphorylationYLSYYRSYLGRLMKV
HHHHHHHHHHHHHCC		12.27-
312PhosphorylationGRLMKVQYEEVAEKD
HHHHCCCHHHHHHHC		19.62-
330UbiquitinationGVEDTAKKGFFSKPS
CCCCHHHCCCCCCCC		59.49-
337PhosphorylationKGFFSKPSLRSRNTI
CCCCCCCCCCCCCEE		39.9023186163
343PhosphorylationPSLRSRNTIFTLGTR
CCCCCCCEEEEECCC		19.1628857561
352PhosphorylationFTLGTRGSVISPTEL
EEECCCCCCCCCCCC		17.0030266825
355PhosphorylationGTRGSVISPTELEAP
CCCCCCCCCCCCCCC		24.5030266825
357PhosphorylationRGSVISPTELEAPIL
CCCCCCCCCCCCCEE		46.5430266825
368PhosphorylationAPILVPHTAQRGEQR
CCEECCCCCCCCCCC		20.5827080861
459UbiquitinationRFRNIAAKRDVPALD
HHHHHHHCCCCHHHH		39.86-
459UbiquitinationRFRNIAAKRDVPALD
HHHHHHHCCCCHHHH		39.86-
490PhosphorylationILEMNVQSVRSTDPQ
HHHHCHHHHHCCCHH		18.4024719451
493PhosphorylationMNVQSVRSTDPQRLG
HCHHHHHCCCHHHCC		34.7024719451
504PhosphorylationQRLGGLDTRPHYITR
HHCCCCCCCCHHHHH		51.6624719451
525UbiquitinationSALVSINQTIPNERT
HHHHHHHCCCCCHHH		38.85-
555PhosphorylationLRVAAEFSSRKEQLV
HHHHHHHHCCHHHEE		22.2724275569
584UbiquitinationERAADDSKEVESFQQ
HHHCCCHHHHHHHHH		73.1621906983
650UbiquitinationRGFGSSWKSSVESLS
HHCCHHHHHHHHHHC		34.50-
652PhosphorylationFGSSWKSSVESLSQD
CCHHHHHHHHHHCHH		26.61-
655PhosphorylationSWKSSVESLSQDVMR
HHHHHHHHHCHHHHH		31.03-
657PhosphorylationKSSVESLSQDVMRSF
HHHHHHHCHHHHHHH		33.3527050516
661SulfoxidationESLSQDVMRSFTNFR
HHHCHHHHHHHCCCC		3.9021406390
693PhosphorylationHRFHRVLSQPQLRAL
HHHHHHHCCHHHHHC		36.6427499020
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS52_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS52_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS52_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS53_HUMANVPS53physical
20685960
VPS52_HUMANVPS52physical
20685960
VPS51_HUMANVPS51physical
20685960
VPS54_HUMANVPS54physical
20685960
VRK1_HUMANVRK1physical
22939629
TEAD4_HUMANTEAD4physical
25416956
TPM3_HUMANTPM3physical
25416956
TRAF6_HUMANTRAF6physical
25416956
LMO4_HUMANLMO4physical
25416956
STX11_HUMANSTX11physical
25416956
UBP2_HUMANUSP2physical
25416956
FL2D_HUMANWTAPphysical
25416956
EPMIP_HUMANEPM2AIP1physical
25416956
RNF41_HUMANRNF41physical
25416956
THIOM_HUMANTXN2physical
25416956
KANK2_HUMANKANK2physical
25416956
VPS28_HUMANVPS28physical
25416956
VATD_HUMANATP6V1Dphysical
25416956
MET13_HUMANMETTL13physical
25416956
CA109_HUMANC1orf109physical
25416956
HEAT1_HUMANHEATR1physical
25416956
TB22B_HUMANTBC1D22Bphysical
25416956
SKT_HUMANKIAA1217physical
25416956
THA11_HUMANTHAP11physical
25416956
CC146_HUMANCCDC146physical
25416956
SH24A_HUMANSH2D4Aphysical
25416956
RM11_HUMANMRPL11physical
25416956
F184A_HUMANFAM184Aphysical
25416956
CCD33_HUMANCCDC33physical
25416956
TSSK3_HUMANTSSK3physical
25416956
RRF2M_HUMANGFM2physical
25416956
HAUS1_HUMANHAUS1physical
25416956
KLC3_HUMANKLC3physical
25416956
ZMAT2_HUMANZMAT2physical
25416956
TSTD2_HUMANTSTD2physical
25416956
TEANC_HUMANTCEANCphysical
25416956
PPR18_HUMANPPP1R18physical
25416956
TXLNA_HUMANTXLNAphysical
25416956
RABE2_HUMANRABEP2physical
21516116
FL2D_HUMANWTAPphysical
21516116
RNF41_HUMANRNF41physical
28542518
VPS53_HUMANVPS53physical
28542518
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS52_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory