THA11_HUMAN - dbPTM
THA11_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THA11_HUMAN
UniProt AC Q96EK4
Protein Name THAP domain-containing protein 11
Gene Name THAP11
Organism Homo sapiens (Human).
Sequence Length 314
Subcellular Localization Nucleus . Cytoplasm. May be regulated by shuttling of the protein between the cytoplasm and nucleus..
Protein Description Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity)..
Protein Sequence MPGFTCCVPGCYNNSHRDKALHFYTFPKDAELRRLWLKNVSRAGVSGCFSTFQPTTGHRLCSVHFQGGRKTYTVRVPTIFPLRGVNERKVARRPAGAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQPNLVSASAAVLLTLQATVDSSQAPGSVQPAPITPTGEDVKPIDLTVQVEFAAAEGAAAAAAASELQAATAGLEAAECPMGPQLVVVGEEGFPDTGSDHSYSLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHLRLTEAKLREELREKDRLLAMAVIRKKHGM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationVPGCYNNSHRDKALH
CCCCCCCCCCCCEEE
19.0927251789
19UbiquitinationYNNSHRDKALHFYTF
CCCCCCCCEEEEEEC
53.4522505724
24PhosphorylationRDKALHFYTFPKDAE
CCCEEEEEECCCCHH
9.2029496907
25PhosphorylationDKALHFYTFPKDAEL
CCEEEEEECCCCHHH
32.3020068231
28UbiquitinationLHFYTFPKDAELRRL
EEEEECCCCHHHHHH
66.4429967540
38UbiquitinationELRRLWLKNVSRAGV
HHHHHHHHCCHHHCC
43.6622817900
42MethylationLWLKNVSRAGVSGCF
HHHHCCHHHCCCCHH
30.95115918405
62PhosphorylationTTGHRLCSVHFQGGR
CCCCEEEEEEEECCC
24.1827080861
78PhosphorylationTYTVRVPTIFPLRGV
EEEEECCEEEECCCC
32.18-
83MethylationVPTIFPLRGVNERKV
CCEEEECCCCCHHHH
47.4554559953
163O-linked_GlycosylationVLLTLQATVDSSQAP
HHHHHHHCCCCCCCC
16.3429351928
274UbiquitinationILALMEVKMKEMKGS
HHHHHHHHHHHCCCC
30.8329967540
276UbiquitinationALMEVKMKEMKGSIR
HHHHHHHHHCCCCHH
49.27-
281PhosphorylationKMKEMKGSIRHLRLT
HHHHCCCCHHHHHHC
15.7820068231
291UbiquitinationHLRLTEAKLREELRE
HHHHCHHHHHHHHHH
41.6729967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THA11_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THA11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THA11_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
THA11_HUMANTHAP11physical
18585351
SIN3A_HUMANSIN3Aphysical
18585351
HDAC1_HUMANHDAC1physical
18585351
HCFC1_HUMANHCFC1physical
18585351
HCFC1_HUMANHCFC1physical
22371484
TPX2_HUMANTPX2physical
21988832
CI016_HUMANC9orf16physical
18330356
LRC45_HUMANLRRC45physical
18330356
PFD6_HUMANPFDN6physical
18330356
PRS8_HUMANPSMC5physical
18330356
ACTA_HUMANACTA2physical
26186194
OGT1_HUMANOGTphysical
26186194
HCFC1_HUMANHCFC1physical
26186194
HCFC1_HUMANHCFC1physical
28514442
OGT1_HUMANOGTphysical
28514442
PKN3_HUMANPKN3physical
27173435
NCK5L_HUMANNCKAP5Lphysical
27173435
TFPT_HUMANTFPTphysical
27173435
YETS4_HUMANYEATS4physical
27173435
TUFT1_HUMANTUFT1physical
27173435
GOGA5_HUMANGOLGA5physical
27173435
CLOCK_HUMANCLOCKphysical
27173435
PSMD9_HUMANPSMD9physical
27173435
VPS53_HUMANVPS53physical
27173435
DZIP3_HUMANDZIP3physical
27173435
GRAP1_HUMANGRIPAP1physical
27173435
RCOR1_HUMANRCOR1physical
27173435
VPS50_HUMANCCDC132physical
27173435
CCD93_HUMANCCDC93physical
27173435
PF21A_HUMANPHF21Aphysical
27173435
CAVN1_HUMANPTRFphysical
27173435
HAUS6_HUMANHAUS6physical
27173435
RPR1A_HUMANRPRD1Aphysical
27173435
BMAL1_HUMANARNTLphysical
27173435
RABX5_HUMANRABGEF1physical
27173435

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THA11_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-25, AND MASSSPECTROMETRY.

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