UniProt ID | THA11_HUMAN | |
---|---|---|
UniProt AC | Q96EK4 | |
Protein Name | THAP domain-containing protein 11 | |
Gene Name | THAP11 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 314 | |
Subcellular Localization | Nucleus . Cytoplasm. May be regulated by shuttling of the protein between the cytoplasm and nucleus.. | |
Protein Description | Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).. | |
Protein Sequence | MPGFTCCVPGCYNNSHRDKALHFYTFPKDAELRRLWLKNVSRAGVSGCFSTFQPTTGHRLCSVHFQGGRKTYTVRVPTIFPLRGVNERKVARRPAGAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQPNLVSASAAVLLTLQATVDSSQAPGSVQPAPITPTGEDVKPIDLTVQVEFAAAEGAAAAAAASELQAATAGLEAAECPMGPQLVVVGEEGFPDTGSDHSYSLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHLRLTEAKLREELREKDRLLAMAVIRKKHGM | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
15 | Phosphorylation | VPGCYNNSHRDKALH CCCCCCCCCCCCEEE | 19.09 | 27251789 | |
19 | Ubiquitination | YNNSHRDKALHFYTF CCCCCCCCEEEEEEC | 53.45 | 22505724 | |
24 | Phosphorylation | RDKALHFYTFPKDAE CCCEEEEEECCCCHH | 9.20 | 29496907 | |
25 | Phosphorylation | DKALHFYTFPKDAEL CCEEEEEECCCCHHH | 32.30 | 20068231 | |
28 | Ubiquitination | LHFYTFPKDAELRRL EEEEECCCCHHHHHH | 66.44 | 29967540 | |
38 | Ubiquitination | ELRRLWLKNVSRAGV HHHHHHHHCCHHHCC | 43.66 | 22817900 | |
42 | Methylation | LWLKNVSRAGVSGCF HHHHCCHHHCCCCHH | 30.95 | 115918405 | |
62 | Phosphorylation | TTGHRLCSVHFQGGR CCCCEEEEEEEECCC | 24.18 | 27080861 | |
78 | Phosphorylation | TYTVRVPTIFPLRGV EEEEECCEEEECCCC | 32.18 | - | |
83 | Methylation | VPTIFPLRGVNERKV CCEEEECCCCCHHHH | 47.45 | 54559953 | |
163 | O-linked_Glycosylation | VLLTLQATVDSSQAP HHHHHHHCCCCCCCC | 16.34 | 29351928 | |
274 | Ubiquitination | ILALMEVKMKEMKGS HHHHHHHHHHHCCCC | 30.83 | 29967540 | |
276 | Ubiquitination | ALMEVKMKEMKGSIR HHHHHHHHHCCCCHH | 49.27 | - | |
281 | Phosphorylation | KMKEMKGSIRHLRLT HHHHCCCCHHHHHHC | 15.78 | 20068231 | |
291 | Ubiquitination | HLRLTEAKLREELRE HHHHCHHHHHHHHHH | 41.67 | 29967540 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of THA11_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of THA11_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of THA11_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-25, AND MASSSPECTROMETRY. |