| UniProt ID | THA11_HUMAN | |
|---|---|---|
| UniProt AC | Q96EK4 | |
| Protein Name | THAP domain-containing protein 11 | |
| Gene Name | THAP11 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 314 | |
| Subcellular Localization | Nucleus . Cytoplasm. May be regulated by shuttling of the protein between the cytoplasm and nucleus.. | |
| Protein Description | Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).. | |
| Protein Sequence | MPGFTCCVPGCYNNSHRDKALHFYTFPKDAELRRLWLKNVSRAGVSGCFSTFQPTTGHRLCSVHFQGGRKTYTVRVPTIFPLRGVNERKVARRPAGAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQPNLVSASAAVLLTLQATVDSSQAPGSVQPAPITPTGEDVKPIDLTVQVEFAAAEGAAAAAAASELQAATAGLEAAECPMGPQLVVVGEEGFPDTGSDHSYSLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHLRLTEAKLREELREKDRLLAMAVIRKKHGM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | VPGCYNNSHRDKALH CCCCCCCCCCCCEEE | 19.09 | 27251789 | |
| 19 | Ubiquitination | YNNSHRDKALHFYTF CCCCCCCCEEEEEEC | 53.45 | 22505724 | |
| 24 | Phosphorylation | RDKALHFYTFPKDAE CCCEEEEEECCCCHH | 9.20 | 29496907 | |
| 25 | Phosphorylation | DKALHFYTFPKDAEL CCEEEEEECCCCHHH | 32.30 | 20068231 | |
| 28 | Ubiquitination | LHFYTFPKDAELRRL EEEEECCCCHHHHHH | 66.44 | 29967540 | |
| 38 | Ubiquitination | ELRRLWLKNVSRAGV HHHHHHHHCCHHHCC | 43.66 | 22817900 | |
| 42 | Methylation | LWLKNVSRAGVSGCF HHHHCCHHHCCCCHH | 30.95 | 115918405 | |
| 62 | Phosphorylation | TTGHRLCSVHFQGGR CCCCEEEEEEEECCC | 24.18 | 27080861 | |
| 78 | Phosphorylation | TYTVRVPTIFPLRGV EEEEECCEEEECCCC | 32.18 | - | |
| 83 | Methylation | VPTIFPLRGVNERKV CCEEEECCCCCHHHH | 47.45 | 54559953 | |
| 163 | O-linked_Glycosylation | VLLTLQATVDSSQAP HHHHHHHCCCCCCCC | 16.34 | 29351928 | |
| 274 | Ubiquitination | ILALMEVKMKEMKGS HHHHHHHHHHHCCCC | 30.83 | 29967540 | |
| 276 | Ubiquitination | ALMEVKMKEMKGSIR HHHHHHHHHCCCCHH | 49.27 | - | |
| 281 | Phosphorylation | KMKEMKGSIRHLRLT HHHHCCCCHHHHHHC | 15.78 | 20068231 | |
| 291 | Ubiquitination | HLRLTEAKLREELRE HHHHCHHHHHHHHHH | 41.67 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of THA11_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of THA11_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of THA11_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-25, AND MASSSPECTROMETRY. | |
