CAVN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAVN1_HUMAN
• UniProt AC: Q6NZI2
• Protein Name: Caveolae-associated protein 1 {ECO:0000312|HGNC:HGNC:9688}
• Gene Name: CAVIN1 {ECO:0000312|HGNC:HGNC:9688}
• Organism: Homo sapiens (Human).
• Sequence Length: 390
• Subcellular Localization: Membrane, caveola . Cell membrane . Microsome . Endoplasmic reticulum . Cytoplasm, cytosol . Mitochondrion . Nucleus . Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Colocalizes with CAV1 in lipid rafts in
• Protein Description: Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. [PubMed: 18056712]
• Protein Sequence: MEDPTLYIVERPLPGYPDAEAPEPSSAGAQAAEEPSGAGSEELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSISKSLKESEALPEKEGEELGEGERPEEDAAALELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPAERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGQVEVLKATEMVEVGADDDEGGAERGEAGDLRRGSSPDVHALLEITEESDAVLVDKSDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDPTLYI -------CCCCCEEE		15242332
5	Phosphorylation	---MEDPTLYIVERP ---CCCCCEEEEECC		20639409
7	Phosphorylation	-MEDPTLYIVERPLP -CCCCCEEEEECCCC		25106551
16	Phosphorylation	VERPLPGYPDAEAPE EECCCCCCCCCCCCC		20639409
25	Phosphorylation	DAEAPEPSSAGAQAA CCCCCCCCCHHHHCC		26657352
26	Phosphorylation	AEAPEPSSAGAQAAE CCCCCCCCHHHHCCC		26657352
36	Phosphorylation	AQAAEEPSGAGSEEL HHCCCCCCCCCCHHH		29255136
40	Phosphorylation	EEPSGAGSEELIKSD CCCCCCCCHHHHHHC		29255136
46	Phosphorylation	GSEELIKSDQVNGVL CCHHHHHHCCCCCEE		22777824
50 (in isoform 3)	Ubiquitination	-		21890473
53 (in isoform 3)	Ubiquitination	-		21890473
56	Phosphorylation	VNGVLVLSLLDKIIG CCCEEHHHHHHHHHH		22199227
60	Ubiquitination	LVLSLLDKIIGAVDQ EHHHHHHHHHHHHHH		22817900
64 (in isoform 3)	Ubiquitination	-		21890473
68 (in isoform 3)	Ubiquitination	-		21890473
77 (in isoform 3)	Ubiquitination	-		21890473
82	Sulfoxidation	LEERQAEMEGAVQSI HHHHHHHHHHHHHHH		30846556
88	Phosphorylation	EMEGAVQSIQGELSK HHHHHHHHHHHHHHH		26657352
88 (in isoform 2)	Phosphorylation	-		21902226
92 (in isoform 3)	Ubiquitination	-		21890473
94	Phosphorylation	QSIQGELSKLGKAHA HHHHHHHHHHCCCCC		27251275
95	Ubiquitination	SIQGELSKLGKAHAT HHHHHHHHHCCCCCC		23000965
95 (in isoform 1)	Ubiquitination	-		21890473
98	Ubiquitination	GELSKLGKAHATTSN HHHHHHCCCCCCCHH		23000965
98 (in isoform 1)	Ubiquitination	-		21890473
102	Phosphorylation	KLGKAHATTSNTVSK HHCCCCCCCHHHHHH		23403867
103	Phosphorylation	LGKAHATTSNTVSKL HCCCCCCCHHHHHHH		23403867
104	Phosphorylation	GKAHATTSNTVSKLL CCCCCCCHHHHHHHH		23403867
106	Phosphorylation	AHATTSNTVSKLLEK CCCCCHHHHHHHHHH		21406692
107 (in isoform 3)	Ubiquitination	-		21890473
108	Phosphorylation	ATTSNTVSKLLEKVR CCCHHHHHHHHHHHH		23403867
109	Acetylation	TTSNTVSKLLEKVRK CCHHHHHHHHHHHHC		23236377
109	Malonylation	TTSNTVSKLLEKVRK CCHHHHHHHHHHHHC		26320211
109	Ubiquitination	TTSNTVSKLLEKVRK CCHHHHHHHHHHHHC		23000965
109 (in isoform 1)	Ubiquitination	-		21890473
113	Ubiquitination	TVSKLLEKVRKVSVN HHHHHHHHHHCCCCC		23000965
113 (in isoform 1)	Ubiquitination	-		21890473
116	Sumoylation	KLLEKVRKVSVNVKT HHHHHHHCCCCCHHH		-
116	Sumoylation	KLLEKVRKVSVNVKT HHHHHHHCCCCCHHH		28112733
116	Ubiquitination	KLLEKVRKVSVNVKT HHHHHHHCCCCCHHH		23000965
116 (in isoform 3)	Ubiquitination	-		21890473
118	Phosphorylation	LEKVRKVSVNVKTVR HHHHHCCCCCHHHHH		23911959
120 (in isoform 3)	Ubiquitination	-		21890473
122	Malonylation	RKVSVNVKTVRGSLE HCCCCCHHHHHHHHH		26320211
122	Sumoylation	RKVSVNVKTVRGSLE HCCCCCHHHHHHHHH		28112733
122	Ubiquitination	RKVSVNVKTVRGSLE HCCCCCHHHHHHHHH		23000965
122 (in isoform 1)	Ubiquitination	-		21890473
123	Phosphorylation	KVSVNVKTVRGSLER CCCCCHHHHHHHHHH		20068231
125 (in isoform 3)	Ubiquitination	-		21890473
127	Phosphorylation	NVKTVRGSLERQAGQ CHHHHHHHHHHHCCC		28355574
128 (in isoform 3)	Ubiquitination	-		21890473
136	2-Hydroxyisobutyrylation	ERQAGQIKKLEVNEA HHHCCCEEEEECCHH		-
136	Ubiquitination	ERQAGQIKKLEVNEA HHHCCCEEEEECCHH		23000965
137	Malonylation	RQAGQIKKLEVNEAE HHCCCEEEEECCHHH		26320211
137	Ubiquitination	RQAGQIKKLEVNEAE HHCCCEEEEECCHHH		23000965
137 (in isoform 1)	Ubiquitination	-		21890473
152	Acetylation	LLRRRNFKVMIYQDE HHHHCCCEEEEEECC		26051181
152	Malonylation	LLRRRNFKVMIYQDE HHHHCCCEEEEEECC		26320211
152	Ubiquitination	LLRRRNFKVMIYQDE HHHHCCCEEEEEECC		23000965
152 (in isoform 1)	Ubiquitination	-		21890473
154	Sulfoxidation	RRRNFKVMIYQDEVK HHCCCEEEEEECCCC		30846556
156	Phosphorylation	RNFKVMIYQDEVKLP CCCEEEEEECCCCCC		21945579
161	Sumoylation	MIYQDEVKLPAKLSI EEEECCCCCCCEEEE		-
161	Acetylation	MIYQDEVKLPAKLSI EEEECCCCCCCEEEE		26051181
161	Malonylation	MIYQDEVKLPAKLSI EEEECCCCCCCEEEE		26320211
161	Sumoylation	MIYQDEVKLPAKLSI EEEECCCCCCCEEEE		25114211
161	Ubiquitination	MIYQDEVKLPAKLSI EEEECCCCCCCEEEE		23000965
161 (in isoform 1)	Ubiquitination	-		21890473
165	2-Hydroxyisobutyrylation	DEVKLPAKLSISKSL CCCCCCCEEEECCCH		-
165	Acetylation	DEVKLPAKLSISKSL CCCCCCCEEEECCCH		19813393
165	Malonylation	DEVKLPAKLSISKSL CCCCCCCEEEECCCH		26320211
165	Sumoylation	DEVKLPAKLSISKSL CCCCCCCEEEECCCH		28112733
165	Ubiquitination	DEVKLPAKLSISKSL CCCCCCCEEEECCCH		23000965
165 (in isoform 1)	Ubiquitination	-		21890473
167	Phosphorylation	VKLPAKLSISKSLKE CCCCCEEEECCCHHH		29255136
169	Phosphorylation	LPAKLSISKSLKESE CCCEEEECCCHHHHH		30266825
170	2-Hydroxyisobutyrylation	PAKLSISKSLKESEA CCEEEECCCHHHHHC		-
170	Malonylation	PAKLSISKSLKESEA CCEEEECCCHHHHHC		26320211
170	Sumoylation	PAKLSISKSLKESEA CCEEEECCCHHHHHC		28112733
170	Ubiquitination	PAKLSISKSLKESEA CCEEEECCCHHHHHC		23000965
170 (in isoform 1)	Ubiquitination	-		21890473
171	Phosphorylation	AKLSISKSLKESEAL CEEEECCCHHHHHCC		28355574
173	Sumoylation	LSISKSLKESEALPE EEECCCHHHHHCCCH		-
173	Malonylation	LSISKSLKESEALPE EEECCCHHHHHCCCH		32601280
173	Sumoylation	LSISKSLKESEALPE EEECCCHHHHHCCCH		-
173	Ubiquitination	LSISKSLKESEALPE EEECCCHHHHHCCCH		23000965
173 (in isoform 1)	Ubiquitination	-		21890473
175	Phosphorylation	ISKSLKESEALPEKE ECCCHHHHHCCCHHH		28176443
181	Ubiquitination	ESEALPEKEGEELGE HHHCCCHHHCCCCCC		-
202	Phosphorylation	DAAALELSSDEAVEV HHHHHHCCCCCCEEH		28176443
203	Phosphorylation	AAALELSSDEAVEVE HHHHHCCCCCCEEHH		28176443
209 (in isoform 2)	Ubiquitination	-		21890473
216	Phosphorylation	VEEVIEESRAERIKR HHHHHHHHHHHHHHH		28176443
227 (in isoform 2)	Ubiquitination	-		21890473
233	Ubiquitination	LRRVDDFKKAFSKEK CCCHHHHHHHHCHHH		27667366
237	Phosphorylation	DDFKKAFSKEKMEKT HHHHHHHCHHHHHHH		24719451
238	Ubiquitination	DFKKAFSKEKMEKTK HHHHHHCHHHHHHHC		27667366
244	O-linked_Glycosylation	SKEKMEKTKVRTREN CHHHHHHHCCCCHHH		30379171
254	2-Hydroxyisobutyrylation	RTRENLEKTRLKTKE CCHHHHHHHCCHHHH		-
254	Ubiquitination	RTRENLEKTRLKTKE CCHHHHHHHCCHHHH		29967540
258	Ubiquitination	NLEKTRLKTKENLEK HHHHHCCHHHHHHHH		33845483
259	Phosphorylation	LEKTRLKTKENLEKT HHHHCCHHHHHHHHH		-
260	Ubiquitination	EKTRLKTKENLEKTR HHHCCHHHHHHHHHH		33845483
265	2-Hydroxyisobutyrylation	KTKENLEKTRHTLEK HHHHHHHHHHHHHHH		-
265	Ubiquitination	KTKENLEKTRHTLEK HHHHHHHHHHHHHHH		33845483
266	Phosphorylation	TKENLEKTRHTLEKR HHHHHHHHHHHHHHH		28176443
269	Phosphorylation	NLEKTRHTLEKRMNK HHHHHHHHHHHHHHH		30576142
272	Ubiquitination	KTRHTLEKRMNKLGT HHHHHHHHHHHHHCC		29967540
272 (in isoform 3)	Ubiquitination	-		21890473
276	Ubiquitination	TLEKRMNKLGTRLVP HHHHHHHHHCCCCCC		33845483
279	Phosphorylation	KRMNKLGTRLVPAER HHHHHHCCCCCCHHH		25867546
296	Ubiquitination	KLKTSRDKLRKSFTP HHHCCHHHHHHHCCC		23000965
299	2-Hydroxyisobutyrylation	TSRDKLRKSFTPDHV CCHHHHHHHCCCCCE		-
299	Acetylation	TSRDKLRKSFTPDHV CCHHHHHHHCCCCCE		27452117
299	Malonylation	TSRDKLRKSFTPDHV CCHHHHHHHCCCCCE		26320211
299	Ubiquitination	TSRDKLRKSFTPDHV CCHHHHHHHCCCCCE		23000965
299 (in isoform 1)	Ubiquitination	-		21890473
300	Phosphorylation	SRDKLRKSFTPDHVV CHHHHHHHCCCCCEE		26846344
302	Phosphorylation	DKLRKSFTPDHVVYA HHHHHHCCCCCEEEE		26846344
308	Phosphorylation	FTPDHVVYARSKTAV CCCCCEEEEECCCEE		25159151
311	Phosphorylation	DHVVYARSKTAVYKV CCEEEEECCCEEEEC		26437602
312	Ubiquitination	HVVYARSKTAVYKVP CEEEEECCCEEEECC		23000965
313	Phosphorylation	VVYARSKTAVYKVPP EEEEECCCEEEECCC		26657352
316	Phosphorylation	ARSKTAVYKVPPFTF EECCCEEEECCCCEE		28152594
317	Ubiquitination	RSKTAVYKVPPFTFH ECCCEEEECCCCEEE		23000965
317 (in isoform 1)	Ubiquitination	-		21890473
326	2-Hydroxyisobutyrylation	PPFTFHVKKIREGQV CCCEEEEEECCCCCC		-
326	Acetylation	PPFTFHVKKIREGQV CCCEEEEEECCCCCC		30591687
326	Sumoylation	PPFTFHVKKIREGQV CCCEEEEEECCCCCC		28112733
326	Ubiquitination	PPFTFHVKKIREGQV CCCEEEEEECCCCCC		32015554
327	Acetylation	PFTFHVKKIREGQVE CCEEEEEECCCCCCE		30591693
337	Ubiquitination	EGQVEVLKATEMVEV CCCCEEEEEEEEEEE		-
341	Sulfoxidation	EVLKATEMVEVGADD EEEEEEEEEEECCCC		28465586
365	Phosphorylation	AGDLRRGSSPDVHAL CCCCCCCCCCCHHHH		30266825
366	Phosphorylation	GDLRRGSSPDVHALL CCCCCCCCCCHHHHH		30266825
376	Phosphorylation	VHALLEITEESDAVL HHHHHHCCCCCCCEE		30266825
379	Phosphorylation	LLEITEESDAVLVDK HHHCCCCCCCEEEEC		30266825
387	Phosphorylation	DAVLVDKSDSD---- CCEEEECCCCC----		30266825
389	Phosphorylation	VLVDKSDSD------ EEEECCCCC------		30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
300	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAVN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAVN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN148_HUMAN	ZNF148	physical	10727401
TFF1_HUMAN	TFF1	physical	9582279
TRI72_HUMAN	TRIM72	physical	21343302
TF3C4_HUMAN	GTF3C4	physical	22939629
TMEDA_HUMAN	TMED10	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
LIPS_HUMAN	LIPE	physical	17026959
MAGI3_HUMAN	MAGI3	physical	28514442
M21D2_HUMAN	MB21D2	physical	28514442
MD1L1_HUMAN	MAD1L1	physical	28514442
ZBTB1_HUMAN	ZBTB1	physical	28514442
ZN622_HUMAN	ZNF622	physical	28514442
FHL2_HUMAN	FHL2	physical	28514442
ZZEF1_HUMAN	ZZEF1	physical	28514442
UTRO_HUMAN	UTRN	physical	28514442
FBX28_HUMAN	FBXO28	physical	28514442
TRI26_HUMAN	TRIM26	physical	28514442
TERF2_HUMAN	TERF2	physical	28514442
HECD3_HUMAN	HECTD3	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442
SNTB2_HUMAN	SNTB2	physical	28514442
OBSL1_HUMAN	OBSL1	physical	28514442
CRBN_HUMAN	CRBN	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
EXOC7_HUMAN	EXOC7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.