| UniProt ID | OBSL1_HUMAN | |
|---|---|---|
| UniProt AC | O75147 | |
| Protein Name | Obscurin-like protein 1 | |
| Gene Name | OBSL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1896 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, perinuclear region . Golgi apparatus . Colocalizes with CUL7 at the Golgi apparatus in neurons (PubMed:21572988). | |
| Protein Description | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. [PubMed: 24793695] | |
| Protein Sequence | MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEGN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Methylation | ------MKASSGDQG ------CCCCCCCCC | 69.18 | 115974445 | |
| 4 | Phosphorylation | ----MKASSGDQGSP ----CCCCCCCCCCC | 46.03 | 29396449 | |
| 5 | Phosphorylation | ---MKASSGDQGSPP ---CCCCCCCCCCCC | 51.77 | 29255136 | |
| 10 | Phosphorylation | ASSGDQGSPPCFLRF CCCCCCCCCCCEEEC | 21.75 | 19664994 | |
| 25 | Phosphorylation | PRPVRVVSGAEAELK CCCEEEECCCCEEEE | 29.45 | - | |
| 107 | Phosphorylation | TVLEPPASDPELQPA EEECCCCCCCCCCCC | 60.52 | 28348404 | |
| 120 | Phosphorylation | PAERPLPSPGSGEGA CCCCCCCCCCCCCCC | 49.96 | 25850435 | |
| 148 | Phosphorylation | RGAEVVLTCRAGGLP CCCEEEEEEECCCCC | 6.58 | 24702127 | |
| 232 | Phosphorylation | QVHQPPESPPADPDE EECCCCCCCCCCCCC | 41.79 | 25850435 | |
| 420 | Phosphorylation | EMRGRVRTVANVTVK EECCCEEEEEEEEEE | 22.55 | - | |
| 425 | Phosphorylation | VRTVANVTVKGPILK EEEEEEEEEECHHHH | 19.12 | - | |
| 516 | Phosphorylation | RVKCVKHSPPGPPIL EEEEECCCCCCCCCH | 27.37 | 21712546 | |
| 528 | Methylation | PILAEMFKGHKNTVL CCHHHHHCCCCCEEE | 59.81 | 115974451 | |
| 737 | O-linked_Glycosylation | TSERVVLTCELSRVD CCCEEEEEEEEECCC | 7.73 | 30379171 | |
| 759 | Phosphorylation | DGQKVEESELLVVKM CCCEEEEEEEEEEEE | 21.75 | 21712546 | |
| 794 | Phosphorylation | ECRTEGVSAFFGVTV EEECCCCEEEECEEE | 30.16 | 23532336 | |
| 896 | O-linked_Glycosylation | TVTITDVSSWIVYPS EEEEEECCEEEEECC | 23.82 | 30379171 | |
| 897 | O-linked_Glycosylation | VTITDVSSWIVYPSG EEEEECCEEEEECCC | 22.22 | 30379171 | |
| 1023 | Phosphorylation | EDAPVRWYKDGLEVE CCCCCCEEECCEEEC | 6.66 | 28258704 | |
| 1032 | Phosphorylation | DGLEVEESEALVLER CCEEECCCEEEEEEC | 18.05 | 28258704 | |
| 1303 | Phosphorylation | PGGPVRWYKDGERLA CCCCEEEEECHHHHH | 6.66 | - | |
| 1308 (in isoform 1) | Phosphorylation | - | 40.87 | 22461510 | |
| 1319 (in isoform 1) | Phosphorylation | - | 54.40 | 22461510 | |
| 1370 | Phosphorylation | VSELTPLTVHEGDDA HHHCCCCEEECCCCC | 22.48 | 24275569 | |
| 1400 | Phosphorylation | LRNGAVVTPGPQVEM EECCEEECCCCCEEE | 18.87 | 23879269 | |
| 1412 | Phosphorylation | VEMAQNGSSRILTLR EEECCCCCCCEEEEC | 24.80 | 23879269 | |
| 1630 | Phosphorylation | IVREVPVTIVRGPHD HEEECCEEEEECCCC | 14.00 | 22210691 | |
| 1645 | O-linked_Glycosylation | LEVTEGDTATFECEL EECCCCCCEEEEEEH | 38.15 | 30379171 | |
| 1669 | Phosphorylation | EKDGNALTPSPRLRL EECCCCCCCCHHHHH | 21.22 | 26471730 | |
| 1671 | Phosphorylation | DGNALTPSPRLRLQA CCCCCCCCHHHHHHH | 19.88 | 26471730 | |
| 1697 | Phosphorylation | CGPSDAGTYSCAVGT CCCCCCCCEEEECCC | 17.62 | - | |
| 1699 | Phosphorylation | PSDAGTYSCAVGTAR CCCCCCEEEECCCCC | 8.74 | - | |
| 1704 | Phosphorylation | TYSCAVGTARAGPVR CEEEECCCCCCCCEE | 13.33 | - | |
| 1833 | Phosphorylation | AVLEVTVSRSGGHVC EEEEEEEECCCCEEE | 16.03 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OBSL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OBSL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OBSL1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 612921 | 3M syndrome 2 (3M2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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