dbPTM

SPTN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPTN2_HUMAN
UniProt AC	O15020
Protein Name	Spectrin beta chain, non-erythrocytic 2
Gene Name	SPTBN2
Organism	Homo sapiens (Human).
Sequence Length	2390
Subcellular Localization	Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Protein Description	Probably plays an important role in neuronal membrane skeleton..
Protein Sequence	MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSTLSPTD ------CCCCCCCCC	43.25	20068231
2	Phosphorylation	------MSSTLSPTD ------CCCCCCCCC	43.25	28857561
3	Phosphorylation	-----MSSTLSPTDF -----CCCCCCCCCH	45.27	20068231
4	Phosphorylation	----MSSTLSPTDFD ----CCCCCCCCCHH	40.31	27642862
6	Phosphorylation	--MSSTLSPTDFDSL --CCCCCCCCCHHCC	26.33	20068231
8	Phosphorylation	MSSTLSPTDFDSLEI CCCCCCCCCHHCCEE	46.02	27642862
12	Phosphorylation	LSPTDFDSLEIQGQY CCCCCHHCCEEECCC	28.09	20068231
19	Phosphorylation	SLEIQGQYSDINNRW CCEEECCCCCCCCCC	18.35	25884760
31	Phosphorylation	NRWDLPDSDWDNDSS CCCCCCCCCCCCCCH	38.37	20873877
37	Phosphorylation	DSDWDNDSSSARLFE CCCCCCCCHHHHHHH	32.23	20873877
38	Phosphorylation	SDWDNDSSSARLFER CCCCCCCHHHHHHHH	30.77	20873877
39	Phosphorylation	DWDNDSSSARLFERS CCCCCCHHHHHHHHH	22.74	20873877
60	Ubiquitination	DEREAVQKKTFTKWV HHHHHHHHHHHHHHH	47.37	23000965
61	Ubiquitination	EREAVQKKTFTKWVN HHHHHHHHHHHHHHH	31.60	23000965
65	Acetylation	VQKKTFTKWVNSHLA HHHHHHHHHHHHHHH	44.98	25953088
65	Malonylation	VQKKTFTKWVNSHLA HHHHHHHHHHHHHHH	44.98	26320211
65	Ubiquitination	VQKKTFTKWVNSHLA HHHHHHHHHHHHHHH	44.98	21890473
65 (in isoform 1)	Ubiquitination	-	44.98	21890473
65 (in isoform 2)	Ubiquitination	-	44.98	21890473
67	Ubiquitination	KKTFTKWVNSHLARV HHHHHHHHHHHHHHH	5.85	23000965
68	Ubiquitination	KTFTKWVNSHLARVT HHHHHHHHHHHHHHH	23.69	23000965
69	Phosphorylation	TFTKWVNSHLARVTC HHHHHHHHHHHHHHH	15.40	28857561
72	Ubiquitination	KWVNSHLARVTCRVG HHHHHHHHHHHHHHH	9.85	21890473
75	Phosphorylation	NSHLARVTCRVGDLY HHHHHHHHHHHHCHH	6.77	-
82	Phosphorylation	TCRVGDLYSDLRDGR HHHHHCHHHHCCCCH	12.60	21406692
83	Phosphorylation	CRVGDLYSDLRDGRN HHHHCHHHHCCCCHH	37.15	21406692
99	Phosphorylation	LRLLEVLSGEILPKP HHHHHHHCCCCCCCC	39.29	-
108	Ubiquitination	EILPKPTKGRMRIHC CCCCCCCCCCCCCEE	53.71	-
121	Acetylation	HCLENVDKALQFLKE EECCCHHHHHHHHHH	46.87	23749302
121	Ubiquitination	HCLENVDKALQFLKE EECCCHHHHHHHHHH	46.87	30230243
136	Sulfoxidation	QKVHLENMGSHDIVD CCCCHHCCCCCCCCC	4.20	28183972
166	Phosphorylation	RFQIQDISVETEDNK HHHHCCCCCCCCCCC	23.38	24732914
169	Phosphorylation	IQDISVETEDNKEKK HCCCCCCCCCCCCCC	46.62	24732914
173	Acetylation	SVETEDNKEKKSAKD CCCCCCCCCCCCHHH	81.09	26051181
186	Glutathionylation	KDALLLWCQMKTAGY HHHHHHHHHHHCCCC	2.60	22555962
217	Acetylation	AFNAIVHKHRPDLLD HHHHHHHCCCCCCCC	30.34	21466224
227	Phosphorylation	PDLLDFESLKKCNAH CCCCCHHHHHHCCCC	45.54	27251275
229	Acetylation	LLDFESLKKCNAHYN CCCHHHHHHCCCCCC	65.64	26051181
268	Phosphorylation	VDQPDEKSIITYVAT CCCCCHHHHHHHHHH	19.71	22817900
277	Phosphorylation	ITYVATYYHYFSKMK HHHHHHHHHHHHHHH	5.91	-
284	2-Hydroxyisobutyrylation	YHYFSKMKALAVEGK HHHHHHHHHHHCCCH	43.94	-
284	Ubiquitination	YHYFSKMKALAVEGK HHHHHHHHHHHCCCH	43.94	27667366
291	Ubiquitination	KALAVEGKRIGKVLD HHHHCCCHHHHHHHH	27.60	27667366
336	Phosphorylation	NDRQLANSLSGVQNQ CHHHHHHHHHHHHHH	20.50	27174698
338	Phosphorylation	RQLANSLSGVQNQLQ HHHHHHHHHHHHHHH	36.42	27174698
346	Phosphorylation	GVQNQLQSFNSYRTV HHHHHHHHCCCCCCC	34.68	27174698
349	Phosphorylation	NQLQSFNSYRTVEKP HHHHHCCCCCCCCCC	17.62	27174698
350	Phosphorylation	QLQSFNSYRTVEKPP HHHHCCCCCCCCCCC	16.06	27174698
358	Ubiquitination	RTVEKPPKFTEKGNL CCCCCCCCCCCCCCE	73.73	30230243
362	Ubiquitination	KPPKFTEKGNLEVLL CCCCCCCCCCEEEEE	50.47	30230243
384	Phosphorylation	RANNQKVYTPREGRL HHCCCCCCCCCCCCC	20.33	26270265
385	Phosphorylation	ANNQKVYTPREGRLI HCCCCCCCCCCCCCH	20.89	26270265
393	Phosphorylation	PREGRLISDINKAWE CCCCCCHHHHHHHHH	36.71	24076635
442	Phosphorylation	AMRETWLSENQRLVS HHHHHHHCHHHHHHC	26.51	25867546
449	Phosphorylation	SENQRLVSQDNFGLE CHHHHHHCCCCHHHH	36.09	27251275
477	Phosphorylation	IETDIVAYSGRVQAV CCCCEEEECCCHHHH	10.77	-
602	Acetylation	LRFCNPGKEYRPCDP HHHCCCCCCCCCCCH	53.48	26051181
691	Phosphorylation	TALRGEMSGRLGPLK HHHCCCCCCCCCCCE	19.23	-
771	Phosphorylation	VDALRLVSSPELGHD HHHHHHHCCCCCCCC	44.78	25849741
772	Phosphorylation	DALRLVSSPELGHDE HHHHHHCCCCCCCCH	18.21	25849741
781	Phosphorylation	ELGHDEFSTQALARQ CCCCCHHHHHHHHHH	19.98	23186163
782	Phosphorylation	LGHDEFSTQALARQH CCCCHHHHHHHHHHH	24.15	23186163
802	Phosphorylation	EIRSHRPTLDALREQ HHHHCCCCHHHHHHH	36.91	25332170
834	Phosphorylation	VPTLERHYEELQARA CCCHHHHHHHHHHHH	19.81	27642862
955	Phosphorylation	DGKKAALTSALSIQN HHHHHHHHHHHHCCC	13.76	25072903
956	Phosphorylation	GKKAALTSALSIQNY HHHHHHHHHHHCCCH	28.23	25072903
959	Phosphorylation	AALTSALSIQNYHLE HHHHHHHHCCCHHEE	23.11	25072903
963	Phosphorylation	SALSIQNYHLECTET HHHHCCCHHEEHHHH	7.45	25072903
968	Phosphorylation	QNYHLECTETQAWMR CCHHEEHHHHHHHHH	32.46	25072903
970	Phosphorylation	YHLECTETQAWMREK HHEEHHHHHHHHHHH	12.87	25072903
1045	Phosphorylation	ARLREVQTGWEDLRA HHHHHHHHCHHHHHH	49.81	22210691
1060	Phosphorylation	TMRRREESLGEARRL HHHHHHHHHHHHHHH	36.60	-
1073	Phosphorylation	RLQDFLRSLDDFQAW HHHHHHHCHHHHHHH	37.99	28857561
1240	Phosphorylation	EAGRQLVSEGNIHAD HHHHHHHHHCCCCHH	48.67	28787133
1255	Phosphorylation	KIREKADSIERRHKK HHHHHHHHHHHHHHH	31.07	29496963
1300	Phosphorylation	WIDEKMLTAQDVSYD HHCHHHCCCCCCCHH	20.83	-
1305	Phosphorylation	MLTAQDVSYDEARNL HCCCCCCCHHHHHHH	34.85	-
1306	Phosphorylation	LTAQDVSYDEARNLH CCCCCCCHHHHHHHH	20.04	-
1315	Ubiquitination	EARNLHTKWQKHQAF HHHHHHHHHHHHHHH	36.56	29967540
1344	Phosphorylation	DKEGRELTLEKPELK CHHCCCCCCCCHHHH	28.28	28348404
1416	Phosphorylation	DDYGKDLTSVNILLK CCCCCCCHHHHHHHH	40.54	21406692
1417	Phosphorylation	DYGKDLTSVNILLKK CCCCCCHHHHHHHHH	22.06	21406692
1437	Ubiquitination	WEMAVREKEVEAIQA HHHHHHHHHHHHHHH	57.40	29967540
1447	Ubiquitination	EAIQAQAKALAQEDQ HHHHHHHHHHHHHCC	31.67	29967540
1529	2-Hydroxyisobutyrylation	SVQLLMKKNQTLQKE HHHHHHHHCHHHHHH	40.08	-
1532	Phosphorylation	LLMKKNQTLQKEIQG HHHHHCHHHHHHHCC	40.32	28555341
1622	Phosphorylation	EKAKDELSAQAEVKK HHHHHHHHHHHHHHH	19.11	27732954
1674	Acetylation	IRQAQVDKLYAGLKE EHHHHHHHHHHHHHH	44.53	25953088
1674	Ubiquitination	IRQAQVDKLYAGLKE EHHHHHHHHHHHHHH	44.53	-
1676	Phosphorylation	QAQVDKLYAGLKELA HHHHHHHHHHHHHHH	12.36	22461510
1726	Phosphorylation	SHELGQDYEHVTMLR HHHCCCCHHHHHHHH	10.47	22817900
1753	Phosphorylation	IGQERVDSANALANG CCHHHHHHHHHHHHC	22.14	24719451
1801	Phosphorylation	GQVLAAAYELQRFLH HHHHHHHHHHHHHHH	16.67	22817900
1820	Ubiquitination	ALARVQHKQQQLPDG HHHHHHHHHHCCCCC	32.48	-
1845	Phosphorylation	LQRRHCAYEHDIQAL HHHHHHHHHHHHHHH	21.13	20068231
1853	Phosphorylation	EHDIQALSPQVQQVQ HHHHHHHCHHHEECC	19.12	20068231
1868	Ubiquitination	DDGHRLQKAYAGDKA CCCHHHHHHHCCCHH	48.21	32142685
1896	Phosphorylation	WAQLQGSSAARRQLL HHHHCCCHHHHHHHH	32.54	23532336
1909	2-Hydroxyisobutyrylation	LLLDTTDKFRFFKAV HHHCCCCHHHHHHHH	36.03	-
1940	Phosphorylation	QERPRDVSSADLVIK CCCCCCCCHHHEEEE	24.89	20068231
1941	Phosphorylation	ERPRDVSSADLVIKN CCCCCCCHHHEEEEC	26.17	20068231
1964	Phosphorylation	EARADRFSSCIDMGK HHHHHHHHHHHHHHH	25.79	26546556
1965	Phosphorylation	ARADRFSSCIDMGKE HHHHHHHHHHHHHHH	16.63	28857561
1979	Phosphorylation	ELLARSHYAAEEISE HHHHHCHHHHHHHHH	14.57	22817900
1987	Ubiquitination	AAEEISEKLSQLQAR HHHHHHHHHHHHHHH	46.80	29967540
2038	Phosphorylation	SQEPLVRSAELGCTV CCCCCCCHHCCCCCH	20.72	28348404
2043	Glutathionylation	VRSAELGCTVDEVES CCHHCCCCCHHHHHH	5.39	22555962
2050	Phosphorylation	CTVDEVESLIKRHEA CCHHHHHHHHHHHHH	40.34	24719451
2053	Ubiquitination	DEVESLIKRHEAFQK HHHHHHHHHHHHHHH	53.66	-
2060	Ubiquitination	KRHEAFQKSAVAWEE HHHHHHHHHHHHHHH	33.65	29967540
2074	Acetylation	ERFCALEKLTALEER HHHHHHHHHHHHHHH	52.57	26051181
2074	Ubiquitination	ERFCALEKLTALEER HHHHHHHHHHHHHHH	52.57	29967540
2149	Phosphorylation	VCTDGEPSQPLLGQQ EECCCCCCCCCCCCC	39.88	26074081
2161	Phosphorylation	GQQRLEHSSFPEGPG CCCCCCCCCCCCCCC	25.05	24732914
2162	Phosphorylation	QQRLEHSSFPEGPGP CCCCCCCCCCCCCCC	46.88	24732914
2171	Phosphorylation	PEGPGPGSGDEANGP CCCCCCCCCCCCCCC	46.32	29255136
2192	Phosphorylation	RTRGPAPSAMPQSRS CCCCCCCCCCCCCCC	39.03	-
2199	Phosphorylation	SAMPQSRSTESAHAA CCCCCCCCCCCCCCC	41.60	24275569
2200	Phosphorylation	AMPQSRSTESAHAAT CCCCCCCCCCCCCCC	32.61	26471730
2202	Phosphorylation	PQSRSTESAHAATLP CCCCCCCCCCCCCCC	25.99	26471730
2236	Acetylation	QEMEAFGKKAANRSW HHHHHHHHHHHCCCC	32.55	30592635
2237	Acetylation	EMEAFGKKAANRSWQ HHHHHHHHHHCCCCC	53.78	30592641
2254	Phosphorylation	YCVLRRGSLGFYKDA EEEEECCCCCCCCCC	24.41	25307156
2258	Phosphorylation	RRGSLGFYKDAKAAS ECCCCCCCCCCHHHH	13.22	23312004
2259	Acetylation	RGSLGFYKDAKAASA CCCCCCCCCCHHHHC	49.28	26051181
2262	Ubiquitination	LGFYKDAKAASAGVP CCCCCCCHHHHCCCC	55.40	29967540
2289	Phosphorylation	QGSVAFDYRKRKHVF CCCEEEECCCCCEEE	16.16	28102081
2304	Ubiquitination	KLGLQDGKEYLFQAK EEECCCCHHHEEECC	52.02	29967540
2318	Phosphorylation	KDEAEMSSWLRVVNA CCHHHHHHHHHHHHH	28.90	24719451
2354	Phosphorylation	RGMTRAMTMPPVSPV CCCCCCCCCCCCCCC	26.07	21712546
2359	Phosphorylation	AMTMPPVSPVGAEGP CCCCCCCCCCCCCCC	21.46	28355574
2371	Phosphorylation	EGPVVLRSKDGRERE CCCEEEECCCCCHHH	30.82	20860994
2384	Phosphorylation	REREKRFSFFKKNK- HHHHHHHCCHHCCC-	33.53	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPTN2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPTN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPTN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTZ_HUMAN	ACTR1A	physical	11357136
ACTB_HUMAN	ACTB	physical	11357136
ACTZ_HUMAN	ACTR1A	physical	11461920
ACTB_HUMAN	ACTB	physical	11461920
UN13B_HUMAN	UNC13B	physical	9704016

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
600224	Spinocerebellar ataxia 5 (SCA5)
615386	Spinocerebellar ataxia, autosomal recessive, 14 (SCAR14)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPTN2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2171 AND SER-2359, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2359, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2171, AND MASSSPECTROMETRY.	17081983 [Abstract]