UN13B_HUMAN - dbPTM
UN13B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UN13B_HUMAN
UniProt AC O14795
Protein Name Protein unc-13 homolog B
Gene Name UNC13B
Organism Homo sapiens (Human).
Sequence Length 1591
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein. Cell membrane. Cell junction, synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity)..
Protein Description Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity)..
Protein Sequence MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGLSVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHKILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSMQSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationKRAKFQGSPDKFNTY
EEHHCCCCCCCCCEE		21.1020873877
19UbiquitinationKFQGSPDKFNTYVTL
HCCCCCCCCCEEEEE		43.8521890473
19UbiquitinationKFQGSPDKFNTYVTL
HCCCCCCCCCEEEEE		43.852189047
84PhosphorylationTVWIALKTIRQSDEE
HHHHHHHHHHCCCCC		23.42-
88PhosphorylationALKTIRQSDEEGPGE
HHHHHHCCCCCCCCC		36.82-
113PhosphorylationKDDEICGTRNPTPHK
CCCCCCCCCCCCCCE		23.9028985074
117PhosphorylationICGTRNPTPHKILLD
CCCCCCCCCCEEEEE		41.3928985074
157PhosphorylationALGADNEYSSQEESQ
HCCCCCCCCCHHHHH		21.63-
170PhosphorylationSQRKPLPTAAAQCSF
HHCCCCCCHHHHCCC		36.2923663014
176PhosphorylationPTAAAQCSFEDPDSA
CCHHHHCCCCCCCCC		21.4225159151
182PhosphorylationCSFEDPDSAVDDRDS
CCCCCCCCCCCCCCC		35.2627732954
222PhosphorylationQFPVPVRSPQQLLLQ
CCCCCCCCHHHEECC		27.5621815630
231PhosphorylationQQLLLQGSSRDSCND
HHEECCCCCCCCCCH		14.8328857561
232PhosphorylationQLLLQGSSRDSCNDS
HEECCCCCCCCCCHH		47.1028857561
239PhosphorylationSRDSCNDSMQSYDLD
CCCCCCHHHHHCCCC		12.5324114839
242PhosphorylationSCNDSMQSYDLDYPE
CCCHHHHHCCCCCCC		16.3924114839
243PhosphorylationCNDSMQSYDLDYPER
CCHHHHHCCCCCCCC		12.0224114839
247PhosphorylationMQSYDLDYPERRAIS
HHHCCCCCCCCCCCC		17.8126074081
254PhosphorylationYPERRAISPTSSSRY
CCCCCCCCCCCCCCC		22.5729255136
256PhosphorylationERRAISPTSSSRYGS
CCCCCCCCCCCCCCC		34.1629255136
257PhosphorylationRRAISPTSSSRYGSS
CCCCCCCCCCCCCCC		29.6929255136
258PhosphorylationRAISPTSSSRYGSSC
CCCCCCCCCCCCCCC		22.7029255136
259PhosphorylationAISPTSSSRYGSSCN
CCCCCCCCCCCCCCC		29.3229255136
261PhosphorylationSPTSSSRYGSSCNVS
CCCCCCCCCCCCCCC		24.2526074081
263PhosphorylationTSSSRYGSSCNVSQG
CCCCCCCCCCCCCCC		23.8426074081
264PhosphorylationSSSRYGSSCNVSQGS
CCCCCCCCCCCCCCC		12.8326074081
268PhosphorylationYGSSCNVSQGSSQLS
CCCCCCCCCCCHHHH		18.1626074081
271PhosphorylationSCNVSQGSSQLSELD
CCCCCCCCHHHHHHH		13.7926074081
272PhosphorylationCNVSQGSSQLSELDQ
CCCCCCCHHHHHHHH		41.8026074081
275PhosphorylationSQGSSQLSELDQYHE
CCCCHHHHHHHHHHH		28.6026074081
280PhosphorylationQLSELDQYHEQDDDH
HHHHHHHHHHCCCCC		13.6423312004
290PhosphorylationQDDDHRETDSIHSCH
CCCCCCCCCCHHHCC		34.7024275569
292PhosphorylationDDHRETDSIHSCHSS
CCCCCCCCHHHCCCC		29.6229449344
295PhosphorylationRETDSIHSCHSSHSL
CCCCCHHHCCCCCCC		16.3223312004
298PhosphorylationDSIHSCHSSHSLSRD
CCHHHCCCCCCCCCC		33.7929449344
299PhosphorylationSIHSCHSSHSLSRDG
CHHHCCCCCCCCCCC		8.0724275569
301PhosphorylationHSCHSSHSLSRDGQA
HHCCCCCCCCCCCCC		29.9523312004
303PhosphorylationCHSSHSLSRDGQAGF
CCCCCCCCCCCCCCC		31.1923312004
320PhosphorylationQEKPLEVTGQAEKEA
CCCCCEECCHHHHHH		17.7528555341
350UbiquitinationPPDLVLQKDHFLGPQ
CCCCEECCCCCCCCH		49.35-
359PhosphorylationHFLGPQESFPEENAS
CCCCCHHCCCCCCCC		40.6326657352
366PhosphorylationSFPEENASSPFTQAR
CCCCCCCCCHHHHHH		50.5621712546
367PhosphorylationFPEENASSPFTQARA
CCCCCCCCHHHHHHH		22.9425159151
370PhosphorylationENASSPFTQARAHWI
CCCCCHHHHHHHHHH		25.3823663014
438UbiquitinationLSLVQSRKAGITSAM
HHHHHHHHCCCCHHH		57.10-
449PhosphorylationTSAMATRTSLKDEEL
CHHHCCCCCCCHHHH		33.7723312004
450PhosphorylationSAMATRTSLKDEELK
HHHCCCCCCCHHHHH		30.0823312004
461PhosphorylationEELKSHVYKKTLQAL
HHHHHHHHHHHHHHH		11.0118083107
509O-linked_GlycosylationARQGMRCSECGVKCH
HHCCCCHHHCCCCHH		26.0930379171
577MethylationRDVFTVNKAAHVQQM
HHHHCCCCHHHHHHH		42.48115978949
585UbiquitinationAAHVQQMKTVKQSVL
HHHHHHHHHHHHHHH		45.92-
586PhosphorylationAHVQQMKTVKQSVLD
HHHHHHHHHHHHHHC		27.82-
588UbiquitinationVQQMKTVKQSVLDGT
HHHHHHHHHHHHCCC		41.93-
605PhosphorylationWSAKITITVVCAQGL
CEEEEEEEEEECCCC		9.7617924679
618PhosphorylationGLQAKDKTGSSDPYV
CCCCCCCCCCCCCEE		53.0529978859
620PhosphorylationQAKDKTGSSDPYVTV
CCCCCCCCCCCEEEE		36.4829978859
621PhosphorylationAKDKTGSSDPYVTVQ
CCCCCCCCCCEEEEE		43.9029978859
624PhosphorylationKTGSSDPYVTVQVSK
CCCCCCCEEEEEEEC		17.4729978859
626PhosphorylationGSSDPYVTVQVSKTK
CCCCCEEEEEEECCC		10.2029978859
630PhosphorylationPYVTVQVSKTKKRTK
CEEEEEEECCCCEEE		19.9529978859
632PhosphorylationVTVQVSKTKKRTKTI
EEEEEECCCCEEEEE		34.0029978859
637UbiquitinationSKTKKRTKTIFGNLN
ECCCCEEEEECCCCC		43.59-
658PhosphorylationFHFECHNSSDRIKVR
CEEECCCCCCCEEEE		15.2220873877
659PhosphorylationHFECHNSSDRIKVRV
EEECCCCCCCEEEEE		35.9020873877
674UbiquitinationWDEDDDIKSRVKQRL
ECCCCHHHHHHHHHH		38.92-
755PhosphorylationENLFHYLTDIQGSGG
CCHHHHHHHCCCCCC		24.7226074081
760PhosphorylationYLTDIQGSGGVRIPE
HHHHCCCCCCEECCC		18.9226074081
777PhosphorylationGDDAWKVYFDETAQE
CCCCEEEEECHHHHH		11.1126074081
793PhosphorylationVDEFAMRYGIESIYQ
HHHHHHHHCHHHHHH		14.9028985074
803PhosphorylationESIYQAMTHFACLSS
HHHHHHHHHHHHHCC		19.5028985074
809PhosphorylationMTHFACLSSKYMCPG
HHHHHHHCCCCCCCC		25.3528985074
812PhosphorylationFACLSSKYMCPGVPA
HHHHCCCCCCCCHHH		13.09-
867PhosphorylationLLDQLHNSLRIDLST
HHHHHHHHHCCCHHH		14.3128857561
892PhosphorylationERLQDLKSTVDLLTS
HHHHHHHHHHHHHHH		40.7430622161
893PhosphorylationRLQDLKSTVDLLTSI
HHHHHHHHHHHHHHH		19.2230622161
898PhosphorylationKSTVDLLTSITFFRM
HHHHHHHHHHHHHHH		25.9430622161
899PhosphorylationSTVDLLTSITFFRMK
HHHHHHHHHHHHHHH		21.4330622161
901PhosphorylationVDLLTSITFFRMKVQ
HHHHHHHHHHHHHHH		19.2530622161
912PhosphorylationMKVQELQSPPRASQV
HHHHHHCCCCCHHHH		49.8825159151
917PhosphorylationLQSPPRASQVVKDCV
HCCCCCHHHHHHHHH		25.4525627689
944PhosphorylationNNCHDLYSRQYQLKQ
HCHHHHHHHCHHHHC		21.8724719451
1137PhosphorylationDPSILAHYMRRFAKT
CHHHHHHHHHHHHHH		6.16-
1144PhosphorylationYMRRFAKTIGKVLMQ
HHHHHHHHHHHHHHH		31.37-
1152PhosphorylationIGKVLMQYADILSKD
HHHHHHHHHHHHCCC		7.71-
1251PhosphorylationVRGTGNASPDARASA
HCCCCCCCHHHHHHH		27.5826074081
1330O-linked_GlycosylationFTAAKELSHLSKLKD
HHHHHHHHHHHHHHH		24.3930379171
1333O-linked_GlycosylationAKELSHLSKLKDHMV
HHHHHHHHHHHHHHH		30.4430379171
1344PhosphorylationDHMVREETRNLTPKQ
HHHHHHHHCCCCHHH		21.8022985185
1376PhosphorylationGGNGLKKTFLEKSPD
CCCHHHHHHHHHCCC		31.6826074081
1381PhosphorylationKKTFLEKSPDLQSLR
HHHHHHHCCCHHHHH		17.8026074081
1386PhosphorylationEKSPDLQSLRYALSL
HHCCCHHHHHHHHHH		23.3126074081
1389PhosphorylationPDLQSLRYALSLYTQ
CCHHHHHHHHHHHHH		19.7218083107
1394PhosphorylationLRYALSLYTQTTDTL
HHHHHHHHHHCHHHH		8.0718083107
1566PhosphorylationLTILRILSQRSNDEV
HHHHHHHHHCCCHHH		22.6024719451
1582PhosphorylationREFVKLKSESRSTEE
HHHHHHHHHCCCCCC		51.7624719451
1586PhosphorylationKLKSESRSTEEGS--
HHHHHCCCCCCCC--		49.8324719451
1587PhosphorylationLKSESRSTEEGS---
HHHHCCCCCCCC---		36.6224719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UN13B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UN13B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UN13B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STX1A_HUMANSTX1Aphysical
8999968
SPTN2_HUMANSPTBN2physical
9704016
STX1B_HUMANSTX1Bphysical
8999968
RIMS1_HUMANRIMS1physical
11343654
DOC2A_HUMANDOC2Aphysical
9195900
VAMP2_HUMANVAMP2physical
8999968
SNP25_HUMANSNAP25physical
8999968
RB27A_HUMANRAB27Aphysical
24043286
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UN13B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-605, AND MASSSPECTROMETRY.

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