STX1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX1B_HUMAN
• UniProt AC: P61266
• Protein Name: Syntaxin-1B
• Gene Name: STX1B
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Subcellular Localization: Isoform 1: Membrane ; Single-pass type IV membrane protein .; Isoform 2: Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and
• Protein Description: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)..
• Protein Sequence: MKDRTQELRSAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVLASSIGGTLGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DRTQELRSAKDSDDE HHHHHHHHCCCCCCH	52.90	18510355
14	Phosphorylation	ELRSAKDSDDEEEVV HHHHCCCCCCHHHEE	46.37	21082442
45	Ubiquitination	EIRGCIEKLSEDVEQ HHHHHHHHHHHHHHH	37.08	30230243
58	Phosphorylation	EQVKKQHSAILAAPN HHHHHHHHHHHHCCC	17.95	19060867
69	Ubiquitination	AAPNPDEKTKQELED HCCCCCHHHHHHHHH	69.29	32142685
93	Ubiquitination	NKVRSKLKAIEQSIE HHHHHHHHHHHHHHH	51.56	30230243
98	Phosphorylation	KLKAIEQSIEQEEGL HHHHHHHHHHHHHCC	18.46	24076635
108	Phosphorylation	QEEGLNRSSADLRIR HHHCCCCCCHHHHHH	28.89	23312004
109	Phosphorylation	EEGLNRSSADLRIRK HHCCCCCCHHHHHHH	23.67	24076635
117	Phosphorylation	ADLRIRKTQHSTLSR HHHHHHHHHCCHHHH	22.97	22985185
121	Phosphorylation	IRKTQHSTLSRKFVE HHHHHCCHHHHHHHH	26.99	22985185
133	Phosphorylation	FVEVMTEYNATQSKY HHHHHHHCCCCHHHH	10.84	28331001
139	Ubiquitination	EYNATQSKYRDRCKD HCCCCHHHHHHHHHH	34.19	32142685
160	Phosphorylation	EITGRTTTNEELEDM HHHCCCCCHHHHHHH	39.77	21082442
170	Phosphorylation	ELEDMLESGKLAIFT HHHHHHHHCCEEEEC	36.95	29083192
172	Ubiquitination	EDMLESGKLAIFTDD HHHHHHCCEEEECCC	43.98	30230243
181	Ubiquitination	AIFTDDIKMDSQMTK EEECCCCCCCHHHHH	43.58	32142685
188	Ubiquitination	KMDSQMTKQALNEIE CCCHHHHHHHHHHHH	28.38	32142685
196	Phosphorylation	QALNEIETRHNEIIK HHHHHHHHHHHHHHH	42.78	-
248	Phosphorylation	DYVERAVSDTKKAVK HHHHHHHHHHHHHHH	38.28	26657352
251	Ubiquitination	ERAVSDTKKAVKYQS HHHHHHHHHHHHHHC	43.66	32142685
256	Phosphorylation	DTKKAVKYQSKARRK HHHHHHHHHCHHHHC	16.06	29116813
258	Phosphorylation	KKAVKYQSKARRKKI HHHHHHHCHHHHCHH	25.78	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STX1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNP23_HUMAN	SNAP23	physical	12651853
VAPB_HUMAN	VAPB	physical	12651853
VAMP1_HUMAN	VAMP1	physical	12093152
VAMP2_HUMAN	VAMP2	physical	12093152
VAPB_HUMAN	VAPB	physical	24885147

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616172: Generalized epilepsy with febrile seizures plus 9 (GEFSP9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.