DOC2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOC2A_HUMAN
• UniProt AC: Q14183
• Protein Name: Double C2-like domain-containing protein alpha
• Gene Name: DOC2A
• Organism: Homo sapiens (Human).
• Sequence Length: 400
• Subcellular Localization: Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein . Cell junction, synapse, synaptosome. Colocalizes to synaptic vesicles.
• Protein Description: Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells..
• Protein Sequence: MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGGGGEAPAHLVPLALAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLTSELPPAAGALSSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
139	Ubiquitination	HLLPGACKANKLKTK HCCCCCHHHCCCCCC	55.23	29967540
162	Phosphorylation	VWNEDLTYSGITDDD CCCCCCCCCCCCCHH	16.52	27642862
171	Phosphorylation	GITDDDITHKVLRIA CCCCHHHHHEEEEEE	23.73	-
204	Phosphorylation	PLRRLKPSQKKHFNI CHHHCCHHHCCCEEE	53.71	30631047
221	Phosphorylation	ERQVPLASPSSMSAA ECCCCCCCHHHHHHH	32.76	29978859
223	Phosphorylation	QVPLASPSSMSAALR CCCCCCHHHHHHHHH	35.86	29978859
224	Phosphorylation	VPLASPSSMSAALRG CCCCCHHHHHHHHHH	21.82	29978859
226	Phosphorylation	LASPSSMSAALRGIS CCCHHHHHHHHHHHH	16.61	29978859
233	Phosphorylation	SAALRGISCYLKELE HHHHHHHHHHHHHHH	10.26	28555341
258	Phosphorylation	ERGRILLSLSYSSRR HHCEEEEEECCHHHH	16.30	29759185
260	Phosphorylation	GRILLSLSYSSRRRG CEEEEEECCHHHHCC	21.42	29759185
262	Phosphorylation	ILLSLSYSSRRRGLL EEEEECCHHHHCCHH	17.62	29759185
263	Phosphorylation	LLSLSYSSRRRGLLV EEEECCHHHHCCHHH	22.90	29759185
294	Phosphorylation	SDPYVKTYLRPDVDK CCHHHHHHCCCCCCC	8.59	-
313	Phosphorylation	KTCVKKKTLNPEFNE CCCCCCCCCCHHHCH	40.42	-
329	Phosphorylation	FFYEIELSTLATKTL HEEEEEHHHCCCCEE	14.48	-
333	Phosphorylation	IELSTLATKTLEVTV EEHHHCCCCEEEEEE	27.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOC2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOC2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOC2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UN13B_HUMAN	UNC13B	physical	9195900
UN13B_HUMAN	UNC13B	physical	9736751
GDS1_HUMAN	RAP1GDS1	physical	24722188
UBS3B_HUMAN	UBASH3B	physical	24722188
TT21B_HUMAN	TTC21B	physical	26186194
DOC2B_HUMAN	DOC2B	physical	26186194
UBS3B_HUMAN	UBASH3B	physical	26186194
KCD21_HUMAN	KCTD21	physical	26186194
DOC2B_HUMAN	DOC2B	physical	28514442
TT21B_HUMAN	TTC21B	physical	28514442
KCD21_HUMAN	KCTD21	physical	28514442
UBS3B_HUMAN	UBASH3B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.