TT21B_HUMAN - dbPTM
TT21B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TT21B_HUMAN
UniProt AC Q7Z4L5
Protein Name Tetratricopeptide repeat protein 21B
Gene Name TTC21B
Organism Homo sapiens (Human).
Sequence Length 1316
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme.
Protein Description Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Negatively modulates the SHH signal transduction (By similarity)..
Protein Sequence MDSQELKTLINYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREFEAIKNKQDVSLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWHIGRHDKAREYIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFALLGKAQCLEMRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLLQDSQNVEALRMQALYYVCREGDIEKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCGRSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSALVGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLNDVLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISVLETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGASTKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAKLEPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVFENLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVEQALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSWLLLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKYSNRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
95PhosphorylationDREAILESDARVKEQ
CHHHHHHCHHHHHHH		32.88-
104AcetylationARVKEQRKGAGEKAL
HHHHHHHCCHHHHHH		53.457492013
109AcetylationQRKGAGEKALYHAGL
HHCCHHHHHHHHHHH		42.657492023
136UbiquitinationEYIDRMIKISDGSKQ
HHHHHHEECCCCCCC		27.15-
142UbiquitinationIKISDGSKQGHVLKA
EECCCCCCCCCHHHH		66.87-
160PhosphorylationITRGKEPYTKKALKY
CCCCCCCCCHHHHHH		32.08-
166UbiquitinationPYTKKALKYFEEGLQ
CCCHHHHHHHHHHCC		53.40-
243PhosphorylationQRLLLQDSQNVEALR
HHHHHCCCCCHHHHH		15.6426471730
308UbiquitinationRSQLILQKIQTLLER
CHHHHHHHHHHHHHH		33.08-
349PhosphorylationEALKWYKTAMTLDET
HHHHHHHHCCCCCHH		13.13-
352PhosphorylationKWYKTAMTLDETSVS
HHHHHCCCCCHHHHH		28.70-
575UbiquitinationIKAQSQKKMGEIADA
HHHHHHHHHHHHHHH		44.49-
591PhosphorylationKTLHMAMSLPGMKRI
HHHHHHHCCCCCHHC		23.1322210691
648PhosphorylationQDAIHEFSGTSEEVR
HHHHHHHCCCCCHHE		37.87-
675PhosphorylationGDIERALSILQNVTA
CCHHHHHHHHHHCCC		21.9220071362
693UbiquitinationYFIEAREKMADIYLK
CHHHHHHHHHHHHHH		33.56-
705UbiquitinationYLKHRKDKMLYITCF
HHHCCCCCCCHHHHH		33.56-
761UbiquitinationKDGTLASKMGKALIK
CCCCHHHHHHHHHHH		46.17-
777PhosphorylationHNYSMAITYYEAALK
CCCHHHHHHHHHHHH		15.5426503514
778PhosphorylationNYSMAITYYEAALKT
CCHHHHHHHHHHHHH		8.0026503514
779PhosphorylationYSMAITYYEAALKTG
CHHHHHHHHHHHHHC		7.1626503514
846UbiquitinationKVYSKMEKLGDAITA
HHHHHHHHHHHHHHH		55.03-
880UbiquitinationPDAVPAQKHLAAEIC
CCCCHHHHHHHHHHH		42.57-
892UbiquitinationEICAEIAKHSVAQRD
HHHHHHHHHHHHHCH		41.91-
894PhosphorylationCAEIAKHSVAQRDYE
HHHHHHHHHHHCHHH		20.5924719451
900PhosphorylationHSVAQRDYEKAIKFY
HHHHHCHHHHHHHHH		22.8624719451
902UbiquitinationVAQRDYEKAIKFYRE
HHHCHHHHHHHHHHH		49.54-
905UbiquitinationRDYEKAIKFYREALV
CHHHHHHHHHHHHHH		41.00-
947PhosphorylationQCALLLQSDQDNEAA
HHHHHHHCCCCCHHH		36.8924043423
955PhosphorylationDQDNEAATMMMADLM
CCCCHHHHHHHHHHH		16.7924043423
1020UbiquitinationEKRNSRAKLEPGFQY
HHHCCCCCCCCCCHH		52.88-
1061PhosphorylationDWGQNALYNMIEICL
CCHHHHHHHHHHHHH		10.56-
1106UbiquitinationLAVRTAEKLLKELKP
HHHHHHHHHHHHHCC		57.57-
1134UbiquitinationNYCLMATKQKSNVEQ
HEEEHHHCCCCCHHH		46.30-
1136UbiquitinationCLMATKQKSNVEQAL
EEHHHCCCCCHHHHH		45.62-
1185UbiquitinationNQLKRIAKMNWNAID
HHHHHHHHCCCCCCC		30.32-
1212UbiquitinationDIYIQSAKYDMAEDL
HHHHHHCCCCCHHHH		47.21-
1213PhosphorylationIYIQSAKYDMAEDLL
HHHHHCCCCCHHHHH		15.63-
1221UbiquitinationDMAEDLLKRCLRHNR
CCHHHHHHHHHHHCC		48.65-
1229PhosphorylationRCLRHNRSCCKAYEY
HHHHHCCHHHHHHHH		29.2327251275
1243AcetylationYMGYIMEKEQAYTDA
HHHHHHHHHHHHHHH		37.4312655253
1278UbiquitinationKLAFNYLKAKRYVDS
HHHHHHHHHHCCCCH		41.31-
1309UbiquitinationIRKDILDKARASLRP
HHHHHHHHHHHHCCC		36.01-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TT21B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TT21B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TT21B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TT21B_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TT21B_HUMAN

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Related Literatures of Post-Translational Modification

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