DOC2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOC2B_HUMAN
• UniProt AC: Q14184
• Protein Name: Double C2-like domain-containing protein beta
• Gene Name: DOC2B {ECO:0000312|HGNC:HGNC:2986}
• Organism: Homo sapiens (Human).
• Sequence Length: 412
• Subcellular Localization: Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein. Translocates to the plasma membrane in a calcium-dependent manner..
• Protein Description: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity)..
• Protein Sequence: MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
211	Phosphorylation	DEDMIRKTLRISVCD CHHHHHHHCCEEECC	16.06	-
215	Phosphorylation	IRKTLRISVCDEDKF HHHHCCEEECCCCCC	15.40	-
259	Phosphorylation	KQLPVDKTEDKSLEE CCCCCCCCCCCCHHH	44.98	26657352
263	Phosphorylation	VDKTEDKSLEERGRI CCCCCCCCHHHHCCE	54.02	26657352
273	Phosphorylation	ERGRILISLKYSSQK HHCCEEEEEEECCCC	18.50	24719451
301	Phosphorylation	AAMDANGYSDPYVKT HHHHCCCCCCHHHHH	15.09	-
305	Phosphorylation	ANGYSDPYVKTYLRP CCCCCCHHHHHHCCC	21.40	-
309	Phosphorylation	SDPYVKTYLRPDVDK CCHHHHHHCCCCCCC	8.59	-
411	Phosphorylation	ELPGAVLSD------ CCCCCCCCC------	34.37	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
34	S	Phosphorylation	Kinase	PKCI	P41743	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOC2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOC2B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DOC2B_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.