RIMS1_HUMAN - dbPTM
RIMS1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIMS1_HUMAN
UniProt AC Q86UR5
Protein Name Regulating synaptic membrane exocytosis protein 1
Gene Name RIMS1
Organism Homo sapiens (Human).
Sequence Length 1692
Subcellular Localization Cell membrane
Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane
Peripheral membrane protein.
Protein Description Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes. [PubMed: 23999003]
Protein Sequence MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGNDQGKPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTKSVTRQDISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
81PhosphorylationENQPHQPSPRLHQQF
CCCCCCCCHHHHHHH		18.9729759185
90PhosphorylationRLHQQFESYKEQVRK
HHHHHHHHHHHHHHH		42.6729759185
91PhosphorylationLHQQFESYKEQVRKI
HHHHHHHHHHHHHHH		16.0229759185
218PhosphorylationRLQERSRSQTPLSTA
HHHHHHHHCCCHHHH		39.3924076635
220PhosphorylationQERSRSQTPLSTAAA
HHHHHHCCCHHHHHH		27.6924076635
316PhosphorylationERKERRESRRLEKGR
HHHHHHHHHHHHHCC		22.3826074081
324PhosphorylationRRLEKGRSQDYPDTP
HHHHHCCCCCCCCCH		35.7526074081
327PhosphorylationEKGRSQDYPDTPEKR
HHCCCCCCCCCHHHC		8.7226074081
330PhosphorylationRSQDYPDTPEKRDEG
CCCCCCCCHHHCCCC		28.9226074081
355PhosphorylationEEDYQTRYRSDPNLA
HHHHHHHHCCCCCCC		20.1827251275
357PhosphorylationDYQTRYRSDPNLARY
HHHHHHCCCCCCCCC		48.7822617229
381 (in isoform 12)Phosphorylation-4.7525921289
384 (in isoform 12)Phosphorylation-15.0725921289
391PhosphorylationARHERRHSDVALPRT
HHHHHHHCCCCCCCC		31.7827966365
398O-linked_GlycosylationSDVALPRTEAGAALP
CCCCCCCCHHHCCCC		28.3930379171
398PhosphorylationSDVALPRTEAGAALP
CCCCCCCCHHHCCCC		28.3923312004
420PhosphorylationAPAAARASPPDSPRA
CCHHHHCCCCCCCCC		31.2624076635
428PhosphorylationPPDSPRAYSAERTAE
CCCCCCCCCCCHHCC		15.0829083192
429PhosphorylationPDSPRAYSAERTAET
CCCCCCCCCCHHCCC		23.7529083192
430 (in isoform 10)Phosphorylation-9.5225332170
433PhosphorylationRAYSAERTAETRAPG
CCCCCCHHCCCCCCC		21.9829083192
445PhosphorylationAPGAKQLTNHSPPAP
CCCHHHHCCCCCCCC		28.5225307156
448PhosphorylationAKQLTNHSPPAPRHG
HHHHCCCCCCCCCCC		34.3524076635
480 (in isoform 10)Phosphorylation-27.99-
482 (in isoform 10)Phosphorylation-4.69-
488SumoylationAVLMRKAKREKVETM
HHHHHHHHHHHHHHH		65.21-
488SumoylationAVLMRKAKREKVETM
HHHHHHHHHHHHHHH		65.21-
496 (in isoform 9)Phosphorylation-6.3825332170
500PhosphorylationETMLRNDSLSSDQSE
HHHHHCCCCCCCCCC		33.43-
506PhosphorylationDSLSSDQSESVRPSP
CCCCCCCCCCCCCCC		36.51-
510 (in isoform 12)Phosphorylation-34.9525332170
511 (in isoform 13)Phosphorylation-49.3725332170
518 (in isoform 10)Phosphorylation-53.02-
520AcetylationPPKPHRSKRGGKKRQ
CCCCCCCCCCCCCCC		55.837340215
520 (in isoform 10)Phosphorylation-55.8322468782
525 (in isoform 10)Phosphorylation-51.6522468782
529PhosphorylationGGKKRQMSVSSSEEE
CCCCCCCCCCCCCCC		15.5430576142
531PhosphorylationKKRQMSVSSSEEEGV
CCCCCCCCCCCCCCC		22.3430576142
533PhosphorylationRQMSVSSSEEEGVST
CCCCCCCCCCCCCCC		41.3330576142
539PhosphorylationSSEEEGVSTPEYTSC
CCCCCCCCCCCCCCC		49.4530576142
543PhosphorylationEGVSTPEYTSCEDVE
CCCCCCCCCCCCCEE		12.7322468782
544PhosphorylationGVSTPEYTSCEDVEL
CCCCCCCCCCCCEEC		25.8222468782
546 (in isoform 9)Phosphorylation-3.90-
548 (in isoform 9)Phosphorylation-43.44-
553PhosphorylationCEDVELESESVSEKG
CCCEECCCCCCCCCC		48.0422468782
557PhosphorylationELESESVSEKGDLDY
ECCCCCCCCCCCCCE		42.7630576142
560 (in isoform 12)Phosphorylation-36.34-
562 (in isoform 12)Phosphorylation-6.59-
575 (in isoform 13)Phosphorylation-38.02-
577 (in isoform 13)Phosphorylation-38.4022468782
578PhosphorylationTWHSRETSPISSHPV
HCCCCCCCCCCCCCC		18.5825307156
582 (in isoform 13)Phosphorylation-32.3122468782
584 (in isoform 9)Phosphorylation-27.47-
586 (in isoform 9)Phosphorylation-23.8822468782
591 (in isoform 9)Phosphorylation-72.8422468782
606PhosphorylationRVILNKRTTMPKDSG
EEEECCCCCCCCCCC		29.1122210691
626PhosphorylationKVVGGKMTDLGRLGA
EEECCEECCHHHHHH		31.4020068231
636PhosphorylationGRLGAFITKVKKGSL
HHHHHHHHHCCCCCH		24.2720068231
642PhosphorylationITKVKKGSLADVVGH
HHHCCCCCHHHHHCH		29.30-
668PhosphorylationGKPLPGATNEEVYNI
CEECCCCCCHHHHHH		49.4228450419
709PhosphorylationSSHPPLESSSSSFES
CCCCCCCCCCCHHHH		43.11-
710PhosphorylationSHPPLESSSSSFESQ
CCCCCCCCCCHHHHH		25.51-
712PhosphorylationPPLESSSSSFESQKM
CCCCCCCCHHHHHCC		40.7825307156
713PhosphorylationPLESSSSSFESQKME
CCCCCCCHHHHHCCC		34.6725307156
725PhosphorylationKMERPSISVISPTSP
CCCCCCEEEECCCCC		20.1022199227
728PhosphorylationRPSISVISPTSPGAL
CCCEEEECCCCCCHH		21.7022199227
730PhosphorylationSISVISPTSPGALKD
CEEEECCCCCCHHCC		40.5422199227
731PhosphorylationISVISPTSPGALKDA
EEEECCCCCCHHCCC		25.4030576142
781PhosphorylationDGRPRNPYVKMYFLP
CCCCCCCCEEEEECC		19.09-
785PhosphorylationRNPYVKMYFLPDRSD
CCCCEEEEECCCCCC		9.03-
831PhosphorylationRERMLEITVWDQPRV
HHHHHEEEEECCCCC		13.2324961811
869PhosphorylationPHWYKLQTHDESSLP
CCEEEEECCCCCCCC		41.5527251275
873PhosphorylationKLQTHDESSLPLPQP
EEECCCCCCCCCCCC		43.1427251275
874PhosphorylationLQTHDESSLPLPQPS
EECCCCCCCCCCCCC		31.7727251275
881PhosphorylationSLPLPQPSPFMPRRH
CCCCCCCCCCCCCCC		26.0625159151
905PhosphorylationLQRSQRISDSDISDY
HHHHHCCCCCCCCCC		33.0025921289
907PhosphorylationRSQRISDSDISDYEV
HHHCCCCCCCCCCCC		30.0125921289
907 (in isoform 5)Phosphorylation-30.0125921289
907 (in isoform 7)Phosphorylation-30.0125921289
907 (in isoform 8)Phosphorylation-30.0125921289
910PhosphorylationRISDSDISDYEVDDG
CCCCCCCCCCCCCCC		38.8525921289
910 (in isoform 5)Phosphorylation-38.8525921289
910 (in isoform 7)Phosphorylation-38.8525921289
910 (in isoform 8)Phosphorylation-38.8525921289
912PhosphorylationSDSDISDYEVDDGIG
CCCCCCCCCCCCCCC		15.8625921289
926NitrationGVVPPVGYRSSARES
CCCCCCCCCCCCCCC		13.93-
926PhosphorylationGVVPPVGYRSSARES
CCCCCCCCCCCCCCC		13.93-
967PhosphorylationNDQGKPRSRLPNVPL
CCCCCCCCCCCCCCC		46.85-
977PhosphorylationPNVPLQRSLDEIHPT
CCCCCCCCHHHCCCC		27.4925307156
987PhosphorylationEIHPTRRSRSPTRHH
HCCCCCCCCCCCCCC		33.5428634120
991PhosphorylationTRRSRSPTRHHDASR
CCCCCCCCCCCCCCC		43.8328634120
997PhosphorylationPTRHHDASRSPVDHR
CCCCCCCCCCCCCCC		39.07-
1014PhosphorylationDVDSQYLSEQDSELL
CCCHHHCCHHCCHHE		28.4223898821
1031PhosphorylationPRAKRGRSAECLHTT
CCCCCCCCHHHHHHH		31.1023898821
1036 (in isoform 7)Phosphorylation-36.5325332170
1037 (in isoform 3)Phosphorylation-16.7525332170
1037 (in isoform 6)Phosphorylation-16.7525332170
1049 (in isoform 8)Phosphorylation-31.53-
1051 (in isoform 8)Phosphorylation-51.7322468782
1056 (in isoform 8)Phosphorylation-49.2922468782
1065PhosphorylationSSHWNIYSSILPAHT
CCCCCCHHHCCCCCC		13.70-
1066PhosphorylationSHWNIYSSILPAHTK
CCCCCHHHCCCCCCC		15.92-
1076PhosphorylationPAHTKTKSVTRQDIS
CCCCCCCCCCCCHHH		33.67-
1092PhosphorylationHHECFNSTVLRFTDE
HHHHHCCHHHHHCCH		25.3524719451
1100 (in isoform 7)Phosphorylation-5.25-
1102 (in isoform 7)Phosphorylation-5.2622468782
1107 (in isoform 7)Phosphorylation-44.3822468782
1128PhosphorylationRPDTSLHSPERERGR
CCCCCCCCCCHHCCC		33.4823532336
1129 (in isoform 6)Phosphorylation-33.64-
1131 (in isoform 6)Phosphorylation-42.1522468782
1136 (in isoform 6)Phosphorylation-19.8822468782
1147PhosphorylationLDRRRPPSPRIQIQH
CCCCCCCCCCCEEEE		29.5026846344
1163PhosphorylationSPENDRHSRKSERSS
CCCCCCCCCHHHHHH		42.1523186163
1179O-linked_GlycosylationQKQTRKGTASDAERV
HHHHCCCCHHHHHHH		26.4830379171
1179PhosphorylationQKQTRKGTASDAERV
HHHHCCCCHHHHHHH		26.48-
1189PhosphorylationDAERVLPTCLSRRGH
HHHHHHHHHHHHCCC		23.1722985185
1192PhosphorylationRVLPTCLSRRGHAAP
HHHHHHHHHCCCCCC		23.2929449344
1215PhosphorylationRGKHPARSRSSEHSS
CCCCCCCCCCCCHHH		38.3222210691
1217PhosphorylationKHPARSRSSEHSSIR
CCCCCCCCCCHHHHH		41.1322210691
1222PhosphorylationSRSSEHSSIRTLCSM
CCCCCHHHHHHHHHH		20.2822210691
1252PhosphorylationTRMHRQRSPTQSPPA
HHHHHCCCCCCCCCC		24.7820873877
1254PhosphorylationMHRQRSPTQSPPADT
HHHCCCCCCCCCCCC		42.8127251275
1256PhosphorylationRQRSPTQSPPADTSF
HCCCCCCCCCCCCCC		35.0224076635
1261PhosphorylationTQSPPADTSFSSRRG
CCCCCCCCCCCCCCC		33.50-
1305PhosphorylationKVHRFKQTTGSGSSQ
EEEEHHCCCCCCCCH		33.4425907765
1306PhosphorylationVHRFKQTTGSGSSQE
EEEHHCCCCCCCCHH		27.1925907765
1308PhosphorylationRFKQTTGSGSSQELD
EHHCCCCCCCCHHCC		33.1525907765
1310PhosphorylationKQTTGSGSSQELDRE
HCCCCCCCCHHCCHH		30.4625907765
1311PhosphorylationQTTGSGSSQELDREQ
CCCCCCCCHHCCHHH		31.0625627689
1319PhosphorylationQELDREQYSKYNIHK
HHCCHHHHHHHCCCH		11.4622817900
1320PhosphorylationELDREQYSKYNIHKD
HCCHHHHHHHCCCHH		28.4925907765
1322PhosphorylationDREQYSKYNIHKDQY
CHHHHHHHCCCHHHH		17.2622817900
1329PhosphorylationYNIHKDQYRSCDNVS
HCCCHHHHHCCCCCC		18.0322817900
1331PhosphorylationIHKDQYRSCDNVSAK
CCHHHHHCCCCCCCC		22.3825159151
1336PhosphorylationYRSCDNVSAKSSDSD
HHCCCCCCCCCCCCC		35.9118669648
1339PhosphorylationCDNVSAKSSDSDVSD
CCCCCCCCCCCCHHH		38.8120873877
1340PhosphorylationDNVSAKSSDSDVSDV
CCCCCCCCCCCHHHH		40.1918669648
1342PhosphorylationVSAKSSDSDVSDVSA
CCCCCCCCCHHHHHH		41.6918669648
1345PhosphorylationKSSDSDVSDVSAISR
CCCCCCHHHHHHHHC		36.97-
1348PhosphorylationDSDVSDVSAISRTSS
CCCHHHHHHHHCCCC		25.52-
1353PhosphorylationDVSAISRTSSASRLS
HHHHHHCCCCCHHHH		21.9022210691
1354PhosphorylationVSAISRTSSASRLSS
HHHHHCCCCCHHHHC		23.8522210691
1355PhosphorylationSAISRTSSASRLSST
HHHHCCCCCHHHHCC		29.6522210691
1357PhosphorylationISRTSSASRLSSTSF
HHCCCCCHHHHCCCC		35.38-
1359 (in isoform 3)Phosphorylation-4.3722210691
1361PhosphorylationSSASRLSSTSFMSEQ
CCCHHHHCCCCCCCC		32.4425627689
1363PhosphorylationASRLSSTSFMSEQSE
CHHHHCCCCCCCCCC		22.3922210691
1369PhosphorylationTSFMSEQSERPRGRI
CCCCCCCCCCCCCCC		31.3622210691
1377O-linked_GlycosylationERPRGRISSFTPKMQ
CCCCCCCCCCCHHHC		20.3130379171
1390PhosphorylationMQGRRMGTSGRSIMK
HCCCCCCCCCCHHHH		20.7529759185
1391PhosphorylationQGRRMGTSGRSIMKS
CCCCCCCCCCHHHHE		26.8624732914
1394PhosphorylationRMGTSGRSIMKSTSV
CCCCCCCHHHHEEEC		30.4729759185
1406PhosphorylationTSVSGEMYTLEHNDG
EECCCCEEEEECCCC		12.1330576142
1407PhosphorylationSVSGEMYTLEHNDGS
ECCCCEEEEECCCCC		25.1030576142
1414PhosphorylationTLEHNDGSQSDTAVG
EEECCCCCCCCCEEE		29.4030576142
1416PhosphorylationEHNDGSQSDTAVGTV
ECCCCCCCCCEEEEE		38.3330576142
1418PhosphorylationNDGSQSDTAVGTVGA
CCCCCCCCEEEEECC		28.6125627689
1422PhosphorylationQSDTAVGTVGAGGKK
CCCCEEEEECCCCCC		14.7918669648
1433PhosphorylationGGKKRRSSLSAKVVA
CCCCCCCCCHHHHHE		25.2427282143
1435PhosphorylationKKRRSSLSAKVVAIV
CCCCCCCHHHHHEEE		28.1727282143
1443PhosphorylationAKVVAIVSRRSRSTS
HHHHEEEECCCCCHH		18.8320393185
1446PhosphorylationVAIVSRRSRSTSQLS
HEEEECCCCCHHHCC		29.4923898821
1448PhosphorylationIVSRRSRSTSQLSQT
EEECCCCCHHHCCCC		33.3927251275
1449PhosphorylationVSRRSRSTSQLSQTE
EECCCCCHHHCCCCH		21.2727251275
1450PhosphorylationSRRSRSTSQLSQTES
ECCCCCHHHCCCCHH		30.3025159151
1455PhosphorylationSTSQLSQTESGHKKL
CHHHCCCCHHHHHHH		28.83-
1457PhosphorylationSQLSQTESGHKKLKS
HHCCCCHHHHHHHHH		49.97-
1463UbiquitinationESGHKKLKSTIQRST
HHHHHHHHHHHHHHH		55.20-
1486PhosphorylationRKMVRQPSRESTDGS
HHHHCCCCCCCCCCC		40.1030576142
1489PhosphorylationVRQPSRESTDGSINS
HCCCCCCCCCCCCCC		30.5926657352
1490PhosphorylationRQPSRESTDGSINSY
CCCCCCCCCCCCCCC		39.3626657352
1493PhosphorylationSRESTDGSINSYSSE
CCCCCCCCCCCCCCC		22.7726657352
1496PhosphorylationSTDGSINSYSSEGNL
CCCCCCCCCCCCCCE		25.4020873877
1497PhosphorylationTDGSINSYSSEGNLI
CCCCCCCCCCCCCEE		16.2420873877
1498PhosphorylationDGSINSYSSEGNLIF
CCCCCCCCCCCCEEC		23.0220873877
1499PhosphorylationGSINSYSSEGNLIFP
CCCCCCCCCCCEECC		41.0930576142
1514PhosphorylationGVRLGADSQFSDFLD
CCCCCCCCHHHHHHC		32.3720873877
1517PhosphorylationLGADSQFSDFLDGLG
CCCCCHHHHHHCCCC		21.5920873877
1562PhosphorylationVEVIRARSLTQKPGS
EEEEEEECCCCCCCC		34.4819413330
1564PhosphorylationVIRARSLTQKPGSKS
EEEEECCCCCCCCCC		35.4719413330
1576PhosphorylationSKSTPAPYVKVYLLE
CCCCCCCEEEEEEEC		18.27-
1580PhosphorylationPAPYVKVYLLENGAC
CCCEEEEEEECCCEE		10.39-
1613PhosphorylationQSLVFDESPQGKVLQ
CCCEECCCCCCCEEE		25.1125159151
1627PhosphorylationQVIVWGDYGRMDHKC
EEEEEECCCCCCHHH		11.5922817900
1662PhosphorylationWYKLFPPSSLVDPTL
HHHHCCHHHHCCCCC		36.2226552605
1663PhosphorylationYKLFPPSSLVDPTLT
HHHCCHHHHCCCCCC		37.8826552605
1668PhosphorylationPSSLVDPTLTPLTRR
HHHHCCCCCCHHHHH		38.5126552605
1670PhosphorylationSLVDPTLTPLTRRAS
HHCCCCCCHHHHHHH		20.8028387310
1673PhosphorylationDPTLTPLTRRASQSS
CCCCCHHHHHHHHHH		21.2228387310
1677PhosphorylationTPLTRRASQSSLESS
CHHHHHHHHHHHHHC		28.8725159151
1679PhosphorylationLTRRASQSSLESSTG
HHHHHHHHHHHHCCC		34.1025159151
1680PhosphorylationTRRASQSSLESSTGP
HHHHHHHHHHHCCCC		28.6325159151
1683PhosphorylationASQSSLESSTGPPCI
HHHHHHHHCCCCCCC		38.1925159151
1684PhosphorylationSQSSLESSTGPPCIR
HHHHHHHCCCCCCCC		28.1822199227
1685PhosphorylationQSSLESSTGPPCIRS
HHHHHHCCCCCCCCC		64.0922199227
1692PhosphorylationTGPPCIRS-------
CCCCCCCC-------		25.3518669648
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIMS1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIMS1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIMS1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
1433F_HUMANYWHAHphysical
12871946
UN13B_HUMANUNC13Bphysical
11343654
RAB3A_HUMANRAB3Aphysical
11343654
UN13B_HUMANUNC13Bphysical
12163476
ERC2_HUMANERC2physical
12163476
Drug and Disease Associations
Kegg Disease
H00481 Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); R
OMIM Disease
603649Cone-rod dystrophy 7 (CORD7)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIMS1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1677; SER-1680; SER-1683AND SER-1692, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1670; SER-1677; SER-1679AND SER-1680, AND MASS SPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1677 AND SER-1680, ANDMASS SPECTROMETRY.

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