dbPTM

RAB3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAB3A_HUMAN
UniProt AC	P20336
Protein Name	Ras-related protein Rab-3A
Gene Name	RAB3A
Organism	Homo sapiens (Human).
Sequence Length	220
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side .
Protein Description	Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal..
Protein Sequence	MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLSDQQVPPHQDCAC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	KTSFLFRYADDSFTP CEEEEEEECCCCCCC	13.67	22817900
65	Phosphorylation	DFKVKTIYRNDKRIK CEEEEEEEECCCEEE	14.48	-
78	Phosphorylation	IKLQIWDTAGQERYR EEEEEECCCCHHHHH	20.07	28857561
84	Phosphorylation	DTAGQERYRTITTAY CCCCHHHHHHHHHHH	16.03	19060867
86	Phosphorylation	AGQERYRTITTAYYR CCHHHHHHHHHHHHH	17.46	26824392
88	Phosphorylation	QERYRTITTAYYRGA HHHHHHHHHHHHHCC	12.54	-
89	Phosphorylation	ERYRTITTAYYRGAM HHHHHHHHHHHHCCC	14.60	24961811
91	Phosphorylation	YRTITTAYYRGAMGF HHHHHHHHHHCCCEE	7.51	21951684
92	Phosphorylation	RTITTAYYRGAMGFI HHHHHHHHHCCCEEE	10.50	21951684
102	Phosphorylation	AMGFILMYDITNEES CCEEEEEEECCCHHH	10.76	21951684
123	Phosphorylation	WSTQIKTYSWDNAQV CCCEEEEEEECCCEE	11.63	-
173	Ubiquitination	AKDNINVKQTFERLV HCCCCCHHHHHHHHH	38.85	-
188	Phosphorylation	DVICEKMSESLDTAD HHHHHHHHHCCCCCC	34.79	25850435
190	Phosphorylation	ICEKMSESLDTADPA HHHHHHHCCCCCCCC	25.00	25159151
193	Phosphorylation	KMSESLDTADPAVTG HHHHCCCCCCCCCCC	37.95	29514088
218	Geranylgeranylation	QVPPHQDCAC----- CCCCCCCCCC-----	3.15	1648736
218	Geranylgeranylation	QVPPHQDCAC----- CCCCCCCCCC-----	3.15	1648736
220	Methylation	PPHQDCAC------- CCCCCCCC-------	7.82	1648736
220	Geranylgeranylation	PPHQDCAC------- CCCCCCCC-------	7.82	1648736
220	Geranylgeranylation	PPHQDCAC------- CCCCCCCC-------	7.82	1648736

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
86	T	Phosphorylation	Kinase	LRRK2	Q5S007	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
86	T	Phosphorylation		26824392
Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAB3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RP3A_HUMAN	RPH3A	physical	10025402
SYTL4_HUMAN	SYTL4	physical	11773082
RAE1_HUMAN	CHM	physical	12535645
SYTL4_HUMAN	SYTL4	physical	11865063
SYUA_HUMAN	SNCA	physical	15207266
SYUA_HUMAN	SNCA	physical	15854772
BICL2_MOUSE	Ccdc64b	physical	20360680
MSS4_HUMAN	RABIF	physical	25416956
RAB3I_HUMAN	RAB3IP	physical	25416956
RAE2_HUMAN	CHML	physical	26186194
RAE1_HUMAN	CHM	physical	26186194
SYTL4_HUMAN	SYTL4	physical	26186194
RAB3B_HUMAN	RAB3B	physical	26186194
MOCOS_HUMAN	MOCOS	physical	26186194
RB33B_HUMAN	RAB33B	physical	26186194
PGTA_HUMAN	RABGGTA	physical	26186194
VW5B2_HUMAN	VWA5B2	physical	26186194
MOG1_HUMAN	RANGRF	physical	26186194
CAF17_HUMAN	IBA57	physical	26186194
WIPI3_HUMAN	WDR45B	physical	26186194
RAB3B_HUMAN	RAB3B	physical	28514442
SYTL4_HUMAN	SYTL4	physical	28514442
RAE1_HUMAN	CHM	physical	28514442
RAE2_HUMAN	CHML	physical	28514442
MOG1_HUMAN	RANGRF	physical	28514442
RB33B_HUMAN	RAB33B	physical	28514442
GDIA_HUMAN	GDI1	physical	28514442
MOCOS_HUMAN	MOCOS	physical	28514442
VW5B2_HUMAN	VWA5B2	physical	28514442
GDIB_HUMAN	GDI2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAB3A_HUMAN

Related Literatures of Post-Translational Modification

Prenylation
Reference	PubMed
"Rab geranylgeranyl transferase catalyzes the geranylgeranylation ofadjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A."; Farnsworth C.C., Seabra M.C., Ericsson L.H., Gelb M.H., Glomset J.A.; Proc. Natl. Acad. Sci. U.S.A. 91:11963-11967(1994). Cited for: ISOPRENYLATION AT CYS-218 AND CYS-220, AND MASS SPECTROMETRY.	7991565 [Abstract]
"Isoprenoid modification of rab proteins terminating in CC or CXCmotifs."; Khosravi-Far R., Lutz R.J., Cox A.D., Conroy L., Bourne J.R.,Sinensky M., Balch W.E., Buss J.E., Der C.J.; Proc. Natl. Acad. Sci. U.S.A. 88:6264-6268(1991). Cited for: ISOPRENYLATION AT CYS-218 AND CYS-220.	1648736 [Abstract]