WIPI3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WIPI3_HUMAN
• UniProt AC: Q5MNZ6
• Protein Name: WD repeat domain phosphoinositide-interacting protein 3
• Gene Name: WDR45B
• Organism: Homo sapiens (Human).
• Sequence Length: 344
• Protein Sequence: MNLLPCNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKRNKQSSLASASFLPKYFSSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGSYYKFLFNPKGECIRDVYAQFLEMTDDKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Ubiquitination	VYNTDPLKEKEKQEF EECCCCCCHHHHHHH	72.61	21906983
44	Ubiquitination	NTDPLKEKEKQEFLE CCCCCCHHHHHHHHH	69.49	22817900
46	Ubiquitination	DPLKEKEKQEFLEGG CCCCHHHHHHHHHCC	67.22	22817900
65	Phosphorylation	EMLFRCNYLALVGGG HHHHHCCEEEEECCC	9.29	28152594
88	Ubiquitination	KVMIWDDLKKKTVIE CEEEEECCCCCEEEE	8.98	23000965
89	Ubiquitination	VMIWDDLKKKTVIEI EEEEECCCCCEEEEE	60.25	32015554
92	Phosphorylation	WDDLKKKTVIEIEFS EECCCCCEEEEEEEE	35.28	28634298
99	Phosphorylation	TVIEIEFSTEVKAVK EEEEEEEECCEEEEE	15.74	28634298
100	Phosphorylation	VIEIEFSTEVKAVKL EEEEEEECCEEEEEE	50.55	28634298
137	Phosphorylation	HQLHVFETCYNPKGL CEEEEEEEEECCCCE	14.61	22210691
139	Phosphorylation	LHVFETCYNPKGLCV EEEEEEEECCCCEEE	41.75	22210691
145	Ubiquitination	CYNPKGLCVLCPNSN EECCCCEEEECCCCC	2.75	23000965
148	Ubiquitination	PKGLCVLCPNSNNSL CCCEEEECCCCCCCE	1.17	23000965
160	Ubiquitination	NSLLAFPGTHTGHVQ CCEEEECCCCCCEEE	24.55	21890473
165	Ubiquitination	FPGTHTGHVQLVDLA ECCCCCCEEEEEECC	12.81	23000965
172	Ubiquitination	HVQLVDLASTEKPPV EEEEEECCCCCCCCC	15.22	23000965
189	Phosphorylation	PAHEGVLSCIALNLQ CCCCCHHHHEEEECC	10.89	29759185
202	Phosphorylation	LQGTRIATASEKGTL CCCCEEEEECCCCCE	28.48	29759185
204	Phosphorylation	GTRIATASEKGTLIR CCEEEEECCCCCEEE	35.17	29759185
206	Malonylation	RIATASEKGTLIRIF EEEEECCCCCEEEEE	55.49	26320211
206	2-Hydroxyisobutyrylation	RIATASEKGTLIRIF EEEEECCCCCEEEEE	55.49	-
206	Ubiquitination	RIATASEKGTLIRIF EEEEECCCCCEEEEE	55.49	23000965
229	Ubiquitination	QELRRGSQAANIYCI HHHHHCCCCCEEEEE	47.52	23000965
232	Ubiquitination	RRGSQAANIYCINFN HHCCCCCEEEEEECC	28.86	23000965
244	Ubiquitination	NFNQDASLICVSSDH ECCCCCCEEEEECCC	3.64	21890473
249	Ubiquitination	ASLICVSSDHGTVHI CCEEEEECCCCEEEE	17.15	23000965
263	Ubiquitination	IFAAEDPKRNKQSSL EEEECCCCCCCCCCH	79.51	23000965
266	Ubiquitination	AEDPKRNKQSSLASA ECCCCCCCCCCHHCH	56.44	23000965
278	Ubiquitination	ASASFLPKYFSSKWS HCHHHCHHHHCCCCC	62.16	23000965
283	Ubiquitination	LPKYFSSKWSFSKFQ CHHHHCCCCCCCCCC	45.73	23000965
285	Phosphorylation	KYFSSKWSFSKFQVP HHHCCCCCCCCCCCC	24.31	24719451
325	Ubiquitination	YKFLFNPKGECIRDV EEEEECCCCHHHHHH	69.33	33845483
333	Phosphorylation	GECIRDVYAQFLEMT CHHHHHHHHHHHHHC	10.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WIPI3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WIPI3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WIPI3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UBX10_HUMAN	UBXN10	physical	26389662

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.