VW5B2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VW5B2_HUMAN
• UniProt AC: Q8N398
• Protein Name: von Willebrand factor A domain-containing protein 5B2
• Gene Name: VWA5B2
• Organism: Homo sapiens (Human).
• Sequence Length: 1253
• Protein Sequence: MPGLYCPSSWTPLPLTDSWVRACANGPCLSVRARLTYRNPQPQPVDGVFVYPLAEAEVVSGFEAEAAGRRVSFQLQSRRRSQAACCRALGPGLGTPTPRRCAQGHLVLDLAQARSTLVLPTGIIAAAGTMTVTLHSSRELPSRPDGVLHVALPTVLTPLAPPGPPGPPRPPGLCDDSGPVTLLMLPSSPTSCFGVGSLQEEGLAWEELAAPRDVFSGPARCPAPYTFSFEMLVTGPCLLAGLESPSHALRADAPPHASSAATICVTLAEGHHCDRALEILLHPSEPHQPHLMLEGGSLSSAEYEARVRARRDFQRLQRRDSDGDRQVWFLQRRFHKDILLNPVLALSFCPDLSSKPGHLGTATRELLFLLDSSSVAHKDAIVLAVKSLPPQTLINLAVFGTLVQPLFPESRPCSDDAVQLICESIETLQVPSGPPDVLAALDWAVGQPQHRAYPRQLFLLTAASPMAATTHRTLELMRWHRGTARCFSFGLGPTCHQLLQGLSALSRGQAYFLRPGQRLQPMLVQALRKALEPALSDISVDWFVPDTVEALLTPREIPALYPGDQLLGYCSLFRVDGFRSRPPGGQEPGWQSSGGSVFPSPEEAPSAASPGTEPTGTSEPLGTGTVSAELSSPWAARDSEQSTDALTDPVTDPGPNPSDTAIWRRIFQSSYIREQYVLTHCSASPEPGPGSTGSSESPGSQGPGSPEGSAPLEPPSQQGCRSLAWGEPAGSRSCPLPAPTPAPFKVGALSTEVLGRQHRAALAGRSLSSPPGRANQVPGRPRKPSLGAILDGPSPEPGQQLGQGLDDSGNLLSPAPMDWDMLMEPPFLFTAVPPSGELAPPAVPPQAPRCHVVIRGLCGEQPMCWEVGVGLETLWGPGDGSQPPSPPVREAAWDQALHRLTAASVVRDNEQLALRGGAETTADRGHARRCWLRALQTSKVSSAPSCFTCPVAVDATTREVLPGALQVCSSEPAEPPGTPPASHSHLDAAPLPTVVYSKGLQRGSPAGAWDSDQNGNSKRALGDPATPTEGPRRPPPRPPCRLSMGRRHKLCSPDPGQANNSEGSDHDYLPLVRLQEAPGSFRLDAPFCAAVRISQERLCRASPFAVHRASLSPTSASLPWALLGPGVGQGDSATASCSPSPSSGSEGPGQVDSGRGSDTEASEGAEGLGGTDLRGRTWATAVALAWLEHRCAAAFDEWELTAAKADCWLRAQHLPDGLDLAALKAAARGLFLLLRHWDQNLQLHLLCYSPANV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	RVSFQLQSRRRSQAA CEEHHHHCHHHHHHH	36.03	27499020
95	Phosphorylation	ALGPGLGTPTPRRCA HHCCCCCCCCCCCHH	29.09	23312004
97	Phosphorylation	GPGLGTPTPRRCAQG CCCCCCCCCCCHHCC	29.30	23312004
299	Phosphorylation	MLEGGSLSSAEYEAR EEECCCCCHHHHHHH	29.24	-
303	Phosphorylation	GSLSSAEYEARVRAR CCCCHHHHHHHHHHH	18.01	-
310	Phosphorylation	YEARVRARRDFQRLQ HHHHHHHHHHHHHHH	28.30	-
321	Phosphorylation	QRLQRRDSDGDRQVW HHHHHHCCCHHHHHH	41.50	27422710
410	Phosphorylation	VQPLFPESRPCSDDA CCCCCCCCCCCCHHH	41.58	22210691
536	Phosphorylation	KALEPALSDISVDWF HHHHHHHCCCCCCEE	34.70	-
539	Phosphorylation	EPALSDISVDWFVPD HHHHCCCCCCEECCC	21.00	-
547	Phosphorylation	VDWFVPDTVEALLTP CCEECCCHHHHHCCC	17.74	-
660	Phosphorylation	PGPNPSDTAIWRRIF CCCCHHHHHHHHHHH	25.12	-
669	Phosphorylation	IWRRIFQSSYIREQY HHHHHHHHHHHCEEE	17.85	23312004
670	Phosphorylation	WRRIFQSSYIREQYV HHHHHHHHHHCEEEE	17.50	28857561
671	Phosphorylation	RRIFQSSYIREQYVL HHHHHHHHHCEEEEE	14.83	25884760
722	Phosphorylation	PSQQGCRSLAWGEPA CCCCCCCCCCCCCCC	26.90	23312004
731	Phosphorylation	AWGEPAGSRSCPLPA CCCCCCCCCCCCCCC	24.11	23312004
733	Phosphorylation	GEPAGSRSCPLPAPT CCCCCCCCCCCCCCC	23.06	27499020
739	Phosphorylation	RSCPLPAPTPAPFKV CCCCCCCCCCCCCEE	36.65	-
740	Phosphorylation	SCPLPAPTPAPFKVG CCCCCCCCCCCCEEC	33.90	23312004
750	Phosphorylation	PFKVGALSTEVLGRQ CCEECCCCHHHHCHH	23.22	23312004
751	Phosphorylation	FKVGALSTEVLGRQH CEECCCCHHHHCHHH	30.85	23312004
758	Phosphorylation	TEVLGRQHRAALAGR HHHHCHHHHHHHCCC	21.71	27251275
766	Phosphorylation	RAALAGRSLSSPPGR HHHHCCCCCCCCCCC	31.52	26657352
768	Phosphorylation	ALAGRSLSSPPGRAN HHCCCCCCCCCCCCC	41.88	30266825
769	Phosphorylation	LAGRSLSSPPGRANQ HCCCCCCCCCCCCCC	40.17	30266825
913	Methylation	VRDNEQLALRGGAET HCCCCHHHHCCCCCC	8.56	-
924	Methylation	GAETTADRGHARRCW CCCCCCCHHHHHHHH	36.01	115919873
967	Phosphorylation	VLPGALQVCSSEPAE CCCCCEECCCCCCCC	3.39	27251275
969	Phosphorylation	PGALQVCSSEPAEPP CCCEECCCCCCCCCC	38.59	26657352
978	Phosphorylation	EPAEPPGTPPASHSH CCCCCCCCCCCCCCC	31.69	26657352
984	Phosphorylation	GTPPASHSHLDAAPL CCCCCCCCCCCCCCC	24.21	28857561
1015	Phosphorylation	AWDSDQNGNSKRALG CCCCCCCCCCCCCCC	33.87	-
1026	Phosphorylation	RALGDPATPTEGPRR CCCCCCCCCCCCCCC	35.81	26657352
1052	Phosphorylation	GRRHKLCSPDPGQAN CCCCCCCCCCCCCCC	42.65	27050516
1102	Phosphorylation	QERLCRASPFAVHRA HHHHHHCCCCCEEEC	10.95	23403867
1157	Phosphorylation	QVDSGRGSDTEASEG CCCCCCCCCCCCHHC	39.74	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VW5B2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VW5B2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VW5B2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of VW5B2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.