| UniProt ID | RP3A_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y2J0 | |
| Protein Name | Rabphilin-3A | |
| Gene Name | RPH3A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 694 | |
| Subcellular Localization |
Cell junction, synapse. Membrane Peripheral membrane protein. |
|
| Protein Description | Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).. | |
| Protein Sequence | MTDTVFSNSSNRWMYPSDRPLQSNDKEQLQAGWSVHPGGQPDRQRKQEELTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASEARMSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPGTTAPPREERTGGVGGYPAVGAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 51 | Phosphorylation | QRKQEELTDEEKEII HHHHHHCCHHHHHHH | 44.65 | 20166139 | |
| 110 | Phosphorylation | EQLGMLGSACVVCED CHHCCCCCEEEECCC | 17.97 | - | |
| 206 | Phosphorylation | RAPARGDSEDRRGPG CCCCCCCCCCCCCCC | 44.19 | - | |
| 226 | Methylation | DPASAPGRGNYGPPV CCCCCCCCCCCCCCC | 29.17 | - | |
| 242 | Phosphorylation | RASEARMSSSSRDSE CHHHHHCCCCCCCCC | 22.86 | - | |
| 243 | Phosphorylation | ASEARMSSSSRDSES HHHHHCCCCCCCCCC | 24.00 | - | |
| 244 | Phosphorylation | SEARMSSSSRDSESW HHHHCCCCCCCCCCC | 23.29 | - | |
| 245 | Phosphorylation | EARMSSSSRDSESWD HHHCCCCCCCCCCCC | 41.89 | 30576142 | |
| 248 | Phosphorylation | MSSSSRDSESWDHSG CCCCCCCCCCCCCCC | 32.21 | - | |
| 250 | Phosphorylation | SSSRDSESWDHSGGA CCCCCCCCCCCCCCC | 41.58 | 22210691 | |
| 260 | Phosphorylation | HSGGAGDSSRSPAGL CCCCCCCCCCCHHHH | 27.08 | 22210691 | |
| 263 | Phosphorylation | GAGDSSRSPAGLRRA CCCCCCCCHHHHHCC | 22.50 | 26670566 | |
| 272 | Phosphorylation | AGLRRANSVQASRPA HHHHCCCCCCCCCCC | 18.02 | 24117733 | |
| 276 | Phosphorylation | RANSVQASRPAPGSV CCCCCCCCCCCCCCC | 23.00 | 24117733 | |
| 282 | Phosphorylation | ASRPAPGSVQSPAPP CCCCCCCCCCCCCCC | 18.87 | 27732954 | |
| 285 | Phosphorylation | PAPGSVQSPAPPQPG CCCCCCCCCCCCCCC | 22.37 | 27732954 | |
| 296 | Phosphorylation | PQPGQPGTPGGSRPG CCCCCCCCCCCCCCC | 25.99 | 27732954 | |
| 300 | Phosphorylation | QPGTPGGSRPGPGPA CCCCCCCCCCCCCCC | 41.01 | 27732954 | |
| 333 | Phosphorylation | APPREERTGGVGGYP CCCCHHHCCCCCCCC | 41.38 | 23403867 | |
| 356 | Phosphorylation | MSHPSGPYSQASAAA CCCCCCCHHHHCCCC | 19.55 | 25884760 | |
| 357 | Phosphorylation | SHPSGPYSQASAAAP CCCCCCHHHHCCCCC | 23.54 | 25884760 | |
| 424 | Phosphorylation | KGLKPMDSNGLADPY CCCCCCCCCCCCCCE | 26.92 | 24719451 | |
| 477 | Phosphorylation | DEDMQRKTLRISVCD CHHHHHCEEEEEECC | 24.37 | - | |
| 481 | Phosphorylation | QRKTLRISVCDEDKF HHCEEEEEECCCCCC | 15.40 | - | |
| 692 | Phosphorylation | LQNENHVSSD----- HHHCCCCCCC----- | 22.65 | 27732954 | |
| 693 | Phosphorylation | QNENHVSSD------ HHCCCCCCC------ | 46.37 | 29507054 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RP3A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RP3A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RP3A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RAB3A_HUMAN | RAB3A | physical | 8636125 | |
| RAB3B_HUMAN | RAB3B | physical | 8636125 | |
| GCH1_HUMAN | GCH1 | physical | 7802677 | |
| ADDB_HUMAN | ADD2 | physical | 7707875 | |
| DOC2B_HUMAN | DOC2B | physical | 28514442 | |
| RAB8B_HUMAN | RAB8B | physical | 28514442 | |
| RB27A_HUMAN | RAB27A | physical | 28514442 | |
| RAB8A_HUMAN | RAB8A | physical | 28514442 | |
| UBE3A_HUMAN | UBE3A | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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