RB33B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RB33B_HUMAN
• UniProt AC: Q9H082
• Protein Name: Ras-related protein Rab-33B
• Gene Name: RAB33B
• Organism: Homo sapiens (Human).
• Sequence Length: 229
• Subcellular Localization: Golgi apparatus membrane ; Lipid-anchor . Golgi apparatus, cis-Golgi network . Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm.
• Protein Description: Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation..
• Protein Sequence: MAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQPPDNGIILKPEPKPAMTCWC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	O-linked_Glycosylation	GDSNVGKTCLTYRFC CCCCCCCCHHHHHCC	13.56	31637018
83	Acetylation	EIDGERIKIQLWDTA EECCEEEEEEEECCC	30.53	26051181
89	Phosphorylation	IKIQLWDTAGQERFR EEEEEECCCCHHHHH	22.55	28857561
98	Phosphorylation	GQERFRKSMVQHYYR CHHHHHHHHHHHHHH	21.67	30108239
149	Ubiquitination	PRILVGNKCDLRSAI CCEEECCCCCHHHHC	24.17	-
154	Phosphorylation	GNKCDLRSAIQVPTD CCCCCHHHHCCCCHH	36.70	22210691
165	Ubiquitination	VPTDLAQKFADTHSM CCHHHHHHHHHCCCC	36.59	-
227	Geranylgeranylation	EPKPAMTCWC----- CCCCCCCCCC-----	1.93	-
229	Methylation	KPAMTCWC------- CCCCCCCC-------	4.32	-
229	Geranylgeranylation	KPAMTCWC------- CCCCCCCC-------	4.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RB33B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RB33B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RB33B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RABE1_HUMAN	RABEP1	physical	11718716
GOGA2_HUMAN	GOLGA2	physical	11718716
A16L1_HUMAN	ATG16L1	physical	18448665
MLP3A_HUMAN	MAP1LC3A	physical	18448665

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.