MOG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOG1_HUMAN
• UniProt AC: Q9HD47
• Protein Name: Ran guanine nucleotide release factor
• Gene Name: RANGRF
• Organism: Homo sapiens (Human).
• Sequence Length: 186
• Subcellular Localization: Nucleus . Cytoplasm, perinuclear region . Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . May shuttle between the nucleus and cytoplasm.
• Protein Description: May regulate the intracellular trafficking of RAN. [PubMed: 11290418 Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1]
• Protein Sequence: MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDPNIFGPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Phosphorylation	ARAVHVESVQPLSLE CEEEEEEEECCCCHH	25.59	25693802
89	Phosphorylation	VESVQPLSLENLALR EEEECCCCHHHHHHH	40.08	25693802
108	Ubiquitination	EAWVLSGKQQIAKEN HHHHHCCHHHHHHHH	35.34	22817900
113	Ubiquitination	SGKQQIAKENQQVAK CCHHHHHHHHHHHHH	59.85	22817900
113 (in isoform 3)	Ubiquitination	-	59.85	-
113 (in isoform 1)	Ubiquitination	-	59.85	21890473
113 (in isoform 2)	Ubiquitination	-	59.85	21890473
120	Ubiquitination	KENQQVAKDVTLHQA HHHHHHHHHHHHHHH	54.60	22817900
120 (in isoform 1)	Ubiquitination	-	54.60	21890473
120 (in isoform 2)	Ubiquitination	-	54.60	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MOG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAN_HUMAN	RAN	physical	10811801
RAN_HUMAN	RAN	physical	11290418
THUM1_HUMAN	THUMPD1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.