PGTA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGTA_HUMAN
• UniProt AC: Q92696
• Protein Name: Geranylgeranyl transferase type-2 subunit alpha
• Gene Name: RABGGTA
• Organism: Homo sapiens (Human).
• Sequence Length: 567
• Protein Description: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A..
• Protein Sequence: MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MHGRLKVKTSEEQAE CCCCCCCCCHHHHHH	44.75	-
9	Phosphorylation	HGRLKVKTSEEQAEA CCCCCCCCHHHHHHH	44.34	29514088
10	Phosphorylation	GRLKVKTSEEQAEAK CCCCCCCHHHHHHHH	33.16	29514088
17	Ubiquitination	SEEQAEAKRLEREQK HHHHHHHHHHHHHHH	49.36	24816145
30	Phosphorylation	QKLKLYQSATQAVFQ HHHHHHHHHHHHHHH	21.52	28857561
38	Ubiquitination	ATQAVFQKRQAGELD HHHHHHHHHHCCCCC	34.71	21906983
47	Phosphorylation	QAGELDESVLELTSQ HCCCCCHHHHHHHHH	31.50	24043423
52	Phosphorylation	DESVLELTSQILGAN CHHHHHHHHHHHCCC	14.81	24043423
53	Phosphorylation	ESVLELTSQILGANP HHHHHHHHHHHCCCC	28.04	24043423
64	Phosphorylation	GANPDFATLWNCRRE CCCCCHHHHHHHHHH	32.09	24043423
80	Ubiquitination	LQQLETQKSPEELAA HHHHHHCCCHHHHHH	75.33	29967540
98	Phosphorylation	AELGFLESCLRVNPK HHHCHHHHHHCCCCC	22.16	-
105	Ubiquitination	SCLRVNPKSYGTWHH HHHCCCCCHHCCHHH	51.62	-
169	Phosphorylation	EELAFTDSLITRNFS HHHHCCCCHHHCCCC	20.72	24719451
329	Ubiquitination	WTAGDVQKECVLLKG EEECCHHHHEEEEEC	53.59	-
329	Acetylation	WTAGDVQKECVLLKG EEECCHHHHEEEEEC	53.59	25038526
335	Ubiquitination	QKECVLLKGRQEGWC HHHEEEEECCCCCCC	48.13	29967540
335	Acetylation	QKECVLLKGRQEGWC HHHEEEEECCCCCCC	48.13	25953088
360	Ubiquitination	RCELSVEKSTVLQSE EEEEECCCHHHHHHH	49.63	29967540
362	Phosphorylation	ELSVEKSTVLQSELE EEECCCHHHHHHHHH	35.98	-
366	Phosphorylation	EKSTVLQSELESCKE CCHHHHHHHHHHHHH	39.73	-
370	Phosphorylation	VLQSELESCKELQEL HHHHHHHHHHHHHHH	43.01	-
372	Ubiquitination	QSELESCKELQELEP HHHHHHHHHHHHHCC	71.40	29967540
402	Ubiquitination	LDPLLYEKETLQYFQ HHHHHCCHHHHHHHH	42.30	-
404	Phosphorylation	PLLYEKETLQYFQTL HHHCCHHHHHHHHHH	30.17	21406692
407	Phosphorylation	YEKETLQYFQTLKAV CCHHHHHHHHHHHHC	10.77	21406692
410	Phosphorylation	ETLQYFQTLKAVDPM HHHHHHHHHHHCCCC	21.96	21406692
412	Ubiquitination	LQYFQTLKAVDPMRA HHHHHHHHHCCCCCC	50.15	21906983
428	Ubiquitination	YLDDLRSKFLLENSV HHHHHHHHHHHHCCC	33.33	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGTA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGTA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGTA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PFD2_HUMAN	PFDN2	physical	22863883
LA_HUMAN	SSB	physical	22863883
SAE2_HUMAN	UBA2	physical	22863883
PFD3_HUMAN	VBP1	physical	22863883
ETFB_HUMAN	ETFB	physical	26344197
DPCD_HUMAN	DPCD	physical	28514442
RAE2_HUMAN	CHML	physical	28514442
RAE1_HUMAN	CHM	physical	28514442
G3P_HUMAN	GAPDH	physical	28514442
YKT6_HUMAN	YKT6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.