PFD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PFD2_HUMAN
• UniProt AC: Q9UHV9
• Protein Name: Prefoldin subunit 2
• Gene Name: PFDN2
• Organism: Homo sapiens (Human).
• Sequence Length: 154
• Subcellular Localization: Nucleus . Cytoplasm . Mitochondrion .
• Protein Description: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins..
• Protein Sequence: MAENSGRAGKSSGSGAGKGAVSAEQVIAGFNRLRQEQRGLASKAAELEMELNEHSLVIDTLKEVDETRKCYRMVGGVLVERTVKEVLPALENNKEQIQKIIETLTQQLQAKGKELNEFREKHNIRLMGEDEKPAAKENSEGAGAKASSAGVLVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	ENSGRAGKSSGSGAG CCCCCCCCCCCCCCC	40.23	18527925
11	Phosphorylation	NSGRAGKSSGSGAGK CCCCCCCCCCCCCCC	38.73	24719451
12	Phosphorylation	SGRAGKSSGSGAGKG CCCCCCCCCCCCCCC	40.23	20860994
14	Phosphorylation	RAGKSSGSGAGKGAV CCCCCCCCCCCCCCC	27.67	28464451
18	Malonylation	SSGSGAGKGAVSAEQ CCCCCCCCCCCCHHH	43.07	26320211
18	Ubiquitination	SSGSGAGKGAVSAEQ CCCCCCCCCCCCHHH	43.07	21906983
18	Acetylation	SSGSGAGKGAVSAEQ CCCCCCCCCCCCHHH	43.07	26051181
22	Phosphorylation	GAGKGAVSAEQVIAG CCCCCCCCHHHHHHH	26.08	28464451
38	Methylation	NRLRQEQRGLASKAA HHHHHHHHHHHHHHH	41.14	115487065
43	Ubiquitination	EQRGLASKAAELEME HHHHHHHHHHHHHHH	46.11	21906983
49	Sulfoxidation	SKAAELEMELNEHSL HHHHHHHHHHCCCCC	12.72	30846556
73	Sulfoxidation	ETRKCYRMVGGVLVE HHHHHHHHHCCEEHH	1.01	21406390
84	Ubiquitination	VLVERTVKEVLPALE EEHHHHHHHHHHHHH	41.30	-
94	Ubiquitination	LPALENNKEQIQKII HHHHHCCHHHHHHHH	63.68	21906983
94	Acetylation	LPALENNKEQIQKII HHHHHCCHHHHHHHH	63.68	26051181
99	Ubiquitination	NNKEQIQKIIETLTQ CCHHHHHHHHHHHHH	47.48	21906983
111	Malonylation	LTQQLQAKGKELNEF HHHHHHHCCHHHHHH	58.52	26320211
111	Ubiquitination	LTQQLQAKGKELNEF HHHHHHHCCHHHHHH	58.52	-
113	Acetylation	QQLQAKGKELNEFRE HHHHHCCHHHHHHHH	59.32	26051181
113	Ubiquitination	QQLQAKGKELNEFRE HHHHHCCHHHHHHHH	59.32	-
127	Sulfoxidation	EKHNIRLMGEDEKPA HHHCCCCCCCCCCCC	3.87	28183972
132	Ubiquitination	RLMGEDEKPAAKENS CCCCCCCCCCCCCCC	52.88	21906983
132	Acetylation	RLMGEDEKPAAKENS CCCCCCCCCCCCCCC	52.88	23749302
136	Acetylation	EDEKPAAKENSEGAG CCCCCCCCCCCCCCC	60.58	26051181
136	Ubiquitination	EDEKPAAKENSEGAG CCCCCCCCCCCCCCC	60.58	21906983
145	Ubiquitination	NSEGAGAKASSAGVL CCCCCCCCCCCCCCC	48.13	21906983
147	Phosphorylation	EGAGAKASSAGVLVS CCCCCCCCCCCCCCC	21.73	27251275
148	Phosphorylation	GAGAKASSAGVLVS- CCCCCCCCCCCCCC-	33.62	27251275
154	Phosphorylation	SSAGVLVS------- CCCCCCCC-------	30.28	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PFD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PFD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PFD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PFD3_HUMAN	VBP1	physical	14634002
PFD3_HUMAN	VBP1	physical	22939629
PFD6_HUMAN	PFDN6	physical	22939629
PFD4_HUMAN	PFDN4	physical	22939629
PFD5_HUMAN	PFDN5	physical	22939629
PIMT_HUMAN	PCMT1	physical	22939629
PFD4_HUMAN	PFDN4	physical	22863883
CD2AP_HUMAN	CD2AP	physical	26344197
FLNA_HUMAN	FLNA	physical	26344197
HINT1_HUMAN	HINT1	physical	26344197
NUP50_HUMAN	NUP50	physical	26344197
PFD5_HUMAN	PFDN5	physical	26344197
AAKB1_HUMAN	PRKAB1	physical	26344197
SLMAP_HUMAN	SLMAP	physical	26344197
PFD3_HUMAN	VBP1	physical	26344197
WDR92_HUMAN	WDR92	physical	26344197
PFD3_HUMAN	VBP1	physical	28514442
DCA12_HUMAN	DCAF12	physical	28514442
PFD5_HUMAN	PFDN5	physical	28514442
DTL_HUMAN	DTL	physical	28514442
DCAF4_HUMAN	DCAF4	physical	28514442
UXT_HUMAN	UXT	physical	28514442
DDB2_HUMAN	DDB2	physical	28514442
PFD1_HUMAN	PFDN1	physical	28514442
CDK17_HUMAN	CDK17	physical	28514442
KTNB1_HUMAN	KATNB1	physical	28514442
PI51A_HUMAN	PIP5K1A	physical	28514442
RMP_HUMAN	URI1	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
PDRG1_HUMAN	PDRG1	physical	28514442
EYA4_HUMAN	EYA4	physical	28514442
WAPL_HUMAN	WAPAL	physical	28514442
SPT6H_HUMAN	SUPT6H	physical	28514442
LIMD1_HUMAN	LIMD1	physical	28514442
BACD1_HUMAN	KCTD13	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.