dbPTM

SPT6H_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPT6H_HUMAN
UniProt AC	Q7KZ85
Protein Name	Transcription elongation factor SPT6
Gene Name	SUPT6H
Organism	Homo sapiens (Human).
Sequence Length	1726
Subcellular Localization	Nucleus .
Protein Description	Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A..
Protein Sequence	MSDFVESEAEESEEEYNDEGEVVPRVTKKFVEEEDDDEEEEEENLDDQDEQGNLKGFINDDDDEDEGEEDEGSDSGDSEDDVGHKKRKRTSFDDRLEDDDFDLIEENLGVKVKRGQKYRRVKKMSDDEDDDEEEYGKEEHEKEAIAEEIFQDGEGEEGQEAMEAPMAPPEEEEEDDEESDIDDFIVDDDGQPLKKPKWRKKLPGYTDAALQEAQEIFGVDFDYDEFEKYNEYDEELEEEYEYEDDEAEGEIRVRPKKTTKKRVSRRSIFEMYEPSELESSHLTDQDNEIRATDLPERFQLRSIPVKGAEDDELEEEADWIYRNAFATPTISLQESCDYLDRGQPASSFSRKGPSTIQKIKEALGFMRNQHFEVPFIAFYRKEYVEPELHINDLWRVWQWDEKWTQLRIRKENLTRLFEKMQAYQYEQISADPDKPLADGIRALDTTDMERLKDVQSMDELKDVYNHFLLYYGRDIPKMQNAAKASRKKLKRVREEGDEEGEGDEAEDEEQRGPELKQASRRDMYTICQSAGLDGLAKKFGLTPEQFGENLRDSYQRHETEQFPAEPLELAKDYVCSQFPTPEAVLEGARYMVALQIAREPLVRQVLRQTFQERAKLNITPTKKGRKDVDEAHYAYSFKYLKNKPVKELRDDQFLKICLAEDEGLLTTDISIDLKGVEGYGNDQTYFEEIKQFYYRDEFSHQVQEWNRQRTMAIERALQQFLYVQMAKELKNKLLAEAKEYVIKACSRKLYNWLRVAPYRPDQQVEEDDDFMDENQGKGIRVLGIAFSSARDHPVFCALVNGEGEVTDFLRLPHFTKRRTAWREEEREKKAQDIETLKKFLLNKKPHVVTVAGENRDAQMLIEDVKRIVHELDQGQQLSSIGVELVDNELAILYMNSKKSEAEFRDYPPVLRQAVSLARRIQDPLIEFAQVCSSDEDILCLKFHPLQEHVVKEELLNALYCEFINRVNEVGVDVNRAIAHPYSQALIQYVCGLGPRKGTHLLKILKQNNTRLESRTQLVTMCHMGPKVFMNCAGFLKIDTASLGDSTDSYIEVLDGSRVHPETYEWARKMAVDALEYDESAEDANPAGALEEILENPERLKDLDLDAFAEELERQGYGDKHITLYDIRAELSCRYKDLRTAYRSPNTEEIFNMLTKETPETFYIGKLIICNVTGIAHRRPQGESYDQAIRNDETGLWQCPFCQQDNFPELSEVWNHFDSGSCPGQAIGVKTRLDNGVTGFIPTKFLSDKVVKRPEERVKVGMTVHCRIMKIDIEKFSADLTCRTSDLMDRNNEWKLPKDTYYDFDAEAADHKQEEDMKRKQQRTTYIKRVIAHPSFHNINFKQAEKMMETMDQGDVIIRPSSKGENHLTVTWKVSDGIYQHVDVREEGKENAFSLGATLWINSEEFEDLDEIVARYVQPMASFARDLLNHKYYQDCSGGDRKKLEELLIKTKKEKPTFIPYFICACKELPGKFLLGYQPRGKPRIEYVTVTPEGFRYRGQIFPTVNGLFRWFKDHYQDPVPGITPSSSSRTRTPASINATPANINLADLTRAVNALPQNMTSQMFSAIAAVTGQGQNPNATPAQWASSQYGYGGSGGGSSAYHVFPTPAQQPVATPLMTPSYSYTTPSQPITTPQYHQLQASTTPQSAQAQPQPSSSSRQRQQQPKSNSHAAIDWGKMAEQWLQEKEAERRKQKQRLTPRPSPSPMIESTPMSIAGDATPLLDEMDR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDFVESEA ------CCCCCCCCH	51.57	21406692
2	Phosphorylation	------MSDFVESEA ------CCCCCCCCH	51.57	22617229
7	Phosphorylation	-MSDFVESEAEESEE -CCCCCCCCHHHCHH	36.48	28355574
12	Phosphorylation	VESEAEESEEEYNDE CCCCHHHCHHHHCCC	41.64	28355574
16	Phosphorylation	AEESEEEYNDEGEVV HHHCHHHHCCCCCCC	31.06	24300666
17 (in isoform 2)	Phosphorylation	-	44.10	25159151
20 (in isoform 2)	Phosphorylation	-	35.54	25159151
21 (in isoform 2)	Phosphorylation	-	37.99	25159151
27	Phosphorylation	GEVVPRVTKKFVEEE CCCCCCHHHHHHCCC	29.78	23090842
29	Acetylation	VVPRVTKKFVEEEDD CCCCHHHHHHCCCCC	45.32	26051181
29	Ubiquitination	VVPRVTKKFVEEEDD CCCCHHHHHHCCCCC	45.32	29967540
62 (in isoform 2)	Ubiquitination	-	65.15	21890473
73	Phosphorylation	EGEEDEGSDSGDSED CCCCCCCCCCCCCCC	26.93	23927012
75	Phosphorylation	EEDEGSDSGDSEDDV CCCCCCCCCCCCCCC	46.31	23927012
78	Phosphorylation	EGSDSGDSEDDVGHK CCCCCCCCCCCCCCC	46.58	23927012
90	Phosphorylation	GHKKRKRTSFDDRLE CCCCCCCCCHHHHCC	36.46	30266825
91	Phosphorylation	HKKRKRTSFDDRLED CCCCCCCCHHHHCCC	30.61	30266825
95	Methylation	KRTSFDDRLEDDDFD CCCCHHHHCCCCCCC	41.65	115917629
125	O-linked_Glycosylation	YRRVKKMSDDEDDDE EEEEECCCCCCCCCH	51.28	30059200
125	Phosphorylation	YRRVKKMSDDEDDDE EEEEECCCCCCCCCH	51.28	22167270
135	Phosphorylation	EDDDEEEYGKEEHEK CCCCHHHHCHHHHHH	36.46	23403867
160 (in isoform 2)	Ubiquitination	-	61.92	21890473
179	Phosphorylation	EEEDDEESDIDDFIV HCCCCCCCCCCCEEE	37.51	18669648
267	Phosphorylation	KKRVSRRSIFEMYEP CCCCCHHHHHHHCCC	30.44	25159151
272	Phosphorylation	RRSIFEMYEPSELES HHHHHHHCCCHHHHH	19.93	29978859
275	Phosphorylation	IFEMYEPSELESSHL HHHHCCCHHHHHCCC	42.76	28348404
279	Phosphorylation	YEPSELESSHLTDQD CCCHHHHHCCCCCCC	35.36	29496963
279	Ubiquitination	YEPSELESSHLTDQD CCCHHHHHCCCCCCC	35.36	21890473
280	Phosphorylation	EPSELESSHLTDQDN CCHHHHHCCCCCCCC	17.09	27251275
283	Phosphorylation	ELESSHLTDQDNEIR HHHHCCCCCCCCCCC	26.62	30576142
290 (in isoform 2)	Ubiquitination	-	25.84	21890473
292	Phosphorylation	QDNEIRATDLPERFQ CCCCCCCCCCCHHHE	28.37	22817900
306	Ubiquitination	QLRSIPVKGAEDDEL EEECCCCCCCCCCHH	47.23	32015554
327	Phosphorylation	IYRNAFATPTISLQE HHHCCCCCCCEEHHH	17.95	28348404
329	Phosphorylation	RNAFATPTISLQESC HCCCCCCCEEHHHHC	20.88	28348404
331	Phosphorylation	AFATPTISLQESCDY CCCCCCEEHHHHCCC	26.86	28348404
331 (in isoform 2)	Ubiquitination	-	26.86	21890473
347	Phosphorylation	DRGQPASSFSRKGPS CCCCCCHHHCCCCHH	29.37	17081983
351	Ubiquitination	PASSFSRKGPSTIQK CCHHHCCCCHHHHHH	74.17	29967540
354	Phosphorylation	SFSRKGPSTIQKIKE HHCCCCHHHHHHHHH	46.97	18669648
354	Ubiquitination	SFSRKGPSTIQKIKE HHCCCCHHHHHHHHH	46.97	24816145
358	Ubiquitination	KGPSTIQKIKEALGF CCHHHHHHHHHHHCH	52.47	29967540
360	Ubiquitination	PSTIQKIKEALGFMR HHHHHHHHHHHCHHH	43.93	-
393	Ubiquitination	PELHINDLWRVWQWD CCEEHHHHHHHHHCC	2.45	22817900
402	Ubiquitination	RVWQWDEKWTQLRIR HHHHCCHHHHHHHHH	53.74	21890473
402	Acetylation	RVWQWDEKWTQLRIR HHHHCCHHHHHHHHH	53.74	88961
402	Ubiquitination	RVWQWDEKWTQLRIR HHHHCCHHHHHHHHH	53.74	21890473
402 (in isoform 1)	Ubiquitination	-	53.74	21890473
402 (in isoform 3)	Ubiquitination	-	53.74	21890473
414	Ubiquitination	RIRKENLTRLFEKMQ HHHHHHHHHHHHHHH	36.59	22817900
415	Ubiquitination	IRKENLTRLFEKMQA HHHHHHHHHHHHHHH	40.31	21890473
419	Ubiquitination	NLTRLFEKMQAYQYE HHHHHHHHHHHHHHH	29.04	29967540
434	Ubiquitination	QISADPDKPLADGIR HCCCCCCCCCCCCCC	47.52	29967540
452	Ubiquitination	TTDMERLKDVQSMDE CCCHHHHHCCCCHHH	63.17	29967540
456	Phosphorylation	ERLKDVQSMDELKDV HHHHCCCCHHHHHHH	28.22	-
464	Phosphorylation	MDELKDVYNHFLLYY HHHHHHHHHHHHHHH	17.04	-
470	Phosphorylation	VYNHFLLYYGRDIPK HHHHHHHHHCCCHHH	13.16	-
477	Ubiquitination	YYGRDIPKMQNAAKA HHCCCHHHHHHHHHH	54.15	24816145
499	Ubiquitination	VREEGDEEGEGDEAE HHHCCCCCCCCCHHH	68.25	24816145
511	Methylation	EAEDEEQRGPELKQA HHHCHHHHCHHHHHH	66.95	115917625
516	Ubiquitination	EQRGPELKQASRRDM HHHCHHHHHHHHHHH	42.00	21906983
516 (in isoform 1)	Ubiquitination	-	42.00	21890473
516 (in isoform 3)	Ubiquitination	-	42.00	21890473
537	Ubiquitination	AGLDGLAKKFGLTPE CCCHHHHHHHCCCHH	54.39	22817900
538	Ubiquitination	GLDGLAKKFGLTPEQ CCHHHHHHHCCCHHH	38.77	21890473
538	Ubiquitination	GLDGLAKKFGLTPEQ CCHHHHHHHCCCHHH	38.77	22817900
538 (in isoform 1)	Ubiquitination	-	38.77	21890473
538 (in isoform 3)	Ubiquitination	-	38.77	21890473
590	Phosphorylation	AVLEGARYMVALQIA HHHHHHHHHHHHHHH	8.73	20068231
615	Ubiquitination	QTFQERAKLNITPTK HHHHHHHCCCCCCCC	48.57	-
619	Phosphorylation	ERAKLNITPTKKGRK HHHCCCCCCCCCCCC	24.67	25159151
621	Phosphorylation	AKLNITPTKKGRKDV HCCCCCCCCCCCCCC	36.42	20068231
622	Ubiquitination	KLNITPTKKGRKDVD CCCCCCCCCCCCCCC	55.20	24816145
633	Phosphorylation	KDVDEAHYAYSFKYL CCCCHHHHHHHHHHH	17.81	28152594
635	Phosphorylation	VDEAHYAYSFKYLKN CCHHHHHHHHHHHCC	13.89	28152594
636	Phosphorylation	DEAHYAYSFKYLKNK CHHHHHHHHHHHCCC	13.69	24719451
638	Ubiquitination	AHYAYSFKYLKNKPV HHHHHHHHHHCCCCH	43.67	-
670	Phosphorylation	GLLTTDISIDLKGVE CCEEEEEEEECCCCC	16.92	24961811
685	Phosphorylation	GYGNDQTYFEEIKQF CCCCCHHHHHHHHHH	11.89	-
721	Ubiquitination	ERALQQFLYVQMAKE HHHHHHHHHHHHHHH	3.39	20972266
722	Phosphorylation	RALQQFLYVQMAKEL HHHHHHHHHHHHHHH	7.02	29888752
732	Ubiquitination	MAKELKNKLLAEAKE HHHHHHHHHHHHHHH	43.20	29967540
738	2-Hydroxyisobutyrylation	NKLLAEAKEYVIKAC HHHHHHHHHHHHHHH	40.87	-
738	Ubiquitination	NKLLAEAKEYVIKAC HHHHHHHHHHHHHHH	40.87	29967540
740	Phosphorylation	LLAEAKEYVIKACSR HHHHHHHHHHHHHHH	13.53	21712546
743	Acetylation	EAKEYVIKACSRKLY HHHHHHHHHHHHHHH	33.04	19608861
746	Phosphorylation	EYVIKACSRKLYNWL HHHHHHHHHHHHHHH	36.99	21712546
777	Ubiquitination	FMDENQGKGIRVLGI CCCCCCCCCEEEEEE	41.21	-
816	Ubiquitination	LRLPHFTKRRTAWRE HCCCHHHCCCHHHHH	38.65	-
835	Phosphorylation	KKAQDIETLKKFLLN HHHHHHHHHHHHHHC	44.18	20068231
843	Ubiquitination	LKKFLLNKKPHVVTV HHHHHHCCCCCEEEE	68.59	29967540
844	Ubiquitination	KKFLLNKKPHVVTVA HHHHHCCCCCEEEEC	39.00	22053931
859	Sulfoxidation	GENRDAQMLIEDVKR CCCCCHHHHHHHHHH	4.34	21406390
879	Ubiquitination	DQGQQLSSIGVELVD HCCCCHHHHCEEEEC	31.77	21890473
882	Ubiquitination	QQLSSIGVELVDNEL CCHHHHCEEEECCCE	4.98	22817900
915	Phosphorylation	PVLRQAVSLARRIQD HHHHHHHHHHHHHCC	21.23	24719451
977	Ubiquitination	GVDVNRAIAHPYSQA CCCHHHHHCCCCHHH	3.06	21890473
1002	Ubiquitination	RKGTHLLKILKQNNT CCCHHHHHHHHHCCC	52.96	21890473
1002	Acetylation	RKGTHLLKILKQNNT CCCHHHHHHHHHCCC	52.96	26051181
1002	Ubiquitination	RKGTHLLKILKQNNT CCCHHHHHHHHHCCC	52.96	22817900
1002 (in isoform 1)	Ubiquitination	-	52.96	21890473
1005	Ubiquitination	THLLKILKQNNTRLE HHHHHHHHHCCCCCC	55.22	22817900
1039	Phosphorylation	AGFLKIDTASLGDST CCEEEEEHHCCCCCC	22.94	20873877
1041	Phosphorylation	FLKIDTASLGDSTDS EEEEEHHCCCCCCCC	34.67	20873877
1045	Phosphorylation	DTASLGDSTDSYIEV EHHCCCCCCCCCEEE	32.11	25627689
1046	Phosphorylation	TASLGDSTDSYIEVL HHCCCCCCCCCEEEC	33.43	25627689
1048	Phosphorylation	SLGDSTDSYIEVLDG CCCCCCCCCEEECCC	28.26	30576142
1049	Phosphorylation	LGDSTDSYIEVLDGS CCCCCCCCEEECCCC	12.15	20873877
1062	Phosphorylation	GSRVHPETYEWARKM CCCCCHHHHHHHHHH	31.06	18452278
1063	Phosphorylation	SRVHPETYEWARKMA CCCCHHHHHHHHHHH	14.07	18452278
1076	Phosphorylation	MAVDALEYDESAEDA HHHHHHCCCCCCCCC	26.34	27642862
1079	Phosphorylation	DALEYDESAEDANPA HHHCCCCCCCCCCCC	33.78	18452278
1100	Ubiquitination	LENPERLKDLDLDAF HHCHHHHHCCCHHHH	63.57	21890473
1100	Ubiquitination	LENPERLKDLDLDAF HHCHHHHHCCCHHHH	63.57	22053931
1100 (in isoform 1)	Ubiquitination	-	63.57	21890473
1120	Ubiquitination	RQGYGDKHITLYDIR HCCCCCCCEEEEEHH	24.01	21890473
1122	Phosphorylation	GYGDKHITLYDIRAE CCCCCCEEEEEHHHH	20.98	24719451
1124	Phosphorylation	GDKHITLYDIRAELS CCCCEEEEEHHHHHH	10.73	24719451
1125	Ubiquitination	DKHITLYDIRAELSC CCCEEEEEHHHHHHH	27.32	22817900
1134	Phosphorylation	RAELSCRYKDLRTAY HHHHHHCHHHHHHHH	17.12	24719451
1139	Phosphorylation	CRYKDLRTAYRSPNT HCHHHHHHHHCCCCH	35.02	24719451
1141	Phosphorylation	YKDLRTAYRSPNTEE HHHHHHHHCCCCHHH	15.83	22210691
1154	Phosphorylation	EEIFNMLTKETPETF HHHHHHHHCCCCCCE	18.96	22210691
1172	Phosphorylation	KLIICNVTGIAHRRP EEEEEECCCCCCCCC	14.63	-
1183	Phosphorylation	HRRPQGESYDQAIRN CCCCCCCCHHHHHHC	40.61	28555341
1218	Ubiquitination	EVWNHFDSGSCPGQA HHHHHCCCCCCCCCE	31.49	21890473
1222	Ubiquitination	HFDSGSCPGQAIGVK HCCCCCCCCCEEEEE	39.36	22817900
1243	Ubiquitination	VTGFIPTKFLSDKVV CCCCCCCHHHCCCCC	38.66	21890473
1243	Acetylation	VTGFIPTKFLSDKVV CCCCCCCHHHCCCCC	38.66	25953088
1243	Ubiquitination	VTGFIPTKFLSDKVV CCCCCCCHHHCCCCC	38.66	21890473
1243 (in isoform 1)	Ubiquitination	-	38.66	21890473
1248	Acetylation	PTKFLSDKVVKRPEE CCHHHCCCCCCCHHH	45.62	25953088
1248	Ubiquitination	PTKFLSDKVVKRPEE CCHHHCCCCCCCHHH	45.62	22817900
1269	2-Hydroxyisobutyrylation	TVHCRIMKIDIEKFS EEEEEEEECCHHHHC	34.55	-
1269	Acetylation	TVHCRIMKIDIEKFS EEEEEEEECCHHHHC	34.55	25953088
1274	Acetylation	IMKIDIEKFSADLTC EEECCHHHHCCCCEE	44.98	26051181
1274	Ubiquitination	IMKIDIEKFSADLTC EEECCHHHHCCCCEE	44.98	29967540
1276	Phosphorylation	KIDIEKFSADLTCRT ECCHHHHCCCCEEEH	31.76	23403867
1280	Phosphorylation	EKFSADLTCRTSDLM HHHCCCCEEEHHHHC	10.65	23879269
1283	Phosphorylation	SADLTCRTSDLMDRN CCCCEEEHHHHCCCC	28.83	23879269
1284	Phosphorylation	ADLTCRTSDLMDRNN CCCEEEHHHHCCCCC	14.92	23879269
1289	Methylation	RTSDLMDRNNEWKLP EHHHHCCCCCCCCCC	33.63	115917621
1294	Ubiquitination	MDRNNEWKLPKDTYY CCCCCCCCCCCCCCC	49.05	29967540
1297	Ubiquitination	NNEWKLPKDTYYDFD CCCCCCCCCCCCCCC	73.47	29967540
1341	Ubiquitination	SFHNINFKQAEKMME HHCCCCHHHHHHHHH	44.07	21890473
1341	Ubiquitination	SFHNINFKQAEKMME HHCCCCHHHHHHHHH	44.07	22817900
1341 (in isoform 1)	Ubiquitination	-	44.07	21890473
1343	Ubiquitination	HNINFKQAEKMMETM CCCCHHHHHHHHHHC	20.97	22817900
1345	Ubiquitination	INFKQAEKMMETMDQ CCHHHHHHHHHHCCC	46.71	22817900
1348	Ubiquitination	KQAEKMMETMDQGDV HHHHHHHHHCCCCCE	37.17	21890473
1378	Phosphorylation	WKVSDGIYQHVDVRE EEEECCEEEEEECCH	9.71	-
1389	Ubiquitination	DVREEGKENAFSLGA ECCHHCCCCCEECCC	65.73	21890473
1415	Phosphorylation	LDEIVARYVQPMASF HHHHHHHHHHHHHHH	8.16	26330541
1421	Phosphorylation	RYVQPMASFARDLLN HHHHHHHHHHHHHHC	17.12	26330541
1430	Acetylation	ARDLLNHKYYQDCSG HHHHHCCCCCCCCCC	44.58	26051181
1450	Phosphorylation	LEELLIKTKKEKPTF HHHHHHHHCCCCCCC	40.11	26074081
1454	Acetylation	LIKTKKEKPTFIPYF HHHHCCCCCCCCCEE	59.23	25953088
1456	Phosphorylation	KTKKEKPTFIPYFIC HHCCCCCCCCCEEEE	45.31	26074081
1460	Phosphorylation	EKPTFIPYFICACKE CCCCCCCEEEEECCC	10.76	26074081
1466	Acetylation	PYFICACKELPGKFL CEEEEECCCCCCCEE	43.70	26051181
1466	Ubiquitination	PYFICACKELPGKFL CEEEEECCCCCCCEE	43.70	22817900
1471	Ubiquitination	ACKELPGKFLLGYQP ECCCCCCCEEECCCC	30.79	21890473
1471	Acetylation	ACKELPGKFLLGYQP ECCCCCCCEEECCCC	30.79	25953088
1471	Ubiquitination	ACKELPGKFLLGYQP ECCCCCCCEEECCCC	30.79	22817900
1471 (in isoform 1)	Ubiquitination	-	30.79	21890473
1486	Phosphorylation	RGKPRIEYVTVTPEG CCCCCEEEEEECCCC	10.07	28152594
1488	Phosphorylation	KPRIEYVTVTPEGFR CCCEEEEEECCCCEE	20.12	28152594
1512	Ubiquitination	NGLFRWFKDHYQDPV HHHHHHHHHHCCCCC	36.31	21890473
1512	Ubiquitination	NGLFRWFKDHYQDPV HHHHHHHHHHCCCCC	36.31	22817900
1512 (in isoform 1)	Ubiquitination	-	36.31	21890473
1515	Phosphorylation	FRWFKDHYQDPVPGI HHHHHHHCCCCCCCC	25.41	23403867
1523	O-linked_Glycosylation	QDPVPGITPSSSSRT CCCCCCCCCCCCCCC	24.04	30059200
1523	Phosphorylation	QDPVPGITPSSSSRT CCCCCCCCCCCCCCC	24.04	29255136
1525	O-linked_Glycosylation	PVPGITPSSSSRTRT CCCCCCCCCCCCCCC	33.91	30059200
1525	Phosphorylation	PVPGITPSSSSRTRT CCCCCCCCCCCCCCC	33.91	23401153
1526	O-linked_Glycosylation	VPGITPSSSSRTRTP CCCCCCCCCCCCCCC	33.27	30059200
1526	Phosphorylation	VPGITPSSSSRTRTP CCCCCCCCCCCCCCC	33.27	30266825
1527	O-linked_Glycosylation	PGITPSSSSRTRTPA CCCCCCCCCCCCCCC	28.33	30059200
1527	Phosphorylation	PGITPSSSSRTRTPA CCCCCCCCCCCCCCC	28.33	30266825
1528	O-linked_Glycosylation	GITPSSSSRTRTPAS CCCCCCCCCCCCCCC	39.35	30059200
1528	Phosphorylation	GITPSSSSRTRTPAS CCCCCCCCCCCCCCC	39.35	30266825
1530	Phosphorylation	TPSSSSRTRTPASIN CCCCCCCCCCCCCCC	40.62	23927012
1532	O-linked_Glycosylation	SSSSRTRTPASINAT CCCCCCCCCCCCCCC	23.69	30059200
1532	Phosphorylation	SSSSRTRTPASINAT CCCCCCCCCCCCCCC	23.69	29255136
1535	O-linked_Glycosylation	SRTRTPASINATPAN CCCCCCCCCCCCCCC	19.99	30059200
1535	Phosphorylation	SRTRTPASINATPAN CCCCCCCCCCCCCCC	19.99	29255136
1539	Phosphorylation	TPASINATPANINLA CCCCCCCCCCCCCHH	20.60	23927012
1549	Phosphorylation	NINLADLTRAVNALP CCCHHHHHHHHHHCC	19.68	23403867
1553	Ubiquitination	ADLTRAVNALPQNMT HHHHHHHHHCCCCHH	34.47	22505724
1562	Ubiquitination	LPQNMTSQMFSAIAA CCCCHHHHHHHHHHH	27.98	22505724
1580	Phosphorylation	QGQNPNATPAQWASS CCCCCCCCHHHHHCC	26.29	26074081
1614	Phosphorylation	PAQQPVATPLMTPSY CCCCCCCCCCCCCCC	19.72	26074081
1618	Phosphorylation	PVATPLMTPSYSYTT CCCCCCCCCCCCCCC	19.43	26074081
1620	Phosphorylation	ATPLMTPSYSYTTPS CCCCCCCCCCCCCCC	19.97	26074081
1621	Phosphorylation	TPLMTPSYSYTTPSQ CCCCCCCCCCCCCCC	13.60	26074081
1622	Phosphorylation	PLMTPSYSYTTPSQP CCCCCCCCCCCCCCC	21.97	26074081
1623	Phosphorylation	LMTPSYSYTTPSQPI CCCCCCCCCCCCCCC	13.34	26074081
1641	Phosphorylation	QYHQLQASTTPQSAQ CCEEECCCCCCCHHC	21.61	-
1666	Phosphorylation	QRQQQPKSNSHAAID HHHHCCCCCCCCHHH	50.69	25159151
1668	Phosphorylation	QQQPKSNSHAAIDWG HHCCCCCCCCHHHHH	22.92	28555341
1676	Acetylation	HAAIDWGKMAEQWLQ CCHHHHHHHHHHHHH	30.59	19608861
1676	Ubiquitination	HAAIDWGKMAEQWLQ CCHHHHHHHHHHHHH	30.59	29967540
1685	Ubiquitination	AEQWLQEKEAERRKQ HHHHHHHHHHHHHHH	49.62	22505724
1697	Phosphorylation	RKQKQRLTPRPSPSP HHHHHCCCCCCCCCC	21.31	23927012
1701	Phosphorylation	QRLTPRPSPSPMIES HCCCCCCCCCCCEEC	39.01	25159151
1703	Phosphorylation	LTPRPSPSPMIESTP CCCCCCCCCCEECCC	31.29	25159151
1708	Phosphorylation	SPSPMIESTPMSIAG CCCCCEECCCCCCCC	27.21	26503892
1709	Phosphorylation	PSPMIESTPMSIAGD CCCCEECCCCCCCCC	15.38	26503892
1712	Phosphorylation	MIESTPMSIAGDATP CEECCCCCCCCCCCH	15.53	23927012
1718	Phosphorylation	MSIAGDATPLLDEMD CCCCCCCCHHCCCCC	21.14	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1523	T	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPT6H_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPT6H_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPB1_HUMAN	POLR2A	physical	17234882
PAAF1_HUMAN	PAAF1	physical	22316138
APC7_HUMAN	ANAPC7	physical	26344197
NUCL_HUMAN	NCL	physical	26344197
SPT4H_HUMAN	SUPT4H1	physical	26344197
SPT5H_HUMAN	SUPT5H	physical	26344197
BRE1B_HUMAN	RNF40	physical	24441044

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPT6H_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-743 AND LYS-1676, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-75; SER-78;THR-1532; SER-1535; THR-1539; THR-1697; SER-1701; SER-1703 ANDTHR-1718, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-12; THR-1697 ANDTHR-1718, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-75; SER-78;SER-179; SER-267; THR-1523; SER-1526; THR-1532; SER-1535; THR-1539;SER-1701; SER-1703 AND THR-1718, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1532; SER-1535;THR-1539; SER-1701 AND THR-1718, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, AND MASSSPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-75; SER-78 ANDSER-125, AND MASS SPECTROMETRY.	17081983 [Abstract]