NUCL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUCL_HUMAN
• UniProt AC: P19338
• Protein Name: Nucleolin
• Gene Name: NCL
• Organism: Homo sapiens (Human).
• Sequence Length: 710
• Subcellular Localization: Nucleus, nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
• Protein Description: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats..
• Protein Sequence: MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Methylation	-----MVKLAKAGKN -----CCCHHHCCCC	41.24	22638801
9	Acetylation	VKLAKAGKNQGDPKK CCHHHCCCCCCCCCC	51.46	19608861
15	Acetylation	GKNQGDPKKMAPPPK CCCCCCCCCCCCCCC	60.98	23353999
16	Acetylation	KNQGDPKKMAPPPKE CCCCCCCCCCCCCCC	45.76	7825055
17	Sulfoxidation	NQGDPKKMAPPPKEV CCCCCCCCCCCCCCC	9.39	30846556
28	Phosphorylation	PKEVEEDSEDEEMSE CCCCCCCCCCHHCCC	50.67	20201521
34	Phosphorylation	DSEDEEMSEDEEDDS CCCCHHCCCCCCCCC	45.21	20201521
41	Phosphorylation	SEDEEDDSSGEEVVI CCCCCCCCCCCEEEE	53.19	20201521
42	Phosphorylation	EDEEDDSSGEEVVIP CCCCCCCCCCEEEEC	58.16	20201521
59	Phosphorylation	KGKKAAATSAKKVVV CCCCCCCCCCCEEEE	25.21	25367160
60	Phosphorylation	GKKAAATSAKKVVVS CCCCCCCCCCEEEEC	33.11	29496963
62	2-Hydroxyisobutyrylation	KAAATSAKKVVVSPT CCCCCCCCEEEECCC	45.96	-
62	Acetylation	KAAATSAKKVVVSPT CCCCCCCCEEEECCC	45.96	24846139
63	2-Hydroxyisobutyrylation	AAATSAKKVVVSPTK CCCCCCCEEEECCCC	39.72	-
63	Acetylation	AAATSAKKVVVSPTK CCCCCCCEEEECCCC	39.72	23353999
63	Ubiquitination	AAATSAKKVVVSPTK CCCCCCCEEEECCCC	39.72	-
67	Phosphorylation	SAKKVVVSPTKKVAV CCCEEEECCCCCEEE	18.42	29255136
69	Phosphorylation	KKVVVSPTKKVAVAT CEEEECCCCCEEEEC	35.67	22167270
70	2-Hydroxyisobutyrylation	KVVVSPTKKVAVATP EEEECCCCCEEEECC	48.94	-
70	Acetylation	KVVVSPTKKVAVATP EEEECCCCCEEEECC	48.94	23353999
70	Ubiquitination	KVVVSPTKKVAVATP EEEECCCCCEEEECC	48.94	-
71	2-Hydroxyisobutyrylation	VVVSPTKKVAVATPA EEECCCCCEEEECCC	37.59	-
71	Acetylation	VVVSPTKKVAVATPA EEECCCCCEEEECCC	37.59	133267
71	Ubiquitination	VVVSPTKKVAVATPA EEECCCCCEEEECCC	37.59	-
76	Phosphorylation	TKKVAVATPAKKAAV CCCEEEECCCHHCCC	19.72	23927012
79	2-Hydroxyisobutyrylation	VAVATPAKKAAVTPG EEEECCCHHCCCCCC	44.12	-
79	Acetylation	VAVATPAKKAAVTPG EEEECCCHHCCCCCC	44.12	23353999
79	Succinylation	VAVATPAKKAAVTPG EEEECCCHHCCCCCC	44.12	23954790
79	Ubiquitination	VAVATPAKKAAVTPG EEEECCCHHCCCCCC	44.12	-
80	Acetylation	AVATPAKKAAVTPGK EEECCCHHCCCCCCC	43.62	23353999
80	Ubiquitination	AVATPAKKAAVTPGK EEECCCHHCCCCCCC	43.62	-
84	Phosphorylation	PAKKAAVTPGKKAAA CCHHCCCCCCCCCCC	22.92	30266825
87	2-Hydroxyisobutyrylation	KAAVTPGKKAAATPA HCCCCCCCCCCCCCC	40.20	-
87	Acetylation	KAAVTPGKKAAATPA HCCCCCCCCCCCCCC	40.20	23353999
87	Succinylation	KAAVTPGKKAAATPA HCCCCCCCCCCCCCC	40.20	23954790
88	Acetylation	AAVTPGKKAAATPAK CCCCCCCCCCCCCCC	49.53	23353999
92	Phosphorylation	PGKKAAATPAKKTVT CCCCCCCCCCCCCCC	21.03	26055452
95	Acetylation	KAAATPAKKTVTPAK CCCCCCCCCCCCCCC	50.62	25953088
96	Acetylation	AAATPAKKTVTPAKA CCCCCCCCCCCCCCE	50.78	26051181
97	Phosphorylation	AATPAKKTVTPAKAV CCCCCCCCCCCCCEE	28.98	30266825
99	Phosphorylation	TPAKKTVTPAKAVTT CCCCCCCCCCCEECC	23.82	23401153
102	Acetylation	KKTVTPAKAVTTPGK CCCCCCCCEECCCCC	44.59	19608861
102	Malonylation	KKTVTPAKAVTTPGK CCCCCCCCEECCCCC	44.59	26320211
102	Ubiquitination	KKTVTPAKAVTTPGK CCCCCCCCEECCCCC	44.59	19608861
105	Phosphorylation	VTPAKAVTTPGKKGA CCCCCEECCCCCCCC	31.94	23401153
106	Phosphorylation	TPAKAVTTPGKKGAT CCCCEECCCCCCCCC	24.36	23401153
109	2-Hydroxyisobutyrylation	KAVTTPGKKGATPGK CEECCCCCCCCCCCC	49.60	-
109	Acetylation	KAVTTPGKKGATPGK CEECCCCCCCCCCCC	49.60	21466224
110	Acetylation	AVTTPGKKGATPGKA EECCCCCCCCCCCCE	60.74	21466224
110	Ubiquitination	AVTTPGKKGATPGKA EECCCCCCCCCCCCE	60.74	-
113	Phosphorylation	TPGKKGATPGKALVA CCCCCCCCCCCEEEE	41.04	23401153
116	2-Hydroxyisobutyrylation	KKGATPGKALVATPG CCCCCCCCEEEECCC	39.49	-
116	Acetylation	KKGATPGKALVATPG CCCCCCCCEEEECCC	39.49	19608861
116	Malonylation	KKGATPGKALVATPG CCCCCCCCEEEECCC	39.49	32601280
116	Methylation	KKGATPGKALVATPG CCCCCCCCEEEECCC	39.49	69987
116	Ubiquitination	KKGATPGKALVATPG CCCCCCCCEEEECCC	39.49	19608861
121	Phosphorylation	PGKALVATPGKKGAA CCCEEEECCCCCCCC	25.70	22167270
124	Acetylation	ALVATPGKKGAAIPA EEEECCCCCCCCCCC	49.60	19608861
124	Malonylation	ALVATPGKKGAAIPA EEEECCCCCCCCCCC	49.60	26320211
124	Succinylation	ALVATPGKKGAAIPA EEEECCCCCCCCCCC	49.60	23954790
124	Ubiquitination	ALVATPGKKGAAIPA EEEECCCCCCCCCCC	49.60	19608861
125	Acetylation	LVATPGKKGAAIPAK EEECCCCCCCCCCCC	60.75	23353999
125	Ubiquitination	LVATPGKKGAAIPAK EEECCCCCCCCCCCC	60.75	-
132	Acetylation	KGAAIPAKGAKNGKN CCCCCCCCCCCCCCC	54.79	23236377
135	Acetylation	AIPAKGAKNGKNAKK CCCCCCCCCCCCCCC	74.93	23353999
145	Phosphorylation	KNAKKEDSDEEEDDD CCCCCCCCCCCCCCC	48.27	20201521
153	Phosphorylation	DEEEDDDSEEDEEDD CCCCCCCCCCCCCCC	50.29	20201521
184	Phosphorylation	AAAAAPASEDEDDED HHHHCCCCCCCCCCC	44.51	20201521
206	Phosphorylation	DDDEEDDSEEEAMET CCCCCCCCHHHHHHH	60.26	20201521
213	Phosphorylation	SEEEAMETTPAKGKK CHHHHHHHCCCCCCC	25.62	26503892
214	Phosphorylation	EEEAMETTPAKGKKA HHHHHHHCCCCCCCC	14.14	23927012
220	Acetylation	TTPAKGKKAAKVVPV HCCCCCCCCCEEEEE	63.34	26051181
223	Sumoylation	AKGKKAAKVVPVKAK CCCCCCCEEEEEEEE	48.93	-
223	2-Hydroxyisobutyrylation	AKGKKAAKVVPVKAK CCCCCCCEEEEEEEE	48.93	-
223	Acetylation	AKGKKAAKVVPVKAK CCCCCCCEEEEEEEE	48.93	23749302
223	Sumoylation	AKGKKAAKVVPVKAK CCCCCCCEEEEEEEE	48.93	-
223	Ubiquitination	AKGKKAAKVVPVKAK CCCCCCCEEEEEEEE	48.93	-
228	Acetylation	AAKVVPVKAKNVAED CCEEEEEEEECCCCC	47.80	25953088
274	Acetylation	EEEEEPVKEAPGKRK HHHHCCHHCCCCHHH	59.89	26051181
282	2-Hydroxyisobutyrylation	EAPGKRKKEMAKQKA CCCCHHHHHHHHHHC	57.67	-
294	Sumoylation	QKAAPEAKKQKVEGT HHCCHHHHHHHCCCC	54.82	-
294	2-Hydroxyisobutyrylation	QKAAPEAKKQKVEGT HHCCHHHHHHHCCCC	54.82	-
294	Acetylation	QKAAPEAKKQKVEGT HHCCHHHHHHHCCCC	54.82	19811559
294	Sumoylation	QKAAPEAKKQKVEGT HHCCHHHHHHHCCCC	54.82	-
297	Acetylation	APEAKKQKVEGTEPT CHHHHHHHCCCCCCC	51.65	23236377
297	Sumoylation	APEAKKQKVEGTEPT CHHHHHHHCCCCCCC	51.65	25114211
301	O-linked_Glycosylation	KKQKVEGTEPTTAFN HHHHCCCCCCCCHHH	25.86	32119511
301	Phosphorylation	KKQKVEGTEPTTAFN HHHHCCCCCCCCHHH	25.86	22817900
304	Phosphorylation	KVEGTEPTTAFNLFV HCCCCCCCCHHHHEE	25.23	22817900
305	Phosphorylation	VEGTEPTTAFNLFVG CCCCCCCCHHHHEEE	39.71	22817900
318	Acetylation	VGNLNFNKSAPELKT EECCCCCCCCHHHHC	43.80	19608861
318	Ubiquitination	VGNLNFNKSAPELKT EECCCCCCCCHHHHC	43.80	19608861
324	Sumoylation	NKSAPELKTGISDVF CCCCHHHHCCCCHHH	42.94	-
324	2-Hydroxyisobutyrylation	NKSAPELKTGISDVF CCCCHHHHCCCCHHH	42.94	-
324	Acetylation	NKSAPELKTGISDVF CCCCHHHHCCCCHHH	42.94	23236377
324	Malonylation	NKSAPELKTGISDVF CCCCHHHHCCCCHHH	42.94	26320211
324	Sumoylation	NKSAPELKTGISDVF CCCCHHHHCCCCHHH	42.94	25114211
324	Ubiquitination	NKSAPELKTGISDVF CCCCHHHHCCCCHHH	42.94	21890473
325	Phosphorylation	KSAPELKTGISDVFA CCCHHHHCCCCHHHH	52.99	21712546
328	Phosphorylation	PELKTGISDVFAKND HHHHCCCCHHHHCCC	29.12	28450419
333	2-Hydroxyisobutyrylation	GISDVFAKNDLAVVD CCCHHHHCCCEEEEE	39.26	-
333	Acetylation	GISDVFAKNDLAVVD CCCHHHHCCCEEEEE	39.26	19608861
333	Methylation	GISDVFAKNDLAVVD CCCHHHHCCCEEEEE	39.26	22638777
333	Ubiquitination	GISDVFAKNDLAVVD CCCHHHHCCCEEEEE	39.26	21906983
342	Methylation	DLAVVDVRIGMTRKF CEEEEEEEECCEEEC	18.45	115484609
346	Phosphorylation	VDVRIGMTRKFGYVD EEEEECCEEECCCCC	26.03	21601212
348	2-Hydroxyisobutyrylation	VRIGMTRKFGYVDFE EEECCEEECCCCCCC	33.69	-
348	Acetylation	VRIGMTRKFGYVDFE EEECCEEECCCCCCC	33.69	25953088
348	Malonylation	VRIGMTRKFGYVDFE EEECCEEECCCCCCC	33.69	26320211
348	Ubiquitination	VRIGMTRKFGYVDFE EEECCEEECCCCCCC	33.69	21890473
351	Nitration	GMTRKFGYVDFESAE CCEEECCCCCCCCHH	10.44	-
351	Phosphorylation	GMTRKFGYVDFESAE CCEEECCCCCCCCHH	10.44	28152594
356	Phosphorylation	FGYVDFESAEDLEKA CCCCCCCCHHHHHHH	36.63	22617229
362	Ubiquitination	ESAEDLEKALELTGL CCHHHHHHHHHHHCC	66.62	-
367	Phosphorylation	LEKALELTGLKVFGN HHHHHHHHCCEEECC	30.97	30266825
370	Acetylation	ALELTGLKVFGNEIK HHHHHCCEEECCEEE	36.54	23954790
370	Succinylation	ALELTGLKVFGNEIK HHHHHCCEEECCEEE	36.54	23954790
370	Sumoylation	ALELTGLKVFGNEIK HHHHHCCEEECCEEE	36.54	28112733
370	Ubiquitination	ALELTGLKVFGNEIK HHHHHCCEEECCEEE	36.54	21890473
377	Sumoylation	KVFGNEIKLEKPKGK EEECCEEEECCCCCC	44.40	-
377	2-Hydroxyisobutyrylation	KVFGNEIKLEKPKGK EEECCEEEECCCCCC	44.40	-
377	Acetylation	KVFGNEIKLEKPKGK EEECCEEEECCCCCC	44.40	19608861
377	Malonylation	KVFGNEIKLEKPKGK EEECCEEEECCCCCC	44.40	26320211
377	Succinylation	KVFGNEIKLEKPKGK EEECCEEEECCCCCC	44.40	23954790
377	Sumoylation	KVFGNEIKLEKPKGK EEECCEEEECCCCCC	44.40	28112733
377	Ubiquitination	KVFGNEIKLEKPKGK EEECCEEEECCCCCC	44.40	19608861
382	Ubiquitination	EIKLEKPKGKDSKKE EEEECCCCCCCCHHH	84.99	-
387	Acetylation	KPKGKDSKKERDART CCCCCCCHHHHHHHH	69.64	7720357
388	Acetylation	PKGKDSKKERDARTL CCCCCCHHHHHHHHH	63.03	19817283
398	Acetylation	DARTLLAKNLPYKVT HHHHHHHHCCCCCCC	60.01	19608861
398	Malonylation	DARTLLAKNLPYKVT HHHHHHHHCCCCCCC	60.01	26320211
398	Ubiquitination	DARTLLAKNLPYKVT HHHHHHHHCCCCCCC	60.01	21890473
402	Phosphorylation	LLAKNLPYKVTQDEL HHHHCCCCCCCHHHH	22.66	28152594
403	Sumoylation	LAKNLPYKVTQDELK HHHCCCCCCCHHHHH	36.55	-
403	2-Hydroxyisobutyrylation	LAKNLPYKVTQDELK HHHCCCCCCCHHHHH	36.55	-
403	Acetylation	LAKNLPYKVTQDELK HHHCCCCCCCHHHHH	36.55	19608861
403	Malonylation	LAKNLPYKVTQDELK HHHCCCCCCCHHHHH	36.55	26320211
403	Sumoylation	LAKNLPYKVTQDELK HHHCCCCCCCHHHHH	36.55	19608861
403	Ubiquitination	LAKNLPYKVTQDELK HHHCCCCCCCHHHHH	36.55	21890473
405	Phosphorylation	KNLPYKVTQDELKEV HCCCCCCCHHHHHHH	26.59	25159151
410	2-Hydroxyisobutyrylation	KVTQDELKEVFEDAA CCCHHHHHHHHHHHH	50.19	-
410	Acetylation	KVTQDELKEVFEDAA CCCHHHHHHHHHHHH	50.19	26822725
410	Succinylation	KVTQDELKEVFEDAA CCCHHHHHHHHHHHH	50.19	23954790
410	Ubiquitination	KVTQDELKEVFEDAA CCCHHHHHHHHHHHH	50.19	-
420	Methylation	FEDAAEIRLVSKDGK HHHHHHEEEEECCCC	22.12	115484601
423	Phosphorylation	AAEIRLVSKDGKSKG HHHEEEEECCCCCCC	29.62	20068231
424	2-Hydroxyisobutyrylation	AEIRLVSKDGKSKGI HHEEEEECCCCCCCE	64.12	-
424	Acetylation	AEIRLVSKDGKSKGI HHEEEEECCCCCCCE	64.12	23749302
427	Acetylation	RLVSKDGKSKGIAYI EEEECCCCCCCEEEE	60.16	-
428	Phosphorylation	LVSKDGKSKGIAYIE EEECCCCCCCEEEEE	41.46	20068231
429	2-Hydroxyisobutyrylation	VSKDGKSKGIAYIEF EECCCCCCCEEEEEE	58.80	-
429	Acetylation	VSKDGKSKGIAYIEF EECCCCCCCEEEEEE	58.80	26051181
429	Malonylation	VSKDGKSKGIAYIEF EECCCCCCCEEEEEE	58.80	26320211
429	Ubiquitination	VSKDGKSKGIAYIEF EECCCCCCCEEEEEE	58.80	-
433	Phosphorylation	GKSKGIAYIEFKTEA CCCCCEEEEEEECHH	10.08	28152594
437	2-Hydroxyisobutyrylation	GIAYIEFKTEADAEK CEEEEEEECHHHHHH	32.44	-
437	Acetylation	GIAYIEFKTEADAEK CEEEEEEECHHHHHH	32.44	25953088
437	Sumoylation	GIAYIEFKTEADAEK CEEEEEEECHHHHHH	32.44	-
438	O-linked_Glycosylation	IAYIEFKTEADAEKT EEEEEEECHHHHHHH	41.55	32119511
444	Acetylation	KTEADAEKTFEEKQG ECHHHHHHHHHHHCC	61.30	23749302
444	Succinylation	KTEADAEKTFEEKQG ECHHHHHHHHHHHCC	61.30	23954790
444	Ubiquitination	KTEADAEKTFEEKQG ECHHHHHHHHHHHCC	61.30	-
449	2-Hydroxyisobutyrylation	AEKTFEEKQGTEIDG HHHHHHHHCCCEECC	46.99	-
449	Acetylation	AEKTFEEKQGTEIDG HHHHHHHHCCCEECC	46.99	26051181
449	Ubiquitination	AEKTFEEKQGTEIDG HHHHHHHHCCCEECC	46.99	-
452	Phosphorylation	TFEEKQGTEIDGRSI HHHHHCCCEECCEEE	27.55	25159151
458	Phosphorylation	GTEIDGRSISLYYTG CCEECCEEEEEEEEC	23.27	25159151
460	Phosphorylation	EIDGRSISLYYTGEK EECCEEEEEEEECCC	16.15	23401153
462	Phosphorylation	DGRSISLYYTGEKGQ CCEEEEEEEECCCCC	7.68	25159151
463	Phosphorylation	GRSISLYYTGEKGQN CEEEEEEEECCCCCC	17.35	28152594
464	Phosphorylation	RSISLYYTGEKGQNQ EEEEEEEECCCCCCC	25.88	25159151
467	2-Hydroxyisobutyrylation	SLYYTGEKGQNQDYR EEEEECCCCCCCCCC	68.11	-
467	Acetylation	SLYYTGEKGQNQDYR EEEEECCCCCCCCCC	68.11	23954790
467	Succinylation	SLYYTGEKGQNQDYR EEEEECCCCCCCCCC	68.11	23954790
467	Ubiquitination	SLYYTGEKGQNQDYR EEEEECCCCCCCCCC	68.11	-
473	Phosphorylation	EKGQNQDYRGGKNST CCCCCCCCCCCCCCC	11.03	28152594
474	Methylation	KGQNQDYRGGKNSTW CCCCCCCCCCCCCCC	56.53	80700959
477	Acetylation	NQDYRGGKNSTWSGE CCCCCCCCCCCCCCC	51.02	23749302
477	Ubiquitination	NQDYRGGKNSTWSGE CCCCCCCCCCCCCCC	51.02	21890473
479	Phosphorylation	DYRGGKNSTWSGESK CCCCCCCCCCCCCCC	34.44	29978859
480	Phosphorylation	YRGGKNSTWSGESKT CCCCCCCCCCCCCCE	32.80	29978859
482	Phosphorylation	GGKNSTWSGESKTLV CCCCCCCCCCCCEEE	32.54	21815630
485	Phosphorylation	NSTWSGESKTLVLSN CCCCCCCCCEEEEEC	34.17	29978859
486	Sumoylation	STWSGESKTLVLSNL CCCCCCCCEEEEECC	41.39	-
486	Ubiquitination	STWSGESKTLVLSNL CCCCCCCCEEEEECC	41.39	-
487	Phosphorylation	TWSGESKTLVLSNLS CCCCCCCEEEEECCC	31.23	24732914
491	Phosphorylation	ESKTLVLSNLSYSAT CCCEEEEECCCCCCC	28.39	24732914
494	Phosphorylation	TLVLSNLSYSATEET EEEEECCCCCCCHHH	22.69	25159151
495	Phosphorylation	LVLSNLSYSATEETL EEEECCCCCCCHHHH	12.90	28387310
496	Phosphorylation	VLSNLSYSATEETLQ EEECCCCCCCHHHHH	25.91	25159151
498	Phosphorylation	SNLSYSATEETLQEV ECCCCCCCHHHHHHH	28.54	21712546
501	Phosphorylation	SYSATEETLQEVFEK CCCCCHHHHHHHHHH	27.75	24732914
508	Ubiquitination	TLQEVFEKATFIKVP HHHHHHHHCCEEECC	41.06	-
513	2-Hydroxyisobutyrylation	FEKATFIKVPQNQNG HHHCCEEECCCCCCC	43.61	-
513	Acetylation	FEKATFIKVPQNQNG HHHCCEEECCCCCCC	43.61	19608861
513	Malonylation	FEKATFIKVPQNQNG HHHCCEEECCCCCCC	43.61	26320211
513	Sumoylation	FEKATFIKVPQNQNG HHHCCEEECCCCCCC	43.61	28112733
513	Ubiquitination	FEKATFIKVPQNQNG HHHCCEEECCCCCCC	43.61	21890473
521	Acetylation	VPQNQNGKSKGYAFI CCCCCCCCCCCEEEE	57.45	25953088
521	Ubiquitination	VPQNQNGKSKGYAFI CCCCCCCCCCCEEEE	57.45	21890473
522	Phosphorylation	PQNQNGKSKGYAFIE CCCCCCCCCCEEEEE	32.48	28442448
523	Acetylation	QNQNGKSKGYAFIEF CCCCCCCCCEEEEEE	60.47	26051181
523	Methylation	QNQNGKSKGYAFIEF CCCCCCCCCEEEEEE	60.47	24129315
523	Ubiquitination	QNQNGKSKGYAFIEF CCCCCCCCCEEEEEE	60.47	-
525	Nitration	QNGKSKGYAFIEFAS CCCCCCCEEEEEEEC	11.32	-
525	Phosphorylation	QNGKSKGYAFIEFAS CCCCCCCEEEEEEEC	11.32	28152594
532	Phosphorylation	YAFIEFASFEDAKEA EEEEEEECHHHHHHH	34.19	27732954
537	Ubiquitination	FASFEDAKEALNSCN EECHHHHHHHHHHCC	56.70	-
542	Phosphorylation	DAKEALNSCNKREIE HHHHHHHHCCHHHCC	21.66	26074081
543	S-nitrosocysteine	AKEALNSCNKREIEG HHHHHHHCCHHHCCC	7.28	-
543	S-nitrosylation	AKEALNSCNKREIEG HHHHHHHCCHHHCCC	7.28	19483679
545	2-Hydroxyisobutyrylation	EALNSCNKREIEGRA HHHHHCCHHHCCCCE	56.59	-
545	Acetylation	EALNSCNKREIEGRA HHHHHCCHHHCCCCE	56.59	23749302
545	Ubiquitination	EALNSCNKREIEGRA HHHHHCCHHHCCCCE	56.59	21890473
561	Methylation	RLELQGPRGSPNARS EEEECCCCCCCCCCC	66.11	54557497
563	Phosphorylation	ELQGPRGSPNARSQP EECCCCCCCCCCCCC	19.09	22167270
568	Phosphorylation	RGSPNARSQPSKTLF CCCCCCCCCCCCEEE	43.99	26074081
571	Phosphorylation	PNARSQPSKTLFVKG CCCCCCCCCEEEEEC	30.54	26074081
572	2-Hydroxyisobutyrylation	NARSQPSKTLFVKGL CCCCCCCCEEEEECC	56.80	-
572	Acetylation	NARSQPSKTLFVKGL CCCCCCCCEEEEECC	56.80	19608861
572	Ubiquitination	NARSQPSKTLFVKGL CCCCCCCCEEEEECC	56.80	21906983
573	Phosphorylation	ARSQPSKTLFVKGLS CCCCCCCEEEEECCC	29.75	26074081
577	Sumoylation	PSKTLFVKGLSEDTT CCCEEEEECCCCCCC	46.96	-
577	2-Hydroxyisobutyrylation	PSKTLFVKGLSEDTT CCCEEEEECCCCCCC	46.96	-
577	Acetylation	PSKTLFVKGLSEDTT CCCEEEEECCCCCCC	46.96	19608861
577	Sumoylation	PSKTLFVKGLSEDTT CCCEEEEECCCCCCC	46.96	28112733
577	Ubiquitination	PSKTLFVKGLSEDTT CCCEEEEECCCCCCC	46.96	21906983
580	Phosphorylation	TLFVKGLSEDTTEET EEEEECCCCCCCHHH	41.94	25159151
583	Phosphorylation	VKGLSEDTTEETLKE EECCCCCCCHHHHHH	31.86	30266825
584	Phosphorylation	KGLSEDTTEETLKES ECCCCCCCHHHHHHH	44.11	30266825
587	Phosphorylation	SEDTTEETLKESFDG CCCCCHHHHHHHCCC	36.58	23927012
589	2-Hydroxyisobutyrylation	DTTEETLKESFDGSV CCCHHHHHHHCCCCE	59.75	-
589	Acetylation	DTTEETLKESFDGSV CCCHHHHHHHCCCCE	59.75	26051181
589	Sumoylation	DTTEETLKESFDGSV CCCHHHHHHHCCCCE	59.75	25114211
589	Ubiquitination	DTTEETLKESFDGSV CCCHHHHHHHCCCCE	59.75	21890473
591	Phosphorylation	TEETLKESFDGSVRA CHHHHHHHCCCCEEE	27.35	25159151
595	Phosphorylation	LKESFDGSVRARIVT HHHHCCCCEEEEEEE	15.41	30108239
597	Methylation	ESFDGSVRARIVTDR HHCCCCEEEEEEEEC	21.61	115484593
602	Phosphorylation	SVRARIVTDRETGSS CEEEEEEEECCCCCC	27.28	28176443
604	Methylation	RARIVTDRETGSSKG EEEEEEECCCCCCCC	33.73	54557501
606	Phosphorylation	RIVTDRETGSSKGFG EEEEECCCCCCCCCC	43.17	25159151
608	Phosphorylation	VTDRETGSSKGFGFV EEECCCCCCCCCCCC	35.97	25159151
609	Phosphorylation	TDRETGSSKGFGFVD EECCCCCCCCCCCCC	37.84	25159151
610	2-Hydroxyisobutyrylation	DRETGSSKGFGFVDF ECCCCCCCCCCCCCC	61.01	-
610	Acetylation	DRETGSSKGFGFVDF ECCCCCCCCCCCCCC	61.01	23954790
610	Malonylation	DRETGSSKGFGFVDF ECCCCCCCCCCCCCC	61.01	26320211
610	Ubiquitination	DRETGSSKGFGFVDF ECCCCCCCCCCCCCC	61.01	21890473
619	O-linked_Glycosylation	FGFVDFNSEEDAKAA CCCCCCCCHHHHHHH	42.21	32119511
619	Phosphorylation	FGFVDFNSEEDAKAA CCCCCCCCHHHHHHH	42.21	19664994
624	2-Hydroxyisobutyrylation	FNSEEDAKAAKEAME CCCHHHHHHHHHHHH	62.29	-
624	Acetylation	FNSEEDAKAAKEAME CCCHHHHHHHHHHHH	62.29	23954790
624	Malonylation	FNSEEDAKAAKEAME CCCHHHHHHHHHHHH	62.29	26320211
624	Sumoylation	FNSEEDAKAAKEAME CCCHHHHHHHHHHHH	62.29	28112733
624	Ubiquitination	FNSEEDAKAAKEAME CCCHHHHHHHHHHHH	62.29	-
627	Acetylation	EEDAKAAKEAMEDGE HHHHHHHHHHHHHCC	51.36	27452117
627	Malonylation	EEDAKAAKEAMEDGE HHHHHHHHHHHHHCC	51.36	26320211
627	Succinylation	EEDAKAAKEAMEDGE HHHHHHHHHHHHHCC	51.36	23954790
639	2-Hydroxyisobutyrylation	DGEIDGNKVTLDWAK HCCCCCCEEEEEECC	41.97	-
639	Acetylation	DGEIDGNKVTLDWAK HCCCCCCEEEEEECC	41.97	23236377
639	Ubiquitination	DGEIDGNKVTLDWAK HCCCCCCEEEEEECC	41.97	-
641	O-linked_Glycosylation	EIDGNKVTLDWAKPK CCCCCEEEEEECCCC	22.17	32119511
641	Phosphorylation	EIDGNKVTLDWAKPK CCCCCEEEEEECCCC	22.17	21998300
646	2-Hydroxyisobutyrylation	KVTLDWAKPKGEGGF EEEEEECCCCCCCCC	42.90	-
646	Acetylation	KVTLDWAKPKGEGGF EEEEEECCCCCCCCC	42.90	19608861
646	Methylation	KVTLDWAKPKGEGGF EEEEEECCCCCCCCC	42.90	19608861
646	Ubiquitination	KVTLDWAKPKGEGGF EEEEEECCCCCCCCC	42.90	19608861
656	Asymmetric dimethylarginine	GEGGFGGRGGGRGGF CCCCCCCCCCCCCCC	40.75	-
656	Methylation	GEGGFGGRGGGRGGF CCCCCCCCCCCCCCC	40.75	20679175
660	Asymmetric dimethylarginine	FGGRGGGRGGFGGRG CCCCCCCCCCCCCCC	45.39	-
660	Methylation	FGGRGGGRGGFGGRG CCCCCCCCCCCCCCC	45.39	20679179
666	Asymmetric dimethylarginine	GRGGFGGRGGGRGGR CCCCCCCCCCCCCCC	40.75	-
666	Methylation	GRGGFGGRGGGRGGR CCCCCCCCCCCCCCC	40.75	97799393
670	Asymmetric dimethylarginine	FGGRGGGRGGRGGFG CCCCCCCCCCCCCCC	47.90	-
670	Methylation	FGGRGGGRGGRGGFG CCCCCCCCCCCCCCC	47.90	80700943
673	Asymmetric dimethylarginine	RGGGRGGRGGFGGRG CCCCCCCCCCCCCCC	44.90	-
673	Methylation	RGGGRGGRGGFGGRG CCCCCCCCCCCCCCC	44.90	80700951
679	Dimethylation	GRGGFGGRGRGGFGG CCCCCCCCCCCCCCC	31.82	-
679	Methylation	GRGGFGGRGRGGFGG CCCCCCCCCCCCCCC	31.82	8427429
681	Dimethylation	GGFGGRGRGGFGGRG CCCCCCCCCCCCCCC	40.47	-
681	Methylation	GGFGGRGRGGFGGRG CCCCCCCCCCCCCCC	40.47	24383057
687	Dimethylation	GRGGFGGRGGFRGGR CCCCCCCCCCCCCCC	42.30	-
687	Methylation	GRGGFGGRGGFRGGR CCCCCCCCCCCCCCC	42.30	24383063
691	Methylation	FGGRGGFRGGRGGGG CCCCCCCCCCCCCCC	50.35	18763407
694	Dimethylation	RGGFRGGRGGGGDHK CCCCCCCCCCCCCCC	43.33	-
694	Methylation	RGGFRGGRGGGGDHK CCCCCCCCCCCCCCC	43.33	30988615
707	Phosphorylation	HKPQGKKTKFE---- CCCCCCCCCCC----	44.44	21998300

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
76	T	Phosphorylation	Kinase	CDC7	O00311	PSP
76	T	Phosphorylation	Kinase	CDK2	P24941	PSP
121	T	Phosphorylation	Kinase	CDC7	O00311	PSP
121	T	Phosphorylation	Kinase	CDK1	P06493	PSP
121	T	Phosphorylation	Kinase	CDK2	P24941	PSP
328	S	Phosphorylation	Kinase	AMPKA1	Q13131	PSP
641	T	Phosphorylation	Kinase	AKT1	P31749	PSP
641	T	Phosphorylation	Kinase	CDK1	P06493	PSP
707	T	Phosphorylation	Kinase	AKT1	P31749	PSP
707	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUCL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUCL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERT_HUMAN	TERT	physical	15371412
S10AB_HUMAN	S100A11	physical	14623863
SP1_HUMAN	SP1	physical	14623863
CSK22_HUMAN	CSNK2A2	physical	8663258
PP1B_HUMAN	PPP1CB	physical	12185196
TOP1_HUMAN	TOP1	physical	9512561
MK_HUMAN	MDK	physical	12147681
NPM_HUMAN	NPM1	physical	8620867
P53_HUMAN	TP53	physical	12138209
MDM2_HUMAN	MDM2	physical	16751805
ANM5_HUMAN	PRMT5	physical	17974993
STAU1_HUMAN	STAU1	physical	15303970
MDM2_HUMAN	MDM2	physical	22103682
NPM_HUMAN	NPM1	physical	22362753
NPM3_HUMAN	NPM3	physical	22362753
GZF1_HUMAN	GZF1	physical	17674968
RL21_HUMAN	RPL21	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RL7A_HUMAN	RPL7A	physical	22939629
RL19_HUMAN	RPL19	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL14_HUMAN	RPL14	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RL18A_HUMAN	RPL18A	physical	22939629
RL18_HUMAN	RPL18	physical	22939629
RL15_HUMAN	RPL15	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RL24_HUMAN	RPL24	physical	22939629
RL11_HUMAN	RPL11	physical	22939629
RL8_HUMAN	RPL8	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
PTBP1_HUMAN	PTBP1	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RL3_HUMAN	RPL3	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RL9_HUMAN	RPL9	physical	22939629
SF3B4_HUMAN	SF3B4	physical	22939629
PHF5A_HUMAN	PHF5A	physical	22939629
RCN1_HUMAN	RCN1	physical	22939629
RBM42_HUMAN	RBM42	physical	22939629
RFXAP_HUMAN	RFXAP	physical	22939629
PNPT1_HUMAN	PNPT1	physical	22939629
QCR2_HUMAN	UQCRC2	physical	22939629
RADI_HUMAN	RDX	physical	22939629
RT26_HUMAN	MRPS26	physical	22939629
SEPT9_HUMAN	SEPT9	physical	22939629
SCOT1_HUMAN	OXCT1	physical	22939629
TYY1_HUMAN	YY1	physical	22939629
H2AX_HUMAN	H2AFX	physical	23145133
XRCC6_HUMAN	XRCC6	physical	23145133
RPA34_HUMAN	CD3EAP	physical	23145133
NBN_HUMAN	NBN	physical	23145133
IL7RA_HUMAN	IL7R	physical	23151878
ZN689_HUMAN	ZNF689	physical	16568080
LA_HUMAN	SSB	physical	18292223
IGSF8_HUMAN	IGSF8	physical	23463506
CD81_HUMAN	CD81	physical	23463506
ICAM1_HUMAN	ICAM1	physical	23463506
VCAM1_HUMAN	VCAM1	physical	23463506
HMGA1_HUMAN	HMGA1	physical	18850631
PGH1_HUMAN	PTGS1	physical	17320986
BIG1_HUMAN	ARFGEF1	physical	14973189
NUP62_HUMAN	NUP62	physical	14973189
P85A_HUMAN	PIK3R1	physical	16571724
HNRPD_HUMAN	HNRNPD	physical	16571724
NUCL_HUMAN	NCL	physical	25313645
APC1_HUMAN	ANAPC1	physical	26344197
APC7_HUMAN	ANAPC7	physical	26344197
AN32B_HUMAN	ANP32B	physical	26344197
DAXX_HUMAN	DAXX	physical	26344197
EBP2_HUMAN	EBNA1BP2	physical	26344197
IF2P_HUMAN	EIF5B	physical	26344197
T2FA_HUMAN	GTF2F1	physical	26344197
HNRPK_HUMAN	HNRNPK	physical	26344197
NP1L1_HUMAN	NAP1L1	physical	26344197
NP1L4_HUMAN	NAP1L4	physical	26344197
RPAC1_HUMAN	POLR1C	physical	26344197
PTMA_HUMAN	PTMA	physical	26344197
RBM46_HUMAN	RBM46	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RS8_HUMAN	RPS8	physical	26344197
SPT4H_HUMAN	SUPT4H1	physical	26344197
SPT5H_HUMAN	SUPT5H	physical	26344197
TAF4_HUMAN	TAF4	physical	26344197
DCAF1_HUMAN	VPRBP	physical	26344197
WDR43_HUMAN	WDR43	physical	26344197
UBP7_HUMAN	USP7	physical	25695607
UBP7_HUMAN	USP7	physical	26238070
ITAV_HUMAN	ITGAV	physical	23161541
PTPRZ_HUMAN	PTPRZ1	physical	23161541
EGFR_HUMAN	EGFR	physical	25261371
RL26L_HUMAN	RPL26L1	physical	28514442
RL7A_HUMAN	RPL7A	physical	27049334
RS6_HUMAN	RPS6	physical	27049334
RL4_HUMAN	RPL4	physical	27049334
RS8_HUMAN	RPS8	physical	27049334
RL5_HUMAN	RPL5	physical	27049334
RL21_HUMAN	RPL21	physical	27049334
RL27A_HUMAN	RPL27A	physical	27049334
RL31_HUMAN	RPL31	physical	27049334
RL8_HUMAN	RPL8	physical	27049334
RL18_HUMAN	RPL18	physical	27049334
DDX21_HUMAN	DDX21	physical	27049334
RS4X_HUMAN	RPS4X	physical	27049334
H1X_HUMAN	H1FX	physical	27049334
RL35A_HUMAN	RPL35A	physical	27049334
RL6_HUMAN	RPL6	physical	27049334
RS9_HUMAN	RPS9	physical	27049334
RL13_HUMAN	RPL13	physical	27049334
RS3A_HUMAN	RPS3A	physical	27049334
RL13A_HUMAN	RPL13A	physical	27049334
RS26_HUMAN	RPS26	physical	27049334
RS24_HUMAN	RPS24	physical	27049334
RL23A_HUMAN	RPL23A	physical	27049334
RL7_HUMAN	RPL7	physical	27049334
RL9_HUMAN	RPL9	physical	27049334
RL19_HUMAN	RPL19	physical	27049334
RL15_HUMAN	RPL15	physical	27049334
RL28_HUMAN	RPL28	physical	27049334
U2AF2_HUMAN	U2AF2	physical	27049334
RL14_HUMAN	RPL14	physical	27049334
RL1D1_HUMAN	RSL1D1	physical	27049334
MBB1A_HUMAN	MYBBP1A	physical	27049334
RL17_HUMAN	RPL17	physical	27049334
RRP1B_HUMAN	RRP1B	physical	27049334
RL3_HUMAN	RPL3	physical	27049334
RS18_HUMAN	RPS18	physical	27049334
YBOX1_HUMAN	YBX1	physical	27049334
ILF2_HUMAN	ILF2	physical	27049334
RS23_HUMAN	RPS23	physical	27049334
LYAR_HUMAN	LYAR	physical	27049334
EBP2_HUMAN	EBNA1BP2	physical	27049334
RL36_HUMAN	RPL36	physical	27049334
RL18A_HUMAN	RPL18A	physical	27049334
BRX1_HUMAN	BRIX1	physical	27049334
SRSF3_HUMAN	SRSF3	physical	27049334
DDX50_HUMAN	DDX50	physical	27049334
NOG1_HUMAN	GTPBP4	physical	27049334
RL24_HUMAN	RPL24	physical	27049334
RS12_HUMAN	RPS12	physical	27049334
RLA1_HUMAN	RPLP1	physical	27049334
SMD2_HUMAN	SNRPD2	physical	27049334
CDC5L_HUMAN	CDC5L	physical	27049334
MRT4_HUMAN	MRTO4	physical	27049334
SMC3_HUMAN	SMC3	physical	27049334
RS17_HUMAN	RPS17	physical	27049334
RS14_HUMAN	RPS14	physical	27049334
EXOSX_HUMAN	EXOSC10	physical	27049334
HDGR2_HUMAN	HDGFRP2	physical	27049334
SRPK1_HUMAN	SRPK1	physical	27049334
SRP14_HUMAN	SRP14	physical	27049334
RS27_HUMAN	RPS27	physical	27049334
DDX41_HUMAN	DDX41	physical	27049334
U2AF1_HUMAN	U2AF1	physical	27049334
ILF3_HUMAN	ILF3	physical	27049334
DDX18_HUMAN	DDX18	physical	27049334
RL27_HUMAN	RPL27	physical	27049334
RS7_HUMAN	RPS7	physical	27049334
SR140_HUMAN	U2SURP	physical	27049334
SMD1_HUMAN	SNRPD1	physical	27049334
DHX30_HUMAN	DHX30	physical	27049334
RL23_HUMAN	RPL23	physical	27049334
CHD4_HUMAN	CHD4	physical	27049334
GRWD1_HUMAN	GRWD1	physical	27049334
RS13_HUMAN	RPS13	physical	27049334
CG050_HUMAN	C7orf50	physical	27049334
U520_HUMAN	SNRNP200	physical	27049334
SSF1_HUMAN	PPAN	physical	27049334
TSR1_HUMAN	TSR1	physical	27049334
PRP8_HUMAN	PRPF8	physical	27049334
IF6_HUMAN	EIF6	physical	27049334
TXTP_HUMAN	SLC25A1	physical	27049334
PAPD1_HUMAN	MTPAP	physical	27049334
EXOS9_HUMAN	EXOSC9	physical	27049334
TF3C1_HUMAN	GTF3C1	physical	27049334
RPAC1_HUMAN	POLR1C	physical	27049334
PESC_HUMAN	PES1	physical	27049334
SNUT1_HUMAN	SART1	physical	27049334
SMC2_HUMAN	SMC2	physical	27049334
RL12_HUMAN	RPL12	physical	27049334
SMC1A_HUMAN	SMC1A	physical	27049334
SK2L2_HUMAN	SKIV2L2	physical	27049334
GNL3_HUMAN	GNL3	physical	27049334
PUF60_HUMAN	PUF60	physical	27049334
EXOS2_HUMAN	EXOSC2	physical	27049334
SMCA5_HUMAN	SMARCA5	physical	27049334
RBM39_HUMAN	RBM39	physical	27049334
RPB2_HUMAN	POLR2B	physical	27049334
DDX47_HUMAN	DDX47	physical	27049334
CD11A_HUMAN	CDK11A	physical	27049334
ZCCHV_HUMAN	ZC3HAV1	physical	27049334
RLA0_HUMAN	RPLP0	physical	27049334
PRPF3_HUMAN	PRPF3	physical	27049334
ZC3HF_HUMAN	ZC3H15	physical	27049334
RS15_HUMAN	RPS15	physical	27049334
PWP1_HUMAN	PWP1	physical	27049334
SPB1_HUMAN	FTSJ3	physical	27049334
HNRPR_HUMAN	HNRNPR	physical	27049334
RS25_HUMAN	RPS25	physical	27049334
RL22_HUMAN	RPL22	physical	27049334
THOC4_HUMAN	ALYREF	physical	27049334
RS16_HUMAN	RPS16	physical	27049334
NOC4L_HUMAN	NOC4L	physical	27049334
SRRM1_HUMAN	SRRM1	physical	27049334
RT29_HUMAN	DAP3	physical	27049334
RT34_HUMAN	MRPS34	physical	27049334
NOP53_HUMAN	GLTSCR2	physical	27049334
MOGS_HUMAN	MOGS	physical	27049334
RRS1_HUMAN	RRS1	physical	27049334
RRP1_HUMAN	RRP1	physical	27049334
RCL1_HUMAN	RCL1	physical	27049334
RPF2_HUMAN	RPF2	physical	27049334
DHX15_HUMAN	DHX15	physical	27049334
ACL6A_HUMAN	ACTL6A	physical	27049334
IF2B1_HUMAN	IGF2BP1	physical	27049334
RT07_HUMAN	MRPS7	physical	27049334
SNUT2_HUMAN	USP39	physical	27049334
TRI25_HUMAN	TRIM25	physical	27049334
ERH_HUMAN	ERH	physical	27049334
DHX9_HUMAN	DHX9	physical	27049334
CE170_HUMAN	CEP170	physical	27049334
SMCA4_HUMAN	SMARCA4	physical	27049334
RS3_HUMAN	RPS3	physical	27049334
NXF1_HUMAN	NXF1	physical	27049334
HNRPU_HUMAN	HNRNPU	physical	27049334
RL11_HUMAN	RPL11	physical	27049334
RS10_HUMAN	RPS10	physical	27049334
ABCF2_HUMAN	ABCF2	physical	27049334
MSH6_HUMAN	MSH6	physical	27049334
EXOS4_HUMAN	EXOSC4	physical	27049334
RSMN_HUMAN	SNRPN	physical	27049334
RS20_HUMAN	RPS20	physical	27049334
CDC73_HUMAN	CDC73	physical	27049334
RFC3_HUMAN	RFC3	physical	27049334
MIC19_HUMAN	CHCHD3	physical	27049334
ACTN4_HUMAN	ACTN4	physical	27049334

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-9; LYS-102; LYS-116;LYS-124; LYS-132; LYS-318; LYS-333; LYS-377; LYS-398; LYS-403;LYS-513; LYS-572; LYS-577 AND LYS-646, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-34; SER-67;SER-460 AND SER-619, AND MASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145 AND SER-153, ANDMASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; THR-121; SER-145;SER-153 AND SER-619, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; THR-69; THR-76;THR-121; SER-145; SER-153; SER-184; SER-206; THR-214; THR-367; SER-563AND SER-619, AND MASS SPECTROMETRY.
PubMed: 18669648

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; THR-69 AND SER-563,AND MASS SPECTROMETRY.
PubMed: 18187866

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; THR-69; THR-76;THR-106; THR-113; THR-121; SER-563 AND SER-580, AND MASS SPECTROMETRY.
PubMed: 19007248

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; SER-184; THR-214 ANDSER-563, AND MASS SPECTROMETRY.
PubMed: 17287340

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; THR-69; THR-76;THR-121 AND SER-563, AND MASS SPECTROMETRY.
PubMed: 17924679

"Toward a global characterization of the phosphoproteome in prostatecancer cells: identification of phosphoproteins in the LNCaP cellline.";
Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.;
Electrophoresis 28:2027-2034(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145; SER-153; SER-184AND SER-206, AND MASS SPECTROMETRY.
PubMed: 17487921

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-76; THR-121; SER-580 ANDSER-619, AND MASS SPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-34; SER-41;SER-42; SER-67; THR-121; SER-145; SER-153 AND SER-563, AND MASSSPECTROMETRY.
PubMed: 17081983

"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; THR-99; THR-105 ANDSER-563, AND MASS SPECTROMETRY.
PubMed: 16083285

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-67; SER-145 ANDSER-153, AND MASS SPECTROMETRY.
PubMed: 15302935