GZF1_HUMAN - dbPTM
GZF1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GZF1_HUMAN
UniProt AC Q9H116
Protein Name GDNF-inducible zinc finger protein 1
Gene Name GZF1 {ECO:0000312|HGNC:HGNC:15808}
Organism Homo sapiens (Human).
Sequence Length 711
Subcellular Localization Cytoplasm . Nucleus, nucleoplasm . Nucleus, nucleolus . Nuclear localization depends upon NCL.
Protein Description Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression..
Protein Sequence MESGAVLLESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVADFASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQMLESVLLELQNFSESQEVEVSSGSQVSAAPAPRASVATDGPHPSGLTDSLDYPGERASNGMSSDLPPKKSKDKLDKKKEVVKPPYPKIRRASGRLAGRKVFVEIPKKKYTRRLREQQKTAEGDVGDYRCPQDQSPDRVGTEMEQVSKNEGCQAGAELEELSKKAGPEEEEEEEEEDEEGEKKKSNFKCSICEKAFLYEKSFLKHSKHRHGVATEVVYRCDTCGQTFANRCNLKSHQRHVHSSERHFPCELCGKKFKRKKDVKRHVLQVHEGGGERHRCGQCGKGLSSKTALRLHERTHTGDRPYGCTECGARFSQPSALKTHMRIHTGEKPFVCDECGARFTQNHMLIYHKRCHTGERPFMCETCGKSFASKEYLKHHNRIHTGSKPFKCEVCFRTFAQRNSLYQHIKVHTGERPYCCDQCGKQFTQLNALQRHRRIHTGERPFMCNACGRTFTDKSTLRRHTSIHDKNTPWKSFLVIVDGSPKNDDGHKTEQPDEEYVSSKLSDKLLSFAENGHFHNLAAVQDTVPTMQENSSADTACKADDSVVSQDTLLATTISELSELTPQTDSMPTQLHSLSNME
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MESGAVLLES
-----CCCCCEEEEC		30.6530631047
10PhosphorylationSGAVLLESKSSPFNL
CCCEEEECCCCHHHH		37.4930631047
117UbiquitinationLEVAEKLKCLDLSET
HHHHHHHHCCCHHHH		43.76-
166PhosphorylationAAPAPRASVATDGPH
CCCCCCCCCCCCCCC		17.3528555341
175PhosphorylationATDGPHPSGLTDSLD
CCCCCCCCCCCCCCC		43.3228348404
178PhosphorylationGPHPSGLTDSLDYPG
CCCCCCCCCCCCCCC		27.3728348404
180PhosphorylationHPSGLTDSLDYPGER
CCCCCCCCCCCCCCH		20.2223312004
183PhosphorylationGLTDSLDYPGERASN
CCCCCCCCCCCHHCC		20.5923312004
199AcetylationMSSDLPPKKSKDKLD
CCCCCCCCCCHHHCH		68.677925417
207AcetylationKSKDKLDKKKEVVKP
CCHHHCHHCHHCCCC		75.967925427
265PhosphorylationYRCPQDQSPDRVGTE
CCCCCCCCCCCCCCC		36.7423401153
271PhosphorylationQSPDRVGTEMEQVSK
CCCCCCCCCHHHHHH		29.3330266825
277PhosphorylationGTEMEQVSKNEGCQA
CCCHHHHHHCCCCHH		29.4729083192
328PhosphorylationICEKAFLYEKSFLKH
CCHHHHHHHHHHHHH		18.1730576142
331PhosphorylationKAFLYEKSFLKHSKH
HHHHHHHHHHHHCCC		24.7024719451
372PhosphorylationSHQRHVHSSERHFPC
HHCCCCCCCCCCCCH		32.57-
373PhosphorylationHQRHVHSSERHFPCE
HCCCCCCCCCCCCHH		24.62-
428PhosphorylationALRLHERTHTGDRPY
HHHHHHCCCCCCCCC		22.3227251275
430PhosphorylationRLHERTHTGDRPYGC
HHHHCCCCCCCCCCC		39.9223898821
458PhosphorylationKTHMRIHTGEKPFVC
HHHEEEECCCCCEEC		44.6721712546
486PhosphorylationIYHKRCHTGERPFMC
EEECCCCCCCCCEEC		44.3528555341
495PhosphorylationERPFMCETCGKSFAS
CCCEECCCCCCCCCC		22.9430631047
499PhosphorylationMCETCGKSFASKEYL
ECCCCCCCCCCHHHH		16.0130631047
502PhosphorylationTCGKSFASKEYLKHH
CCCCCCCCHHHHHHC		24.8230631047
542PhosphorylationYQHIKVHTGERPYCC
HHCEEECCCCCCCCC		43.6625159151
570PhosphorylationQRHRRIHTGERPFMC
HHHCCCCCCCCCCCC		38.0628555341
605PhosphorylationDKNTPWKSFLVIVDG
CCCCCCCEEEEEECC		21.68-
613PhosphorylationFLVIVDGSPKNDDGH
EEEEECCCCCCCCCC		28.3919664994
629PhosphorylationTEQPDEEYVSSKLSD
CCCCCHHHHHHHHHH		12.0027642862
631PhosphorylationQPDEEYVSSKLSDKL
CCCHHHHHHHHHHHH		22.3630576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GZF1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GZF1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GZF1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NUCL_HUMANNCLphysical
17674968
NFAC1_HUMANNFATC1physical
17674968
YBOX1_HUMANYBX1physical
17674968
NPM_HUMANNPM1physical
17674968
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GZF1_HUMAN

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Related Literatures of Post-Translational Modification

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