dbPTM

RSMN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RSMN_HUMAN
UniProt AC	P63162
Protein Name	Small nuclear ribonucleoprotein-associated protein N
Gene Name	SNRPN
Organism	Homo sapiens (Human).
Sequence Length	240
Subcellular Localization	Nucleus.
Protein Description	May be involved in tissue-specific alternative RNA processing events..
Protein Sequence	MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNAKQPEREEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGVGRAAGRGVPAGVPIPQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAVAATASIAGAPTQYPPGRGTPPPPVGRATPPPGIMAPPPGMRPPMGPPIGLPPARGTPIGMPPPGMRPPPPGIRGPPPPGMRPPRP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTVGKSSKM ------CCCCCHHHH	37.66	20068231
5	Ubiquitination	---MTVGKSSKMLQH ---CCCCCHHHHHHH	47.41	23000965
6	Phosphorylation	--MTVGKSSKMLQHI --CCCCCHHHHHHHH	29.30	20068231
7	Phosphorylation	-MTVGKSSKMLQHID -CCCCCHHHHHHHHC	26.10	29116813
8	Acetylation	MTVGKSSKMLQHIDY CCCCCHHHHHHHHCH	51.20	22634303
8	Ubiquitination	MTVGKSSKMLQHIDY CCCCCHHHHHHHHCH	51.20	23000965
9	Methylation	TVGKSSKMLQHIDYR CCCCHHHHHHHHCHH	4.74	-
9	Ubiquitination	TVGKSSKMLQHIDYR CCCCHHHHHHHHCHH	4.74	-
12	Acetylation	KSSKMLQHIDYRMRC CHHHHHHHHCHHHHH	15.78	-
12	Methylation	KSSKMLQHIDYRMRC CHHHHHHHHCHHHHH	15.78	-
12	Ubiquitination	KSSKMLQHIDYRMRC CHHHHHHHHCHHHHH	15.78	21890473
12	Ubiquitination	KSSKMLQHIDYRMRC CHHHHHHHHCHHHHH	15.78	29901268
15	Phosphorylation	KMLQHIDYRMRCILQ HHHHHHCHHHHHEEC	13.00	29116813
16	Methylation	MLQHIDYRMRCILQD HHHHHCHHHHHEECC	11.43	-
19 (in isoform 2)	Phosphorylation	-	2.38	20068231
24	Ubiquitination	MRCILQDGRIFIGTF HHHEECCCCEEEEEC	16.18	33845483
26	Ubiquitination	CILQDGRIFIGTFKA HEECCCCEEEEECHH	3.45	-
28	Ubiquitination	LQDGRIFIGTFKAFD ECCCCEEEEECHHHH	4.77	32015554
30	Phosphorylation	DGRIFIGTFKAFDKH CCCEEEEECHHHHHC	19.69	23186163
32	Ubiquitination	RIFIGTFKAFDKHMN CEEEEECHHHHHCCC	48.24	23000965
32	Phosphorylation	RIFIGTFKAFDKHMN CEEEEECHHHHHCCC	48.24	-
32	Acetylation	RIFIGTFKAFDKHMN CEEEEECHHHHHCCC	48.24	88801
36	Acetylation	GTFKAFDKHMNLILC EECHHHHHCCCEEEE	38.00	-
36	Ubiquitination	GTFKAFDKHMNLILC EECHHHHHCCCEEEE	38.00	23000965
36	Ubiquitination	GTFKAFDKHMNLILC EECHHHHHCCCEEEE	38.00	21890473
36	Acetylation	GTFKAFDKHMNLILC EECHHHHHCCCEEEE	38.00	133787
40	Ubiquitination	AFDKHMNLILCDCDE HHHHCCCEEEECHHH	2.16	-
40	Acetylation	AFDKHMNLILCDCDE HHHHCCCEEEECHHH	2.16	-
40	Ubiquitination	AFDKHMNLILCDCDE HHHHCCCEEEECHHH	2.16	32015554
54	Ubiquitination	EFRKIKPKNAKQPER HHHCCCCCCCCCCHH	65.62	24816145
64	Ubiquitination	KQPEREEKRVLGLVL CCCHHHHHHHHEEEE	42.95	24816145
80	Sulfoxidation	RGENLVSMTVEGPPP CCCCEEEEEEECCCC	3.66	28183972
80	Ubiquitination	RGENLVSMTVEGPPP CCCCEEEEEEECCCC	3.66	33845483
88	Ubiquitination	TVEGPPPKDTGIARV EEECCCCCCCCEEEE	73.94	23000965
92	Ubiquitination	PPPKDTGIARVPLAG CCCCCCCEEEEECCC	2.10	21890473
92	Ubiquitination	PPPKDTGIARVPLAG CCCCCCCEEEEECCC	2.10	33845483
108	Methylation	AGGPGVGRAAGRGVP CCCCCHHHCCCCCCC	20.89	24390879
108	Dimethylation	AGGPGVGRAAGRGVP CCCCCHHHCCCCCCC	20.89	-
112	Methylation	GVGRAAGRGVPAGVP CHHHCCCCCCCCCCC	37.90	80702323
112	Dimethylation	GVGRAAGRGVPAGVP CHHHCCCCCCCCCCC	37.90	-
147	Methylation	QVMTPQGRGTVAAAA CCCCCCCCHHHHHHH	32.15	18600991
147	Dimethylation	QVMTPQGRGTVAAAA CCCCCCCCHHHHHHH	32.15	-
149	Phosphorylation	MTPQGRGTVAAAAVA CCCCCCHHHHHHHHH	12.95	24260401
158	Phosphorylation	AAAAVAATASIAGAP HHHHHHHHHHHCCCC	15.94	24260401
160	Phosphorylation	AAVAATASIAGAPTQ HHHHHHHHHCCCCCC	14.49	24260401
166	Phosphorylation	ASIAGAPTQYPPGRG HHHCCCCCCCCCCCC	39.95	24260401
168	Phosphorylation	IAGAPTQYPPGRGTP HCCCCCCCCCCCCCC	17.55	24260401
172	Methylation	PTQYPPGRGTPPPPV CCCCCCCCCCCCCCC	52.14	24129315
181	Dimethylation	TPPPPVGRATPPPGI CCCCCCCCCCCCCCC	35.21	-
181	Methylation	TPPPPVGRATPPPGI CCCCCCCCCCCCCCC	35.21	82797065
183	Phosphorylation	PPPVGRATPPPGIMA CCCCCCCCCCCCCCC	34.66	20860994
236	Dimethylation	GPPPPGMRPPRP--- CCCCCCCCCCCC---	43.94	-
236	Methylation	GPPPPGMRPPRP--- CCCCCCCCCCCC---	43.94	-
239	Methylation	PPGMRPPRP------ CCCCCCCCC------	52.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RSMN_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RSMN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RSMN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRIF1_HUMAN	LRIF1	physical	16169070
SH3G3_HUMAN	SH3GL3	physical	16169070
P53_HUMAN	TP53	physical	16169070
RENT1_HUMAN	UPF1	physical	18362360
DSRAD_HUMAN	ADAR	physical	18362360
RFOX1_HUMAN	RBFOX1	physical	24722188
CTBP1_HUMAN	CTBP1	physical	24722188
RU2A_HUMAN	SNRPA1	physical	28514442
SART3_HUMAN	SART3	physical	28514442
CMTR2_HUMAN	CMTR2	physical	28514442
RBM40_HUMAN	RNPC3	physical	28514442
U2AFM_HUMAN	ZRSR2	physical	28514442
ZMAT5_HUMAN	ZMAT5	physical	28514442
FARP1_HUMAN	FARP1	physical	28514442
U1SBP_HUMAN	SNRNP35	physical	28514442
PDCD7_HUMAN	PDCD7	physical	28514442
DPP8_HUMAN	DPP8	physical	28514442
SNR48_HUMAN	SNRNP48	physical	28514442
TGS1_HUMAN	TGS1	physical	28514442
ICLN_HUMAN	CLNS1A	physical	28514442
RU2B_HUMAN	SNRPB2	physical	28514442
STPAP_HUMAN	TUT1	physical	28514442
LSM11_HUMAN	LSM11	physical	28514442
SMD1_HUMAN	SNRPD1	physical	28514442
NADAP_HUMAN	SLC4A1AP	physical	28514442
SMD2_HUMAN	SNRPD2	physical	28514442
PRPF3_HUMAN	PRPF3	physical	28514442
MEPCE_HUMAN	MEPCE	physical	28514442
ANM5_HUMAN	PRMT5	physical	28514442
RU17_HUMAN	SNRNP70	physical	28514442
SNR27_HUMAN	SNRNP27	physical	28514442
SNRPA_HUMAN	SNRPA	physical	28514442
TOE1_HUMAN	TOE1	physical	28514442
SF3A2_HUMAN	SF3A2	physical	28514442
SYF2_HUMAN	SYF2	physical	28514442
PKRI1_HUMAN	PRKRIP1	physical	28514442
PAXB1_HUMAN	PAXBP1	physical	28514442
CSTF1_HUMAN	CSTF1	physical	28514442
EAPP_HUMAN	EAPP	physical	28514442
WBP4_HUMAN	WBP4	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
GEMI8_HUMAN	GEMIN8	physical	28514442
SKAP2_HUMAN	SKAP2	physical	28514442
GEMI5_HUMAN	GEMIN5	physical	28514442
RIOK1_HUMAN	RIOK1	physical	28514442
PRP4_HUMAN	PRPF4	physical	28514442
SF3B1_HUMAN	SF3B1	physical	28514442
HTSF1_HUMAN	HTATSF1	physical	28514442
RU1C_HUMAN	SNRPC	physical	28514442
DDX23_HUMAN	DDX23	physical	28514442
SF3A3_HUMAN	SF3A3	physical	28514442
U520_HUMAN	SNRNP200	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
MEP50_HUMAN	WDR77	physical	28514442
SMD3_HUMAN	SNRPD3	physical	28514442
AQR_HUMAN	AQR	physical	28514442
SPN1_HUMAN	SNUPN	physical	28514442
SF3A1_HUMAN	SF3A1	physical	28514442
COPRS_HUMAN	COPRS	physical	28514442
SF3B2_HUMAN	SF3B2	physical	28514442
PRP6_HUMAN	PRPF6	physical	28514442
PRP8_HUMAN	PRPF8	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
TXN4A_HUMAN	TXNL4A	physical	28514442
TSSC4_HUMAN	TSSC4	physical	28514442
AKA7A_HUMAN	AKAP7	physical	28514442
AKA7G_HUMAN	AKAP7	physical	28514442
CRTAP_HUMAN	CRTAP	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
DGC14_HUMAN	DGCR14	physical	28514442
NOL7_HUMAN	NOL7	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
SF3B4_HUMAN	SF3B4	physical	28514442
LSM6_HUMAN	LSM6	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
LSM8_HUMAN	LSM8	physical	28514442
GPT11_HUMAN	GPATCH11	physical	28514442
PRP31_HUMAN	PRPF31	physical	28514442
GEMI2_HUMAN	GEMIN2	physical	28514442
E41L3_HUMAN	EPB41L3	physical	28514442
LSM4_HUMAN	LSM4	physical	28514442
LSM2_HUMAN	LSM2	physical	28514442
CD2B2_HUMAN	CD2BP2	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
GPTC1_HUMAN	GPATCH1	physical	28514442
BUD31_HUMAN	BUD31	physical	28514442
RBM42_HUMAN	RBM42	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
NH2L1_HUMAN	NHP2L1	physical	28514442
TRA2A_HUMAN	TRA2A	physical	28514442
SF3B5_HUMAN	SF3B5	physical	28514442
U5S1_HUMAN	EFTUD2	physical	28514442
COIL_HUMAN	COIL	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RSMN_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8, AND MASS SPECTROMETRY.	19608861 [Abstract]