PKRI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKRI1_HUMAN
• UniProt AC: Q9H875
• Protein Name: PRKR-interacting protein 1
• Gene Name: PRKRIP1
• Organism: Homo sapiens (Human).
• Sequence Length: 184
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity)..
• Protein Sequence: MASPAASSVRPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEVPSFTMGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASPAASSVR -----CCCCCCCCCC	17.48	25159151
7	Phosphorylation	-MASPAASSVRPPRP -CCCCCCCCCCCCCC	31.32	26074081
8	Phosphorylation	MASPAASSVRPPRPK CCCCCCCCCCCCCCC	19.88	26074081
10	Methylation	SPAASSVRPPRPKKE CCCCCCCCCCCCCCC	37.14	115388773
13	Methylation	ASSVRPPRPKKEPQT CCCCCCCCCCCCCCE	59.35	115488797
15	Methylation	SVRPPRPKKEPQTLV CCCCCCCCCCCCEEE	71.67	115488803
51	Acetylation	KAVPIPEKMSEWAPR CCCCCCHHHHHCCCC	42.23	25953088
70	Phosphorylation	FVRDVMGSSAGAGSG HHHHHHCCCCCCCCC	10.02	29396449
71	Phosphorylation	VRDVMGSSAGAGSGE HHHHHCCCCCCCCCC	25.62	29396449
76	Phosphorylation	GSSAGAGSGEFHVYR CCCCCCCCCCHHHHH	34.32	25159151
82	Phosphorylation	GSGEFHVYRHLRRRE CCCCHHHHHHHHHHH	5.46	21712546
90	Phosphorylation	RHLRRREYQRQDYMD HHHHHHHHHHHHHHH	13.74	-
126	Acetylation	AAEEQTAKRRKKRQK HHHHHHHHHHHHHHH	57.00	25953088
162	Phosphorylation	GQPKEQGSSSSAEAS CCCCCCCCCCCCCCC	27.09	25849741
163	Phosphorylation	QPKEQGSSSSAEASG CCCCCCCCCCCCCCC	34.83	25849741
164	Phosphorylation	PKEQGSSSSAEASGT CCCCCCCCCCCCCCC	34.95	25849741
165	Phosphorylation	KEQGSSSSAEASGTE CCCCCCCCCCCCCCC	31.88	25849741
169	Phosphorylation	SSSSAEASGTEEEEE CCCCCCCCCCCCCCC	37.44	25849741
171	Phosphorylation	SSAEASGTEEEEEVP CCCCCCCCCCCCCCC	37.41	25849741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKRI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKRI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKRI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2AK2_HUMAN	EIF2AK2	physical	12679338
A4_HUMAN	APP	physical	21832049
CEP70_HUMAN	CEP70	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162; SER-163; SER-164;SER-165; SER-169 AND THR-171, AND MASS SPECTROMETRY.
PubMed: 17081983