AKA7A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKA7A_HUMAN
• UniProt AC: O43687
• Protein Name: A-kinase anchor protein 7 isoforms alpha and beta
• Gene Name: AKAP7
• Organism: Homo sapiens (Human).
• Sequence Length: 104
• Subcellular Localization: Isoform Alpha: Lateral cell membrane; Lipid-anchor. Targeted predominantly to the lateral membrane.; Isoform Beta: Apical cell membrane; Lipid-anchor. Targeted predominantly to the apical membrane.
• Protein Description: Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium..
• Protein Sequence: MGQLCCFPFSRDEGKISELESSSSAVLQRYSKDIPSWSSGEKNGGEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNENNRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGQLCCFPF ------CCCCCCEEC	29.21	-
2	Myristoylation	------MGQLCCFPF ------CCCCCCEEC	29.21	9545239
5	S-palmitoylation	---MGQLCCFPFSRD ---CCCCCCEECCCC	1.40	9545239
6	S-palmitoylation	--MGQLCCFPFSRDE --CCCCCCEECCCCC	7.07	9545239
17	Phosphorylation	SRDEGKISELESSSS CCCCCCHHHCHHCCH	39.35	23312004
21	Phosphorylation	GKISELESSSSAVLQ CCHHHCHHCCHHHHH	48.41	26657352
22	Phosphorylation	KISELESSSSAVLQR CHHHCHHCCHHHHHH	20.95	46161483
23	Phosphorylation	ISELESSSSAVLQRY HHHCHHCCHHHHHHH	31.43	23312004
24	Phosphorylation	SELESSSSAVLQRYS HHCHHCCHHHHHHHC	25.09	23532336
31	Phosphorylation	SAVLQRYSKDIPSWS HHHHHHHCCCCCCCC	26.49	23532336
36	Phosphorylation	RYSKDIPSWSSGEKN HHCCCCCCCCCCCCC	39.67	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKA7A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKA7A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKA7A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SP17_HUMAN	SPA17	physical	25416956
ROP1A_HUMAN	ROPN1	physical	25416956
CEP76_HUMAN	CEP76	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events.";
Fraser I.D.C., Tavalin S.J., Lester L.B., Langeberg L.K.,Westphal A.M., Dean R.A., Marrion N.V., Scott J.D.;
EMBO J. 17:2261-2272(1998).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), FUNCTION, SUBCELLULARLOCATION, TISSUE SPECIFICITY, MYRISTOYLATION AT GLY-2, ANDPALMITOYLATION AT CYS-5 AND CYS-6.
PubMed: 9545239

Palmitoylation

"A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events.";
Fraser I.D.C., Tavalin S.J., Lester L.B., Langeberg L.K.,Westphal A.M., Dean R.A., Marrion N.V., Scott J.D.;
EMBO J. 17:2261-2272(1998).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), FUNCTION, SUBCELLULARLOCATION, TISSUE SPECIFICITY, MYRISTOYLATION AT GLY-2, ANDPALMITOYLATION AT CYS-5 AND CYS-6.
PubMed: 9545239