ROP1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ROP1A_HUMAN
• UniProt AC: Q9HAT0
• Protein Name: Ropporin-1A
• Gene Name: ROPN1
• Organism: Homo sapiens (Human).
• Sequence Length: 212
• Subcellular Localization: Cell projection, cilium, flagellum . In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.
• Protein Description: Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation..
• Protein Sequence: MAQTDKPTCIPPELPKMLKEFAKAAIRVQPQDLIQWAADYFEALSRGETPPVRERSERVALCNRAELTPELLKILHSQVAGRLIIRAEELAQMWKVVNLPTDLFNSVMNVGRFTEEIEWLKFLALACSALGVTITKTLKIVCEVLSCDHNGGSPRIPFSTFQFLYTYIAKVDGEISASHVSRMLNYMEQEVIGPDGIITVNDFTQNPRVQLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	ADYFEALSRGETPPV HHHHHHHHCCCCCCC	45.33	30622161
49	Phosphorylation	EALSRGETPPVRERS HHHHCCCCCCCCCHH	35.40	30622161
56	Phosphorylation	TPPVRERSERVALCN CCCCCCHHHHHHHCC	25.63	30622161
77	Phosphorylation	ELLKILHSQVAGRLI HHHHHHHHHHCHHHE	23.93	30622161
101	Phosphorylation	WKVVNLPTDLFNSVM HHHCCCCHHHHHHHH	48.80	25693802
106	Phosphorylation	LPTDLFNSVMNVGRF CCHHHHHHHHCCCCH	18.53	30622161
146	Phosphorylation	KIVCEVLSCDHNGGS HHHHHHHCCCCCCCC	23.75	-
153	Phosphorylation	SCDHNGGSPRIPFST CCCCCCCCCCCCHHH	16.65	-
159	Phosphorylation	GSPRIPFSTFQFLYT CCCCCCHHHHHHHHH	23.98	23898821
178	Phosphorylation	VDGEISASHVSRMLN CCCEEEHHHHHHHHH	20.03	30622161
181	Phosphorylation	EISASHVSRMLNYME EEEHHHHHHHHHHHH	13.42	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ROP1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ROP1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ROP1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ROP1A_HUMAN	ROPN1	physical	25416956
UBE2W_HUMAN	UBE2W	physical	25416956
KIF9_HUMAN	KIF9	physical	25416956
LENG1_HUMAN	LENG1	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
XKR3_HUMAN	XKR3	physical	25416956
CNST_HUMAN	CNST	physical	25416956
RTP5_HUMAN	RTP5	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
ROP1B_HUMAN	ROPN1B	physical	28514442
MBNL1_HUMAN	MBNL1	physical	28514442
KAP3_HUMAN	PRKAR2B	physical	28514442
S27A2_HUMAN	SLC27A2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.