CNST_HUMAN - dbPTM
CNST_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CNST_HUMAN
UniProt AC Q6PJW8
Protein Name Consortin
Gene Name CNST
Organism Homo sapiens (Human).
Sequence Length 725
Subcellular Localization Cell membrane
Single-pass membrane protein . Golgi apparatus, trans-Golgi network membrane
Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle . Located predominantly in the trans-Golgi network. Probably trafficks between the tr
Protein Description Required for targeting of connexins to the plasma membrane..
Protein Sequence MDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSDSAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAVTYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKESQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIEGIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDGSENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSDESCLSLDDLAKRIEIAEVVPTEGLVSILKKRNDTVGDHPAQMQHKPSKRRVRFQEIDDSLDQDEVGGGSCILLVLLCIATVFLSVGGTALYCTFGDMESPVCTDFADNMDFYYTKLLQGVAELKHWIYLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MDDSDTPTYYL
----CCCCCCCCEEE		38.8427642862
8PhosphorylationMDDSDTPTYYLQIEP
CCCCCCCCEEEEECC		27.2227642862
9PhosphorylationDDSDTPTYYLQIEPQ
CCCCCCCEEEEECCC		11.9027642862
113PhosphorylationKKIPGKRSPRSKKGT
CCCCCCCCCCCCCCC		28.3127282143
175PhosphorylationLVLQSLFSLIRGEVE
HHHHHHHHHHHCCHH		28.3428270605
266UbiquitinationEDFERLTKICATHQD
HHHHHHHHHHHHCCC		40.1429967540
278UbiquitinationHQDPLLSKHKIAAVE
CCCCCHHHHHHHHHH		49.2229967540
286AcetylationHKIAAVEKSQERKCS
HHHHHHHHHHHCCCC		51.3325953088
287PhosphorylationKIAAVEKSQERKCST
HHHHHHHHHHCCCCC		24.6226074081
293PhosphorylationKSQERKCSTQLLVSE
HHHHCCCCCEEEECC		23.4023927012
294PhosphorylationSQERKCSTQLLVSED
HHHCCCCCEEEECCC		32.4823927012
299PhosphorylationCSTQLLVSEDPKEGG
CCCEEEECCCCCCCC		35.9323927012
326PhosphorylationGTESSKESQHTVEPL
CCCCCCCCCCCCCCC		30.8828270605
329PhosphorylationSSKESQHTVEPLGSS
CCCCCCCCCCCCCCC		20.9428270605
335PhosphorylationHTVEPLGSSPCCHQM
CCCCCCCCCCCEEEC		38.5025627689
336PhosphorylationTVEPLGSSPCCHQMD
CCCCCCCCCCEEECC		21.8425627689
346PhosphorylationCHQMDVQTDSPSLSV
EEECCCCCCCCCEEE		37.9928270605
348PhosphorylationQMDVQTDSPSLSVTA
ECCCCCCCCCEEEEE		21.5625159151
350PhosphorylationDVQTDSPSLSVTAGK
CCCCCCCCEEEEECH		36.9128270605
352PhosphorylationQTDSPSLSVTAGKDH
CCCCCCEEEEECHHH		23.0428270605
354PhosphorylationDSPSLSVTAGKDHME
CCCCEEEEECHHHHH		26.7328270605
429PhosphorylationKVFLSSKSKTEPLIS
CEEECCCCCCCCCCC		46.9223898821
431PhosphorylationFLSSKSKTEPLISPG
EECCCCCCCCCCCCC		50.3423898821
436PhosphorylationSKTEPLISPGCDRIP
CCCCCCCCCCCCCCC		23.9521815630
452PhosphorylationALISEGKYSQAQRKE
HHHCCCCCCHHHHHH		19.5123403867
453PhosphorylationLISEGKYSQAQRKEL
HHCCCCCCHHHHHHH		23.6423403867
536AcetylationAPEEKGDKDDQLNKE
CCCHHCCCCHHCCHH		72.3918530575
544PhosphorylationDDQLNKETEDYLNSL
CHHCCHHHHHHHHHH		35.4528796482
547PhosphorylationLNKETEDYLNSLLEG
CCHHHHHHHHHHHHH		11.1028796482
616PhosphorylationEIAEVVPTEGLVSIL
EEEEEECCHHHHHHH		30.9524043423
621PhosphorylationVPTEGLVSILKKRND
ECCHHHHHHHHHCCC		27.5224719451
629PhosphorylationILKKRNDTVGDHPAQ
HHHHCCCCCCCCHHH		29.9129052541
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CNST_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CNST_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CNST_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CXB2_HUMANGJB2physical
19864490
CXB6_HUMANGJB6physical
19864490
CXB3_HUMANGJB3physical
19864490
CXB1_HUMANGJB1physical
19864490
CXA1_HUMANGJA1physical
19864490
CXG1_HUMANGJC1physical
19864490
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CNST_HUMAN

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Related Literatures of Post-Translational Modification

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