CXG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXG1_HUMAN
• UniProt AC: P36383
• Protein Name: Gap junction gamma-1 protein
• Gene Name: GJC1
• Organism: Homo sapiens (Human).
• Sequence Length: 396
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
• Protein Description: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell..
• Protein Sequence: MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQNNPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
115	Methylation	DKKAARSKPYAMRWK HHHHHHCCCCHHHHH	36.17	23644510
141	Phosphorylation	NEEDPMMYPEMELES CCCCCCCCCCCHHCC	6.98	26471730
148	Phosphorylation	YPEMELESDKENKEQ CCCCHHCCCCCCHHC	67.61	21406692
150	Ubiquitination	EMELESDKENKEQSQ CCHHCCCCCCHHCCC	72.90	21906983
261	Phosphorylation	GFGTIRDSLNSKRRE CHHHHHHHHHHHCHH	21.43	28674151
265	Ubiquitination	IRDSLNSKRRELEDP HHHHHHHHCHHCCCC	55.17	-
295	Ubiquitination	PGYNIAVKPDQIQYT CCCCEEECCCCCEEE	33.58	21906983
301	Phosphorylation	VKPDQIQYTELSNAK ECCCCCEEEEHHHCC	12.10	25884760
308	Ubiquitination	YTELSNAKIAYKQNK EEEHHHCCEEHHHCC	31.92	-
312	Ubiquitination	SNAKIAYKQNKANTA HHCCEEHHHCCCCCH	38.07	-
315	Ubiquitination	KIAYKQNKANTAQEQ CEEHHHCCCCCHHHH	40.29	-
318	Phosphorylation	YKQNKANTAQEQQYG HHHCCCCCHHHHHHC	34.28	30266825
324	Phosphorylation	NTAQEQQYGSHEENL CCHHHHHHCCCCCCC	21.93	21082442
326	Phosphorylation	AQEQQYGSHEENLPA HHHHHHCCCCCCCCH	23.85	23663014
356	Phosphorylation	LDLAVQAYSHQNNPH HHHHHHHHHCCCCCC	6.92	25884760
357	Phosphorylation	DLAVQAYSHQNNPHG HHHHHHHHCCCCCCC	22.93	25884760
371	Acetylation	GPREKKAKVGSKAGS CCHHHHHCCCCCCCC	56.88	18529861
380	Ubiquitination	GSKAGSNKSTASSKS CCCCCCCCCCCCCCC	51.37	-
391	Ubiquitination	SSKSGDGKTSVWI-- CCCCCCCCCEECC--	42.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXTL2_HUMAN	EXTL2	physical	26186194
UBQL4_HUMAN	UBQLN4	physical	25583071
PSMD2_HUMAN	PSMD2	physical	25583071
EXTL2_HUMAN	EXTL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.