CXB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXB1_HUMAN
• UniProt AC: P08034
• Protein Name: Gap junction beta-1 protein
• Gene Name: GJB1
• Organism: Homo sapiens (Human).
• Sequence Length: 283
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
• Protein Description: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell..
• Protein Sequence: MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCNSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEVKRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQRRSNPPSRKGSGFGHRLSPEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEKSDRCSAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MNWTGLYTLLS ----CCCHHHHHHHH	16.59	24043423
7	Phosphorylation	-MNWTGLYTLLSGVN -CCCHHHHHHHHCCC	9.18	24043423
8	Phosphorylation	MNWTGLYTLLSGVNR CCCHHHHHHHHCCCC	26.68	24043423
176	Phosphorylation	DVYPCPNTVDCFVSR EEEECCCCEEEEECC	11.67	-
182	Phosphorylation	NTVDCFVSRPTEKTV CCEEEEECCCCCHHH	16.58	22817900
185	Phosphorylation	DCFVSRPTEKTVFTV EEEECCCCCHHHHHH	49.34	22817900
225	Phosphorylation	ARRAQRRSNPPSRKG HHHHHHHCCCCCCCC	56.74	27470641
229	Phosphorylation	QRRSNPPSRKGSGFG HHHCCCCCCCCCCCC	48.13	27470641
233	Phosphorylation	NPPSRKGSGFGHRLS CCCCCCCCCCCCCCC	33.70	26657352
240	Phosphorylation	SGFGHRLSPEYKQNE CCCCCCCCHHHHHHH	18.68	27470641
243	Phosphorylation	GHRLSPEYKQNEINK CCCCCHHHHHHHHHH	22.66	27470641
250	Ubiquitination	YKQNEINKLLSEQDG HHHHHHHHHHHCCCC	57.37	-
253	Phosphorylation	NEINKLLSEQDGSLK HHHHHHHHCCCCCHH	43.58	23312004
258	Phosphorylation	LLSEQDGSLKDILRR HHHCCCCCHHHHHHH	40.30	29255136
260	Ubiquitination	SEQDGSLKDILRRSP HCCCCCHHHHHHHCC	44.41	-
266	Phosphorylation	LKDILRRSPGTGAGL HHHHHHHCCCCCCCH	22.65	29255136
269	Phosphorylation	ILRRSPGTGAGLAEK HHHHCCCCCCCHHHH	27.52	27470641
276	Ubiquitination	TGAGLAEKSDRCSAC CCCCHHHHCCCCCCC	52.64	-
277	Phosphorylation	GAGLAEKSDRCSAC- CCCHHHHCCCCCCC-	23.07	11723288
281	Phosphorylation	AEKSDRCSAC----- HHHCCCCCCC-----	33.30	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
229	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
229	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
233	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
233	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
233	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
233	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
243	Y	Phosphorylation	Kinase	EPHA1	P21709	PSP
243	Y	Phosphorylation	Kinase	EPHB1	P54762	PSP
243	Y	Phosphorylation	Kinase	RON	Q04912	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLAK_HUMAN	JUP	physical	7971964
CAV1_HUMAN	CAV1	physical	11980479
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• H00264: Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atroph
• OMIM Disease
• 302800: Charcot-Marie-Tooth disease, X-linked dominant, 1 (CMTX1)
• 145900: Dejerine-Sottas syndrome (DSS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.