| UniProt ID | CXB3_HUMAN | |
|---|---|---|
| UniProt AC | O75712 | |
| Protein Name | Gap junction beta-3 protein | |
| Gene Name | GJB3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 270 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. Cell junction, gap junction. |
|
| Protein Description | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.. | |
| Protein Sequence | MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCTNVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCAKLYDNAGKKHGGLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGASAVCIVLTICELCYLICHRVLRGLHKDKPRGGCSPSSSASRASTCRCHHKLVEAGEVDPDPGNNKLQASAPNLTPI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 72 | Phosphorylation | YDNYFPISNIRLWAL CCCCCCHHHHHHHHH | 26.83 | 24719451 | |
| 228 | Phosphorylation | DKPRGGCSPSSSASR CCCCCCCCCCCHHHH | 30.96 | 23090842 | |
| 230 | Phosphorylation | PRGGCSPSSSASRAS CCCCCCCCCHHHHHC | 22.19 | 23090842 | |
| 231 | Phosphorylation | RGGCSPSSSASRAST CCCCCCCCHHHHHCC | 33.05 | 23090842 | |
| 232 | Phosphorylation | GGCSPSSSASRASTC CCCCCCCHHHHHCCC | 34.30 | 23090842 | |
| 234 | Phosphorylation | CSPSSSASRASTCRC CCCCCHHHHHCCCCC | 30.26 | 23090842 | |
| 237 | Phosphorylation | SSSASRASTCRCHHK CCHHHHHCCCCCCCC | 27.25 | 23090842 | |
| 238 | Phosphorylation | SSASRASTCRCHHKL CHHHHHCCCCCCCCH | 11.72 | 23090842 | |
| 259 | Ubiquitination | DPDPGNNKLQASAPN CCCCCCCCCCCCCCC | 46.07 | 2190698 | |
| 263 | Phosphorylation | GNNKLQASAPNLTPI CCCCCCCCCCCCCCC | 31.16 | 22617229 | |
| 268 | Phosphorylation | QASAPNLTPI----- CCCCCCCCCC----- | 26.10 | 23090842 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CXB3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CXB3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CXB3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CXB2_HUMAN | GJB2 | genetic | 19050930 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00604 | Deafness, autosomal dominant | |||||
| H00605 | Deafness, autosomal recessive | |||||
| H00710 | Erythrokeratodermia variabilis | |||||
| OMIM Disease | ||||||
| 133200 | Erythrokeratodermia variabilis (EKV) | |||||
| 612644 | Deafness, autosomal dominant, 2B (DFNA2B) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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