CE57L_HUMAN - dbPTM
CE57L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CE57L_HUMAN
UniProt AC Q8IYX8
Protein Name Centrosomal protein CEP57L1
Gene Name CEP57L1
Organism Homo sapiens (Human).
Sequence Length 460
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Description Centrosomal protein which may be required for microtubule attachment to centrosomes..
Protein Sequence MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MDSELMHSIV
-----CCHHHHHHHH		31.1925002506
8PhosphorylationMDSELMHSIVGSYHK
CCHHHHHHHHCCCCC		12.6625002506
12PhosphorylationLMHSIVGSYHKPPER
HHHHHHCCCCCCCHH		17.1125002506
13PhosphorylationMHSIVGSYHKPPERV
HHHHHCCCCCCCHHE		14.1325002506
15UbiquitinationSIVGSYHKPPERVFV
HHHCCCCCCCHHEEC		54.77-
42PhosphorylationHPANLEVTSPKILHS
CCCCCEECCCCCCCC		29.9025159151
43PhosphorylationPANLEVTSPKILHSP
CCCCEECCCCCCCCC		29.3928165663
45UbiquitinationNLEVTSPKILHSPNS
CCEECCCCCCCCCCH		58.63-
49PhosphorylationTSPKILHSPNSQALI
CCCCCCCCCCHHHHH		23.4922199227
52PhosphorylationKILHSPNSQALILAL
CCCCCCCHHHHHHHH		21.8822199227
60UbiquitinationQALILALKTLQEKIH
HHHHHHHHHHHHHHH		41.40-
65UbiquitinationALKTLQEKIHRLELE
HHHHHHHHHHHHHHH		30.74-
91AcetylationSREAAQYKKALENET
HHHHHHHHHHHHCHH		21.3528734561
92UbiquitinationREAAQYKKALENETN
HHHHHHHHHHHCHHH		53.95-
110AcetylationLAHQELIKQKKDISI
HHHHHHHHHHCCHHH		69.5528734569
110UbiquitinationLAHQELIKQKKDISI
HHHHHHHHHHCCHHH		69.55-
147UbiquitinationVLNVEREKNMILEQQ
HHCHHHHHHHHHHHH		59.02-
167UbiquitinationEKEQDQMKLYAKLEK
HHHHHHHHHHHHHHH		32.48-
169PhosphorylationEQDQMKLYAKLEKLD
HHHHHHHHHHHHHHH		9.0029496907
171UbiquitinationDQMKLYAKLEKLDVL
HHHHHHHHHHHHHHH		43.55-
174UbiquitinationKLYAKLEKLDVLEKE
HHHHHHHHHHHHHHH		61.50-
180UbiquitinationEKLDVLEKECFRLTT
HHHHHHHHHHHHHHC		56.47-
202UbiquitinationKIKHLEEKLKEEEHQ
HHHHHHHHHHHHHHH		56.32-
202MethylationKIKHLEEKLKEEEHQ
HHHHHHHHHHHHHHH		56.32-
228UbiquitinationQTGLEISKIIMSSVS
HHHHHHHHHHHHHHH		41.74-
233PhosphorylationISKIIMSSVSNLKHS
HHHHHHHHHHHCCCC		16.5120166139
235PhosphorylationKIIMSSVSNLKHSKE
HHHHHHHHHCCCCHH		38.0920166139
238UbiquitinationMSSVSNLKHSKEKKK
HHHHHHCCCCHHHCC		50.51-
248AcetylationKEKKKSSKKTKCIKR
HHHCCCCCCCCHHHC		72.117460687
249AcetylationEKKKSSKKTKCIKRR
HHCCCCCCCCHHHCC		55.987460695
274UbiquitinationALPFVAEKMRQHRDP
CHHHHHHHHHHCCCC		29.64-
286UbiquitinationRDPHILQKPFNVTET
CCCCHHCCCCCCCCC		48.4021890473
338PhosphorylationQDELDQMSMEHQELL
HHHHHHHHHHHHHHH		18.52-
351PhosphorylationLLKQMKETESHSVCD
HHHHHHHHCCCCCCC		36.9527732954
353PhosphorylationKQMKETESHSVCDDI
HHHHHHCCCCCCCHH		28.6027732954
355PhosphorylationMKETESHSVCDDIEC
HHHHCCCCCCCHHHH		33.4527732954
374UbiquitinationLLKKMEIKGEQISKL
HHHHCCCCHHHHHHH		42.99-
380UbiquitinationIKGEQISKLKKHQDS
CCHHHHHHHHHHHHH		66.99-
382UbiquitinationGEQISKLKKHQDSVC
HHHHHHHHHHHHHHH		52.53-
383UbiquitinationEQISKLKKHQDSVCK
HHHHHHHHHHHHHHH		57.86-
390UbiquitinationKHQDSVCKLQQKVQN
HHHHHHHHHHHHHHH		47.37-
394UbiquitinationSVCKLQQKVQNSKMS
HHHHHHHHHHHCCHH		32.59-
399UbiquitinationQQKVQNSKMSEASGI
HHHHHHCCHHHHHCC		54.73-
411PhosphorylationSGIQQEDSYPKGSKN
HCCCCCCCCCCCCCC		42.4524719451
422PhosphorylationGSKNIKNSPRKCLTD
CCCCCCCCCCCCCCC		22.5324719451
425UbiquitinationNIKNSPRKCLTDTNL
CCCCCCCCCCCCCCC		36.66-
428PhosphorylationNSPRKCLTDTNLFQK
CCCCCCCCCCCCCCC		50.69-
435UbiquitinationTDTNLFQKNSSFHPI
CCCCCCCCCCCCCCE		52.00-
438PhosphorylationNLFQKNSSFHPIRVH
CCCCCCCCCCCEEEE		36.65-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CE57L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CE57L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CE57L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CE57L_HUMANCEP57L1physical
25416956
MESH1_HUMANHDDC3physical
25416956
BRCA1_HUMANBRCA1physical
25184681
VPS28_HUMANVPS28physical
21516116
CEP55_HUMANCEP55physical
21516116
ZGPAT_HUMANZGPATphysical
21516116
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CE57L_HUMAN

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Related Literatures of Post-Translational Modification

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