MESH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MESH1_HUMAN
• UniProt AC: Q8N4P3
• Protein Name: Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
• Gene Name: HDDC3
• Organism: Homo sapiens (Human).
• Sequence Length: 179
• Protein Description: ppGpp hydrolyzing enzyme involved in starvation response..
• Protein Sequence: MGSEAAQLLEAADFAARKHRQQRRKDPEGTPYINHPIGVARILTHEAGITDIVVLQAALLHDTVEDTDTTLDEVELHFGAQVRRLVEEVTDDKTLPKLERKRLQVEQAPHSSPGAKLVKLADKLYNLRDLNRCTPEGWSEHRVQEYFEWAAQVVKGLQGTNRQLEEALKHLFKQRGLTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGSEAAQLL ------CCHHHHHHH	33.91	19413330
3	Phosphorylation	-----MGSEAAQLLE -----CCHHHHHHHH	23.82	-
25	Ubiquitination	KHRQQRRKDPEGTPY HHHHHHHCCCCCCCC	78.72	24816145
25	Malonylation	KHRQQRRKDPEGTPY HHHHHHHCCCCCCCC	78.72	26320211
25	Acetylation	KHRQQRRKDPEGTPY HHHHHHHCCCCCCCC	78.72	19608861
90	Phosphorylation	RRLVEEVTDDKTLPK HHHHHHHCCCCCCCH	41.58	19664994
93	Acetylation	VEEVTDDKTLPKLER HHHHCCCCCCCHHHH	55.56	23954790
93	Ubiquitination	VEEVTDDKTLPKLER HHHHCCCCCCCHHHH	55.56	24816145
93	2-Hydroxyisobutyrylation	VEEVTDDKTLPKLER HHHHCCCCCCCHHHH	55.56	-
93	Malonylation	VEEVTDDKTLPKLER HHHHCCCCCCCHHHH	55.56	26320211
97	Acetylation	TDDKTLPKLERKRLQ CCCCCCCHHHHHCCH	67.12	19608861
97	Malonylation	TDDKTLPKLERKRLQ CCCCCCCHHHHHCCH	67.12	26320211
119	Ubiquitination	SPGAKLVKLADKLYN CCCHHHHHHHHHHHC	48.68	22817900
123	Acetylation	KLVKLADKLYNLRDL HHHHHHHHHHCCHHH	47.46	19608861
123	Ubiquitination	KLVKLADKLYNLRDL HHHHHHHHHHCCHHH	47.46	22817900
123	2-Hydroxyisobutyrylation	KLVKLADKLYNLRDL HHHHHHHHHHCCHHH	47.46	-
123 (in isoform 1)	Ubiquitination	-	47.46	21890473
123 (in isoform 2)	Ubiquitination	-	47.46	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MESH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MESH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MESH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
VATC1_HUMAN	ATP6V1C1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-25; LYS-97 AND LYS-123, ANDMASS SPECTROMETRY.
PubMed: 19608861