VATC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATC1_HUMAN
• UniProt AC: P21283
• Protein Name: V-type proton ATPase subunit C 1
• Gene Name: ATP6V1C1
• Organism: Homo sapiens (Human).
• Sequence Length: 382
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTLKKLREVLHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTEFWLISA ------CCEEEEEEC	39.63	27486199
2	Acetylation	------MTEFWLISA ------CCEEEEEEC	39.63	22223895
21	Ubiquitination	TCQQTWEKLHAATSK HHHHHHHHHHHHCCC	36.81	-
21	Acetylation	TCQQTWEKLHAATSK HHHHHHHHHHHHCCC	36.81	25953088
28	Ubiquitination	KLHAATSKNNNLAVT HHHHHCCCCCCEEEE	60.38	21890473
71	Ubiquitination	FVEGVVKKVAQYMAD HHHHHHHHHHHHHHH	31.06	-
75	Phosphorylation	VVKKVAQYMADVLED HHHHHHHHHHHHHHH	5.64	21815630
84	2-Hydroxyisobutyrylation	ADVLEDSKDKVQENL HHHHHHCHHHHHHHH	74.10	-
111	2-Hydroxyisobutyrylation	RFQWDMAKYPIKQSL HHCHHHHCCCHHHHH	44.94	-
115	Malonylation	DMAKYPIKQSLKNIS HHHCCCHHHHHCCHH	29.36	32601280
127	Ubiquitination	NISEIIAKGVTQIDN CHHHHHHHCCHHCCH	43.43	-
137	2-Hydroxyisobutyrylation	TQIDNDLKSRASAYN HHCCHHHHHHHHHHH	40.53	-
137	Ubiquitination	TQIDNDLKSRASAYN HHCCHHHHHHHHHHH	40.53	21890473
137	Acetylation	TQIDNDLKSRASAYN HHCCHHHHHHHHHHH	40.53	27452117
143	Phosphorylation	LKSRASAYNNLKGNL HHHHHHHHHHHHHHH	11.33	29496907
147	Ubiquitination	ASAYNNLKGNLQNLE HHHHHHHHHHHHHHH	48.12	21890473
156	Ubiquitination	NLQNLERKNAGSLLT HHHHHHHHCHHHHHH	41.60	-
160	Phosphorylation	LERKNAGSLLTRSLA HHHHCHHHHHHHHHH	20.14	24719451
165	Phosphorylation	AGSLLTRSLAEIVKK HHHHHHHHHHHHHCC	27.05	28857561
171	Ubiquitination	RSLAEIVKKDDFVLD HHHHHHHCCCCCEEC	57.03	-
171	2-Hydroxyisobutyrylation	RSLAEIVKKDDFVLD HHHHHHHCCCCCEEC	57.03	-
225	S-nitrosylation	EDQDSYLCNVTLFRK CCCCCHHHHHHHHHH	2.67	19483679
225	S-nitrosocysteine	EDQDSYLCNVTLFRK CCCCCHHHHHHHHHH	2.67	-
225	Glutathionylation	EDQDSYLCNVTLFRK CCCCCHHHHHHHHHH	2.67	22555962
232	Ubiquitination	CNVTLFRKAVDDFRH HHHHHHHHHHHHHHH	45.48	-
245	Ubiquitination	RHKARENKFIVRDFQ HHHHHCCCCEEECCC	31.54	-
269	Phosphorylation	KEEMNRLSTDKKKQF HHHHHHHCCHHHHHH	31.18	25627689
274	2-Hydroxyisobutyrylation	RLSTDKKKQFGPLVR HHCCHHHHHHHHHHH	57.51	-
344	Phosphorylation	ELYKHLDSSAAAIID HHHHHCCCCHHHHHC	28.39	18077418
362	Phosphorylation	DIPGLNLSQQEYYPY CCCCCCCCCCCCCCE	28.83	25159151
367	Phosphorylation	NLSQQEYYPYVYYKI CCCCCCCCCEEEEEE	6.32	22817900
376	S-nitrosocysteine	YVYYKIDCNLLEFK- EEEEEEECCEEECC-	4.38	-
376	S-nitrosylation	YVYYKIDCNLLEFK- EEEEEEECCEEECC-	4.38	19483679

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATE1_HUMAN	ATP6V1E1	physical	22939629
AN32E_HUMAN	ANP32E	physical	22863883
ARFP1_HUMAN	ARFIP1	physical	22863883
ATG7_HUMAN	ATG7	physical	22863883
SRC8_HUMAN	CTTN	physical	22863883
DNM1L_HUMAN	DNM1L	physical	22863883
ERF3A_HUMAN	GSPT1	physical	22863883
ERF3B_HUMAN	GSPT2	physical	22863883
TF2AA_HUMAN	GTF2A1	physical	22863883
IDE_HUMAN	IDE	physical	22863883
NS1BP_HUMAN	IVNS1ABP	physical	22863883
LC7L2_HUMAN	LUC7L2	physical	22863883
NASP_HUMAN	NASP	physical	22863883
PAWR_HUMAN	PAWR	physical	22863883
PSMG3_HUMAN	PSMG3	physical	22863883
RADI_HUMAN	RDX	physical	22863883
SYSC_HUMAN	SARS	physical	22863883
GLYC_HUMAN	SHMT1	physical	22863883
GLYM_HUMAN	SHMT2	physical	22863883
SNX1_HUMAN	SNX1	physical	22863883
SNX2_HUMAN	SNX2	physical	22863883
SNX6_HUMAN	SNX6	physical	22863883
STAT1_HUMAN	STAT1	physical	22863883
TSN_HUMAN	TSN	physical	22863883
VPS29_HUMAN	VPS29	physical	22863883
VPS35_HUMAN	VPS35	physical	22863883
VATC1_HUMAN	ATP6V1C1	physical	25416956
ATLA3_HUMAN	ATL3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.