VATE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATE1_HUMAN
• UniProt AC: P36543
• Protein Name: V-type proton ATPase subunit E 1
• Gene Name: ATP6V1E1
• Organism: Homo sapiens (Human).
• Sequence Length: 226
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANRKFLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALSDADVQ ------CCCCHHHHH	18.77	25944712
4	Phosphorylation	----MALSDADVQKQ ----CCCCHHHHHHH	22.63	24719451
10	Acetylation	LSDADVQKQIKHMMA CCHHHHHHHHHHHHH	54.56	25953088
10	Ubiquitination	LSDADVQKQIKHMMA CCHHHHHHHHHHHHH	54.56	-
42	Ubiquitination	EEEFNIEKGRLVQTQ HHHHCCCCCCCHHHH	45.60	21906983
52	Malonylation	LVQTQRLKIMEYYEK CHHHHHHHHHHHHHH	42.04	32601280
52	Acetylation	LVQTQRLKIMEYYEK CHHHHHHHHHHHHHH	42.04	22424773
56	Phosphorylation	QRLKIMEYYEKKEKQ HHHHHHHHHHHHHHH	10.27	21082442
57	Phosphorylation	RLKIMEYYEKKEKQI HHHHHHHHHHHHHHH	14.15	25884760
59	Malonylation	KIMEYYEKKEKQIEQ HHHHHHHHHHHHHHH	50.54	26320211
59	Acetylation	KIMEYYEKKEKQIEQ HHHHHHHHHHHHHHH	50.54	25953088
59	Ubiquitination	KIMEYYEKKEKQIEQ HHHHHHHHHHHHHHH	50.54	-
69	Ubiquitination	KQIEQQKKIQMSNLM HHHHHHHHHCHHHHH	33.56	-
72	Sulfoxidation	EQQKKIQMSNLMNQA HHHHHHCHHHHHHHH	3.06	21406390
76	Sulfoxidation	KIQMSNLMNQARLKV HHCHHHHHHHHHHHH	4.01	30846556
99	Ubiquitination	TDLLNEAKQRLSKVV HHHHHHHHHHHHHHH	29.76	-
103	Phosphorylation	NEAKQRLSKVVKDTT HHHHHHHHHHHCCCC	26.12	-
138	Ubiquitination	RMIVRCRKQDFPLVK CEEEEECCCCCHHHH	58.82	-
138	Malonylation	RMIVRCRKQDFPLVK CEEEEECCCCCHHHH	58.82	26320211
145	Ubiquitination	KQDFPLVKAAVQKAI CCCCHHHHHHHHHHC	38.01	-
145	Malonylation	KQDFPLVKAAVQKAI CCCCHHHHHHHHHHC	38.01	26320211
156	Ubiquitination	QKAIPMYKIATKNDV HHHCCHHHCCCCCCC	21.44	-
156	Acetylation	QKAIPMYKIATKNDV HHHCCHHHCCCCCCC	21.44	25953088
191	Ubiquitination	YNGDRKIKVSNTLES ECCCCEEEECCCHHH	42.52	-
191	Acetylation	YNGDRKIKVSNTLES ECCCCEEEECCCHHH	42.52	23749302
193	O-linked_Glycosylation	GDRKIKVSNTLESRL CCCEEEECCCHHHHH	21.06	30379171
207	Sulfoxidation	LDLIAQQMMPEVRGA HHHHHHHHCHHHHHH	3.00	21406390
208	Sulfoxidation	DLIAQQMMPEVRGAL HHHHHHHCHHHHHHH	1.91	30846556

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XRCC6_HUMAN	XRCC6	physical	16169070
VATG1_HUMAN	ATP6V1G1	physical	16169070
ALDOA_HUMAN	ALDOA	physical	11399750
ALDOB_HUMAN	ALDOB	physical	11399750
ALDOC_HUMAN	ALDOC	physical	11399750
A4_HUMAN	APP	physical	21832049
VATG1_HUMAN	ATP6V1G1	physical	22939629
VATH_HUMAN	ATP6V1H	physical	22939629
VPP1_HUMAN	ATP6V0A1	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
VPP3_HUMAN	TCIRG1	physical	22939629
YBOX1_HUMAN	YBX1	physical	22939629
XPP1_HUMAN	XPNPEP1	physical	22939629
ZFR_HUMAN	ZFR	physical	22939629
ZN827_HUMAN	ZNF827	physical	22939629
ZNT5_HUMAN	SLC30A5	physical	22939629
YES_HUMAN	YES1	physical	22939629
SAMH1_HUMAN	SAMHD1	physical	22863883
AT1B1_HUMAN	ATP1B1	physical	26344197
VATA_HUMAN	ATP6V1A	physical	26344197
VATB2_HUMAN	ATP6V1B2	physical	26344197
VATD_HUMAN	ATP6V1D	physical	26344197
VATF_HUMAN	ATP6V1F	physical	26344197
VATH_HUMAN	ATP6V1H	physical	26344197
COX41_HUMAN	COX4I1	physical	26344197
NDUS8_HUMAN	NDUFS8	physical	26344197
TMOD2_HUMAN	TMOD2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-56, AND MASSSPECTROMETRY.
PubMed: 18083107