VATB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATB2_HUMAN
• UniProt AC: P21281
• Protein Name: V-type proton ATPase subunit B, brain isoform
• Gene Name: ATP6V1B2
• Organism: Homo sapiens (Human).
• Sequence Length: 511
• Subcellular Localization: Endomembrane system; Peripheral membrane protein. Melanosome. Endomembrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
• Protein Description: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MALRAMRGIVN ----CHHHHHHCHHC	19.46	-
7	Methylation	-MALRAMRGIVNGAA -CHHHHHHCHHCCCC	30.60	-
39	Phosphorylation	ALAVSRNYLSQPRLT HHHHCCCCCCCCCCE	13.45	28152594
41	Phosphorylation	AVSRNYLSQPRLTYK HHCCCCCCCCCCEEE	27.98	24719451
44	Methylation	RNYLSQPRLTYKTVS CCCCCCCCCEEEEEC	31.83	-
48	Acetylation	SQPRLTYKTVSGVNG CCCCCEEEEECCCCC	36.90	25953088
48	Malonylation	SQPRLTYKTVSGVNG CCCCCEEEEECCCCC	36.90	26320211
48	Ubiquitination	SQPRLTYKTVSGVNG CCCCCEEEEECCCCC	36.90	-
49	Phosphorylation	QPRLTYKTVSGVNGP CCCCEEEEECCCCCC	14.97	-
51	Phosphorylation	RLTYKTVSGVNGPLV CCEEEEECCCCCCEE	42.11	-
64	2-Hydroxyisobutyrylation	LVILDHVKFPRYAEI EEEEECCCCCCCEEE	46.35	-
64	Ubiquitination	LVILDHVKFPRYAEI EEEEECCCCCCCEEE	46.35	21890473
64	Ubiquitination	LVILDHVKFPRYAEI EEEEECCCCCCCEEE	46.35	21890473
67	Methylation	LDHVKFPRYAEIVHL EECCCCCCCEEEEEE	46.56	-
68	Phosphorylation	DHVKFPRYAEIVHLT ECCCCCCCEEEEEEE	14.61	28152594
81	2-Hydroxyisobutyrylation	LTLPDGTKRSGQVLE EECCCCCCCCCCEEE	50.53	-
83	Phosphorylation	LPDGTKRSGQVLEVS CCCCCCCCCCEEEEE	34.82	21712546
90	Phosphorylation	SGQVLEVSGSKAVVQ CCCEEEEECCEEEEE	28.15	25693802
92	Phosphorylation	QVLEVSGSKAVVQVF CEEEEECCEEEEEEE	15.22	25693802
103	Phosphorylation	VQVFEGTSGIDAKKT EEEEECCCCCCCCCC	44.61	24719451
108	Malonylation	GTSGIDAKKTSCEFT CCCCCCCCCCEEEEC	53.49	26320211
108	Ubiquitination	GTSGIDAKKTSCEFT CCCCCCCCCCEEEEC	53.49	-
108	2-Hydroxyisobutyrylation	GTSGIDAKKTSCEFT CCCCCCCCCCEEEEC	53.49	-
108	Acetylation	GTSGIDAKKTSCEFT CCCCCCCCCCEEEEC	53.49	25953088
109	Malonylation	TSGIDAKKTSCEFTG CCCCCCCCCEEEECC	47.60	26320211
109	2-Hydroxyisobutyrylation	TSGIDAKKTSCEFTG CCCCCCCCCEEEECC	47.60	-
109	Ubiquitination	TSGIDAKKTSCEFTG CCCCCCCCCEEEECC	47.60	-
112	S-nitrosylation	IDAKKTSCEFTGDIL CCCCCCEEEECCCCC	6.37	2212679
124	Phosphorylation	DILRTPVSEDMLGRV CCCCCCCCHHHCHHH	29.14	-
127	Sulfoxidation	RTPVSEDMLGRVFNG CCCCCHHHCHHHCCC	3.62	30846556
137	Ubiquitination	RVFNGSGKPIDRGPV HHCCCCCCCCCCCCE	40.26	-
154	Sulfoxidation	AEDFLDIMGQPINPQ EHHHHHHCCCCCCCC	3.99	21406390
162	Glutathionylation	GQPINPQCRIYPEEM CCCCCCCCCCCHHHH	2.77	22555962
169	Sulfoxidation	CRIYPEEMIQTGISA CCCCHHHHHHHCHHH	2.34	30846556
180	Sulfoxidation	GISAIDGMNSIARGQ CHHHHHCCCHHHCCC	2.93	30846556
182	Phosphorylation	SAIDGMNSIARGQKI HHHHCCCHHHCCCCC	14.56	18452278
185	Methylation	DGMNSIARGQKIPIF HCCCHHHCCCCCCEE	46.54	-
188	Ubiquitination	NSIARGQKIPIFSAA CHHHCCCCCCEEECC	53.96	-
222	Phosphorylation	KSKDVVDYSEENFAI CCCCCCCCCHHHHHH	13.33	-
289	Glutathionylation	AEFLAYQCEKHVLVI HHHHHHHHHCCEEEE	4.98	22555962
326	Phosphorylation	GRRGFPGYMYTDLAT CCCCCCCCHHHHHHH	6.28	21406692
327	Sulfoxidation	RRGFPGYMYTDLATI CCCCCCCHHHHHHHH	3.44	30846556
328	Phosphorylation	RGFPGYMYTDLATIY CCCCCCHHHHHHHHH	6.66	21406692
329	Phosphorylation	GFPGYMYTDLATIYE CCCCCHHHHHHHHHH	14.17	21406692
333	Phosphorylation	YMYTDLATIYERAGR CHHHHHHHHHHHHCC	31.24	21406692
335	Phosphorylation	YTDLATIYERAGRVE HHHHHHHHHHHCCCC	8.60	21406692
389	Phosphorylation	QLHNRQIYPPINVLP CCCCCCCCCCHHHHH	8.46	20068231
397	Phosphorylation	PPINVLPSLSRLMKS CCHHHHHHHHHHHHH	34.51	20068231
399	Phosphorylation	INVLPSLSRLMKSAI HHHHHHHHHHHHHHH	27.92	20068231
403	Ubiquitination	PSLSRLMKSAIGEGM HHHHHHHHHHHCCCC	41.13	-
404	Phosphorylation	SLSRLMKSAIGEGMT HHHHHHHHHHCCCCC	15.91	21082442
410	Sulfoxidation	KSAIGEGMTRKDHAD HHHHCCCCCCCCHHH	2.59	30846556
457	Ubiquitination	LYLEFLQKFERNFIA HHHHHHHHHHHHCCC	51.87	-
460	Methylation	EFLQKFERNFIAQGP HHHHHHHHHCCCCCC	46.63	-
498	Phosphorylation	MLKRIPQSTLSEFYP HHHCCCHHHHHHHCC	26.43	28857561
499	Phosphorylation	LKRIPQSTLSEFYPR HHCCCHHHHHHHCCC	29.11	24076635
501	Phosphorylation	RIPQSTLSEFYPRDS CCCHHHHHHHCCCCC	26.25	28857561
506	Methylation	TLSEFYPRDSAKH-- HHHHHCCCCCCCC--	38.85	-
508	Phosphorylation	SEFYPRDSAKH---- HHHCCCCCCCC----	40.26	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATE1_HUMAN	ATP6V1E1	physical	22939629
VATD_HUMAN	ATP6V1D	physical	22939629
VATH_HUMAN	ATP6V1H	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
WDR5_HUMAN	WDR5	physical	22939629
YIF1B_HUMAN	YIF1B	physical	22939629
ANCHR_HUMAN	ZFYVE19	physical	22939629
VIGLN_HUMAN	HDLBP	physical	22939629
ZYX_HUMAN	ZYX	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
ZBED1_HUMAN	ZBED1	physical	22939629
CUL2_HUMAN	CUL2	physical	22863883
CSDE1_HUMAN	CSDE1	physical	22863883
GANAB_HUMAN	GANAB	physical	22863883
GMPPB_HUMAN	GMPPB	physical	22863883
HYOU1_HUMAN	HYOU1	physical	22863883
PLAK_HUMAN	JUP	physical	22863883
MSH6_HUMAN	MSH6	physical	22863883
SPT5H_HUMAN	SUPT5H	physical	22863883
SWP70_HUMAN	SWAP70	physical	22863883
XRCC6_HUMAN	XRCC6	physical	22863883
ITF2_HUMAN	TCF4	physical	25416956
ABCF3_HUMAN	ABCF3	physical	26344197
ATPG_HUMAN	ATP5C1	physical	26344197
VA0D1_HUMAN	ATP6V0D1	physical	26344197
VATA_HUMAN	ATP6V1A	physical	26344197
VATF_HUMAN	ATP6V1F	physical	26344197
VATH_HUMAN	ATP6V1H	physical	26344197
XPO2_HUMAN	CSE1L	physical	26344197
MCA3_HUMAN	EEF1E1	physical	26344197
GCC1_HUMAN	GCC1	physical	26344197
SYIC_HUMAN	IARS	physical	26344197
CNOT9_HUMAN	RQCD1	physical	26344197
RUVB1_HUMAN	RUVBL1	physical	26344197
TMOD2_HUMAN	TMOD2	physical	26344197
TBA1C_HUMAN	TUBA1C	physical	26344197
WDR61_HUMAN	WDR61	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB05260: Gallium nitrate