GANAB_HUMAN - dbPTM
GANAB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GANAB_HUMAN
UniProt AC Q14697
Protein Name Neutral alpha-glucosidase AB
Gene Name GANAB
Organism Homo sapiens (Human).
Sequence Length 944
Subcellular Localization Endoplasmic reticulum . Golgi apparatus . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Description Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. [PubMed: 10929008 Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia]
Protein Sequence MAAVAAVAARRRRSWASLVLAFLGVCLGITLAVDRSNFKTCEESSFCKRQRSIRPGLSPYRALLDSLQLGPDSLTVHLIHEVTKVLLVLELQGLQKNMTRFRIDELEPRRPRYRVPDVLVADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLEFEHQRAPRVSQGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNPMALYGSVPVLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTDVRWMSETGIIDVFLLLGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLASKRRKLVAIVDPHIKVDSGYRVHEELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEGSAPNLFVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAEWDHLKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWYTLLYQAHREGIPVMRPLWVQYPQDVTTFNIDDQYLLGDALLVHPVSDSGAHGVQVYLPGQGEVWYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSECMKDDPITLFVALSPQGTAQGELFLDDGHTFNYQTRQEFLLRRFSFSGNTLVSSSADPEGHFETPIWIERVVIIGAGKPAAVVLQTKGSPESRLSFQHDPETSVLVLRKPGINVASDWSIHLR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36PhosphorylationITLAVDRSNFKTCEE
HHHHHCCCCCCCHHH		42.00-
39UbiquitinationAVDRSNFKTCEESSF
HHCCCCCCCHHHCHH		57.42-
39AcetylationAVDRSNFKTCEESSF
HHCCCCCCCHHHCHH		57.4225953088
40PhosphorylationVDRSNFKTCEESSFC
HCCCCCCCHHHCHHH		22.4722617229
47S-nitrosylationTCEESSFCKRQRSIR
CHHHCHHHCCCCCCC		3.712212679
48MethylationCEESSFCKRQRSIRP
HHHCHHHCCCCCCCC		49.94-
48AcetylationCEESSFCKRQRSIRP
HHHCHHHCCCCCCCC		49.9425953088
48UbiquitinationCEESSFCKRQRSIRP
HHHCHHHCCCCCCCC		49.94-
52PhosphorylationSFCKRQRSIRPGLSP
HHHCCCCCCCCCCCH		18.0110929008
58PhosphorylationRSIRPGLSPYRALLD
CCCCCCCCHHHHHHH		26.2924719451
58 (in isoform 2)Phosphorylation-26.2924719451
60PhosphorylationIRPGLSPYRALLDSL
CCCCCCHHHHHHHHH		12.7324719451
60 (in isoform 2)Phosphorylation-12.7324719451
94 (in isoform 3)Ubiquitination-4.1721890473
97N-linked_GlycosylationELQGLQKNMTRFRID
HHHHHHHHCCEEEHH		24.893881423
113PhosphorylationLEPRRPRYRVPDVLV
CCCCCCCCCCCCEEE		20.7428152594
120 (in isoform 3)Ubiquitination-5.9621890473
123 (in isoform 3)Ubiquitination-16.6821890473
129PhosphorylationDPPIARLSVSGRDEN
CCCEEEEEECCCCCC		14.5327794612
131PhosphorylationPIARLSVSGRDENSV
CEEEEEECCCCCCEE		25.4127794612
140 (in isoform 3)Ubiquitination-3.5821890473
141PhosphorylationDENSVELTMAEGPYK
CCCEEEEEEEECCEE		10.79-
142SulfoxidationENSVELTMAEGPYKI
CCEEEEEEEECCEEE		5.0930846556
147PhosphorylationLTMAEGPYKIILTAR
EEEEECCEEEEEEEC		26.1929978859
164MethylationRLDLLEDRSLLLSVN
EEEECCCCCEEEEEE		21.59-
165PhosphorylationLDLLEDRSLLLSVNA
EEECCCCCEEEEEEC		35.3721712546
172 (in isoform 3)Ubiquitination-12.5521890473
182MethylationLLEFEHQRAPRVSQG
HHHEECCCCCCCCCC		48.76-
187PhosphorylationHQRAPRVSQGSKDPA
CCCCCCCCCCCCCCC		30.0627135362
190PhosphorylationAPRVSQGSKDPAEGD
CCCCCCCCCCCCCCC		26.6729900121
191UbiquitinationPRVSQGSKDPAEGDG
CCCCCCCCCCCCCCC		74.6521906983
204PhosphorylationDGAQPEETPRDGDKP
CCCCCCCCCCCCCCC		23.2025849741
206MethylationAQPEETPRDGDKPEE
CCCCCCCCCCCCCHH		68.88-
212 (in isoform 2)Phosphorylation-78.4224719451
213 (in isoform 2)Ubiquitination-55.7621890473
217UbiquitinationKPEETQGKAEKDEPG
CCHHHCCCCCCCCCC		43.4821906983
220UbiquitinationETQGKAEKDEPGAWE
HHCCCCCCCCCCHHH		72.7221906983
231UbiquitinationGAWEETFKTHSDSKP
CHHHHHEECCCCCCC		53.39-
237UbiquitinationFKTHSDSKPYGPMSV
EECCCCCCCCCCEEE		47.4521906983
239 (in isoform 2)Ubiquitination-37.2821890473
240 (in isoform 3)Ubiquitination-21.6921890473
242 (in isoform 1)Ubiquitination-4.3821890473
242 (in isoform 2)Ubiquitination-4.3821890473
259 (in isoform 2)Ubiquitination-1.6621890473
268 (in isoform 1)Ubiquitination-6.1921890473
269UbiquitinationHADNLRLKVTEGGEP
CCCCEEEEEEECCCE		40.4522053931
271 (in isoform 1)Ubiquitination-27.5921890473
288 (in isoform 1)Ubiquitination-33.7121890473
291 (in isoform 2)Ubiquitination-32.2821890473
320 (in isoform 1)Ubiquitination-40.5721890473
337UbiquitinationAGKTLFGKMMDYLQG
CCCHHHHHHHHHHCC		24.5821906983
338SulfoxidationGKTLFGKMMDYLQGS
CCHHHHHHHHHHCCC		2.2430846556
339SulfoxidationKTLFGKMMDYLQGSG
CHHHHHHHHHHCCCC		3.3130846556
341PhosphorylationLFGKMMDYLQGSGET
HHHHHHHHHCCCCCC		5.30-
345PhosphorylationMMDYLQGSGETPQTD
HHHHHCCCCCCCCCC		22.0921712546
348PhosphorylationYLQGSGETPQTDVRW
HHCCCCCCCCCCCHH		24.99-
351PhosphorylationGSGETPQTDVRWMSE
CCCCCCCCCCHHHHH		37.35-
359 (in isoform 2)Ubiquitination-26.7721890473
375 (in isoform 3)Ubiquitination-3.2121890473
379PhosphorylationISDVFRQYASLTGTQ
HHHHHHHHHHCCCCC		8.23-
388 (in isoform 1)Ubiquitination-3.0121890473
394 (in isoform 3)Ubiquitination-6.5521890473
396PhosphorylationPPLFSLGYHQSRWNY
CCCHHCCCCCCCCCC		11.28-
436AcetylationDIEHADGKRYFTWDP
EEECCCCCEEECCCH		44.4619809771
440PhosphorylationADGKRYFTWDPSRFP
CCCCEEECCCHHHCC		21.7428450419
462UbiquitinationRLASKRRKLVAIVDP
HHHHCCCCEEEEECC		51.88-
472UbiquitinationAIVDPHIKVDSGYRV
EEECCCCCCCCCCCC		36.6321890473
472SumoylationAIVDPHIKVDSGYRV
EEECCCCCCCCCCCC		36.63-
484MethylationYRVHEELRNLGLYVK
CCCCHHHHHCCCEEE		39.34-
489PhosphorylationELRNLGLYVKTRDGS
HHHHCCCEEECCCCC		9.7128152594
491UbiquitinationRNLGLYVKTRDGSDY
HHCCCEEECCCCCCC		25.0421906983
494 (in isoform 2)Ubiquitination-67.2021890473
502GlutathionylationGSDYEGWCWPGSAGY
CCCCCCCCCCCCCCC		4.6422555962
513 (in isoform 2)Ubiquitination-47.9021890473
523 (in isoform 1)Ubiquitination-20.5021890473
542 (in isoform 1)Ubiquitination-26.1021890473
555O-linked_GlycosylationVFNGPEVTMLKDAQH
CCCCCCEEEEECCCC		18.35OGP
563PhosphorylationMLKDAQHYGGWEHRD
EEECCCCCCCCCCCC		12.7826356563
578PhosphorylationVHNIYGLYVHMATAD
HHHEEEEEEEEECCC		5.50-
581SulfoxidationIYGLYVHMATADGLR
EEEEEEEEECCCHHH		2.2430846556
590MethylationTADGLRQRSGGMERP
CCCHHHHCCCCCCCC		30.73-
594SulfoxidationLRQRSGGMERPFVLA
HHHCCCCCCCCHHHH		4.5021406390
608PhosphorylationARAFFAGSQRFGAVW
HHHHHCCCCCCEEEE		18.1123911959
698MethylationSQHNDIIRDALGQRY
CCCHHHHHHHHHHHH		24.39-
790PhosphorylationQKHHGPQTLYLPVTL
HHHCCCCEEEEEEEH		22.09-
792PhosphorylationHHGPQTLYLPVTLSS
HCCCCEEEEEEEHHH		16.61-
796PhosphorylationQTLYLPVTLSSIPVF
CEEEEEEEHHHCCEE		20.98-
802 (in isoform 3)Ubiquitination-6.4321890473
808PhosphorylationPVFQRGGTIVPRWMR
CEEECCCCCCCCCEE		22.94-
811 (in isoform 3)Ubiquitination-21.9921890473
820PhosphorylationWMRVRRSSECMKDDP
CEEECCCHHHCCCCC		32.76-
863MethylationTRQEFLLRRFSFSGN
HHHHHHHHHEEECCC		39.48-
866PhosphorylationEFLLRRFSFSGNTLV
HHHHHHEEECCCEEE		19.3828450419
868PhosphorylationLLRRFSFSGNTLVSS
HHHHEEECCCEEECC		29.9028450419
871PhosphorylationRFSFSGNTLVSSSAD
HEEECCCEEECCCCC		31.8728450419
874PhosphorylationFSGNTLVSSSADPEG
ECCCEEECCCCCCCC		22.9928450419
875PhosphorylationSGNTLVSSSADPEGH
CCCEEECCCCCCCCC		23.2828450419
876PhosphorylationGNTLVSSSADPEGHF
CCEEECCCCCCCCCC		29.2328450419
899UbiquitinationVVIIGAGKPAAVVLQ
EEEECCCCCEEEEEE		30.8321890473
908UbiquitinationAAVVLQTKGSPESRL
EEEEEECCCCHHHHC		44.4221890473
908SuccinylationAAVVLQTKGSPESRL
EEEEEECCCCHHHHC		44.4223954790
916PhosphorylationGSPESRLSFQHDPET
CCHHHHCCCCCCCCC		23.0428450419
921 (in isoform 2)Ubiquitination-44.6421890473
923PhosphorylationSFQHDPETSVLVLRK
CCCCCCCCEEEEEEC		29.5320873877
924PhosphorylationFQHDPETSVLVLRKP
CCCCCCCEEEEEECC		16.2820873877
930UbiquitinationTSVLVLRKPGINVAS
CEEEEEECCCCCCCC		43.36-
930 (in isoform 2)Ubiquitination-43.3621890473
937PhosphorylationKPGINVASDWSIHLR
CCCCCCCCCCEEECC		35.02-
944MethylationSDWSIHLR-------
CCCEEECC-------		30.27-
950 (in isoform 1)Ubiquitination-21890473
959 (in isoform 1)Ubiquitination-21890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GANAB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GANAB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GANAB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GLU2B_HUMANPRKCSHphysical
22939629
PDIA1_HUMANP4HBphysical
22939629
MK08_HUMANMAPK8physical
21988832
RAP1A_HUMANRAP1Aphysical
21988832
ARMX3_HUMANARMCX3physical
22863883
BUB1B_HUMANBUB1Bphysical
22863883
CUTC_HUMANCUTCphysical
22863883
DEK_HUMANDEKphysical
22863883
SYFB_HUMANFARSBphysical
22863883
GARS_HUMANGARSphysical
22863883
HYOU1_HUMANHYOU1physical
22863883
I2BP2_HUMANIRF2BP2physical
22863883
PLAK_HUMANJUPphysical
22863883
MSH6_HUMANMSH6physical
22863883
PLOD2_HUMANPLOD2physical
22863883
GLU2B_HUMANPRKCSHphysical
22863883
PTN12_HUMANPTPN12physical
22863883
SPT5H_HUMANSUPT5Hphysical
22863883
SWP70_HUMANSWAP70physical
22863883
TENS3_HUMANTNS3physical
22863883
TRM1_HUMANTRMT1physical
22863883
MOGS_HUMANMOGSphysical
26344197
RM09_HUMANMRPL9physical
26344197
QCR2_HUMANUQCRC2physical
26344197
UBAC1_HUMANUBAC1physical
28514442
TAB1_HUMANTAB1physical
28514442
TCPB_HUMANCCT2physical
28514442
TCPG_HUMANCCT3physical
28514442
ZN703_HUMANZNF703physical
28514442
TCPA_HUMANTCP1physical
28514442
RUFY3_HUMANRUFY3physical
28514442
TCPE_HUMANCCT5physical
28514442
TCPZ_HUMANCCT6Aphysical
28514442
TCPD_HUMANCCT4physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00491Miglitol
Regulatory Network of GANAB_HUMAN

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Related Literatures of Post-Translational Modification

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