dbPTM

TENS3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TENS3_HUMAN
UniProt AC	Q68CZ2
Protein Name	Tensin-3
Gene Name	TNS3
Organism	Homo sapiens (Human).
Sequence Length	1445
Subcellular Localization	Cell junction, focal adhesion .
Protein Description	May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity)..
Protein Sequence	MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDKVSALMQPSQKRYVQFLSGLLSGSVKMNASPLFLHFVILHGTPNFDTGGVCRPFLKLYQAMQPVYTSGIYNVGPENPSRICIVIEPAQLLKGDVMVKCYHKKYRSATRDVIFRLQFHTGAVQGYGLVFGKEDLDNASKDDRFPDYGKVELVFSATPEKIQGSEHLYNDHGVIVDYNTTDPLIRWDSYENLSADGEVLHTQGPVDGSLYAKVRKKSSSDPGIPGGPQAIPATNSPDHSDHTLSVSSDSGHSTASARTDKTEERLAPGTRRGLSAQEKAELDQLLSGFGLEDPGSSLKEMTDARSKYSGTRHVVPAQVHVNGDAALKDRETDILDDEMPHHDLHSVDSLGTLSSSEGPQSAHLGPFTCHKSSQNSLLSDGFGSNVGEDPQGTLVPDLGLGMDGPYERERTFGSREPKQPQPLLRKPSVSAQMQAYGQSSYSTQTWVRQQQMVVAHQYSFAPDGEARLVSRCPADNPGLVQAQPRVPLTPTRGTSSRVAVQRGVGSGPHPPDTQQPSPSKAFKPRFPGDQVVNGAGPELSTGPSPGSPTLDIDQSIEQLNRLILELDPTFEPIPTHMNALGSQANGSVSPDSVGGGLRASSRLPDTGEGPSRATGRQGSSAEQPLGGRLRKLSLGQYDNDAGGQLPFSKCAWGKAGVDYAPNLPPFPSPADVKETMTPGYPQDLDIIDGRILSSKESMCSTPAFPVSPETPYVKTALRHPPFSPPEPPLSSPASQHKGGREPRSCPETLTHAVGMSESPIGPKSTMLRADASSTPSFQQAFASSCTISSNGPGQRRESSSSAERQWVESSPKPMVSLLGSGRPTGSPLSAEFSGTRKDSPVLSCFPPSELQAPFHSHELSLAEPPDSLAPPSSQAFLGFGTAPVGSGLPPEEDLGALLANSHGASPTPSIPLTATGAADNGFLSHNFLTVAPGHSSHHSPGLQGQGVTLPGQPPLPEKKRASEGDRSLGSVSPSSSGFSSPHSGSTISIPFPNVLPDFSKASEAASPLPDSPGDKLVIVKFVQDTSKFWYKADISREQAIAMLKDKEPGSFIVRDSHSFRGAYGLAMKVATPPPSVLQLNKKAGDLANELVRHFLIECTPKGVRLKGCSNEPYFGSLTALVCQHSITPLALPCKLLIPERDPLEEIAESSPQTAANSAAELLKQGAACNVWYLNSVEMESLTGHQAIQKALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFRRHYPVNSVIFCALDPQDRKWIKDGPSSKVFGFVARKQGSATDNVCHLFAEHDPEQPASAIVNFVSKVMIGSPKKV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Acetylation	VTRMLKSKHGDNYLV HHHHHHHCCCCCEEE	50.44	12437877
55	Phosphorylation	NYLVLNLSEKRYDLT CEEEEECCHHHCCCH	39.74	24719451
57	Ubiquitination	LVLNLSEKRYDLTKL EEEECCHHHCCCHHC	53.54	33845483
63	Ubiquitination	EKRYDLTKLNPKIMD HHHCCCHHCCHHHCC	54.27	33845483
67	Ubiquitination	DLTKLNPKIMDVGWP CCHHCCHHHCCCCCH	49.98	29967540
119	Phosphorylation	GRIGVVISSYMHFTN CCEEEEEEEECCCCC	12.10	24144214
120	Phosphorylation	RIGVVISSYMHFTNV CEEEEEEEECCCCCC	18.49	24144214
121	Phosphorylation	IGVVISSYMHFTNVS EEEEEEEECCCCCCC	6.44	24144214
142	Ubiquitination	LDRFAMKKFYDDKVS HHHHHHHHHHHHHHH	35.75	-
147	Ubiquitination	MKKFYDDKVSALMQP HHHHHHHHHHHHHCH	34.88	29967540
157	Ubiquitination	ALMQPSQKRYVQFLS HHHCHHHHHHHHHHH	50.46	29967540
170	Phosphorylation	LSGLLSGSVKMNASP HHHHHHCCCCCCCCH	18.39	28857561
204	Phosphorylation	CRPFLKLYQAMQPVY CHHHHHHHHHHCCEE	7.82	-
237	Ubiquitination	IEPAQLLKGDVMVKC ECHHHHHCCCEEEEE	62.75	33845483
243	Ubiquitination	LKGDVMVKCYHKKYR HCCCEEEEECCHHHH	15.81	29967540
251	Phosphorylation	CYHKKYRSATRDVIF ECCHHHHHCCCEEEE	30.79	23312004
253	Phosphorylation	HKKYRSATRDVIFRL CHHHHHCCCEEEEEE	28.75	23312004
283	Phosphorylation	KEDLDNASKDDRFPD HHHHCCCCCCCCCCC	42.76	20873877
284	Ubiquitination	EDLDNASKDDRFPDY HHHCCCCCCCCCCCC	62.33	29967540
299	Phosphorylation	GKVELVFSATPEKIQ CEEEEEEECCHHHCC	24.61	-
301	Phosphorylation	VELVFSATPEKIQGS EEEEEECCHHHCCCC	30.68	28674419
312	Phosphorylation	IQGSEHLYNDHGVIV CCCCCCCCCCCCEEE	22.05	27642862
321	Phosphorylation	DHGVIVDYNTTDPLI CCCEEECCCCCCCCC	11.96	27642862
323	Phosphorylation	GVIVDYNTTDPLIRW CEEECCCCCCCCCCC	26.75	27642862
324	Phosphorylation	VIVDYNTTDPLIRWD EEECCCCCCCCCCCC	31.79	-
332	Phosphorylation	DPLIRWDSYENLSAD CCCCCCCCCCCCCCC	27.64	22167270
333	Phosphorylation	PLIRWDSYENLSADG CCCCCCCCCCCCCCC	13.33	22167270
337	Phosphorylation	WDSYENLSADGEVLH CCCCCCCCCCCCEEE	35.58	23927012
345	Phosphorylation	ADGEVLHTQGPVDGS CCCCEEEEECCCCCC	30.93	23927012
352	Phosphorylation	TQGPVDGSLYAKVRK EECCCCCCEEEEEEE	17.47	22167270
354	Phosphorylation	GPVDGSLYAKVRKKS CCCCCCEEEEEEECC	13.18	22167270
361	Phosphorylation	YAKVRKKSSSDPGIP EEEEEECCCCCCCCC	37.80	23401153
362	Phosphorylation	AKVRKKSSSDPGIPG EEEEECCCCCCCCCC	47.87	23927012
363	Phosphorylation	KVRKKSSSDPGIPGG EEEECCCCCCCCCCC	55.72	23927012
377	Phosphorylation	GPQAIPATNSPDHSD CCCCCCCCCCCCCCC	30.76	23927012
379	Phosphorylation	QAIPATNSPDHSDHT CCCCCCCCCCCCCCE	27.61	23663014
383	Phosphorylation	ATNSPDHSDHTLSVS CCCCCCCCCCEEEEC	38.17	23927012
386	Phosphorylation	SPDHSDHTLSVSSDS CCCCCCCEEEECCCC	26.22	23663014
388	Phosphorylation	DHSDHTLSVSSDSGH CCCCCEEEECCCCCC	22.55	23663014
390	Phosphorylation	SDHTLSVSSDSGHST CCCEEEECCCCCCCC	25.67	23663014
391	Phosphorylation	DHTLSVSSDSGHSTA CCEEEECCCCCCCCC	33.37	23663014
393	Phosphorylation	TLSVSSDSGHSTASA EEEECCCCCCCCCCC	40.11	23663014
396	Phosphorylation	VSSDSGHSTASARTD ECCCCCCCCCCCCCC	29.24	23663014
397	Phosphorylation	SSDSGHSTASARTDK CCCCCCCCCCCCCCC	20.96	23663014
399	Phosphorylation	DSGHSTASARTDKTE CCCCCCCCCCCCCCH	20.55	23663014
405	Phosphorylation	ASARTDKTEERLAPG CCCCCCCCHHHCCCC	45.98	30242111
413	Phosphorylation	EERLAPGTRRGLSAQ HHHCCCCCCCCCCHH	19.01	30242111
418	Phosphorylation	PGTRRGLSAQEKAEL CCCCCCCCHHHHHHH	30.63	26699800
422	Ubiquitination	RGLSAQEKAELDQLL CCCCHHHHHHHHHHH	34.77	29967540
439	Phosphorylation	FGLEDPGSSLKEMTD CCCCCCCCCHHHHHH	37.57	22199227
440	Phosphorylation	GLEDPGSSLKEMTDA CCCCCCCCHHHHHHH	49.75	26657352
442	Ubiquitination	EDPGSSLKEMTDARS CCCCCCHHHHHHHHH	47.60	29967540
445	Phosphorylation	GSSLKEMTDARSKYS CCCHHHHHHHHHHCC	27.83	28857561
451	Phosphorylation	MTDARSKYSGTRHVV HHHHHHHCCCCCCEE	17.36	22817900
452	Phosphorylation	TDARSKYSGTRHVVP HHHHHHCCCCCCEEE	37.11	25072903
454	Phosphorylation	ARSKYSGTRHVVPAQ HHHHCCCCCCEEEEE	16.20	25072903
471	Ubiquitination	VNGDAALKDRETDIL ECCCHHHCCCCCCCC	50.44	33845483
492	Phosphorylation	HDLHSVDSLGTLSSS CCCCCCCCCCCCCCC	26.92	27251275
515	Phosphorylation	GPFTCHKSSQNSLLS CCEECCCCCCCCCCC	17.31	23403867
516	Phosphorylation	PFTCHKSSQNSLLSD CEECCCCCCCCCCCC	37.88	29802988
519	Phosphorylation	CHKSSQNSLLSDGFG CCCCCCCCCCCCCCC	24.05	27251275
522	Phosphorylation	SSQNSLLSDGFGSNV CCCCCCCCCCCCCCC	40.77	22798277
527	Phosphorylation	LLSDGFGSNVGEDPQ CCCCCCCCCCCCCCC	26.53	27251275
536	Phosphorylation	VGEDPQGTLVPDLGL CCCCCCCCCCCCCCC	21.23	27251275
540	Phosphorylation	PQGTLVPDLGLGMDG CCCCCCCCCCCCCCC	45.98	15951569
545	Sulfoxidation	VPDLGLGMDGPYERE CCCCCCCCCCCCCCC	6.91	30846556
549	Phosphorylation	GLGMDGPYERERTFG CCCCCCCCCCCCCCC	32.90	23403867
557	Phosphorylation	ERERTFGSREPKQPQ CCCCCCCCCCCCCCC	29.31	27470641
561	Ubiquitination	TFGSREPKQPQPLLR CCCCCCCCCCCCCCC	70.61	29967540
569	Ubiquitination	QPQPLLRKPSVSAQM CCCCCCCCCCHHHHH	41.43	-
571	Phosphorylation	QPLLRKPSVSAQMQA CCCCCCCCHHHHHHH	31.57	21945579
573	Phosphorylation	LLRKPSVSAQMQAYG CCCCCCHHHHHHHHC	19.68	21945579
579	Phosphorylation	VSAQMQAYGQSSYST HHHHHHHHCCCCCCH	9.98	21945579
582	Phosphorylation	QMQAYGQSSYSTQTW HHHHHCCCCCCHHHH	27.21	21945579
583	Phosphorylation	MQAYGQSSYSTQTWV HHHHCCCCCCHHHHH	18.40	21945579
584	Phosphorylation	QAYGQSSYSTQTWVR HHHCCCCCCHHHHHH	22.45	21945579
585	Phosphorylation	AYGQSSYSTQTWVRQ HHCCCCCCHHHHHHH	18.91	21945579
586	Phosphorylation	YGQSSYSTQTWVRQQ HCCCCCCHHHHHHHH	23.06	21945579
588	Phosphorylation	QSSYSTQTWVRQQQM CCCCCHHHHHHHHHE	26.47	21945579
601	Phosphorylation	QMVVAHQYSFAPDGE HEEEEEEEEECCCCC	8.90	21945579
602	Phosphorylation	MVVAHQYSFAPDGEA EEEEEEEEECCCCCE	14.36	21945579
628	Methylation	GLVQAQPRVPLTPTR CCCCCCCCCCCCCCC	30.52	115918365
632	Phosphorylation	AQPRVPLTPTRGTSS CCCCCCCCCCCCCCC	19.28	30266825
634	Phosphorylation	PRVPLTPTRGTSSRV CCCCCCCCCCCCCCE	36.17	27987026
637	Phosphorylation	PLTPTRGTSSRVAVQ CCCCCCCCCCCEEEC	21.90	23090842
638	Phosphorylation	LTPTRGTSSRVAVQR CCCCCCCCCCEEECC	20.97	23090842
639	Phosphorylation	TPTRGTSSRVAVQRG CCCCCCCCCEEECCC	30.52	23090842
640	Methylation	PTRGTSSRVAVQRGV CCCCCCCCEEECCCC	21.85	115918369
645	Methylation	SSRVAVQRGVGSGPH CCCEEECCCCCCCCC	34.86	115918373
649	Phosphorylation	AVQRGVGSGPHPPDT EECCCCCCCCCCCCC	46.90	23927012
656	Phosphorylation	SGPHPPDTQQPSPSK CCCCCCCCCCCCCCC	34.57	23927012
660	Phosphorylation	PPDTQQPSPSKAFKP CCCCCCCCCCCCCCC	37.15	29255136
662	Phosphorylation	DTQQPSPSKAFKPRF CCCCCCCCCCCCCCC	40.74	30266825
663	Ubiquitination	TQQPSPSKAFKPRFP CCCCCCCCCCCCCCC	62.31	29967540
683	Phosphorylation	NGAGPELSTGPSPGS CCCCCCCCCCCCCCC	29.65	30183078
684	Phosphorylation	GAGPELSTGPSPGSP CCCCCCCCCCCCCCC	66.78	23663014
687	Phosphorylation	PELSTGPSPGSPTLD CCCCCCCCCCCCCCC	43.15	30278072
690	Phosphorylation	STGPSPGSPTLDIDQ CCCCCCCCCCCCHHH	20.35	30278072
692	Phosphorylation	GPSPGSPTLDIDQSI CCCCCCCCCCHHHHH	38.47	30278072
698	Phosphorylation	PTLDIDQSIEQLNRL CCCCHHHHHHHHHHH	25.09	23663014
712	Phosphorylation	LILELDPTFEPIPTH HHHHCCCCCCCCCCH	40.05	25850435
718	Phosphorylation	PTFEPIPTHMNALGS CCCCCCCCHHHHHCC	34.18	28450419
725	Phosphorylation	THMNALGSQANGSVS CHHHHHCCCCCCCCC	27.28	29507054
730	Phosphorylation	LGSQANGSVSPDSVG HCCCCCCCCCCCCCC	21.16	28450419
732	Phosphorylation	SQANGSVSPDSVGGG CCCCCCCCCCCCCCC	25.37	22617229
735	Phosphorylation	NGSVSPDSVGGGLRA CCCCCCCCCCCCCEE	26.50	21712546
749	Phosphorylation	ASSRLPDTGEGPSRA ECCCCCCCCCCCCCC	34.88	21712546
762	Phosphorylation	RATGRQGSSAEQPLG CCCCCCCCCCCCCCC	20.31	29255136
763	Phosphorylation	ATGRQGSSAEQPLGG CCCCCCCCCCCCCCC	42.52	29255136
771	Methylation	AEQPLGGRLRKLSLG CCCCCCCCEEEECCC	29.53	24396603
774	Ubiquitination	PLGGRLRKLSLGQYD CCCCCEEEECCCCCC	47.20	29967540
776	Phosphorylation	GGRLRKLSLGQYDND CCCEEEECCCCCCCC	33.23	22167270
780	Phosphorylation	RKLSLGQYDNDAGGQ EEECCCCCCCCCCCC	18.21	23927012
791	Phosphorylation	AGGQLPFSKCAWGKA CCCCCCCCCCCCCCC	25.53	21945579
797	Methylation	FSKCAWGKAGVDYAP CCCCCCCCCCCCCCC	31.13	115980035
802	Phosphorylation	WGKAGVDYAPNLPPF CCCCCCCCCCCCCCC	22.88	21945579
811	Phosphorylation	PNLPPFPSPADVKET CCCCCCCCCCCCCCC	32.85	21945579
816	Ubiquitination	FPSPADVKETMTPGY CCCCCCCCCCCCCCC	48.27	29967540
818	Phosphorylation	SPADVKETMTPGYPQ CCCCCCCCCCCCCCC	22.19	21945579
819	Sulfoxidation	PADVKETMTPGYPQD CCCCCCCCCCCCCCC	4.46	30846556
820	Phosphorylation	ADVKETMTPGYPQDL CCCCCCCCCCCCCCC	22.45	21945579
823	Phosphorylation	KETMTPGYPQDLDII CCCCCCCCCCCCCEE	10.02	21945579
836	Phosphorylation	IIDGRILSSKESMCS EECCEECCCCCCCCC	36.67	22199227
837	Phosphorylation	IDGRILSSKESMCST ECCEECCCCCCCCCC	36.68	22199227
838	Ubiquitination	DGRILSSKESMCSTP CCEECCCCCCCCCCC	50.89	29967540
840	Phosphorylation	RILSSKESMCSTPAF EECCCCCCCCCCCCC	28.91	21945579
843	Phosphorylation	SSKESMCSTPAFPVS CCCCCCCCCCCCCCC	28.87	21945579
844	Phosphorylation	SKESMCSTPAFPVSP CCCCCCCCCCCCCCC	17.44	21945579
850	Phosphorylation	STPAFPVSPETPYVK CCCCCCCCCCCCCHH	19.77	21945579
853	Phosphorylation	AFPVSPETPYVKTAL CCCCCCCCCCHHHHH	24.25	21945579
855	Phosphorylation	PVSPETPYVKTALRH CCCCCCCCHHHHHCC	23.23	21945579
858	Phosphorylation	PETPYVKTALRHPPF CCCCCHHHHHCCCCC	22.38	30576142
866	Phosphorylation	ALRHPPFSPPEPPLS HHCCCCCCCCCCCCC	45.37	22167270
873	Phosphorylation	SPPEPPLSSPASQHK CCCCCCCCCCCHHCC	39.80	23401153
874	Phosphorylation	PPEPPLSSPASQHKG CCCCCCCCCCHHCCC	31.97	29255136
877	Phosphorylation	PPLSSPASQHKGGRE CCCCCCCHHCCCCCC	35.88	29255136
887	Phosphorylation	KGGREPRSCPETLTH CCCCCCCCCCCHHHH	44.75	28731282
891	Phosphorylation	EPRSCPETLTHAVGM CCCCCCCHHHHHCCC	23.31	29396449
893	Phosphorylation	RSCPETLTHAVGMSE CCCCCHHHHHCCCCC	18.40	28450419
899	Phosphorylation	LTHAVGMSESPIGPK HHHHCCCCCCCCCCC	29.06	23401153
901	Phosphorylation	HAVGMSESPIGPKST HHCCCCCCCCCCCCC	17.95	30266825
915	Phosphorylation	TMLRADASSTPSFQQ CCCCCCCCCCHHHHH	34.98	28857561
916	Phosphorylation	MLRADASSTPSFQQA CCCCCCCCCHHHHHH	46.16	25159151
917	Phosphorylation	LRADASSTPSFQQAF CCCCCCCCHHHHHHH	22.06	25159151
919	Phosphorylation	ADASSTPSFQQAFAS CCCCCCHHHHHHHHH	35.46	25159151
926	Phosphorylation	SFQQAFASSCTISSN HHHHHHHHCCEECCC	21.35	21712546
927	Phosphorylation	FQQAFASSCTISSNG HHHHHHHCCEECCCC	16.32	27251275
929	Phosphorylation	QAFASSCTISSNGPG HHHHHCCEECCCCCC	26.33	27251275
931	Phosphorylation	FASSCTISSNGPGQR HHHCCEECCCCCCCC	10.29	21712546
932	Phosphorylation	ASSCTISSNGPGQRR HHCCEECCCCCCCCC	41.79	21712546
941	Phosphorylation	GPGQRRESSSSAERQ CCCCCCCCCCHHHHH	33.44	27273156
942	Phosphorylation	PGQRRESSSSAERQW CCCCCCCCCHHHHHH	24.45	22199227
943	Phosphorylation	GQRRESSSSAERQWV CCCCCCCCHHHHHHH	42.73	22199227
944	Phosphorylation	QRRESSSSAERQWVE CCCCCCCHHHHHHHH	35.78	22199227
952	Phosphorylation	AERQWVESSPKPMVS HHHHHHHCCCCCCEE	42.18	20068231
953	Phosphorylation	ERQWVESSPKPMVSL HHHHHHCCCCCCEEE	24.36	25159151
959	Phosphorylation	SSPKPMVSLLGSGRP CCCCCCEEECCCCCC	16.18	20068231
963	Phosphorylation	PMVSLLGSGRPTGSP CCEEECCCCCCCCCC	31.43	22199227
967	Phosphorylation	LLGSGRPTGSPLSAE ECCCCCCCCCCCCEE	49.26	25159151
969	Phosphorylation	GSGRPTGSPLSAEFS CCCCCCCCCCCEEEC	25.75	19664994
972	Phosphorylation	RPTGSPLSAEFSGTR CCCCCCCCEEECCCC	29.18	25850435
976	Phosphorylation	SPLSAEFSGTRKDSP CCCCEEECCCCCCCC	30.66	22199227
978	Phosphorylation	LSAEFSGTRKDSPVL CCEEECCCCCCCCCC	33.09	25850435
982	Phosphorylation	FSGTRKDSPVLSCFP ECCCCCCCCCCCCCC	21.68	24275569
1044	Phosphorylation	LGALLANSHGASPTP HHHHHHCCCCCCCCC	20.07	22798277
1105	Phosphorylation	LPEKKRASEGDRSLG CCCHHCCCCCCCCCC	46.26	29514088
1110	Phosphorylation	RASEGDRSLGSVSPS CCCCCCCCCCCCCCC	41.65	22199227
1113	Phosphorylation	EGDRSLGSVSPSSSG CCCCCCCCCCCCCCC	25.39	29496963
1115	Phosphorylation	DRSLGSVSPSSSGFS CCCCCCCCCCCCCCC	22.29	30278072
1117	Phosphorylation	SLGSVSPSSSGFSSP CCCCCCCCCCCCCCC	29.63	28450419
1118	Phosphorylation	LGSVSPSSSGFSSPH CCCCCCCCCCCCCCC	37.55	28450419
1119	Phosphorylation	GSVSPSSSGFSSPHS CCCCCCCCCCCCCCC	48.47	28450419
1122	Phosphorylation	SPSSSGFSSPHSGST CCCCCCCCCCCCCCE	46.62	28348404
1123	Phosphorylation	PSSSGFSSPHSGSTI CCCCCCCCCCCCCEE	25.11	19276368
1126	Phosphorylation	SGFSSPHSGSTISIP CCCCCCCCCCEEEEC	37.51	21712546
1128	Phosphorylation	FSSPHSGSTISIPFP CCCCCCCCEEEECCC	26.11	29496963
1129	Phosphorylation	SSPHSGSTISIPFPN CCCCCCCEEEECCCC	23.44	29496963
1131	Phosphorylation	PHSGSTISIPFPNVL CCCCCEEEECCCCCC	25.05	28450419
1142	Phosphorylation	PNVLPDFSKASEAAS CCCCCCCHHHHHHCC	34.39	26330541
1143	Ubiquitination	NVLPDFSKASEAASP CCCCCCHHHHHHCCC	56.79	29967540
1145	Phosphorylation	LPDFSKASEAASPLP CCCCHHHHHHCCCCC	31.35	30266825
1149	Phosphorylation	SKASEAASPLPDSPG HHHHHHCCCCCCCCC	33.73	19664994
1154	Phosphorylation	AASPLPDSPGDKLVI HCCCCCCCCCCEEEE	28.92	29255136
1158	Ubiquitination	LPDSPGDKLVIVKFV CCCCCCCEEEEEEEE	51.04	33845483
1163	Ubiquitination	GDKLVIVKFVQDTSK CCEEEEEEEEECCCC	28.79	33845483
1170	Ubiquitination	KFVQDTSKFWYKADI EEEECCCCHHEECCC	41.85	29967540
1173	Phosphorylation	QDTSKFWYKADISRE ECCCCHHEECCCCHH	10.22	19732724
1174	Ubiquitination	DTSKFWYKADISREQ CCCCHHEECCCCHHH	30.13	29967540
1187	Ubiquitination	EQAIAMLKDKEPGSF HHHHHHHHCCCCCCE	54.38	29967540
1189	Ubiquitination	AIAMLKDKEPGSFIV HHHHHHCCCCCCEEE	65.31	29967540
1193	Phosphorylation	LKDKEPGSFIVRDSH HHCCCCCCEEEECCC	23.63	20873877
1199	Phosphorylation	GSFIVRDSHSFRGAY CCEEEECCCCCCCCE	15.51	26699800
1201	Phosphorylation	FIVRDSHSFRGAYGL EEEECCCCCCCCEEE	22.16	25159151
1206	Phosphorylation	SHSFRGAYGLAMKVA CCCCCCCEEEEEEEC	18.59	19732724
1210	Sulfoxidation	RGAYGLAMKVATPPP CCCEEEEEEECCCCC	4.28	30846556
1214	Phosphorylation	GLAMKVATPPPSVLQ EEEEEECCCCCCHHH	39.04	21815630
1218	Phosphorylation	KVATPPPSVLQLNKK EECCCCCCHHHHHHH	41.03	23312004
1224	Ubiquitination	PSVLQLNKKAGDLAN CCHHHHHHHHHHHHH	53.22	29967540
1225	Ubiquitination	SVLQLNKKAGDLANE CHHHHHHHHHHHHHH	57.43	29967540
1242	Phosphorylation	RHFLIECTPKGVRLK HHHHHCCCCCCEECC	18.42	28555341
1244	Ubiquitination	FLIECTPKGVRLKGC HHHCCCCCCEECCCC	52.46	33845483
1249	Ubiquitination	TPKGVRLKGCSNEPY CCCCEECCCCCCCCC	47.51	-
1252	Phosphorylation	GVRLKGCSNEPYFGS CEECCCCCCCCCCHH	53.55	26356563
1256	Phosphorylation	KGCSNEPYFGSLTAL CCCCCCCCCHHHHHH	17.88	19732724
1259	Phosphorylation	SNEPYFGSLTALVCQ CCCCCCHHHHHHHHC	16.79	26356563
1261	Phosphorylation	EPYFGSLTALVCQHS CCCCHHHHHHHHCCC	21.46	-
1292	Phosphorylation	PLEEIAESSPQTAAN HHHHHHHHCHHHHHH	37.99	28450419
1293	Phosphorylation	LEEIAESSPQTAANS HHHHHHHCHHHHHHH	16.72	25159151
1296	Phosphorylation	IAESSPQTAANSAAE HHHHCHHHHHHHHHH	30.99	28450419
1300	Phosphorylation	SPQTAANSAAELLKQ CHHHHHHHHHHHHHH	24.91	28450419
1335	Phosphorylation	QAIQKALSITLVQEP HHHHHHHCEEEECCC	20.56	28348404
1337	Phosphorylation	IQKALSITLVQEPPP HHHHHCEEEECCCCC	19.94	24719451
1392	Ubiquitination	PQDRKWIKDGPSSKV HHCCCHHHCCCCHHE	56.36	29967540
1398	Ubiquitination	IKDGPSSKVFGFVAR HHCCCCHHEEEEEEE	46.01	29967540
1406	Ubiquitination	VFGFVARKQGSATDN EEEEEEECCCCCCCC	49.64	29967540
1441	Phosphorylation	VSKVMIGSPKKV--- HHHHHCCCCCCC---	23.71	17001009

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1173	Y	Phosphorylation	Kinase	SRC	P12931	PSP
1206	Y	Phosphorylation	Kinase	SRC	P12931	PSP
1256	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TENS3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TENS3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN12_HUMAN	PTPN12	physical	22863883
CTNL1_HUMAN	CTNNAL1	physical	27880917
DMD_HUMAN	DMD	physical	27880917
DTNB_HUMAN	DTNB	physical	27880917
P5CR2_HUMAN	PYCR2	physical	27880917
SNTB1_HUMAN	SNTB1	physical	27880917
SNTB2_HUMAN	SNTB2	physical	27880917
UTRO_HUMAN	UTRN	physical	27880917

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TENS3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-780 AND SER-850, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-632; SER-660; SER-776;SER-866; SER-873; SER-901; SER-1149; SER-1154 AND SER-1293, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-732, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-776 AND TYR-780, ANDMASS SPECTROMETRY.	17389395 [Abstract]
"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules."; Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.; Mol. Cell. Proteomics 4:1240-1250(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332; TYR-354; SER-776AND TYR-780, AND MASS SPECTROMETRY.	15951569 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-632, AND MASSSPECTROMETRY.	16964243 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-354; TYR-601; TYR-780AND TYR-855, AND MASS SPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-333 AND TYR-354, ANDMASS SPECTROMETRY.	18083107 [Abstract]