UniProt ID | DMD_HUMAN | |
---|---|---|
UniProt AC | P11532 | |
Protein Name | Dystrophin | |
Gene Name | DMD | |
Organism | Homo sapiens (Human). | |
Sequence Length | 3685 | |
Subcellular Localization |
Cell membrane, sarcolemma Peripheral membrane protein Cytoplasmic side . Cytoplasm, cytoskeleton . Cell junction, synapse, postsynaptic cell membrane . In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to |
|
Protein Description | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.. | |
Protein Sequence | MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
6 (in isoform 10) | Ubiquitination | - | 37.17 | - | |
19 | Acetylation | EREDVQKKTFTKWVN CCCHHHHHHHHHHHH | 31.60 | 7822169 | |
81 | Phosphorylation | LNNVNKALRVLQNNN HHHHHHHHHHHHHCC | 4.09 | 24719451 | |
82 | Phosphorylation | NNVNKALRVLQNNNV HHHHHHHHHHHHCCC | 31.77 | 24719451 | |
209 | Phosphorylation | IARYQLGIEKLLDPE HHHHHHCHHHHCCHH | 6.00 | - | |
212 | Phosphorylation | YQLGIEKLLDPEDVD HHHCHHHHCCHHHCC | 4.21 | - | |
225 | Acetylation | VDTTYPDKKSILMYI CCCCCCCHHHHHHHH | 43.87 | 7668191 | |
240 (in isoform 5) | Ubiquitination | - | 24.57 | 21890473 | |
240 | Ubiquitination | TSLFQVLPQQVSIEA HHHHHHCCCCCCHHH | 24.57 | 21890473 | |
240 | Ubiquitination | TSLFQVLPQQVSIEA HHHHHHCCCCCCHHH | 24.57 | 21890473 | |
255 (in isoform 2) | Ubiquitination | - | 45.48 | - | |
274 (in isoform 2) | Ubiquitination | - | 11.66 | - | |
289 | Phosphorylation | LAQGYERTSSPKPRF HHHCCCCCCCCCCCC | 22.93 | - | |
290 | Phosphorylation | AQGYERTSSPKPRFK HHCCCCCCCCCCCCC | 51.36 | 29396449 | |
291 | Phosphorylation | QGYERTSSPKPRFKS HCCCCCCCCCCCCCC | 36.01 | 29396449 | |
299 | Phosphorylation | PKPRFKSYAYTQAAY CCCCCCCCEEEEEEE | 12.29 | 25307156 | |
302 | Phosphorylation | RFKSYAYTQAAYVTT CCCCCEEEEEEEEEC | 11.99 | 25307156 | |
306 | Phosphorylation | YAYTQAAYVTTSDPT CEEEEEEEEECCCCC | 11.01 | 25307156 | |
313 | Phosphorylation | YVTTSDPTRSPFPSQ EEECCCCCCCCCCCC | 49.09 | - | |
319 | Phosphorylation | PTRSPFPSQHLEAPE CCCCCCCCCCCCCCC | 30.52 | 26657352 | |
331 (in isoform 5) | Phosphorylation | - | 24.34 | 23663014 | |
331 (in isoform 8) | Phosphorylation | - | 24.34 | 23663014 | |
340 (in isoform 5) | Phosphorylation | - | 31.97 | 26055452 | |
340 (in isoform 8) | Phosphorylation | - | 31.97 | 26055452 | |
343 (in isoform 5) | Phosphorylation | - | 28.73 | 25159151 | |
343 (in isoform 8) | Phosphorylation | - | 28.73 | 25159151 | |
344 (in isoform 5) | Phosphorylation | - | 15.19 | 25159151 | |
344 (in isoform 8) | Phosphorylation | - | 15.19 | 25159151 | |
348 (in isoform 5) | Phosphorylation | - | 7.00 | 23663014 | |
348 (in isoform 8) | Phosphorylation | - | 7.00 | 23663014 | |
352 (in isoform 5) | Phosphorylation | - | 3.26 | 23663014 | |
352 (in isoform 8) | Phosphorylation | - | 3.26 | 23663014 | |
354 (in isoform 5) | Phosphorylation | - | 9.36 | 23663014 | |
354 (in isoform 8) | Phosphorylation | - | 9.36 | 23663014 | |
357 | Phosphorylation | EVLSWLLSAEDTLQA HHHHHHHCHHHHHHH | 27.69 | 20068231 | |
390 | Phosphorylation | EGYMMDLTAHQGRVG CCCEEECCCCCCCCH | 20.16 | - | |
404 | Phosphorylation | GNILQLGSKLIGTGK HHHHHHCCCEECCCC | 32.64 | 29396449 | |
467 | Phosphorylation | LNDWLTKTEERTRKM HHHHHHHHHHHHHHH | 37.53 | 18669648 | |
482 (in isoform 5) | Ubiquitination | - | 61.97 | 21890473 | |
482 | Ubiquitination | EEEPLGPDLEDLKRQ HCCCCCCCHHHHHHH | 61.97 | 21890473 | |
487 | Acetylation | GPDLEDLKRQVQQHK CCCHHHHHHHHHHHH | 53.78 | 7683599 | |
488 (in isoform 9) | Phosphorylation | - | 49.56 | 24275569 | |
491 (in isoform 9) | Phosphorylation | - | 31.18 | 24275569 | |
495 | Ubiquitination | RQVQQHKVLQEDLEQ HHHHHHHHHHHHHHH | 6.64 | 21890473 | |
499 (in isoform 9) | Phosphorylation | - | 42.41 | 24719451 | |
513 (in isoform 9) | Phosphorylation | - | 1.74 | 25841592 | |
516 (in isoform 9) | Phosphorylation | - | 2.82 | 28102081 | |
519 (in isoform 9) | Phosphorylation | - | 34.88 | 20068231 | |
562 | Phosphorylation | QDILLKWQRLTEEQC HHHHHHHHHCCHHHH | 28.99 | - | |
585 (in isoform 5) | Phosphorylation | - | 2.69 | 24275569 | |
588 (in isoform 5) | Phosphorylation | - | 26.85 | 24275569 | |
596 (in isoform 5) | Phosphorylation | - | 6.04 | 24719451 | |
598 | Phosphorylation | KDQNEMLSSLQKLAV CCHHHHHHHHHHHHH | 27.91 | 18669648 | |
598 (in isoform 6) | Phosphorylation | - | 27.91 | 24275569 | |
601 (in isoform 6) | Phosphorylation | - | 40.44 | 24275569 | |
609 (in isoform 6) | Phosphorylation | - | 54.49 | 24719451 | |
610 (in isoform 5) | Phosphorylation | - | 14.37 | 25841592 | |
613 (in isoform 5) | Phosphorylation | - | 46.82 | 28102081 | |
614 | Ubiquitination | KADLEKKKQSMGKLY HHHHHHHHHHHHHHH | 59.69 | - | |
616 | Phosphorylation | DLEKKKQSMGKLYSL HHHHHHHHHHHHHHH | 38.08 | - | |
616 (in isoform 5) | Phosphorylation | - | 38.08 | 20068231 | |
622 | Phosphorylation | QSMGKLYSLKQDLLS HHHHHHHHHHHHHHH | 39.26 | 24719451 | |
623 (in isoform 6) | Phosphorylation | - | 3.50 | 25841592 | |
626 (in isoform 6) | Phosphorylation | - | 48.25 | 28102081 | |
629 | Phosphorylation | SLKQDLLSTLKNKSV HHHHHHHHHHCCCCC | 38.70 | 28258704 | |
629 (in isoform 6) | Phosphorylation | - | 38.70 | 20068231 | |
630 | Phosphorylation | LKQDLLSTLKNKSVT HHHHHHHHHCCCCCC | 41.54 | 28258704 | |
644 | Phosphorylation | TQKTEAWLDNFARCW CHHHHHHHHHHHHHH | 5.07 | 24719451 | |
661 | Phosphorylation | LVQKLEKSTAQISQA HHHHHHHHHHHHHHH | 21.43 | 20068231 | |
662 | Phosphorylation | VQKLEKSTAQISQAV HHHHHHHHHHHHHHH | 33.38 | 20068231 | |
665 | Phosphorylation | LEKSTAQISQAVTTT HHHHHHHHHHHHHCC | 2.82 | - | |
666 | Phosphorylation | EKSTAQISQAVTTTQ HHHHHHHHHHHHCCC | 10.45 | 20068231 | |
668 | Phosphorylation | STAQISQAVTTTQPS HHHHHHHHHHCCCCC | 8.20 | - | |
670 | Phosphorylation | AQISQAVTTTQPSLT HHHHHHHHCCCCCCC | 27.43 | 20068231 | |
671 | Phosphorylation | QISQAVTTTQPSLTQ HHHHHHHCCCCCCCC | 19.48 | 20068231 | |
672 | Phosphorylation | ISQAVTTTQPSLTQT HHHHHHCCCCCCCCC | 29.17 | 20068231 | |
675 | Phosphorylation | AVTTTQPSLTQTTVM HHHCCCCCCCCCCCE | 33.94 | 20068231 | |
677 | Phosphorylation | TTTQPSLTQTTVMET HCCCCCCCCCCCEEE | 28.36 | 20068231 | |
679 | Phosphorylation | TQPSLTQTTVMETVT CCCCCCCCCCEEEEE | 19.00 | 20068231 | |
680 | Phosphorylation | QPSLTQTTVMETVTT CCCCCCCCCEEEEEE | 14.19 | 20068231 | |
684 | Phosphorylation | TQTTVMETVTTVTTR CCCCCEEEEEECCCH | 12.69 | 20068231 | |
686 | Phosphorylation | TTVMETVTTVTTREQ CCCEEEEEECCCHHH | 23.98 | 20068231 | |
687 | Phosphorylation | TVMETVTTVTTREQI CCEEEEEECCCHHHH | 16.12 | 20068231 | |
689 | Phosphorylation | METVTTVTTREQILV EEEEEECCCHHHHHH | 20.31 | 20068231 | |
690 | Phosphorylation | ETVTTVTTREQILVK EEEEECCCHHHHHHH | 28.07 | 20068231 | |
691 | Phosphorylation | TVTTVTTREQILVKH EEEECCCHHHHHHHH | 25.18 | - | |
696 | Phosphorylation | TTREQILVKHAQEEL CCHHHHHHHHHHHCC | 4.57 | - | |
700 | Phosphorylation | QILVKHAQEELPPPP HHHHHHHHHCCCCCC | 44.40 | - | |
715 | Phosphorylation | PQKKRQITVDSEIRK CCCCCCEECCHHHHH | 15.21 | 26437602 | |
754 | Phosphorylation | FAIFRKEGNFSDLKE EEEEECCCCHHHHHH | 43.44 | - | |
760 | Ubiquitination | EGNFSDLKEKVNAIE CCCHHHHHHHHHHHH | 61.55 | - | |
808 | Phosphorylation | IKQASEQLNSRWIEF HHHHHHHHHHHHHHH | 5.73 | - | |
812 | Phosphorylation | SEQLNSRWIEFCQLL HHHHHHHHHHHHHHH | 8.35 | - | |
819 | Phosphorylation | WIEFCQLLSERLNWL HHHHHHHHHHHHCHH | 1.74 | - | |
831 | Phosphorylation | NWLEYQNNIIAFYNQ CHHHHHHHHHHHHHH | 16.12 | - | |
848 | Ubiquitination | QLEQMTTTAENWLKI HHHHHHHCHHHHHHC | 23.86 | 21906983 | |
881 | Phosphorylation | KDEVNRLSDLQPQIE HHHHHHHHHCHHHHH | 32.79 | - | |
883 | Phosphorylation | EVNRLSDLQPQIERL HHHHHHHCHHHHHHH | 7.81 | - | |
884 | Phosphorylation | VNRLSDLQPQIERLK HHHHHHCHHHHHHHH | 32.61 | - | |
886 | Phosphorylation | RLSDLQPQIERLKIQ HHHHCHHHHHHHHHH | 36.89 | - | |
887 | Phosphorylation | LSDLQPQIERLKIQS HHHCHHHHHHHHHHH | 4.18 | - | |
888 | Phosphorylation | SDLQPQIERLKIQSI HHCHHHHHHHHHHHH | 46.87 | - | |
892 | Phosphorylation | PQIERLKIQSIALKE HHHHHHHHHHHHCHH | 4.62 | - | |
894 | Phosphorylation | IERLKIQSIALKEKG HHHHHHHHHHCHHCC | 17.19 | 18669648 | |
895 | Phosphorylation | ERLKIQSIALKEKGQ HHHHHHHHHCHHCCC | 2.74 | - | |
923 | Phosphorylation | NHFKQVFSDVQAREK HHHHHHHHHHHHHHH | 37.71 | - | |
937 | Phosphorylation | KELQTIFDTLPPMRY HHHHHHHHCCCCHHH | 43.41 | - | |
939 | Phosphorylation | LQTIFDTLPPMRYQE HHHHHHCCCCHHHHH | 4.89 | 23663014 | |
948 | Phosphorylation | PMRYQETMSAIRTWV CHHHHHHHHHHHHHH | 2.22 | 26055452 | |
948 | Phosphorylation | PMRYQETMSAIRTWV CHHHHHHHHHHHHHH | 2.22 | 24719451 | |
951 | Phosphorylation | YQETMSAIRTWVQQS HHHHHHHHHHHHHHC | 2.94 | 25159151 | |
951 | Phosphorylation | YQETMSAIRTWVQQS HHHHHHHHHHHHHHC | 2.94 | 24719451 | |
952 | Phosphorylation | QETMSAIRTWVQQSE HHHHHHHHHHHHHCC | 23.42 | 25159151 | |
952 | Phosphorylation | QETMSAIRTWVQQSE HHHHHHHHHHHHHCC | 23.42 | 24719451 | |
956 | Phosphorylation | SAIRTWVQQSETKLS HHHHHHHHHCCCCCC | 32.42 | 23663014 | |
960 | Phosphorylation | TWVQQSETKLSIPQL HHHHHCCCCCCCCCC | 42.40 | 23663014 | |
960 | Phosphorylation | TWVQQSETKLSIPQL HHHHHCCCCCCCCCC | 42.40 | 18669648 | |
962 | Phosphorylation | VQQSETKLSIPQLSV HHHCCCCCCCCCCCC | 7.97 | 23663014 | |
967 | Phosphorylation | TKLSIPQLSVTDYEI CCCCCCCCCCCCHHH | 3.59 | - | |
971 | Phosphorylation | IPQLSVTDYEIMEQR CCCCCCCCHHHHHHH | 36.59 | - | |
978 | Phosphorylation | DYEIMEQRLGELQAL CHHHHHHHHHHHHHH | 31.21 | - | |
988 | Phosphorylation | ELQALQSSLQEQQSG HHHHHHHHHHHHHCH | 22.55 | - | |
993 | Ubiquitination | QSSLQEQQSGLYYLS HHHHHHHHCHHHHHH | 38.42 | - | |
1012 | Phosphorylation | EMSKKAPSEISRKYQ HHHHHCCHHHHHHHH | 53.04 | 20860994 | |
1015 | Phosphorylation | KKAPSEISRKYQSEF HHCCHHHHHHHHHHH | 20.76 | 20860994 | |
1017 | Acetylation | APSEISRKYQSEFEE CCHHHHHHHHHHHHH | 40.63 | 70063 | |
1027 | Phosphorylation | SEFEEIEGRWKKLSS HHHHHHHHHHHHHHH | 46.54 | 24719451 | |
1033 | Phosphorylation | EGRWKKLSSQLVEHC HHHHHHHHHHHHHHH | 25.56 | 20068231 | |
1042 | Phosphorylation | QLVEHCQKLEEQMNK HHHHHHHHHHHHHHH | 64.36 | - | |
1043 | Phosphorylation | LVEHCQKLEEQMNKL HHHHHHHHHHHHHHH | 3.45 | - | |
1045 | Phosphorylation | EHCQKLEEQMNKLRK HHHHHHHHHHHHHHH | 66.62 | - | |
1046 | Phosphorylation | HCQKLEEQMNKLRKI HHHHHHHHHHHHHHH | 31.23 | - | |
1047 | Phosphorylation | CQKLEEQMNKLRKIQ HHHHHHHHHHHHHHH | 5.59 | - | |
1051 | Phosphorylation | EEQMNKLRKIQNHIQ HHHHHHHHHHHHHHH | 35.32 | - | |
1053 | Phosphorylation | QMNKLRKIQNHIQTL HHHHHHHHHHHHHHH | 3.91 | - | |
1054 | Phosphorylation | MNKLRKIQNHIQTLK HHHHHHHHHHHHHHH | 38.18 | - | |
1075 | Phosphorylation | DVFLKEEWPALGDSE HHHHHHHCCCCCCHH | 5.64 | 24719451 | |
1081 | Phosphorylation | EWPALGDSEILKKQL HCCCCCCHHHHHHHH | 25.41 | 20068231 | |
1082 | Phosphorylation | WPALGDSEILKKQLK CCCCCCHHHHHHHHH | 58.02 | - | |
1096 | Phosphorylation | KQCRLLVSDIQTIQP HHHCHHHHCHHHHCC | 29.03 | 18669648 | |
1127 | Phosphorylation | EPEFASRLETELKEL CHHHHHHHHHHHHHH | 9.89 | - | |
1136 | Phosphorylation | TELKELNTQWDHMCQ HHHHHHHHHHHHHHH | 43.60 | - | |
1140 | Phosphorylation | ELNTQWDHMCQQVYA HHHHHHHHHHHHHHH | 18.89 | 24719451 | |
1150 | Phosphorylation | QQVYARKEALKGGLE HHHHHHHHHHHCCHH | 54.39 | 24719451 | |
1161 | Phosphorylation | GGLEKTVSLQKDLSE CCHHHHHHHCHHHHH | 30.25 | 20068231 | |
1193 | Phosphorylation | EYKTPDELQKAVEEM CCCCHHHHHHHHHHH | 9.14 | 24275569 | |
1196 | Phosphorylation | TPDELQKAVEEMKRA CHHHHHHHHHHHHHH | 10.86 | 24275569 | |
1201 | Acetylation | QKAVEEMKRAKEEAQ HHHHHHHHHHHHHHH | 53.11 | 19824185 | |
1204 | Phosphorylation | VEEMKRAKEEAQQKE HHHHHHHHHHHHHHH | 61.18 | 24719451 | |
1204 | Phosphorylation | VEEMKRAKEEAQQKE HHHHHHHHHHHHHHH | 61.18 | 24719451 | |
1206 | Phosphorylation | EMKRAKEEAQQKEAK HHHHHHHHHHHHHHH | 51.58 | 24275569 | |
1209 | Phosphorylation | RAKEEAQQKEAKVKL HHHHHHHHHHHHHHH | 53.24 | 24275569 | |
1217 | Phosphorylation | KEAKVKLLTESVNSV HHHHHHHHHHHHHHH | 4.07 | 24719451 | |
1217 | Phosphorylation | KEAKVKLLTESVNSV HHHHHHHHHHHHHHH | 4.07 | 27251275 | |
1218 | Phosphorylation | EAKVKLLTESVNSVI HHHHHHHHHHHHHHH | 36.33 | 25841592 | |
1221 | Phosphorylation | VKLLTESVNSVIAQA HHHHHHHHHHHHHHC | 5.15 | 28102081 | |
1224 | Phosphorylation | LTESVNSVIAQAPPV HHHHHHHHHHHCCHH | 3.38 | 20068231 | |
1224 | Phosphorylation | LTESVNSVIAQAPPV HHHHHHHHHHHCCHH | 3.38 | 24719451 | |
1231 | Phosphorylation | VIAQAPPVAQEALKK HHHHCCHHHHHHHHH | 9.28 | 25841592 | |
1234 | Phosphorylation | QAPPVAQEALKKELE HCCHHHHHHHHHHHH | 46.35 | 28102081 | |
1237 | Phosphorylation | PVAQEALKKELETLT HHHHHHHHHHHHHHH | 51.77 | 20068231 | |
1237 | Phosphorylation | PVAQEALKKELETLT HHHHHHHHHHHHHHH | 51.77 | 27251275 | |
1273 | Phosphorylation | ACWHELLSYLEKANK HHHHHHHHHHHHHCH | 40.05 | 24719451 | |
1288 | Ubiquitination | WLNEVEFKLKTTENI HHHHCCCEEECCCCC | 35.25 | - | |
1415 | Phosphorylation | QEAQKIQSDLTSHEI HHHHHHHHHHHHCCC | 37.75 | 28270605 | |
1418 | Phosphorylation | QKIQSDLTSHEISLE HHHHHHHHHCCCCHH | 32.78 | 28270605 | |
1419 | Phosphorylation | KIQSDLTSHEISLEE HHHHHHHHCCCCHHH | 26.81 | 28270605 | |
1423 | Phosphorylation | DLTSHEISLEEMKKH HHHHCCCCHHHHHHH | 27.09 | 28270605 | |
1442 | Phosphorylation | EAAQRVLSQIDVAQK HHHHHHHHHHHHHHH | 23.41 | 26657352 | |
1455 | O-linked_Glycosylation | QKKLQDVSMKFRLFQ HHHHHHHHHHHHHHC | 25.25 | 30379171 | |
1455 | Phosphorylation | QKKLQDVSMKFRLFQ HHHHHHHHHHHHHHC | 25.25 | - | |
1509 | Phosphorylation | LNHCVNLYKSLSEVK HHHHHHHHHHHHHHH | 8.04 | - | |
1517 | Phosphorylation | KSLSEVKSEVEMVIK HHHHHHHHHHHHHHH | 52.64 | - | |
1525 | Phosphorylation | EVEMVIKTGRQIVQK HHHHHHHHHHHHHHH | 26.86 | - | |
1552 | Phosphorylation | VTALKLHYNELGAKV HHHHHHHHHHHCHHH | 22.29 | - | |
1590 | Phosphorylation | LTEWLAATDMELTKR HHHHHHHCCHHHHHH | 30.21 | 16094384 | |
1592 | Ubiquitination | EWLAATDMELTKRSA HHHHHCCHHHHHHHH | 3.85 | - | |
1598 | O-linked_Glycosylation | DMELTKRSAVEGMPS CHHHHHHHHHCCCCC | 37.92 | 30379171 | |
1611 | Ubiquitination | PSNLDSEVAWGKATQ CCCCHHHHHHCHHHH | 6.68 | - | |
1640 | Ubiquitination | EVGEALKTVLGKKET HHHHHHHHHHCCCCC | 23.08 | - | |
1641 | Ubiquitination | VGEALKTVLGKKETL HHHHHHHHHCCCCCH | 6.75 | - | |
1643 | Phosphorylation | EALKTVLGKKETLVE HHHHHHHCCCCCHHH | 34.35 | - | |
1644 | Ubiquitination | ALKTVLGKKETLVED HHHHHHCCCCCHHHH | 43.19 | - | |
1645 | Ubiquitination | LKTVLGKKETLVEDK HHHHHCCCCCHHHHH | 54.88 | - | |
1647 | Phosphorylation | TVLGKKETLVEDKLS HHHCCCCCHHHHHHH | 45.01 | 20068231 | |
1654 | Phosphorylation | TLVEDKLSLLNSNWI CHHHHHHHHHHCCEE | 36.23 | 20068231 | |
1658 | Phosphorylation | DKLSLLNSNWIAVTS HHHHHHHCCEEEEHH | 33.25 | 20068231 | |
1664 | Phosphorylation | NSNWIAVTSRAEEWL HCCEEEEHHCHHHHH | 11.95 | 20068231 | |
1665 | Phosphorylation | SNWIAVTSRAEEWLN CCEEEEHHCHHHHHH | 23.93 | 20068231 | |
1768 | Phosphorylation | NHRFAAISHRIKTGK HHHHHHHHHHHHCCC | 11.28 | 26437602 | |
1856 | Phosphorylation | IKQQLLQTKHNALKD HHHHHHHHHHHHHHH | 33.95 | 20068231 | |
1911 | Acetylation | PEPRDERKIKEIDRE CCCCCHHHHHHHHHH | 56.96 | 7640467 | |
1921 | 2-Hydroxyisobutyrylation | EIDRELQKKKEELNA HHHHHHHHHHHHHHH | 77.70 | - | |
1937 | Phosphorylation | RRQAEGLSEDGAAMA HHHHCCCCCCCCEEC | 44.49 | 24505115 | |
1953 | Phosphorylation | EPTQIQLSKRWREIE CCCHHHHHHHHHHHH | 12.09 | 24505115 | |
1964 (in isoform 3) | Ubiquitination | - | 16.02 | 21890473 | |
1967 (in isoform 2) | Ubiquitination | - | 30.05 | 21890473 | |
2037 | Phosphorylation | DLFKQEESLKNIKDS HHHHCHHHHHHHHHH | 43.84 | 27251275 | |
2060 | Phosphorylation | DIIHSKKTAALQSAT EEECCCCHHHCCCCC | 22.39 | - | |
2065 | Phosphorylation | KKTAALQSATPVERV CCHHHCCCCCCHHHH | 34.65 | 24719451 | |
2067 | Phosphorylation | TAALQSATPVERVKL HHHCCCCCCHHHHHH | 32.87 | 24719451 | |
2079 | Phosphorylation | VKLQEALSQLDFQWE HHHHHHHHHCCCCHH | 35.43 | 20068231 | |
2157 | Phosphorylation | DGIGQRQTVVRTLNA CCCCCHHHHHHHHCC | 24.13 | 24719451 | |
2176 | Phosphorylation | IIQQSSKTDASILQE HHHHCCCCCHHHHHH | 38.45 | 23898821 | |
2179 | Phosphorylation | QSSKTDASILQEKLG HCCCCCHHHHHHHHC | 27.00 | 23532336 | |
2200 | Phosphorylation | QEVCKQLSDRKKRLE HHHHHHHHHHHHHHH | 32.64 | 20068231 | |
2219 (in isoform 3) | Ubiquitination | - | 42.96 | 21890473 | |
2222 (in isoform 2) | Ubiquitination | - | 44.42 | 21890473 | |
2280 | Phosphorylation | TGGPVLVSAPISPEE CCCCEEEECCCCHHH | 24.94 | 20068231 | |
2284 | Phosphorylation | VLVSAPISPEEQDKL EEEECCCCHHHHHHH | 25.79 | 22468782 | |
2306 | Phosphorylation | NLQWIKVSRALPEKQ CCHHHHHHHCCCCCC | 13.56 | - | |
2432 | Phosphorylation | PDLAPGLTTIGASPT CCCCCCCCCCCCCCC | 23.45 | 28348404 | |
2433 | Phosphorylation | DLAPGLTTIGASPTQ CCCCCCCCCCCCCCC | 23.58 | 28348404 | |
2437 | Phosphorylation | GLTTIGASPTQTVTL CCCCCCCCCCCEEEE | 24.22 | 28348404 | |
2439 | Phosphorylation | TTIGASPTQTVTLVT CCCCCCCCCEEEEEE | 34.08 | 26657352 | |
2441 | Phosphorylation | IGASPTQTVTLVTQP CCCCCCCEEEEEECC | 20.24 | 26657352 | |
2463 | Phosphorylation | ISKLEMPSSLMLEVP HHCCCCCCCCCCCCH | 34.49 | 28258704 | |
2464 | Phosphorylation | SKLEMPSSLMLEVPA HCCCCCCCCCCCCHH | 16.36 | 28258704 | |
2541 | Phosphorylation | AQNLKNKTSNQEART HHHHCCCCCCHHHHH | 42.16 | 24719451 | |
2542 | Phosphorylation | QNLKNKTSNQEARTI HHHCCCCCCHHHHHH | 37.82 | 24719451 | |
2548 | Phosphorylation | TSNQEARTIITDRIE CCCHHHHHHHHHHHH | 24.63 | 26270265 | |
2551 | Phosphorylation | QEARTIITDRIERIQ HHHHHHHHHHHHHHH | 18.51 | 26270265 | |
2651 | Phosphorylation | ALKLLRDYSADDTRK HHHHHHHCCCCCCCH | 10.18 | - | |
2652 | Phosphorylation | LKLLRDYSADDTRKV HHHHHHCCCCCCCHH | 29.52 | 26029660 | |
2656 | Phosphorylation | RDYSADDTRKVHMIT HHCCCCCCCHHEHHH | 32.70 | 26029660 | |
2663 | Phosphorylation | TRKVHMITENINASW CCHHEHHHCCCCHHH | 18.53 | 24719451 | |
2665 | Phosphorylation | KVHMITENINASWRS HHEHHHCCCCHHHHH | 24.94 | - | |
2668 | Phosphorylation | MITENINASWRSIHK HHHCCCCHHHHHHHH | 13.48 | - | |
2669 | Phosphorylation | ITENINASWRSIHKR HHCCCCHHHHHHHHH | 20.66 | 20068231 | |
2672 | Phosphorylation | NINASWRSIHKRVSE CCCHHHHHHHHHHHH | 23.84 | 20068231 | |
2728 | Phosphorylation | KERLLEDSKGVKELM HHHHHHCCHHHHHHH | 23.18 | 26657352 | |
2765 | Phosphorylation | NSQKILRSLEGSDDA HHHHHHHHCCCCCHH | 27.59 | 28270605 | |
2769 | Phosphorylation | ILRSLEGSDDAVLLQ HHHHCCCCCHHHHHH | 23.96 | 28270605 | |
2808 | Acetylation | EASSDQWKRLHLSLQ HCCCHHHHHHHHHHH | 39.18 | 30585699 | |
2864 | Phosphorylation | TKEPVIMSTLETVRI CCCCCHHHCHHHHHH | 20.79 | 25599653 | |
2865 | Phosphorylation | KEPVIMSTLETVRIF CCCCHHHCHHHHHHH | 15.95 | 25599653 | |
2868 | Phosphorylation | VIMSTLETVRIFLTE CHHHCHHHHHHHHCC | 20.42 | 25599653 | |
2885 | Phosphorylation | LEGLEKLYQEPRELP CHHHHHHHCCCCCCC | 23.15 | - | |
2913 | Phosphorylation | KQAEEVNTEWEKLNL HHHHHHCCHHHHHCC | 47.88 | 20873877 | |
2922 | Phosphorylation | WEKLNLHSADWQRKI HHHHCCCCHHHHHHH | 30.96 | 20873877 | |
2993 | Phosphorylation | APLKENVSHVNDLAR CCCCCCHHHHHHHHH | 33.04 | 26437602 | |
3066 | Phosphorylation | GPWERAISPNKVPYY CCHHHCCCCCCCCEE | 22.80 | - | |
3081 | Phosphorylation | INHETQTTCWDHPKM EECCCCCCCCCCHHH | 11.20 | - | |
3094 | Phosphorylation | KMTELYQSLADLNNV HHHHHHHHHHHHCCC | 16.39 | 28857561 | |
3104 | Phosphorylation | DLNNVRFSAYRTAMK HHCCCHHHHHHHHHH | 17.52 | 24719451 | |
3198 | Phosphorylation | TGRIRVLSFKTGIIS CCCEEEEEECCCHHH | 23.11 | 24719451 | |
3287 | Phosphorylation | LFLDWMRLEPQSMVW HHHHHHCCCCCHHCH | 6.96 | - | |
3291 | Phosphorylation | WMRLEPQSMVWLPVL HHCCCCCHHCHHHHH | 26.47 | 20068231 | |
3300 (in isoform 4) | Ubiquitination | - | 18.66 | 21890473 | |
3308 | Ubiquitination | VAAAETAKHQAKCNI HHHHHHHHHHHHCCC | 43.60 | 21890473 | |
3308 (in isoform 1) | Ubiquitination | - | 43.60 | 21890473 | |
3312 | Ubiquitination | ETAKHQAKCNICKEC HHHHHHHHCCCCCCC | 22.65 | - | |
3317 | Ubiquitination | QAKCNICKECPIIGF HHHCCCCCCCCCCCE | 59.56 | - | |
3351 | Ubiquitination | GRVAKGHKMHYPMVE CCCCCCCCCCCCCEE | 35.72 | - | |
3354 | Phosphorylation | AKGHKMHYPMVEYCT CCCCCCCCCCEEECC | 6.90 | - | |
3359 | Phosphorylation | MHYPMVEYCTPTTSG CCCCCEEECCCCCCC | 7.10 | - | |
3361 | Phosphorylation | YPMVEYCTPTTSGED CCCEEECCCCCCCHH | 23.83 | 25159151 | |
3374 | Ubiquitination | EDVRDFAKVLKNKFR HHHHHHHHHHHHHHH | 48.36 | - | |
3390 | Phosphorylation | KRYFAKHPRMGYLPV CCHHCCCCCCCCCCC | 27.52 | - | |
3394 | Phosphorylation | AKHPRMGYLPVQTVL CCCCCCCCCCCEECE | 9.86 | 20068231 | |
3399 | Phosphorylation | MGYLPVQTVLEGDNM CCCCCCEECEECCCC | 27.56 | 18669648 | |
3408 | Phosphorylation | LEGDNMETPVTLINF EECCCCCCCEEEEEE | 16.58 | 18669648 | |
3411 | Phosphorylation | DNMETPVTLINFWPV CCCCCCEEEEEEEEC | 24.11 | 28348404 | |
3416 | Phosphorylation | PVTLINFWPVDSAPA CEEEEEEEECCCCCC | 6.37 | - | |
3420 | Phosphorylation | INFWPVDSAPASSPQ EEEEECCCCCCCCCC | 36.06 | 20068231 | |
3421 | Phosphorylation | NFWPVDSAPASSPQL EEEECCCCCCCCCCC | 10.14 | - | |
3424 | Phosphorylation | PVDSAPASSPQLSHD ECCCCCCCCCCCCCC | 41.30 | 18669648 | |
3425 | Phosphorylation | VDSAPASSPQLSHDD CCCCCCCCCCCCCCC | 20.83 | 18669648 | |
3429 | Phosphorylation | PASSPQLSHDDTHSR CCCCCCCCCCCHHHH | 21.44 | 23663014 | |
3433 | Phosphorylation | PQLSHDDTHSRIEHY CCCCCCCHHHHHHHH | 28.01 | 18669648 | |
3435 | Phosphorylation | LSHDDTHSRIEHYAS CCCCCHHHHHHHHHH | 36.73 | 23663014 | |
3440 | Phosphorylation | THSRIEHYASRLAEM HHHHHHHHHHHHHHH | 8.09 | 30576142 | |
3442 | Phosphorylation | SRIEHYASRLAEMEN HHHHHHHHHHHHHHC | 22.21 | 26437602 | |
3464 | Phosphorylation | DSISPNESIDDEHLL CCCCCCCCCCCHHHH | 37.65 | 22210691 | |
3478 | Phosphorylation | LIQHYCQSLNQDSPL HHHHHHHHCCCCCCC | 26.23 | 22210691 | |
3479 | Phosphorylation | IQHYCQSLNQDSPLS HHHHHHHCCCCCCCC | 2.48 | - | |
3483 | Phosphorylation | CQSLNQDSPLSQPRS HHHCCCCCCCCCCCC | 20.27 | 26657352 | |
3486 | Phosphorylation | LNQDSPLSQPRSPAQ CCCCCCCCCCCCHHH | 41.33 | 24719451 | |
3490 | Phosphorylation | SPLSQPRSPAQILIS CCCCCCCCHHHEEEE | 31.13 | 26055452 | |
3497 | Phosphorylation | SPAQILISLESEERG CHHHEEEEECHHHCC | 23.73 | 26471730 | |
3500 | Phosphorylation | QILISLESEERGELE HEEEEECHHHCCHHH | 50.48 | 18669648 | |
3524 | Phosphorylation | NRNLQAEYDRLKQQH HHHHHHHHHHHHHHH | 14.91 | 28674419 | |
3533 | Phosphorylation | RLKQQHEHKGLSPLP HHHHHHHCCCCCCCC | 27.62 | - | |
3537 | Phosphorylation | QHEHKGLSPLPSPPE HHHCCCCCCCCCCCC | 32.81 | 26055452 | |
3541 | Phosphorylation | KGLSPLPSPPEMMPT CCCCCCCCCCCCCCC | 61.85 | 26055452 | |
3544 | Phosphorylation | SPLPSPPEMMPTSPQ CCCCCCCCCCCCCCC | 52.04 | - | |
3548 | Phosphorylation | SPPEMMPTSPQSPRD CCCCCCCCCCCCHHH | 34.83 | 25159151 | |
3549 | Phosphorylation | PPEMMPTSPQSPRDA CCCCCCCCCCCHHHH | 18.31 | 20201521 | |
3552 | Phosphorylation | MMPTSPQSPRDAELI CCCCCCCCHHHHHHH | 25.86 | 25159151 | |
3555 (in isoform 4) | Ubiquitination | - | 48.02 | 21890473 | |
3563 | Ubiquitination | AELIAEAKLLRQHKG HHHHHHHHHHHHCCC | 39.29 | 21890473 | |
3563 (in isoform 1) | Ubiquitination | - | 39.29 | 21890473 | |
3608 | Phosphorylation | QAEAKVNGTTVSSPS CCHHHCCCEECCCCC | 26.25 | - | |
3609 | Phosphorylation | AEAKVNGTTVSSPST CHHHCCCEECCCCCC | 20.86 | 29255136 | |
3610 | Phosphorylation | EAKVNGTTVSSPSTS HHHCCCEECCCCCCC | 21.57 | 29255136 | |
3611 | Phosphorylation | AKVNGTTVSSPSTSL HHCCCEECCCCCCCC | 5.53 | - | |
3612 | Phosphorylation | KVNGTTVSSPSTSLQ HCCCEECCCCCCCCC | 34.14 | 29255136 | |
3613 | Phosphorylation | VNGTTVSSPSTSLQR CCCEECCCCCCCCCC | 20.66 | 29255136 | |
3615 | Phosphorylation | GTTVSSPSTSLQRSD CEECCCCCCCCCCCC | 32.35 | 29255136 | |
3616 | Phosphorylation | TTVSSPSTSLQRSDS EECCCCCCCCCCCCC | 36.52 | 29255136 | |
3617 | Phosphorylation | TVSSPSTSLQRSDSS ECCCCCCCCCCCCCC | 27.17 | 29255136 | |
3619 | Phosphorylation | SSPSTSLQRSDSSQP CCCCCCCCCCCCCCC | 42.47 | - | |
3620 | Phosphorylation | SPSTSLQRSDSSQPM CCCCCCCCCCCCCCE | 47.96 | - | |
3621 | Phosphorylation | PSTSLQRSDSSQPML CCCCCCCCCCCCCEE | 28.96 | 29255136 | |
3623 | Phosphorylation | TSLQRSDSSQPMLLR CCCCCCCCCCCEEEE | 31.92 | 29255136 | |
3624 | Phosphorylation | SLQRSDSSQPMLLRV CCCCCCCCCCEEEEE | 43.20 | 29255136 | |
3634 | Phosphorylation | MLLRVVGSQTSDSMG EEEEECCCCCCCCCC | 20.76 | 24275569 | |
3636 | Phosphorylation | LRVVGSQTSDSMGEE EEECCCCCCCCCCCC | 35.88 | 24275569 | |
3637 | Phosphorylation | RVVGSQTSDSMGEED EECCCCCCCCCCCCC | 21.76 | 21601212 | |
3639 | Phosphorylation | VGSQTSDSMGEEDLL CCCCCCCCCCCCCCC | 28.58 | 24275569 | |
3647 | Phosphorylation | MGEEDLLSPPQDTST CCCCCCCCCCCCCCC | 41.66 | 28348404 | |
3648 | Phosphorylation | GEEDLLSPPQDTSTG CCCCCCCCCCCCCCC | 30.46 | - | |
3652 | Phosphorylation | LLSPPQDTSTGLEEV CCCCCCCCCCCHHHH | 23.96 | 18669648 | |
3653 | Phosphorylation | LSPPQDTSTGLEEVM CCCCCCCCCCHHHHH | 28.85 | 24275569 | |
3662 | Phosphorylation | GLEEVMEQLNNSFPS CHHHHHHHHHHCCCC | 31.25 | - | |
3666 | Phosphorylation | VMEQLNNSFPSSRGR HHHHHHHCCCCCCCC | 37.14 | 1319059 | |
3670 | Phosphorylation | LNNSFPSSRGRNTPG HHHCCCCCCCCCCCC | 38.70 | 24275569 | |
3675 | Phosphorylation | PSSRGRNTPGKPMRE CCCCCCCCCCCCCCC | 31.86 | 21712546 | |
3684 | Phosphorylation | GKPMREDTM------ CCCCCCCCC------ | 21.74 | 21712546 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DMD_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DMD_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DMD_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
H00294 | Dilated cardiomyopathy (DCM) | |||||
H00552 | Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; X | |||||
H00562 | Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X | |||||
OMIM Disease | ||||||
310200 | Duchenne muscular dystrophy (DMD) | |||||
300376 | Becker muscular dystrophy (BMD) | |||||
302045 | Cardiomyopathy, dilated, X-linked 3B (CMD3B) | |||||
Kegg Drug | ||||||
D09900 | Eteplirsen (USAN/INN) | |||||
D10114 | Drisapersen (USAN) | |||||
D10115 | Drisapersen sodium (USAN) | |||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3616 AND SER-3623, ANDMASS SPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3483; SER-3613;SER-3617; SER-3623; THR-3652 AND SER-3666, AND MASS SPECTROMETRY. | |
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3613, AND MASSSPECTROMETRY. | |
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3621 AND SER-3623, ANDMASS SPECTROMETRY. | |
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry."; Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.; Nat. Methods 2:591-598(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1590, AND MASSSPECTROMETRY. |