DMD_HUMAN - dbPTM
DMD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DMD_HUMAN
UniProt AC P11532
Protein Name Dystrophin
Gene Name DMD
Organism Homo sapiens (Human).
Sequence Length 3685
Subcellular Localization Cell membrane, sarcolemma
Peripheral membrane protein
Cytoplasmic side . Cytoplasm, cytoskeleton . Cell junction, synapse, postsynaptic cell membrane . In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to
Protein Description Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission..
Protein Sequence MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
6 (in isoform 10)Ubiquitination-37.17-
19AcetylationEREDVQKKTFTKWVN
CCCHHHHHHHHHHHH
31.607822169
81PhosphorylationLNNVNKALRVLQNNN
HHHHHHHHHHHHHCC
4.0924719451
82PhosphorylationNNVNKALRVLQNNNV
HHHHHHHHHHHHCCC
31.7724719451
209PhosphorylationIARYQLGIEKLLDPE
HHHHHHCHHHHCCHH
6.00-
212PhosphorylationYQLGIEKLLDPEDVD
HHHCHHHHCCHHHCC
4.21-
225AcetylationVDTTYPDKKSILMYI
CCCCCCCHHHHHHHH
43.877668191
240 (in isoform 5)Ubiquitination-24.5721890473
240UbiquitinationTSLFQVLPQQVSIEA
HHHHHHCCCCCCHHH
24.5721890473
240UbiquitinationTSLFQVLPQQVSIEA
HHHHHHCCCCCCHHH
24.5721890473
255 (in isoform 2)Ubiquitination-45.48-
274 (in isoform 2)Ubiquitination-11.66-
289PhosphorylationLAQGYERTSSPKPRF
HHHCCCCCCCCCCCC
22.93-
290PhosphorylationAQGYERTSSPKPRFK
HHCCCCCCCCCCCCC
51.3629396449
291PhosphorylationQGYERTSSPKPRFKS
HCCCCCCCCCCCCCC
36.0129396449
299PhosphorylationPKPRFKSYAYTQAAY
CCCCCCCCEEEEEEE
12.2925307156
302PhosphorylationRFKSYAYTQAAYVTT
CCCCCEEEEEEEEEC
11.9925307156
306PhosphorylationYAYTQAAYVTTSDPT
CEEEEEEEEECCCCC
11.0125307156
313PhosphorylationYVTTSDPTRSPFPSQ
EEECCCCCCCCCCCC
49.09-
319PhosphorylationPTRSPFPSQHLEAPE
CCCCCCCCCCCCCCC
30.5226657352
331 (in isoform 5)Phosphorylation-24.3423663014
331 (in isoform 8)Phosphorylation-24.3423663014
340 (in isoform 5)Phosphorylation-31.9726055452
340 (in isoform 8)Phosphorylation-31.9726055452
343 (in isoform 5)Phosphorylation-28.7325159151
343 (in isoform 8)Phosphorylation-28.7325159151
344 (in isoform 5)Phosphorylation-15.1925159151
344 (in isoform 8)Phosphorylation-15.1925159151
348 (in isoform 5)Phosphorylation-7.0023663014
348 (in isoform 8)Phosphorylation-7.0023663014
352 (in isoform 5)Phosphorylation-3.2623663014
352 (in isoform 8)Phosphorylation-3.2623663014
354 (in isoform 5)Phosphorylation-9.3623663014
354 (in isoform 8)Phosphorylation-9.3623663014
357PhosphorylationEVLSWLLSAEDTLQA
HHHHHHHCHHHHHHH
27.6920068231
390PhosphorylationEGYMMDLTAHQGRVG
CCCEEECCCCCCCCH
20.16-
404PhosphorylationGNILQLGSKLIGTGK
HHHHHHCCCEECCCC
32.6429396449
467PhosphorylationLNDWLTKTEERTRKM
HHHHHHHHHHHHHHH
37.5318669648
482 (in isoform 5)Ubiquitination-61.9721890473
482UbiquitinationEEEPLGPDLEDLKRQ
HCCCCCCCHHHHHHH
61.9721890473
487AcetylationGPDLEDLKRQVQQHK
CCCHHHHHHHHHHHH
53.787683599
488 (in isoform 9)Phosphorylation-49.5624275569
491 (in isoform 9)Phosphorylation-31.1824275569
495UbiquitinationRQVQQHKVLQEDLEQ
HHHHHHHHHHHHHHH
6.6421890473
499 (in isoform 9)Phosphorylation-42.4124719451
513 (in isoform 9)Phosphorylation-1.7425841592
516 (in isoform 9)Phosphorylation-2.8228102081
519 (in isoform 9)Phosphorylation-34.8820068231
562PhosphorylationQDILLKWQRLTEEQC
HHHHHHHHHCCHHHH
28.99-
585 (in isoform 5)Phosphorylation-2.6924275569
588 (in isoform 5)Phosphorylation-26.8524275569
596 (in isoform 5)Phosphorylation-6.0424719451
598PhosphorylationKDQNEMLSSLQKLAV
CCHHHHHHHHHHHHH
27.9118669648
598 (in isoform 6)Phosphorylation-27.9124275569
601 (in isoform 6)Phosphorylation-40.4424275569
609 (in isoform 6)Phosphorylation-54.4924719451
610 (in isoform 5)Phosphorylation-14.3725841592
613 (in isoform 5)Phosphorylation-46.8228102081
614UbiquitinationKADLEKKKQSMGKLY
HHHHHHHHHHHHHHH
59.69-
616PhosphorylationDLEKKKQSMGKLYSL
HHHHHHHHHHHHHHH
38.08-
616 (in isoform 5)Phosphorylation-38.0820068231
622PhosphorylationQSMGKLYSLKQDLLS
HHHHHHHHHHHHHHH
39.2624719451
623 (in isoform 6)Phosphorylation-3.5025841592
626 (in isoform 6)Phosphorylation-48.2528102081
629PhosphorylationSLKQDLLSTLKNKSV
HHHHHHHHHHCCCCC
38.7028258704
629 (in isoform 6)Phosphorylation-38.7020068231
630PhosphorylationLKQDLLSTLKNKSVT
HHHHHHHHHCCCCCC
41.5428258704
644PhosphorylationTQKTEAWLDNFARCW
CHHHHHHHHHHHHHH
5.0724719451
661PhosphorylationLVQKLEKSTAQISQA
HHHHHHHHHHHHHHH
21.4320068231
662PhosphorylationVQKLEKSTAQISQAV
HHHHHHHHHHHHHHH
33.3820068231
665PhosphorylationLEKSTAQISQAVTTT
HHHHHHHHHHHHHCC
2.82-
666PhosphorylationEKSTAQISQAVTTTQ
HHHHHHHHHHHHCCC
10.4520068231
668PhosphorylationSTAQISQAVTTTQPS
HHHHHHHHHHCCCCC
8.20-
670PhosphorylationAQISQAVTTTQPSLT
HHHHHHHHCCCCCCC
27.4320068231
671PhosphorylationQISQAVTTTQPSLTQ
HHHHHHHCCCCCCCC
19.4820068231
672PhosphorylationISQAVTTTQPSLTQT
HHHHHHCCCCCCCCC
29.1720068231
675PhosphorylationAVTTTQPSLTQTTVM
HHHCCCCCCCCCCCE
33.9420068231
677PhosphorylationTTTQPSLTQTTVMET
HCCCCCCCCCCCEEE
28.3620068231
679PhosphorylationTQPSLTQTTVMETVT
CCCCCCCCCCEEEEE
19.0020068231
680PhosphorylationQPSLTQTTVMETVTT
CCCCCCCCCEEEEEE
14.1920068231
684PhosphorylationTQTTVMETVTTVTTR
CCCCCEEEEEECCCH
12.6920068231
686PhosphorylationTTVMETVTTVTTREQ
CCCEEEEEECCCHHH
23.9820068231
687PhosphorylationTVMETVTTVTTREQI
CCEEEEEECCCHHHH
16.1220068231
689PhosphorylationMETVTTVTTREQILV
EEEEEECCCHHHHHH
20.3120068231
690PhosphorylationETVTTVTTREQILVK
EEEEECCCHHHHHHH
28.0720068231
691PhosphorylationTVTTVTTREQILVKH
EEEECCCHHHHHHHH
25.18-
696PhosphorylationTTREQILVKHAQEEL
CCHHHHHHHHHHHCC
4.57-
700PhosphorylationQILVKHAQEELPPPP
HHHHHHHHHCCCCCC
44.40-
715PhosphorylationPQKKRQITVDSEIRK
CCCCCCEECCHHHHH
15.2126437602
754PhosphorylationFAIFRKEGNFSDLKE
EEEEECCCCHHHHHH
43.44-
760UbiquitinationEGNFSDLKEKVNAIE
CCCHHHHHHHHHHHH
61.55-
808PhosphorylationIKQASEQLNSRWIEF
HHHHHHHHHHHHHHH
5.73-
812PhosphorylationSEQLNSRWIEFCQLL
HHHHHHHHHHHHHHH
8.35-
819PhosphorylationWIEFCQLLSERLNWL
HHHHHHHHHHHHCHH
1.74-
831PhosphorylationNWLEYQNNIIAFYNQ
CHHHHHHHHHHHHHH
16.12-
848UbiquitinationQLEQMTTTAENWLKI
HHHHHHHCHHHHHHC
23.8621906983
881PhosphorylationKDEVNRLSDLQPQIE
HHHHHHHHHCHHHHH
32.79-
883PhosphorylationEVNRLSDLQPQIERL
HHHHHHHCHHHHHHH
7.81-
884PhosphorylationVNRLSDLQPQIERLK
HHHHHHCHHHHHHHH
32.61-
886PhosphorylationRLSDLQPQIERLKIQ
HHHHCHHHHHHHHHH
36.89-
887PhosphorylationLSDLQPQIERLKIQS
HHHCHHHHHHHHHHH
4.18-
888PhosphorylationSDLQPQIERLKIQSI
HHCHHHHHHHHHHHH
46.87-
892PhosphorylationPQIERLKIQSIALKE
HHHHHHHHHHHHCHH
4.62-
894PhosphorylationIERLKIQSIALKEKG
HHHHHHHHHHCHHCC
17.1918669648
895PhosphorylationERLKIQSIALKEKGQ
HHHHHHHHHCHHCCC
2.74-
923PhosphorylationNHFKQVFSDVQAREK
HHHHHHHHHHHHHHH
37.71-
937PhosphorylationKELQTIFDTLPPMRY
HHHHHHHHCCCCHHH
43.41-
939PhosphorylationLQTIFDTLPPMRYQE
HHHHHHCCCCHHHHH
4.8923663014
948PhosphorylationPMRYQETMSAIRTWV
CHHHHHHHHHHHHHH
2.2226055452
948PhosphorylationPMRYQETMSAIRTWV
CHHHHHHHHHHHHHH
2.2224719451
951PhosphorylationYQETMSAIRTWVQQS
HHHHHHHHHHHHHHC
2.9425159151
951PhosphorylationYQETMSAIRTWVQQS
HHHHHHHHHHHHHHC
2.9424719451
952PhosphorylationQETMSAIRTWVQQSE
HHHHHHHHHHHHHCC
23.4225159151
952PhosphorylationQETMSAIRTWVQQSE
HHHHHHHHHHHHHCC
23.4224719451
956PhosphorylationSAIRTWVQQSETKLS
HHHHHHHHHCCCCCC
32.4223663014
960PhosphorylationTWVQQSETKLSIPQL
HHHHHCCCCCCCCCC
42.4023663014
960PhosphorylationTWVQQSETKLSIPQL
HHHHHCCCCCCCCCC
42.4018669648
962PhosphorylationVQQSETKLSIPQLSV
HHHCCCCCCCCCCCC
7.9723663014
967PhosphorylationTKLSIPQLSVTDYEI
CCCCCCCCCCCCHHH
3.59-
971PhosphorylationIPQLSVTDYEIMEQR
CCCCCCCCHHHHHHH
36.59-
978PhosphorylationDYEIMEQRLGELQAL
CHHHHHHHHHHHHHH
31.21-
988PhosphorylationELQALQSSLQEQQSG
HHHHHHHHHHHHHCH
22.55-
993UbiquitinationQSSLQEQQSGLYYLS
HHHHHHHHCHHHHHH
38.42-
1012PhosphorylationEMSKKAPSEISRKYQ
HHHHHCCHHHHHHHH
53.0420860994
1015PhosphorylationKKAPSEISRKYQSEF
HHCCHHHHHHHHHHH
20.7620860994
1017AcetylationAPSEISRKYQSEFEE
CCHHHHHHHHHHHHH
40.6370063
1027PhosphorylationSEFEEIEGRWKKLSS
HHHHHHHHHHHHHHH
46.5424719451
1033PhosphorylationEGRWKKLSSQLVEHC
HHHHHHHHHHHHHHH
25.5620068231
1042PhosphorylationQLVEHCQKLEEQMNK
HHHHHHHHHHHHHHH
64.36-
1043PhosphorylationLVEHCQKLEEQMNKL
HHHHHHHHHHHHHHH
3.45-
1045PhosphorylationEHCQKLEEQMNKLRK
HHHHHHHHHHHHHHH
66.62-
1046PhosphorylationHCQKLEEQMNKLRKI
HHHHHHHHHHHHHHH
31.23-
1047PhosphorylationCQKLEEQMNKLRKIQ
HHHHHHHHHHHHHHH
5.59-
1051PhosphorylationEEQMNKLRKIQNHIQ
HHHHHHHHHHHHHHH
35.32-
1053PhosphorylationQMNKLRKIQNHIQTL
HHHHHHHHHHHHHHH
3.91-
1054PhosphorylationMNKLRKIQNHIQTLK
HHHHHHHHHHHHHHH
38.18-
1075PhosphorylationDVFLKEEWPALGDSE
HHHHHHHCCCCCCHH
5.6424719451
1081PhosphorylationEWPALGDSEILKKQL
HCCCCCCHHHHHHHH
25.4120068231
1082PhosphorylationWPALGDSEILKKQLK
CCCCCCHHHHHHHHH
58.02-
1096PhosphorylationKQCRLLVSDIQTIQP
HHHCHHHHCHHHHCC
29.0318669648
1127PhosphorylationEPEFASRLETELKEL
CHHHHHHHHHHHHHH
9.89-
1136PhosphorylationTELKELNTQWDHMCQ
HHHHHHHHHHHHHHH
43.60-
1140PhosphorylationELNTQWDHMCQQVYA
HHHHHHHHHHHHHHH
18.8924719451
1150PhosphorylationQQVYARKEALKGGLE
HHHHHHHHHHHCCHH
54.3924719451
1161PhosphorylationGGLEKTVSLQKDLSE
CCHHHHHHHCHHHHH
30.2520068231
1193PhosphorylationEYKTPDELQKAVEEM
CCCCHHHHHHHHHHH
9.1424275569
1196PhosphorylationTPDELQKAVEEMKRA
CHHHHHHHHHHHHHH
10.8624275569
1201AcetylationQKAVEEMKRAKEEAQ
HHHHHHHHHHHHHHH
53.1119824185
1204PhosphorylationVEEMKRAKEEAQQKE
HHHHHHHHHHHHHHH
61.1824719451
1204PhosphorylationVEEMKRAKEEAQQKE
HHHHHHHHHHHHHHH
61.1824719451
1206PhosphorylationEMKRAKEEAQQKEAK
HHHHHHHHHHHHHHH
51.5824275569
1209PhosphorylationRAKEEAQQKEAKVKL
HHHHHHHHHHHHHHH
53.2424275569
1217PhosphorylationKEAKVKLLTESVNSV
HHHHHHHHHHHHHHH
4.0724719451
1217PhosphorylationKEAKVKLLTESVNSV
HHHHHHHHHHHHHHH
4.0727251275
1218PhosphorylationEAKVKLLTESVNSVI
HHHHHHHHHHHHHHH
36.3325841592
1221PhosphorylationVKLLTESVNSVIAQA
HHHHHHHHHHHHHHC
5.1528102081
1224PhosphorylationLTESVNSVIAQAPPV
HHHHHHHHHHHCCHH
3.3820068231
1224PhosphorylationLTESVNSVIAQAPPV
HHHHHHHHHHHCCHH
3.3824719451
1231PhosphorylationVIAQAPPVAQEALKK
HHHHCCHHHHHHHHH
9.2825841592
1234PhosphorylationQAPPVAQEALKKELE
HCCHHHHHHHHHHHH
46.3528102081
1237PhosphorylationPVAQEALKKELETLT
HHHHHHHHHHHHHHH
51.7720068231
1237PhosphorylationPVAQEALKKELETLT
HHHHHHHHHHHHHHH
51.7727251275
1273PhosphorylationACWHELLSYLEKANK
HHHHHHHHHHHHHCH
40.0524719451
1288UbiquitinationWLNEVEFKLKTTENI
HHHHCCCEEECCCCC
35.25-
1415PhosphorylationQEAQKIQSDLTSHEI
HHHHHHHHHHHHCCC
37.7528270605
1418PhosphorylationQKIQSDLTSHEISLE
HHHHHHHHHCCCCHH
32.7828270605
1419PhosphorylationKIQSDLTSHEISLEE
HHHHHHHHCCCCHHH
26.8128270605
1423PhosphorylationDLTSHEISLEEMKKH
HHHHCCCCHHHHHHH
27.0928270605
1442PhosphorylationEAAQRVLSQIDVAQK
HHHHHHHHHHHHHHH
23.4126657352
1455O-linked_GlycosylationQKKLQDVSMKFRLFQ
HHHHHHHHHHHHHHC
25.2530379171
1455PhosphorylationQKKLQDVSMKFRLFQ
HHHHHHHHHHHHHHC
25.25-
1509PhosphorylationLNHCVNLYKSLSEVK
HHHHHHHHHHHHHHH
8.04-
1517PhosphorylationKSLSEVKSEVEMVIK
HHHHHHHHHHHHHHH
52.64-
1525PhosphorylationEVEMVIKTGRQIVQK
HHHHHHHHHHHHHHH
26.86-
1552PhosphorylationVTALKLHYNELGAKV
HHHHHHHHHHHCHHH
22.29-
1590PhosphorylationLTEWLAATDMELTKR
HHHHHHHCCHHHHHH
30.2116094384
1592UbiquitinationEWLAATDMELTKRSA
HHHHHCCHHHHHHHH
3.85-
1598O-linked_GlycosylationDMELTKRSAVEGMPS
CHHHHHHHHHCCCCC
37.9230379171
1611UbiquitinationPSNLDSEVAWGKATQ
CCCCHHHHHHCHHHH
6.68-
1640UbiquitinationEVGEALKTVLGKKET
HHHHHHHHHHCCCCC
23.08-
1641UbiquitinationVGEALKTVLGKKETL
HHHHHHHHHCCCCCH
6.75-
1643PhosphorylationEALKTVLGKKETLVE
HHHHHHHCCCCCHHH
34.35-
1644UbiquitinationALKTVLGKKETLVED
HHHHHHCCCCCHHHH
43.19-
1645UbiquitinationLKTVLGKKETLVEDK
HHHHHCCCCCHHHHH
54.88-
1647PhosphorylationTVLGKKETLVEDKLS
HHHCCCCCHHHHHHH
45.0120068231
1654PhosphorylationTLVEDKLSLLNSNWI
CHHHHHHHHHHCCEE
36.2320068231
1658PhosphorylationDKLSLLNSNWIAVTS
HHHHHHHCCEEEEHH
33.2520068231
1664PhosphorylationNSNWIAVTSRAEEWL
HCCEEEEHHCHHHHH
11.9520068231
1665PhosphorylationSNWIAVTSRAEEWLN
CCEEEEHHCHHHHHH
23.9320068231
1768PhosphorylationNHRFAAISHRIKTGK
HHHHHHHHHHHHCCC
11.2826437602
1856PhosphorylationIKQQLLQTKHNALKD
HHHHHHHHHHHHHHH
33.9520068231
1911AcetylationPEPRDERKIKEIDRE
CCCCCHHHHHHHHHH
56.967640467
19212-HydroxyisobutyrylationEIDRELQKKKEELNA
HHHHHHHHHHHHHHH
77.70-
1937PhosphorylationRRQAEGLSEDGAAMA
HHHHCCCCCCCCEEC
44.4924505115
1953PhosphorylationEPTQIQLSKRWREIE
CCCHHHHHHHHHHHH
12.0924505115
1964 (in isoform 3)Ubiquitination-16.0221890473
1967 (in isoform 2)Ubiquitination-30.0521890473
2037PhosphorylationDLFKQEESLKNIKDS
HHHHCHHHHHHHHHH
43.8427251275
2060PhosphorylationDIIHSKKTAALQSAT
EEECCCCHHHCCCCC
22.39-
2065PhosphorylationKKTAALQSATPVERV
CCHHHCCCCCCHHHH
34.6524719451
2067PhosphorylationTAALQSATPVERVKL
HHHCCCCCCHHHHHH
32.8724719451
2079PhosphorylationVKLQEALSQLDFQWE
HHHHHHHHHCCCCHH
35.4320068231
2157PhosphorylationDGIGQRQTVVRTLNA
CCCCCHHHHHHHHCC
24.1324719451
2176PhosphorylationIIQQSSKTDASILQE
HHHHCCCCCHHHHHH
38.4523898821
2179PhosphorylationQSSKTDASILQEKLG
HCCCCCHHHHHHHHC
27.0023532336
2200PhosphorylationQEVCKQLSDRKKRLE
HHHHHHHHHHHHHHH
32.6420068231
2219 (in isoform 3)Ubiquitination-42.9621890473
2222 (in isoform 2)Ubiquitination-44.4221890473
2280PhosphorylationTGGPVLVSAPISPEE
CCCCEEEECCCCHHH
24.9420068231
2284PhosphorylationVLVSAPISPEEQDKL
EEEECCCCHHHHHHH
25.7922468782
2306PhosphorylationNLQWIKVSRALPEKQ
CCHHHHHHHCCCCCC
13.56-
2432PhosphorylationPDLAPGLTTIGASPT
CCCCCCCCCCCCCCC
23.4528348404
2433PhosphorylationDLAPGLTTIGASPTQ
CCCCCCCCCCCCCCC
23.5828348404
2437PhosphorylationGLTTIGASPTQTVTL
CCCCCCCCCCCEEEE
24.2228348404
2439PhosphorylationTTIGASPTQTVTLVT
CCCCCCCCCEEEEEE
34.0826657352
2441PhosphorylationIGASPTQTVTLVTQP
CCCCCCCEEEEEECC
20.2426657352
2463PhosphorylationISKLEMPSSLMLEVP
HHCCCCCCCCCCCCH
34.4928258704
2464PhosphorylationSKLEMPSSLMLEVPA
HCCCCCCCCCCCCHH
16.3628258704
2541PhosphorylationAQNLKNKTSNQEART
HHHHCCCCCCHHHHH
42.1624719451
2542PhosphorylationQNLKNKTSNQEARTI
HHHCCCCCCHHHHHH
37.8224719451
2548PhosphorylationTSNQEARTIITDRIE
CCCHHHHHHHHHHHH
24.6326270265
2551PhosphorylationQEARTIITDRIERIQ
HHHHHHHHHHHHHHH
18.5126270265
2651PhosphorylationALKLLRDYSADDTRK
HHHHHHHCCCCCCCH
10.18-
2652PhosphorylationLKLLRDYSADDTRKV
HHHHHHCCCCCCCHH
29.5226029660
2656PhosphorylationRDYSADDTRKVHMIT
HHCCCCCCCHHEHHH
32.7026029660
2663PhosphorylationTRKVHMITENINASW
CCHHEHHHCCCCHHH
18.5324719451
2665PhosphorylationKVHMITENINASWRS
HHEHHHCCCCHHHHH
24.94-
2668PhosphorylationMITENINASWRSIHK
HHHCCCCHHHHHHHH
13.48-
2669PhosphorylationITENINASWRSIHKR
HHCCCCHHHHHHHHH
20.6620068231
2672PhosphorylationNINASWRSIHKRVSE
CCCHHHHHHHHHHHH
23.8420068231
2728PhosphorylationKERLLEDSKGVKELM
HHHHHHCCHHHHHHH
23.1826657352
2765PhosphorylationNSQKILRSLEGSDDA
HHHHHHHHCCCCCHH
27.5928270605
2769PhosphorylationILRSLEGSDDAVLLQ
HHHHCCCCCHHHHHH
23.9628270605
2808AcetylationEASSDQWKRLHLSLQ
HCCCHHHHHHHHHHH
39.1830585699
2864PhosphorylationTKEPVIMSTLETVRI
CCCCCHHHCHHHHHH
20.7925599653
2865PhosphorylationKEPVIMSTLETVRIF
CCCCHHHCHHHHHHH
15.9525599653
2868PhosphorylationVIMSTLETVRIFLTE
CHHHCHHHHHHHHCC
20.4225599653
2885PhosphorylationLEGLEKLYQEPRELP
CHHHHHHHCCCCCCC
23.15-
2913PhosphorylationKQAEEVNTEWEKLNL
HHHHHHCCHHHHHCC
47.8820873877
2922PhosphorylationWEKLNLHSADWQRKI
HHHHCCCCHHHHHHH
30.9620873877
2993PhosphorylationAPLKENVSHVNDLAR
CCCCCCHHHHHHHHH
33.0426437602
3066PhosphorylationGPWERAISPNKVPYY
CCHHHCCCCCCCCEE
22.80-
3081PhosphorylationINHETQTTCWDHPKM
EECCCCCCCCCCHHH
11.20-
3094PhosphorylationKMTELYQSLADLNNV
HHHHHHHHHHHHCCC
16.3928857561
3104PhosphorylationDLNNVRFSAYRTAMK
HHCCCHHHHHHHHHH
17.5224719451
3198PhosphorylationTGRIRVLSFKTGIIS
CCCEEEEEECCCHHH
23.1124719451
3287PhosphorylationLFLDWMRLEPQSMVW
HHHHHHCCCCCHHCH
6.96-
3291PhosphorylationWMRLEPQSMVWLPVL
HHCCCCCHHCHHHHH
26.4720068231
3300 (in isoform 4)Ubiquitination-18.6621890473
3308UbiquitinationVAAAETAKHQAKCNI
HHHHHHHHHHHHCCC
43.6021890473
3308 (in isoform 1)Ubiquitination-43.6021890473
3312UbiquitinationETAKHQAKCNICKEC
HHHHHHHHCCCCCCC
22.65-
3317UbiquitinationQAKCNICKECPIIGF
HHHCCCCCCCCCCCE
59.56-
3351UbiquitinationGRVAKGHKMHYPMVE
CCCCCCCCCCCCCEE
35.72-
3354PhosphorylationAKGHKMHYPMVEYCT
CCCCCCCCCCEEECC
6.90-
3359PhosphorylationMHYPMVEYCTPTTSG
CCCCCEEECCCCCCC
7.10-
3361PhosphorylationYPMVEYCTPTTSGED
CCCEEECCCCCCCHH
23.8325159151
3374UbiquitinationEDVRDFAKVLKNKFR
HHHHHHHHHHHHHHH
48.36-
3390PhosphorylationKRYFAKHPRMGYLPV
CCHHCCCCCCCCCCC
27.52-
3394PhosphorylationAKHPRMGYLPVQTVL
CCCCCCCCCCCEECE
9.8620068231
3399PhosphorylationMGYLPVQTVLEGDNM
CCCCCCEECEECCCC
27.5618669648
3408PhosphorylationLEGDNMETPVTLINF
EECCCCCCCEEEEEE
16.5818669648
3411PhosphorylationDNMETPVTLINFWPV
CCCCCCEEEEEEEEC
24.1128348404
3416PhosphorylationPVTLINFWPVDSAPA
CEEEEEEEECCCCCC
6.37-
3420PhosphorylationINFWPVDSAPASSPQ
EEEEECCCCCCCCCC
36.0620068231
3421PhosphorylationNFWPVDSAPASSPQL
EEEECCCCCCCCCCC
10.14-
3424PhosphorylationPVDSAPASSPQLSHD
ECCCCCCCCCCCCCC
41.3018669648
3425PhosphorylationVDSAPASSPQLSHDD
CCCCCCCCCCCCCCC
20.8318669648
3429PhosphorylationPASSPQLSHDDTHSR
CCCCCCCCCCCHHHH
21.4423663014
3433PhosphorylationPQLSHDDTHSRIEHY
CCCCCCCHHHHHHHH
28.0118669648
3435PhosphorylationLSHDDTHSRIEHYAS
CCCCCHHHHHHHHHH
36.7323663014
3440PhosphorylationTHSRIEHYASRLAEM
HHHHHHHHHHHHHHH
8.0930576142
3442PhosphorylationSRIEHYASRLAEMEN
HHHHHHHHHHHHHHC
22.2126437602
3464PhosphorylationDSISPNESIDDEHLL
CCCCCCCCCCCHHHH
37.6522210691
3478PhosphorylationLIQHYCQSLNQDSPL
HHHHHHHHCCCCCCC
26.2322210691
3479PhosphorylationIQHYCQSLNQDSPLS
HHHHHHHCCCCCCCC
2.48-
3483PhosphorylationCQSLNQDSPLSQPRS
HHHCCCCCCCCCCCC
20.2726657352
3486PhosphorylationLNQDSPLSQPRSPAQ
CCCCCCCCCCCCHHH
41.3324719451
3490PhosphorylationSPLSQPRSPAQILIS
CCCCCCCCHHHEEEE
31.1326055452
3497PhosphorylationSPAQILISLESEERG
CHHHEEEEECHHHCC
23.7326471730
3500PhosphorylationQILISLESEERGELE
HEEEEECHHHCCHHH
50.4818669648
3524PhosphorylationNRNLQAEYDRLKQQH
HHHHHHHHHHHHHHH
14.9128674419
3533PhosphorylationRLKQQHEHKGLSPLP
HHHHHHHCCCCCCCC
27.62-
3537PhosphorylationQHEHKGLSPLPSPPE
HHHCCCCCCCCCCCC
32.8126055452
3541PhosphorylationKGLSPLPSPPEMMPT
CCCCCCCCCCCCCCC
61.8526055452
3544PhosphorylationSPLPSPPEMMPTSPQ
CCCCCCCCCCCCCCC
52.04-
3548PhosphorylationSPPEMMPTSPQSPRD
CCCCCCCCCCCCHHH
34.8325159151
3549PhosphorylationPPEMMPTSPQSPRDA
CCCCCCCCCCCHHHH
18.3120201521
3552PhosphorylationMMPTSPQSPRDAELI
CCCCCCCCHHHHHHH
25.8625159151
3555 (in isoform 4)Ubiquitination-48.0221890473
3563UbiquitinationAELIAEAKLLRQHKG
HHHHHHHHHHHHCCC
39.2921890473
3563 (in isoform 1)Ubiquitination-39.2921890473
3608PhosphorylationQAEAKVNGTTVSSPS
CCHHHCCCEECCCCC
26.25-
3609PhosphorylationAEAKVNGTTVSSPST
CHHHCCCEECCCCCC
20.8629255136
3610PhosphorylationEAKVNGTTVSSPSTS
HHHCCCEECCCCCCC
21.5729255136
3611PhosphorylationAKVNGTTVSSPSTSL
HHCCCEECCCCCCCC
5.53-
3612PhosphorylationKVNGTTVSSPSTSLQ
HCCCEECCCCCCCCC
34.1429255136
3613PhosphorylationVNGTTVSSPSTSLQR
CCCEECCCCCCCCCC
20.6629255136
3615PhosphorylationGTTVSSPSTSLQRSD
CEECCCCCCCCCCCC
32.3529255136
3616PhosphorylationTTVSSPSTSLQRSDS
EECCCCCCCCCCCCC
36.5229255136
3617PhosphorylationTVSSPSTSLQRSDSS
ECCCCCCCCCCCCCC
27.1729255136
3619PhosphorylationSSPSTSLQRSDSSQP
CCCCCCCCCCCCCCC
42.47-
3620PhosphorylationSPSTSLQRSDSSQPM
CCCCCCCCCCCCCCE
47.96-
3621PhosphorylationPSTSLQRSDSSQPML
CCCCCCCCCCCCCEE
28.9629255136
3623PhosphorylationTSLQRSDSSQPMLLR
CCCCCCCCCCCEEEE
31.9229255136
3624PhosphorylationSLQRSDSSQPMLLRV
CCCCCCCCCCEEEEE
43.2029255136
3634PhosphorylationMLLRVVGSQTSDSMG
EEEEECCCCCCCCCC
20.7624275569
3636PhosphorylationLRVVGSQTSDSMGEE
EEECCCCCCCCCCCC
35.8824275569
3637PhosphorylationRVVGSQTSDSMGEED
EECCCCCCCCCCCCC
21.7621601212
3639PhosphorylationVGSQTSDSMGEEDLL
CCCCCCCCCCCCCCC
28.5824275569
3647PhosphorylationMGEEDLLSPPQDTST
CCCCCCCCCCCCCCC
41.6628348404
3648PhosphorylationGEEDLLSPPQDTSTG
CCCCCCCCCCCCCCC
30.46-
3652PhosphorylationLLSPPQDTSTGLEEV
CCCCCCCCCCCHHHH
23.9618669648
3653PhosphorylationLSPPQDTSTGLEEVM
CCCCCCCCCCHHHHH
28.8524275569
3662PhosphorylationGLEEVMEQLNNSFPS
CHHHHHHHHHHCCCC
31.25-
3666PhosphorylationVMEQLNNSFPSSRGR
HHHHHHHCCCCCCCC
37.141319059
3670PhosphorylationLNNSFPSSRGRNTPG
HHHCCCCCCCCCCCC
38.7024275569
3675PhosphorylationPSSRGRNTPGKPMRE
CCCCCCCCCCCCCCC
31.8621712546
3684PhosphorylationGKPMREDTM------
CCCCCCCCC------
21.7421712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DMD_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DMD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DMD_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNTB1_HUMANSNTB1physical
7844150
DAG1_HUMANDAG1physical
10932245
SNTA1_HUMANSNTA1physical
7890602
ITB1_RATItgb1physical
16935300
FAK1_RATPtk2physical
16935300
DAG1_HUMANDAG1physical
7592992
A4_HUMANAPPphysical
21832049
NEDD4_HUMANNEDD4physical
22939629
SNTB2_HUMANSNTB2physical
22937058
CAVN1_HUMANPTRFphysical
22937058
AHNK_HUMANAHNAKphysical
22937058
NOS1_HUMANNOS1physical
7545544
DTNB_HUMANDTNBphysical
25416956
CTNL1_HUMANCTNNAL1physical
25416956
HAUS1_HUMANHAUS1physical
25416956
DTNB_HUMANDTNBphysical
28514442
DTNA_HUMANDTNAphysical
28514442
CTNL1_HUMANCTNNAL1physical
28514442
SNTA1_HUMANSNTA1physical
28514442
SNTB1_HUMANSNTB1physical
28514442
SNTB2_HUMANSNTB2physical
28514442
LONF3_HUMANLONRF3physical
28514442
HAUS4_HUMANHAUS4physical
28514442
UTRO_HUMANUTRNphysical
28514442
OSBL1_HUMANOSBPL1Aphysical
28514442
HAUS1_HUMANHAUS1physical
28514442
KIF23_HUMANKIF23physical
28514442
SIR2_HUMANSIRT2physical
28514442
TRI41_HUMANTRIM41physical
28514442
CTNA1_HUMANCTNNA1physical
28514442
WDR54_HUMANWDR54physical
28514442
MPP6_HUMANMPP6physical
28514442

Drug and Disease Associations
Kegg Disease
H00294 Dilated cardiomyopathy (DCM)
H00552 Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; X
H00562 Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X
OMIM Disease
310200Duchenne muscular dystrophy (DMD)
300376Becker muscular dystrophy (BMD)
302045Cardiomyopathy, dilated, X-linked 3B (CMD3B)
Kegg Drug
D09900 Eteplirsen (USAN/INN)
D10114 Drisapersen (USAN)
D10115 Drisapersen sodium (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DMD_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3616 AND SER-3623, ANDMASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3483; SER-3613;SER-3617; SER-3623; THR-3652 AND SER-3666, AND MASS SPECTROMETRY.
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3613, AND MASSSPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3621 AND SER-3623, ANDMASS SPECTROMETRY.
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1590, AND MASSSPECTROMETRY.

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