DTNA_HUMAN - dbPTM
DTNA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DTNA_HUMAN
UniProt AC Q9Y4J8
Protein Name Dystrobrevin alpha
Gene Name DTNA
Organism Homo sapiens (Human).
Sequence Length 743
Subcellular Localization Cytoplasm. Cell junction, synapse. Cell membrane. In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane..
Protein Description May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors..
Protein Sequence MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNTELNVSRLEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSREPLHPMFPDQPEKPLNLAHIVDTWPPRPVTSMNDTLFSHSVPSSGSPFITRSSPPKDSEVEQNKLLARAAPAFLKGKGIQYSLNVADRLADEHVLIGLYVNMLRNNPSCMLESSNRLDEEHRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKTQGAGSPRSSPSHTISRPIPMPIRSASACSTPTHTPQDSLTGVGGDVQEAFAQSSRRNLRNDLLVAADSITNTMSSLVKELNSEVGSETESNVDSEFARTQFEDLVPSPTSEKAFLAQIHARKPGYIHSGATTSTMRGDMVTEDADPYVQPEDENYENDSVRQLENELQMEEYLKQKLQDEAYQVSLQG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MIEDSGKRGNTM
---CCCCCCCCCCCH		33.1630631047
7Ubiquitination-MIEDSGKRGNTMAE
-CCCCCCCCCCCHHH		62.17-
22 (in isoform 10)Phosphorylation-3.7429514088
22 (in isoform 11)Phosphorylation-3.7429514088
22 (in isoform 6)Phosphorylation-3.7429514088
22 (in isoform 8)Phosphorylation-3.7429514088
23 (in isoform 10)Phosphorylation-22.1729514088
23 (in isoform 11)Phosphorylation-22.1729514088
23 (in isoform 6)Phosphorylation-22.1729514088
23 (in isoform 8)Phosphorylation-22.1729514088
27 (in isoform 10)Phosphorylation-2.9529514088
27 (in isoform 11)Phosphorylation-2.9529514088
27 (in isoform 6)Phosphorylation-2.9529514088
27 (in isoform 8)Phosphorylation-2.9529514088
30 (in isoform 10)Phosphorylation-5.3329514088
30 (in isoform 11)Phosphorylation-5.3329514088
30 (in isoform 6)Phosphorylation-5.3329514088
30 (in isoform 8)Phosphorylation-5.3329514088
32 (in isoform 10)Phosphorylation-4.1129514088
32 (in isoform 11)Phosphorylation-4.1129514088
32 (in isoform 6)Phosphorylation-4.1129514088
32 (in isoform 8)Phosphorylation-4.1129514088
35 (in isoform 10)Phosphorylation-11.5529514088
35 (in isoform 11)Phosphorylation-11.5529514088
35 (in isoform 6)Phosphorylation-11.5529514088
35 (in isoform 8)Phosphorylation-11.5529514088
36 (in isoform 10)Phosphorylation-18.8829514088
36 (in isoform 11)Phosphorylation-18.8829514088
36 (in isoform 6)Phosphorylation-18.8829514088
36 (in isoform 8)Phosphorylation-18.8829514088
38 (in isoform 10)Phosphorylation-4.5729514088
38 (in isoform 11)Phosphorylation-4.5729514088
38 (in isoform 6)Phosphorylation-4.5729514088
38 (in isoform 8)Phosphorylation-4.5729514088
42 (in isoform 10)Phosphorylation-18.3829514088
42 (in isoform 11)Phosphorylation-18.3829514088
42 (in isoform 6)Phosphorylation-18.3829514088
42 (in isoform 8)Phosphorylation-18.3829514088
44 (in isoform 8)Phosphorylation-7.0626437602
52 (in isoform 10)Phosphorylation-4.1128348404
52 (in isoform 11)Phosphorylation-4.1128348404
53 (in isoform 10)Phosphorylation-3.3224719451
53 (in isoform 11)Phosphorylation-3.3224719451
60 (in isoform 10)Phosphorylation-37.0526437602
60 (in isoform 11)Phosphorylation-37.0526437602
65 (in isoform 11)Phosphorylation-43.2127642862
150PhosphorylationKIMDKLRYIFSMISD
HHHHHHHHHHHHHCC		19.4323403867
153PhosphorylationDKLRYIFSMISDSSG
HHHHHHHHHHCCCCC		12.9725002506
156PhosphorylationRYIFSMISDSSGVMV
HHHHHHHCCCCCCEE		23.8523403867
158PhosphorylationIFSMISDSSGVMVYG
HHHHHCCCCCCEEEE		23.3825002506
159PhosphorylationFSMISDSSGVMVYGR
HHHHCCCCCCEEEEC		40.1625002506
164PhosphorylationDSSGVMVYGRYDQFL
CCCCCEEEECHHHHH		4.2725002506
190PhosphorylationEGPSFGYTEQSARSC
CCCCCCCCHHHHHHH		28.1124719451
193PhosphorylationSFGYTEQSARSCFSQ
CCCCCHHHHHHHHHC		21.2924719451
250PhosphorylationCSYCHSESMMGFRYR
CCCCCCCCCCCCCHH		19.6524076635
289PhosphorylationNQHQMKEYTSWKSPA
CHHHHHHHCCCCCHH		10.6829083192
290PhosphorylationQHQMKEYTSWKSPAK
HHHHHHHCCCCCHHH		29.2427251275
291PhosphorylationHQMKEYTSWKSPAKK
HHHHHHCCCCCHHHH		31.4427251275
294PhosphorylationKEYTSWKSPAKKLTN
HHHCCCCCHHHHHHH		24.6726471730
304PhosphorylationKKLTNALSKSLSCAS
HHHHHHHHHHHCCCC		20.1426437602
306PhosphorylationLTNALSKSLSCASSR
HHHHHHHHHCCCCCC		23.3426437602
308PhosphorylationNALSKSLSCASSREP
HHHHHHHCCCCCCCC		18.0928857561
310 (in isoform 6)Phosphorylation-13.73-
311PhosphorylationSKSLSCASSREPLHP
HHHHCCCCCCCCCCC		33.9728348404
312PhosphorylationKSLSCASSREPLHPM
HHHCCCCCCCCCCCC		23.3428348404
340 (in isoform 13)Phosphorylation-33.9529514088
340 (in isoform 14)Phosphorylation-33.9529514088
340 (in isoform 15)Phosphorylation-33.9529514088
340 (in isoform 16)Phosphorylation-33.9529514088
340 (in isoform 4)Phosphorylation-33.9529514088
340 (in isoform 9)Phosphorylation-33.9529514088
341 (in isoform 13)Phosphorylation-39.2429514088
341 (in isoform 14)Phosphorylation-39.2429514088
341 (in isoform 15)Phosphorylation-39.2429514088
341 (in isoform 16)Phosphorylation-39.2429514088
341 (in isoform 4)Phosphorylation-39.2429514088
341 (in isoform 9)Phosphorylation-39.2429514088
345 (in isoform 13)Phosphorylation-3.7229514088
345 (in isoform 14)Phosphorylation-3.7229514088
345 (in isoform 15)Phosphorylation-3.7229514088
345 (in isoform 16)Phosphorylation-3.7229514088
345 (in isoform 4)Phosphorylation-3.7229514088
345 (in isoform 9)Phosphorylation-3.7229514088
348 (in isoform 13)Phosphorylation-25.3829514088
348 (in isoform 14)Phosphorylation-25.3829514088
348 (in isoform 15)Phosphorylation-25.3829514088
348 (in isoform 16)Phosphorylation-25.3829514088
348 (in isoform 4)Phosphorylation-25.3829514088
348 (in isoform 9)Phosphorylation-25.3829514088
350 (in isoform 13)Phosphorylation-7.2029514088
350 (in isoform 14)Phosphorylation-7.2029514088
350 (in isoform 15)Phosphorylation-7.2029514088
350 (in isoform 16)Phosphorylation-7.2029514088
350 (in isoform 4)Phosphorylation-7.2029514088
350 (in isoform 9)Phosphorylation-7.2029514088
353 (in isoform 13)Phosphorylation-34.2329514088
353 (in isoform 14)Phosphorylation-34.2329514088
353 (in isoform 15)Phosphorylation-34.2329514088
353 (in isoform 16)Phosphorylation-34.2329514088
353 (in isoform 4)Phosphorylation-34.2329514088
353 (in isoform 9)Phosphorylation-34.2329514088
354 (in isoform 13)Phosphorylation-4.4529514088
354 (in isoform 14)Phosphorylation-4.4529514088
354 (in isoform 15)Phosphorylation-4.4529514088
354 (in isoform 16)Phosphorylation-4.4529514088
354 (in isoform 4)Phosphorylation-4.4529514088
354 (in isoform 9)Phosphorylation-4.4529514088
356 (in isoform 13)Phosphorylation-45.2129514088
356 (in isoform 14)Phosphorylation-45.2129514088
356 (in isoform 15)Phosphorylation-45.2129514088
356 (in isoform 16)Phosphorylation-45.2129514088
356 (in isoform 2)Phosphorylation-45.2123898821
356 (in isoform 4)Phosphorylation-45.2129514088
356 (in isoform 5)Phosphorylation-45.2123898821
356 (in isoform 9)Phosphorylation-45.2129514088
357 (in isoform 2)Phosphorylation-36.9023898821
357 (in isoform 5)Phosphorylation-36.9023898821
359PhosphorylationHSVPSSGSPFITRSS
CCCCCCCCCCCCCCC		20.7025850435
360 (in isoform 13)Phosphorylation-28.3429514088
360 (in isoform 14)Phosphorylation-28.3429514088
360 (in isoform 15)Phosphorylation-28.3429514088
360 (in isoform 16)Phosphorylation-28.3429514088
360 (in isoform 4)Phosphorylation-28.3429514088
360 (in isoform 9)Phosphorylation-28.3429514088
362 (in isoform 13)Phosphorylation-3.3826437602
362 (in isoform 14)Phosphorylation-3.3826437602
362 (in isoform 15)Phosphorylation-3.3826437602
362 (in isoform 16)Phosphorylation-3.3826437602
363PhosphorylationSSGSPFITRSSPPKD
CCCCCCCCCCCCCCC		25.5225850435
365PhosphorylationGSPFITRSSPPKDSE
CCCCCCCCCCCCCCH		38.2526437602
365 (in isoform 2)Phosphorylation-38.2526437602
365 (in isoform 5)Phosphorylation-38.2526437602
366PhosphorylationSPFITRSSPPKDSEV
CCCCCCCCCCCCCHH		41.7626437602
411 (in isoform 11)Phosphorylation-3.2327642862
419 (in isoform 11)Phosphorylation-24.3527642862
423 (in isoform 11)Phosphorylation-5.6627642862
440PhosphorylationEHRLIARYAARLAAE
HHHHHHHHHHHHHHH		8.8029978859
446 (in isoform 11)Phosphorylation-23.0727642862
448PhosphorylationAARLAAESSSSQPPQ
HHHHHHHCCCCCCCC		30.6929978859
449PhosphorylationARLAAESSSSQPPQQ
HHHHHHCCCCCCCCC		26.0529978859
450PhosphorylationRLAAESSSSQPPQQR
HHHHHCCCCCCCCCC		42.1229978859
451PhosphorylationLAAESSSSQPPQQRS
HHHHCCCCCCCCCCC		48.9729978859
458PhosphorylationSQPPQQRSAPDISFT
CCCCCCCCCCCEEEE		39.5530266825
463PhosphorylationQRSAPDISFTIDANK
CCCCCCEEEEECCCH		24.5830266825
465PhosphorylationSAPDISFTIDANKQQ
CCCCEEEEECCCHHH		15.9128450419
501PhosphorylationRLEHEQASQPTPEKA
HHHHHHHCCCCHHHH		36.0730266825
502 (in isoform 14)Phosphorylation-49.2322673903
504PhosphorylationHEQASQPTPEKAQQN
HHHHCCCCHHHHHHC		36.1230266825
507 (in isoform 14)Phosphorylation-53.3422673903
513PhosphorylationEKAQQNPTLLAELRL
HHHHHCHHHHHHHHH		41.7924076635
533PhosphorylationDELEQRMSALQESRR
HHHHHHHHHHHHHHH		28.1926437602
538PhosphorylationRMSALQESRRELMVQ
HHHHHHHHHHHHHHH		24.5526552605
555PhosphorylationGLMKLLKTQGAGSPR
HHHHHHHHCCCCCCC		32.0027422710
560PhosphorylationLKTQGAGSPRSSPSH
HHHCCCCCCCCCCCC		19.3327422710
563PhosphorylationQGAGSPRSSPSHTIS
CCCCCCCCCCCCCCC		50.4125159151
564PhosphorylationGAGSPRSSPSHTISR
CCCCCCCCCCCCCCC		31.5325159151
564 (in isoform 3)Phosphorylation-31.5327642862
566PhosphorylationGSPRSSPSHTISRPI
CCCCCCCCCCCCCCC		34.9022617229
568PhosphorylationPRSSPSHTISRPIPM
CCCCCCCCCCCCCCC		25.6126434776
570PhosphorylationSSPSHTISRPIPMPI
CCCCCCCCCCCCCCC		32.9126434776
579PhosphorylationPIPMPIRSASACSTP
CCCCCCCCCCCCCCC		27.5628450419
581PhosphorylationPMPIRSASACSTPTH
CCCCCCCCCCCCCCC		30.9328450419
584PhosphorylationIRSASACSTPTHTPQ
CCCCCCCCCCCCCCC		36.8228450419
585PhosphorylationRSASACSTPTHTPQD
CCCCCCCCCCCCCCH		31.9028450419
587PhosphorylationASACSTPTHTPQDSL
CCCCCCCCCCCCHHC		38.1726657352
589PhosphorylationACSTPTHTPQDSLTG
CCCCCCCCCCHHCCC		25.7328450419
593PhosphorylationPTHTPQDSLTGVGGD
CCCCCCHHCCCCCHH		23.6826657352
595PhosphorylationHTPQDSLTGVGGDVQ
CCCCHHCCCCCHHHH		33.5028450419
605 (in isoform 2)Phosphorylation-6.64-
608PhosphorylationVQEAFAQSSRRNLRN
HHHHHHHHHHHHHHH		23.5326657352
623PhosphorylationDLLVAADSITNTMSS
HHHHHHHHHHHHHHH		26.9626657352
637PhosphorylationSLVKELNSEVGSETE
HHHHHHHHHCCCCCC		46.4128450419
641PhosphorylationELNSEVGSETESNVD
HHHHHCCCCCCCCCC		46.6628355574
643PhosphorylationNSEVGSETESNVDSE
HHHCCCCCCCCCCHH		46.5426657352
645PhosphorylationEVGSETESNVDSEFA
HCCCCCCCCCCHHHH		49.9626657352
649PhosphorylationETESNVDSEFARTQF
CCCCCCCHHHHHHHH		30.2621406692
654PhosphorylationVDSEFARTQFEDLVP
CCHHHHHHHHHHHCC		33.8930266825
662PhosphorylationQFEDLVPSPTSEKAF
HHHHHCCCCCCHHHH		33.0719664994
664PhosphorylationEDLVPSPTSEKAFLA
HHHCCCCCCHHHHHH		54.5830266825
665PhosphorylationDLVPSPTSEKAFLAQ
HHCCCCCCHHHHHHH		40.2530266825
680PhosphorylationIHARKPGYIHSGATT
HHCCCCCCCCCCCCC		12.1822210691
683PhosphorylationRKPGYIHSGATTSTM
CCCCCCCCCCCCCCC		22.1422210691
686PhosphorylationGYIHSGATTSTMRGD
CCCCCCCCCCCCCCC		25.4626437602
687PhosphorylationYIHSGATTSTMRGDM
CCCCCCCCCCCCCCC		22.9726437602
710PhosphorylationVQPEDENYENDSVRQ
CCCCCCCCCCHHHHH		17.6726657352
714PhosphorylationDENYENDSVRQLENE
CCCCCCHHHHHHHHH		30.6822210691
737PhosphorylationQKLQDEAYQVSLQG-
HHHHHHHHHHHCCC-		13.8523186163
740PhosphorylationQDEAYQVSLQG----
HHHHHHHHCCC----		10.2323186163
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DTNA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DTNA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DTNA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DMD_HUMANDMDphysical
9356463
SNTA1_HUMANSNTA1physical
9356463
SC24C_HUMANSEC24Cphysical
22939629
NUP62_HUMANNUP62physical
22939629
MYO1E_HUMANMYO1Ephysical
22939629
PSN1_HUMANPSEN1physical
22939629
SC23A_HUMANSEC23Aphysical
22939629
ZO1_HUMANTJP1physical
15834686
ACTB_HUMANACTBphysical
15834686
NMT1_HUMANNMT1physical
26186194
POTEI_HUMANPOTEIphysical
26186194
SAR1A_HUMANSAR1Aphysical
26186194
DRP2_HUMANDRP2physical
10767429
DMD_HUMANDMDphysical
10767429
UTRO_HUMANUTRNphysical
10767429
POTEI_HUMANPOTEIphysical
28514442
Drug and Disease Associations
Kegg Disease
H01216 Left ventricular noncompaction (LVNC)
OMIM Disease
604169Left ventricular non-compaction 1 (LVNC1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DTNA_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662, AND MASSSPECTROMETRY.

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