dbPTM

ZO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZO1_HUMAN
UniProt AC	Q07157
Protein Name	Tight junction protein ZO-1
Gene Name	TJP1
Organism	Homo sapiens (Human).
Sequence Length	1748
Subcellular Localization	Cell membrane Peripheral membrane protein Cytoplasmic side . Cell junction, tight junction . Cell junction . Cell junction, gap junction. Cell projection, podosome . Moves from the cytoplasm to the cell membrane concurrently with cell-cell contac
Protein Description	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. [PubMed: 7798316]
Protein Sequence	MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVSVLIDHF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSARAAAAK ------CCHHHHHHH	37.45	22210691
10	Phosphorylation	ARAAAAKSTAMEETA HHHHHHHHHHHHHHH	19.37	28857561
11	Phosphorylation	RAAAAKSTAMEETAI HHHHHHHHHHHHHHH	29.35	28857561
16	Phosphorylation	KSTAMEETAIWEQHT HHHHHHHHHHHEECE	15.33	30624053
52	Phosphorylation	PHFQSGETSIVISDV CCCCCCCCEEEEEEH	27.55	24076635
53	Phosphorylation	HFQSGETSIVISDVL CCCCCCCEEEEEEHH	15.57	21712546
103	Malonylation	RKSGKNAKITIRRKK HHCCCCCEEEEEECC	50.18	26320211
117	Phosphorylation	KKVQIPVSRPDPEPV CCEECCCCCCCCCCC	32.51	30266825
125	Phosphorylation	RPDPEPVSDNEEDSY CCCCCCCCCCCCCCC	45.49	29255136
125 (in isoform 2)	Phosphorylation	-	45.49	18669648
131	Phosphorylation	VSDNEEDSYDEEIHD CCCCCCCCCCCCCCC	37.45	29255136
131 (in isoform 2)	Phosphorylation	-	37.45	18669648
132	Phosphorylation	SDNEEDSYDEEIHDP CCCCCCCCCCCCCCC	39.43	29255136
132 (in isoform 2)	Phosphorylation	-	39.43	18669648
141	Phosphorylation	EEIHDPRSGRSGVVN CCCCCCCCCCCCCCC	43.90	17855441
144	Phosphorylation	HDPRSGRSGVVNRRS CCCCCCCCCCCCCCC	39.19	17855441
151	Phosphorylation	SGVVNRRSEKIWPRD CCCCCCCCCCCCCCC	39.75	17855441
153	Ubiquitination	VVNRRSEKIWPRDRS CCCCCCCCCCCCCCH	51.85	-
160	Phosphorylation	KIWPRDRSASRERSL CCCCCCCHHCCCCCC	34.58	29743597
162	Phosphorylation	WPRDRSASRERSLSP CCCCCHHCCCCCCCC	35.60	29743597
166	Phosphorylation	RSASRERSLSPRSDR CHHCCCCCCCCCCCC	28.57	23927012
168	Phosphorylation	ASRERSLSPRSDRRS HCCCCCCCCCCCCCC	21.36	30278072
171	Phosphorylation	ERSLSPRSDRRSVAS CCCCCCCCCCCCHHH	38.56	28555341
175	Phosphorylation	SPRSDRRSVASSQPA CCCCCCCCHHHCCCC	23.95	22167270
178	Phosphorylation	SDRRSVASSQPAKPT CCCCCHHHCCCCCCC	27.61	22167270
179	Phosphorylation	DRRSVASSQPAKPTK CCCCHHHCCCCCCCE	30.37	30266825
183	Ubiquitination	VASSQPAKPTKVTLV HHHCCCCCCCEEEEE	60.96	21906983
183 (in isoform 1)	Ubiquitination	-	60.96	21890473
183 (in isoform 2)	Ubiquitination	-	60.96	21890473
185	Phosphorylation	SSQPAKPTKVTLVKS HCCCCCCCEEEEEEC	37.12	22167270
188	Phosphorylation	PAKPTKVTLVKSRKN CCCCCEEEEEECCCC	27.65	23312004
194	Ubiquitination	VTLVKSRKNEEYGLR EEEEECCCCCCHHHH	75.66	-
204	Phosphorylation	EYGLRLASHIFVKEI CHHHHHHEEEEEEEC	23.00	28555341
212	Phosphorylation	HIFVKEISQDSLAAR EEEEEECCCCCHHHC	29.09	29255136
215	Phosphorylation	VKEISQDSLAARDGN EEECCCCCHHHCCCC	16.57	29255136
235	Phosphorylation	VVLKINGTVTENMSL EEEEECCEEECCCCC	21.55	29523821
237	Phosphorylation	LKINGTVTENMSLTD EEECCEEECCCCCHH	22.83	27251275
241	Phosphorylation	GTVTENMSLTDAKTL CEEECCCCCHHHHHH	39.43	25159151
243	Phosphorylation	VTENMSLTDAKTLIE EECCCCCHHHHHHHH	26.97	27251275
267	Phosphorylation	VQRDERATLLNVPDL EEHHHCCEECCCCCC	37.69	23927012
275	Phosphorylation	LLNVPDLSDSIHSAN ECCCCCCHHHHHHCC	36.37	30266825
277	Phosphorylation	NVPDLSDSIHSANAS CCCCCHHHHHHCCHH	20.87	29255136
277 (in isoform 2)	Phosphorylation	-	20.87	18669648
280	Phosphorylation	DLSDSIHSANASERD CCHHHHHHCCHHHCC	22.88	29255136
280 (in isoform 2)	Phosphorylation	-	22.88	18669648
284	Phosphorylation	SIHSANASERDDISE HHHHCCHHHCCCHHH	32.73	30266825
290	Phosphorylation	ASERDDISEIQSLAS HHHCCCHHHHHHHHH	35.32	30266825
294	Phosphorylation	DDISEIQSLASDHSG CCHHHHHHHHHCCCC	31.40	30266825
297	Phosphorylation	SEIQSLASDHSGRSH HHHHHHHHCCCCCCC	40.94	30266825
300	Phosphorylation	QSLASDHSGRSHDRP HHHHHCCCCCCCCCC	40.67	29255136
303	Phosphorylation	ASDHSGRSHDRPPRR HHCCCCCCCCCCCCC	33.01	28985074
311	Phosphorylation	HDRPPRRSRSRSPDQ CCCCCCCCCCCCCCC	35.57	17081983
313	Phosphorylation	RPPRRSRSRSPDQRS CCCCCCCCCCCCCCC	38.05	30576142
315	Phosphorylation	PRRSRSRSPDQRSEP CCCCCCCCCCCCCCC	33.79	30576142
320	Phosphorylation	SRSPDQRSEPSDHSR CCCCCCCCCCCCCCC	48.50	23927012
323	Phosphorylation	PDQRSEPSDHSRHSP CCCCCCCCCCCCCCC	43.85	23927012
326	Phosphorylation	RSEPSDHSRHSPQQP CCCCCCCCCCCCCCC	36.36	23927012
329	Phosphorylation	PSDHSRHSPQQPSNG CCCCCCCCCCCCCCC	24.24	29255136
329 (in isoform 2)	Phosphorylation	-	24.24	18669648
334	Phosphorylation	RHSPQQPSNGSLRSR CCCCCCCCCCCCCCC	49.86	30266825
337	Phosphorylation	PQQPSNGSLRSRDEE CCCCCCCCCCCCCHH	25.51	30266825
337 (in isoform 2)	Phosphorylation	-	25.51	18669648
340	Phosphorylation	PSNGSLRSRDEERIS CCCCCCCCCCHHHCC	49.75	28985074
347	Phosphorylation	SRDEERISKPGAVST CCCHHHCCCCCCCCC	38.73	23927012
348	Ubiquitination	RDEERISKPGAVSTP CCHHHCCCCCCCCCC	45.13	-
353	Phosphorylation	ISKPGAVSTPVKHAD CCCCCCCCCCCCCCC	26.85	30266825
353 (in isoform 2)	Phosphorylation	-	26.85	18669648
354	Phosphorylation	SKPGAVSTPVKHADD CCCCCCCCCCCCCCC	26.04	30266825
354 (in isoform 2)	Phosphorylation	-	26.04	18669648
363	Phosphorylation	VKHADDHTPKTVEEV CCCCCCCCCCCEEEE	33.21	23927012
363 (in isoform 2)	Phosphorylation	-	33.21	18669648
366	O-linked_Glycosylation	ADDHTPKTVEEVTVE CCCCCCCCEEEEEEC	34.06	31492838
379	Phosphorylation	VERNEKQTPSLPEPK ECCCCCCCCCCCCCC	26.39	25159151
381	Phosphorylation	RNEKQTPSLPEPKPV CCCCCCCCCCCCCCC	61.00	25159151
389	Phosphorylation	LPEPKPVYAQVGQPD CCCCCCCEEECCCCC	10.39	24732914
402	Phosphorylation	PDVDLPVSPSDGVLP CCCCCCCCCCCCCCC	19.42	25159151
404	Phosphorylation	VDLPVSPSDGVLPNS CCCCCCCCCCCCCCC	39.22	24732914
411	Phosphorylation	SDGVLPNSTHEDGIL CCCCCCCCCCCCCCC	29.24	24732914
412	Phosphorylation	DGVLPNSTHEDGILR CCCCCCCCCCCCCCC	35.60	24732914
421	Phosphorylation	EDGILRPSMKLVKFR CCCCCCCCEEEEEEC	23.32	24732914
432	Phosphorylation	VKFRKGDSVGLRLAG EEECCCCCEEEEECC	27.10	17855441
476	Phosphorylation	RVNNVDFTNIIREEA EECCCCCCHHHCHHH	22.50	17855441
502	2-Hydroxyisobutyrylation	EVTILAQKKKDVYRR EEEEEEECCHHHHHH	57.07	-
513	Phosphorylation	VYRRIVESDVGDSFY HHHHHHHCCCCCCEE	27.05	-
518	Phosphorylation	VESDVGDSFYIRTHF HHCCCCCCEEEEEEE	17.64	28152594
520	Phosphorylation	SDVGDSFYIRTHFEY CCCCCCEEEEEEEEE	8.08	28152594
548	Phosphorylation	EVFRVVDTLYNGKLG CEEEEEEEECCCCCC	21.38	-
550	Phosphorylation	FRVVDTLYNGKLGSW EEEEEEECCCCCCCE	24.78	-
553	Ubiquitination	VDTLYNGKLGSWLAI EEEECCCCCCCEEEE	46.14	21890473
553 (in isoform 1)	Ubiquitination	-	46.14	21890473
553 (in isoform 2)	Ubiquitination	-	46.14	21890473
585	Phosphorylation	NRAEQLASVQYTLPK CHHHHHHCCEEECCC	20.53	21945579
588	Phosphorylation	EQLASVQYTLPKTAG HHHHCCEEECCCCCC	14.21	21945579
589	Phosphorylation	QLASVQYTLPKTAGG HHHCCEEECCCCCCC	21.35	21945579
592	Ubiquitination	SVQYTLPKTAGGDRA CCEEECCCCCCCCHH	54.87	21906983
592 (in isoform 1)	Ubiquitination	-	54.87	21890473
592 (in isoform 2)	Ubiquitination	-	54.87	21890473
609	Phosphorylation	WRFRGLRSSKRNLRK HHHHCHHHHHHHHHH	45.30	23403867
610	Phosphorylation	RFRGLRSSKRNLRKS HHHCHHHHHHHHHHC	29.24	23403867
617	Phosphorylation	SKRNLRKSREDLSAQ HHHHHHHCHHHHHCC	34.17	29255136
617 (in isoform 2)	Phosphorylation	-	34.17	18669648
622	Phosphorylation	RKSREDLSAQPVQTK HHCHHHHHCCCCCCC	36.86	23927012
622 (in isoform 2)	Phosphorylation	-	36.86	18669648
628	Phosphorylation	LSAQPVQTKFPAYER HHCCCCCCCCCCHHH	34.58	23403867
633	Phosphorylation	VQTKFPAYERVVLRE CCCCCCCHHHHHHHH	12.42	23312004
648	Phosphorylation	AGFLRPVTIFGPIAD CCCCCEEEEECCHHH	17.17	17855441
669	Phosphorylation	AREEPDIYQIAKSEP HHCCCCHHHHHCCCC	10.97	-
673	Ubiquitination	PDIYQIAKSEPRDAG CCHHHHHCCCCCCCC	57.91	-
681	Phosphorylation	SEPRDAGTDQRSSGI CCCCCCCCCCCCCCE	30.58	25002506
685	Phosphorylation	DAGTDQRSSGIIRLH CCCCCCCCCCEEEHH	27.55	25002506
686	Phosphorylation	AGTDQRSSGIIRLHT CCCCCCCCCEEEHHH	35.88	25159151
695	Ubiquitination	IIRLHTIKQIIDQDK EEEHHHHHHHHHCCC	36.28	21890473
695 (in isoform 1)	Ubiquitination	-	36.28	21890473
695 (in isoform 2)	Ubiquitination	-	36.28	21890473
702	2-Hydroxyisobutyrylation	KQIIDQDKHALLDVT HHHHHCCCCCCCCCC	25.74	-
702	Ubiquitination	KQIIDQDKHALLDVT HHHHHCCCCCCCCCC	25.74	21890473
702 (in isoform 1)	Ubiquitination	-	25.74	21890473
702 (in isoform 2)	Ubiquitination	-	25.74	21890473
709	Phosphorylation	KHALLDVTPNAVDRL CCCCCCCCCCHHHHC	15.53	28985074
718	Phosphorylation	NAVDRLNYAQWYPIV CHHHHCCHHHEEEEE	12.54	27259358
733	Acetylation	VFLNPDSKQGVKTMR EEECCCCCCCCCHHH	59.45	19828933
737	Acetylation	PDSKQGVKTMRMRLC CCCCCCCCHHHHEEC	43.35	19828945
738	Phosphorylation	DSKQGVKTMRMRLCP CCCCCCCHHHHEECH	13.96	17855441
747	Phosphorylation	RMRLCPESRKSARKL HHEECHHHHHHHHHH	30.10	25599653
750	Phosphorylation	LCPESRKSARKLYER ECHHHHHHHHHHHHH	32.00	25599653
770	Phosphorylation	KNNHHLFTTTINLNS HCCCEEEEEEEECCC	29.41	-
772	Phosphorylation	NHHLFTTTINLNSMN CCEEEEEEEECCCCC	12.57	17855441
809	Phosphorylation	EGKADGATSDDLDLH ECCCCCCCCCCCCCC	37.91	30266825
810	Phosphorylation	GKADGATSDDLDLHD CCCCCCCCCCCCCCC	28.70	30266825
821	Phosphorylation	DLHDDRLSYLSAPGS CCCCCHHHHEECCCC	25.56	21945579
822	Phosphorylation	LHDDRLSYLSAPGSE CCCCHHHHEECCCCC	14.85	21945579
824	Phosphorylation	DDRLSYLSAPGSEYS CCHHHHEECCCCCCE	24.96	21945579
828	Phosphorylation	SYLSAPGSEYSMYST HHEECCCCCCEEEEC	32.10	21945579
830	Phosphorylation	LSAPGSEYSMYSTDS EECCCCCCEEEECCC	10.63	21945579
831	Phosphorylation	SAPGSEYSMYSTDSR ECCCCCCEEEECCCC	13.75	21945579
833	Phosphorylation	PGSEYSMYSTDSRHT CCCCCEEEECCCCCC	11.50	21945579
834	Phosphorylation	GSEYSMYSTDSRHTS CCCCEEEECCCCCCC	19.66	21945579
835	Phosphorylation	SEYSMYSTDSRHTSD CCCEEEECCCCCCCC	22.10	21945579
837	Phosphorylation	YSMYSTDSRHTSDYE CEEEECCCCCCCCCC	26.50	21945579
840	Phosphorylation	YSTDSRHTSDYEDTD EECCCCCCCCCCCCC	23.37	24275569
841	Phosphorylation	STDSRHTSDYEDTDT ECCCCCCCCCCCCCC	31.88	25137130
843	Phosphorylation	DSRHTSDYEDTDTEG CCCCCCCCCCCCCCC	18.57	27422710
846	Phosphorylation	HTSDYEDTDTEGGAY CCCCCCCCCCCCCCC	32.64	19845377
848	Phosphorylation	SDYEDTDTEGGAYTD CCCCCCCCCCCCCCH	38.33	25137130
853	Phosphorylation	TDTEGGAYTDQELDE CCCCCCCCCHHHHHH	17.71	30266825
854	Phosphorylation	DTEGGAYTDQELDET CCCCCCCCHHHHHHH	30.58	30266825
861	Phosphorylation	TDQELDETLNDEVGT CHHHHHHHHCCCCCC	30.44	30266825
868	Phosphorylation	TLNDEVGTPPESAIT HHCCCCCCCCHHHCC	40.63	30266825
872	Phosphorylation	EVGTPPESAITRSSE CCCCCCHHHCCCCCC	30.64	30266825
875	Phosphorylation	TPPESAITRSSEPVR CCCHHHCCCCCCCCC	24.98	29523821
877	Phosphorylation	PESAITRSSEPVRED CHHHCCCCCCCCCCC	30.33	21945579
878	Phosphorylation	ESAITRSSEPVREDS HHHCCCCCCCCCCCC	42.50	21945579
885	Phosphorylation	SEPVREDSSGMHHEN CCCCCCCCCCCCCCC	24.84	21945579
886	Phosphorylation	EPVREDSSGMHHENQ CCCCCCCCCCCCCCC	53.08	21945579
894	Phosphorylation	GMHHENQTYPPYSPQ CCCCCCCCCCCCCCC	49.96	21945579
895	Phosphorylation	MHHENQTYPPYSPQA CCCCCCCCCCCCCCC	7.76	21945579
898	Phosphorylation	ENQTYPPYSPQAQPQ CCCCCCCCCCCCCCC	28.60	21945579
899	Phosphorylation	NQTYPPYSPQAQPQP CCCCCCCCCCCCCCC	19.13	21945579
912	Phosphorylation	QPIHRIDSPGFKPAS CCCCCCCCCCCCCHH	25.26	19664994
912 (in isoform 2)	Phosphorylation	-	25.26	25159151
919	Phosphorylation	SPGFKPASQQKAEAS CCCCCCHHHHHHHHC	41.49	23403867
919 (in isoform 2)	Phosphorylation	-	41.49	26356563
923 (in isoform 2)	Phosphorylation	-	17.16	27273156
926	Phosphorylation	SQQKAEASSPVPYLS HHHHHHHCCCCCCCC	27.04	25159151
927	Phosphorylation	QQKAEASSPVPYLSP HHHHHHCCCCCCCCC	36.64	28355574
928 (in isoform 2)	Phosphorylation	-	28.71	28270605
931	Phosphorylation	EASSPVPYLSPETNP HHCCCCCCCCCCCCC	21.75	21712546
933	Phosphorylation	SSPVPYLSPETNPAS CCCCCCCCCCCCCCC	18.17	25159151
936	Phosphorylation	VPYLSPETNPASSTS CCCCCCCCCCCCCCC	50.30	21712546
940	Phosphorylation	SPETNPASSTSAVNH CCCCCCCCCCCCCCC	35.09	22199227
941	Phosphorylation	PETNPASSTSAVNHN CCCCCCCCCCCCCCC	28.61	20068231
942	Phosphorylation	ETNPASSTSAVNHNV CCCCCCCCCCCCCCC	20.43	22199227
943	Phosphorylation	TNPASSTSAVNHNVN CCCCCCCCCCCCCCC	31.97	20068231
952	Phosphorylation	VNHNVNLTNVRLEEP CCCCCCCCCCEECCC	26.85	20068231
960	Phosphorylation	NVRLEEPTPAPSTSY CCEECCCCCCCCCCC	35.05	23403867
964	Phosphorylation	EEPTPAPSTSYSPQA CCCCCCCCCCCCCCC	31.90	30266825
965	Phosphorylation	EPTPAPSTSYSPQAD CCCCCCCCCCCCCCC	30.53	30266825
966	Phosphorylation	PTPAPSTSYSPQADS CCCCCCCCCCCCCCC	28.13	30266825
967	Phosphorylation	TPAPSTSYSPQADSL CCCCCCCCCCCCCCC	25.18	30266825
968	Phosphorylation	PAPSTSYSPQADSLR CCCCCCCCCCCCCCC	15.42	29255136
973	Phosphorylation	SYSPQADSLRTPSTE CCCCCCCCCCCCCCH	23.83	30266825
976	Phosphorylation	PQADSLRTPSTEAAH CCCCCCCCCCCHHHH	27.21	18669648
978	O-linked_Glycosylation	ADSLRTPSTEAAHIM CCCCCCCCCHHHHHH	37.96	31492838
978	Phosphorylation	ADSLRTPSTEAAHIM CCCCCCCCCHHHHHH	37.96	25159151
979	O-linked_Glycosylation	DSLRTPSTEAAHIML CCCCCCCCHHHHHHH	30.74	31492838
979	Phosphorylation	DSLRTPSTEAAHIML CCCCCCCCHHHHHHH	30.74	25159151
992	Phosphorylation	MLRDQEPSLSSHVDP HHHCCCCCCCCCCCC	39.88	26657352
994	Phosphorylation	RDQEPSLSSHVDPTK HCCCCCCCCCCCCCC	23.80	25159151
995	Phosphorylation	DQEPSLSSHVDPTKV CCCCCCCCCCCCCCC	32.59	26657352
1003	Phosphorylation	HVDPTKVYRKDPYPE CCCCCCCCCCCCCCH	17.32	28258704
1008	Phosphorylation	KVYRKDPYPEEMMRQ CCCCCCCCCHHHHHH	33.15	28258704
1025	Phosphorylation	VLKQPAVSHPGHRPD CCCCCCCCCCCCCCC	26.52	17855441
1038	Phosphorylation	PDKEPNLTYEPQLPY CCCCCCCCCCCCCCC	32.26	21945579
1039	Phosphorylation	DKEPNLTYEPQLPYV CCCCCCCCCCCCCCC	28.86	21945579
1051	Phosphorylation	PYVEKQASRDLEQPT CCCCHHHCCCCCCCC	24.67	28355574
1058	Phosphorylation	SRDLEQPTYRYESSS CCCCCCCCEECCCCC	21.96	21945579
1059	Phosphorylation	RDLEQPTYRYESSSY CCCCCCCEECCCCCC	20.20	21945579
1061	Phosphorylation	LEQPTYRYESSSYTD CCCCCEECCCCCCCC	15.11	21945579
1063	Phosphorylation	QPTYRYESSSYTDQF CCCEECCCCCCCCCC	18.69	21945579
1064	Phosphorylation	PTYRYESSSYTDQFS CCEECCCCCCCCCCC	18.54	25394399
1065	Phosphorylation	TYRYESSSYTDQFSR CEECCCCCCCCCCCC	41.13	21815630
1066	Phosphorylation	YRYESSSYTDQFSRN EECCCCCCCCCCCCC	19.11	25159151
1067	Phosphorylation	RYESSSYTDQFSRNY ECCCCCCCCCCCCCH	25.85	28152594
1071	O-linked_Glycosylation	SSYTDQFSRNYEHRL CCCCCCCCCCHHHHC	17.62	31492838
1071	Phosphorylation	SSYTDQFSRNYEHRL CCCCCCCCCCHHHHC	17.62	26356563
1074	Phosphorylation	TDQFSRNYEHRLRYE CCCCCCCHHHHCCHH	16.41	20736484
1087	Phosphorylation	YEDRVPMYEEQWSYY HHCCCCCCHHHHCCC	15.39	27259358
1092	Phosphorylation	PMYEEQWSYYDDKQP CCCHHHHCCCCCCCC	17.32	27732954
1093	Phosphorylation	MYEEQWSYYDDKQPY CCHHHHCCCCCCCCC	14.14	24144214
1094	Phosphorylation	YEEQWSYYDDKQPYP CHHHHCCCCCCCCCC	16.49	24144214
1100	Phosphorylation	YYDDKQPYPSRPPFD CCCCCCCCCCCCCCC	16.02	23403867
1102	Phosphorylation	DDKQPYPSRPPFDNQ CCCCCCCCCCCCCCC	52.13	23403867
1109 (in isoform 2)	Ubiquitination	-	39.18	21890473
1111	Phosphorylation	PPFDNQHSQDLDSRQ CCCCCCCCCCCHHCC	18.67	28355574
1116	Phosphorylation	QHSQDLDSRQHPEES CCCCCCHHCCCHHHH	40.93	21955146
1123	Phosphorylation	SRQHPEESSERGYFP HCCCHHHHCCCCCCC	35.52	30242111
1124	Phosphorylation	RQHPEESSERGYFPR CCCHHHHCCCCCCCC	34.29	30242111
1128	Phosphorylation	EESSERGYFPRFEEP HHHCCCCCCCCCCCC	19.34	-
1139	Phosphorylation	FEEPAPLSYDSRPRY CCCCCCCCCCCCCCH	26.32	21945579
1140	Phosphorylation	EEPAPLSYDSRPRYE CCCCCCCCCCCCCHH	26.14	21945579
1142	Phosphorylation	PAPLSYDSRPRYEQA CCCCCCCCCCCHHCC	35.63	21945579
1146	Phosphorylation	SYDSRPRYEQAPRAS CCCCCCCHHCCCCHH	18.31	20736484
1153	Phosphorylation	YEQAPRASALRHEEQ HHCCCCHHHHCCCCC	29.17	21945579
1165	Phosphorylation	EEQPAPGYDTHGRLR CCCCCCCCCCCCCCC	19.33	21945579
1167	Phosphorylation	QPAPGYDTHGRLRPE CCCCCCCCCCCCCCC	20.11	21945579
1180	Phosphorylation	PEAQPHPSAGPKPAE CCCCCCCCCCCCCHH	42.71	25159151
1188	Phosphorylation	AGPKPAESKQYFEQY CCCCCHHHHHHHHHH	27.45	23312004
1189	Ubiquitination	GPKPAESKQYFEQYS CCCCHHHHHHHHHHH	40.29	21890473
1189 (in isoform 1)	Ubiquitination	-	40.29	21890473
1191	Phosphorylation	KPAESKQYFEQYSRS CCHHHHHHHHHHHHC	16.90	21609022
1195	Phosphorylation	SKQYFEQYSRSYEQV HHHHHHHHHHCHHCC	10.00	27273156
1196	Phosphorylation	KQYFEQYSRSYEQVP HHHHHHHHHCHHCCC	17.91	25348954
1198	Phosphorylation	YFEQYSRSYEQVPPQ HHHHHHHCHHCCCCC	27.38	28152594
1199	Phosphorylation	FEQYSRSYEQVPPQG HHHHHHCHHCCCCCC	14.85	28152594
1269	Ubiquitination	QSVLTRVKMFENKRS HHHHHHHHHHCCCCC	34.28	-
1276	Phosphorylation	KMFENKRSASLETKK HHHCCCCCCCCCCCC	24.66	25159151
1278	Phosphorylation	FENKRSASLETKKDV HCCCCCCCCCCCCCC	28.16	27794612
1281	Phosphorylation	KRSASLETKKDVNDT CCCCCCCCCCCCCCC	49.00	29514088
1282	2-Hydroxyisobutyrylation	RSASLETKKDVNDTG CCCCCCCCCCCCCCC	37.29	-
1321	Ubiquitination	NQFSEHDKTLYRIPE CCCCCCCCCCCCCCC	42.19	-
1322	Phosphorylation	QFSEHDKTLYRIPEP CCCCCCCCCCCCCCC	34.77	21945579
1324	Phosphorylation	SEHDKTLYRIPEPQK CCCCCCCCCCCCCCC	16.24	21945579
1331	Ubiquitination	YRIPEPQKPQLKPPE CCCCCCCCCCCCCCH	45.51	-
1343	Phosphorylation	PPEDIVRSNHYDPEE CCHHHHHCCCCCHHH	19.64	21945579
1346	Phosphorylation	DIVRSNHYDPEEDEE HHHHCCCCCHHHCHH	37.13	21945579
1354	Phosphorylation	DPEEDEEYYRKQLSY CHHHCHHHHHHHHHH	13.41	21945579
1355	Phosphorylation	PEEDEEYYRKQLSYF HHHCHHHHHHHHHHH	18.02	21945579
1357	Ubiquitination	EDEEYYRKQLSYFDR HCHHHHHHHHHHHCH	39.20	-
1360	Phosphorylation	EYYRKQLSYFDRRSF HHHHHHHHHHCHHHH	22.66	26356563
1361	Phosphorylation	YYRKQLSYFDRRSFE HHHHHHHHHCHHHHC	20.35	25394399
1366	O-linked_Glycosylation	LSYFDRRSFENKPPA HHHHCHHHHCCCCCC	37.49	31492838
1366	Phosphorylation	LSYFDRRSFENKPPA HHHHCHHHHCCCCCC	37.49	25159151
1378	Phosphorylation	PPAHIAASHLSEPAK CCCHHHHHCCCCCCC	18.88	23607784
1381	Phosphorylation	HIAASHLSEPAKPAH HHHHHCCCCCCCCCC	35.79	23927012
1385	Acetylation	SHLSEPAKPAHSQNQ HCCCCCCCCCCCCCC	54.15	26051181
1389	Phosphorylation	EPAKPAHSQNQSNFS CCCCCCCCCCCCCCH	32.69	23607784
1393	Phosphorylation	PAHSQNQSNFSSYSS CCCCCCCCCCHHCCC	47.60	24144214
1396	Phosphorylation	SQNQSNFSSYSSKGK CCCCCCCHHCCCCCC	32.39	25159151
1397	Phosphorylation	QNQSNFSSYSSKGKP CCCCCCHHCCCCCCC	25.54	23927012
1398	Phosphorylation	NQSNFSSYSSKGKPP CCCCCHHCCCCCCCC	18.76	23927012
1399	Phosphorylation	QSNFSSYSSKGKPPE CCCCHHCCCCCCCCC	27.76	25849741
1400	Phosphorylation	SNFSSYSSKGKPPEA CCCHHCCCCCCCCCC	36.88	23927012
1413	Phosphorylation	EADGVDRSFGEKRYE CCCCCCCCCCCCCCC	32.89	25159151
1417	Acetylation	VDRSFGEKRYEPIQA CCCCCCCCCCCCCCC	61.74	21339330
1419	Phosphorylation	RSFGEKRYEPIQATP CCCCCCCCCCCCCCC	36.81	21945579
1425	Phosphorylation	RYEPIQATPPPPPLP CCCCCCCCCCCCCCC	21.69	21945579
1433	Phosphorylation	PPPPPLPSQYAQPSQ CCCCCCCCCCCCCCC	43.43	21945579
1435	Phosphorylation	PPPLPSQYAQPSQPV CCCCCCCCCCCCCCC	16.13	21945579
1439	Phosphorylation	PSQYAQPSQPVTSAS CCCCCCCCCCCCEEE	34.73	21945579
1443	Phosphorylation	AQPSQPVTSASLHIH CCCCCCCCEEEEEEE	25.84	21945579
1444	Phosphorylation	QPSQPVTSASLHIHS CCCCCCCEEEEEEEC	18.98	21945579
1446	Phosphorylation	SQPVTSASLHIHSKG CCCCCEEEEEEECCC	21.90	21945579
1451	Phosphorylation	SASLHIHSKGAHGEG EEEEEEECCCCCCCC	31.98	21945579
1468	Phosphorylation	VSLDFQNSLVSKPDP EEEEEHHHCCCCCCC	21.26	24850871
1471	Phosphorylation	DFQNSLVSKPDPPPS EEHHHCCCCCCCCCC	43.71	24850871
1478	Phosphorylation	SKPDPPPSQNKPATF CCCCCCCCCCCCCCC	52.76	28102081
1503	Phosphorylation	AAFYPQKSFPDKAPV HHCCCCCCCCCCCCC	36.44	22617229
1513	Phosphorylation	DKAPVNGTEQTQKTV CCCCCCCCHHCCCCC	21.51	23879269
1516	Phosphorylation	PVNGTEQTQKTVTPA CCCCCHHCCCCCCCC	26.29	23879269
1519	Phosphorylation	GTEQTQKTVTPAYNR CCHHCCCCCCCCCCC	21.57	28985074
1521	Phosphorylation	EQTQKTVTPAYNRFT HHCCCCCCCCCCCCC	13.87	25159151
1521 (in isoform 2)	Ubiquitination	-	13.87	21890473
1524	Phosphorylation	QKTVTPAYNRFTPKP CCCCCCCCCCCCCCC	14.20	21609022
1528	Phosphorylation	TPAYNRFTPKPYTSS CCCCCCCCCCCCCCC	27.45	28152594
1530	Methylation	AYNRFTPKPYTSSAR CCCCCCCCCCCCCCC	47.82	72630861
1532	Phosphorylation	NRFTPKPYTSSARPF CCCCCCCCCCCCCCC	25.94	28152594
1533	Phosphorylation	RFTPKPYTSSARPFE CCCCCCCCCCCCCCC	25.40	28857561
1534	Phosphorylation	FTPKPYTSSARPFER CCCCCCCCCCCCCCC	19.02	28152594
1535	Phosphorylation	TPKPYTSSARPFERK CCCCCCCCCCCCCCC	22.09	28857561
1545	Phosphorylation	PFERKFESPKFNHNL CCCCCCCCCCCCCCC	36.20	29496963
1555	Phosphorylation	FNHNLLPSETAHKPD CCCCCCCCCCCCCCC	47.77	23403867
1557	Phosphorylation	HNLLPSETAHKPDLS CCCCCCCCCCCCCCC	38.10	23403867
1564	Phosphorylation	TAHKPDLSSKTPTSP CCCCCCCCCCCCCCC	36.85	23403867
1565	Phosphorylation	AHKPDLSSKTPTSPK CCCCCCCCCCCCCCC	48.09	23403867
1567	Phosphorylation	KPDLSSKTPTSPKTL CCCCCCCCCCCCCHH	33.47	25159151
1569	Phosphorylation	DLSSKTPTSPKTLVK CCCCCCCCCCCHHHC	63.99	21712546
1570	Phosphorylation	LSSKTPTSPKTLVKS CCCCCCCCCCHHHCC	26.13	25159151
1573	Phosphorylation	KTPTSPKTLVKSHSL CCCCCCCHHHCCCCC	39.92	24732914
1577	Phosphorylation	SPKTLVKSHSLAQPP CCCHHHCCCCCCCCC	15.72	22617229
1579	Phosphorylation	KTLVKSHSLAQPPEF CHHHCCCCCCCCCCC	32.27	25159151
1588	Phosphorylation	AQPPEFDSGVETFSI CCCCCCCCCCEEEEE	50.49	23403867
1592	Phosphorylation	EFDSGVETFSIHAEK CCCCCCEEEEEEECC	21.92	23403867
1594	Phosphorylation	DSGVETFSIHAEKPK CCCCEEEEEEECCCC	22.38	23403867
1601	Ubiquitination	SIHAEKPKYQINNIS EEEECCCCEEECCCC	61.94	21890473
1601 (in isoform 1)	Ubiquitination	-	61.94	21890473
1602	Phosphorylation	IHAEKPKYQINNIST EEECCCCEEECCCCC	24.13	28152594
1608	Phosphorylation	KYQINNISTVPKAIP CEEECCCCCCCCEEE	26.02	28555341
1617	Phosphorylation	VPKAIPVSPSAVEED CCCEEECCCCCCCCC	14.05	29255136
1619	Phosphorylation	KAIPVSPSAVEEDED CEEECCCCCCCCCCC	37.12	29255136
1631	Phosphorylation	DEDEDGHTVVATARG CCCCCCCEEEEEEEE	23.39	23927012
1635	Phosphorylation	DGHTVVATARGIFNS CCCEEEEEEEEEEEC	12.79	23403867
1655	Phosphorylation	SSIETGVSIIIPQGA CCEECCCEEEECCCC	14.93	17855441
1680	Phosphorylation	FKVCRDNSILPPLDK EEECCCCCCCCCCCH	29.77	28674419
1687	Ubiquitination	SILPPLDKEKGETLL CCCCCCCHHHCCCCC	69.84	-
1709	Ubiquitination	PHGLKFLKPVELRLP CCCCCCCCCEEECCC	50.58	2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZO1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAM1_HUMAN	F11R	physical	12953056
JAM2_HUMAN	JAM2	physical	12953056
JAM3_HUMAN	JAM3	physical	12953056
CXA8_HUMAN	GJA8	physical	12808044
CXA3_HUMAN	GJA3	physical	12808044
KIRR1_HUMAN	KIRREL	physical	12578837
ZO2_HUMAN	TJP2	physical	10575001
ZO3_HUMAN	TJP3	physical	10575001
CXA1_HUMAN	GJA1	physical	9707407
ZO2_HUMAN	TJP2	physical	9792688
OCLN_HUMAN	OCLN	physical	12169098
AFAD_HUMAN	MLLT4	physical	10334923
CXD3_HUMAN	GJD3	physical	12154091
YBOX3_HUMAN	YBX3	physical	16508013
ACTN1_HUMAN	ACTN1	physical	16944923
ACTN4_HUMAN	ACTN4	physical	16944923
ACTB_HUMAN	ACTB	physical	16944923
ANXA6_HUMAN	ANXA6	physical	16944923
K2C8_HUMAN	KRT8	physical	16944923
K1C10_HUMAN	KRT10	physical	16944923
K2C1_HUMAN	KRT1	physical	16944923
FLNA_HUMAN	FLNA	physical	16944923
TBB5_HUMAN	TUBB	physical	16944923
TBB4A_HUMAN	TUBB4A	physical	16944923
TBA1C_HUMAN	TUBA1C	physical	16944923
PLEC_HUMAN	PLEC	physical	16944923
SPTN1_HUMAN	SPTAN1	physical	16944923
VIME_HUMAN	VIM	physical	16944923
CXA1_HUMAN	GJA1	physical	16944923
ZPR1_HUMAN	ZPR1	physical	22939629
VMP1_HUMAN	VMP1	physical	17724469
ZO2_HUMAN	TJP2	physical	26344197
OCLN_HUMAN	OCLN	physical	26090670

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZO1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-353 AND THR-354, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; TYR-132; SER-277;SER-280; SER-329; SER-617; SER-912; SER-968 AND SER-1545, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; SER-131; TYR-132;SER-912; SER-927; SER-968; SER-1617 AND SER-1619, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617, AND MASSSPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-168; SER-275;SER-277; SER-280; SER-337; SER-402; THR-868 AND SER-1366, AND MASSSPECTROMETRY.	17081983 [Abstract]