ZO2_HUMAN - dbPTM
ZO2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZO2_HUMAN
UniProt AC Q9UDY2
Protein Name Tight junction protein ZO-2
Gene Name TJP2
Organism Homo sapiens (Human).
Sequence Length 1190
Subcellular Localization Cell junction, adherens junction. Cell membrane
Peripheral membrane protein
Cytoplasmic side. Cell junction, tight junction . Nucleus. Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial
Protein Description Plays a role in tight junctions and adherens junctions..
Protein Sequence MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9 (in isoform 3)Phosphorylation-8.6227762562
9 (in isoform 4)Phosphorylation-8.6227762562
16PhosphorylationFPPRRELSGWLRAPG
CCCHHHHCCCCCCCC		24.1428348404
32PhosphorylationEELIWEQYTVTLQKD
HHEEEEEEEEEEECC		7.5220068231
33PhosphorylationELIWEQYTVTLQKDS
HEEEEEEEEEEECCC		13.5020068231
35PhosphorylationIWEQYTVTLQKDSKR
EEEEEEEEEECCCCC		18.7020068231
49PhosphorylationRGFGIAVSGGRDNPH
CCEEEEEECCCCCCC		26.8928674419
91PhosphorylationRVVMVNGTPMEDVLH
EEEEECCEEHHHHHH		17.7922817900
130PhosphorylationQVAALQASPPLDQDD
EEEEEECCCCCCCCC		17.6819664994
143SulfoxidationDDRAFEVMDEFDGRS
CCCHHHHHHHCCCCC		3.0021406390
150PhosphorylationMDEFDGRSFRSGYSE
HHHCCCCCCCCCCCC		30.4630183078
153PhosphorylationFDGRSFRSGYSERSR
CCCCCCCCCCCCHHC		39.8229496963
155PhosphorylationGRSFRSGYSERSRLN
CCCCCCCCCCHHCCC		14.4921406692
156PhosphorylationRSFRSGYSERSRLNS
CCCCCCCCCHHCCCC		30.0229496963
159PhosphorylationRSGYSERSRLNSHGG
CCCCCCHHCCCCCCC		36.7528176443
161 (in isoform 7)Phosphorylation-8.9927251275
163PhosphorylationSERSRLNSHGGRSRS
CCHHCCCCCCCCCCC		28.2728176443
168PhosphorylationLNSHGGRSRSWEDSP
CCCCCCCCCCCCCCC		33.6630266825
170PhosphorylationSHGGRSRSWEDSPER
CCCCCCCCCCCCCCC		35.7422167270
174PhosphorylationRSRSWEDSPERGRPH
CCCCCCCCCCCCCCC		19.6919664994
181 (in isoform 7)Phosphorylation-35.5027251275
184 (in isoform 7)Phosphorylation-15.7127251275
186PhosphorylationRPHERARSRERDLSR
CCCHHHHHHHHHHHH		37.1922817900
192PhosphorylationRSRERDLSRDRSRGR
HHHHHHHHHHHHHHH		36.1028355574
196PhosphorylationRDLSRDRSRGRSLER
HHHHHHHHHHHHHHH		43.2928102081
200PhosphorylationRDRSRGRSLERGLDQ
HHHHHHHHHHHCCCH		37.0928355574
201 (in isoform 7)Phosphorylation-5.1127251275
205 (in isoform 7)Phosphorylation-7.1927251275
212PhosphorylationLDQDHARTRDRSRGR
CCHHHHHHHHHHHHH		37.3922817900
216PhosphorylationHARTRDRSRGRSLER
HHHHHHHHHHHHHHC		43.2929496963
220PhosphorylationRDRSRGRSLERGLDH
HHHHHHHHHHCCCCC		37.0928355574
232PhosphorylationLDHDFGPSRDRDRDR
CCCCCCCCCCCCCHH		47.3920873877
240PhosphorylationRDRDRDRSRGRSIDQ
CCCCCHHHCCCCCCH		43.2922617229
244PhosphorylationRDRSRGRSIDQDYER
CHHHCCCCCCHHHHH		33.0819664994
249PhosphorylationGRSIDQDYERAYHRA
CCCCCHHHHHHHHHH		11.1527273156
253PhosphorylationDQDYERAYHRAYDPD
CHHHHHHHHHHHCCC		9.6922817900
257PhosphorylationERAYHRAYDPDYERA
HHHHHHHHCCCHHHH		28.1521945579
261PhosphorylationHRAYDPDYERAYSPE
HHHHCCCHHHHCCHH		16.8321945579
263 (in isoform 7)Phosphorylation-32.3727251275
265PhosphorylationDPDYERAYSPEYRRG
CCCHHHHCCHHHHHH		30.8621945579
266PhosphorylationPDYERAYSPEYRRGA
CCHHHHCCHHHHHHC		15.4022167270
269PhosphorylationERAYSPEYRRGARHD
HHHCCHHHHHHCCCC		14.7021945579
275 (in isoform 7)Phosphorylation-32.3327251275
279PhosphorylationGARHDARSRGPRSRS
HCCCCHHHCCCCCCC		43.2222817900
284PhosphorylationARSRGPRSRSREHPH
HHHCCCCCCCCCCCC		37.4322817900
286PhosphorylationSRGPRSRSREHPHSR
HCCCCCCCCCCCCCC		43.1825849741
292PhosphorylationRSREHPHSRSPSPEP
CCCCCCCCCCCCCCC		38.6128355574
294PhosphorylationREHPHSRSPSPEPRG
CCCCCCCCCCCCCCC		32.5128355574
296PhosphorylationHPHSRSPSPEPRGRP
CCCCCCCCCCCCCCC		43.0428355574
297 (in isoform 7)Phosphorylation-60.0227251275
319PhosphorylationKSRANEEYGLRLGSQ
CCCCCCCCCCCCCCE		18.45-
325PhosphorylationEYGLRLGSQIFVKEM
CCCCCCCCEEEEEEC		25.3723403867
325 (in isoform 7)Phosphorylation-25.3727251275
327 (in isoform 7)Phosphorylation-4.6127251275
333PhosphorylationQIFVKEMTRTGLATK
EEEEEECCCCCEEEC		26.60-
335PhosphorylationFVKEMTRTGLATKDG
EEEECCCCCEEECCC		27.64-
339PhosphorylationMTRTGLATKDGNLHE
CCCCCEEECCCCCCC		34.4125367160
356 (in isoform 7)Phosphorylation-21.5527251275
356PhosphorylationIILKINGTVTENMSL
EEEEECCEEECCCCH		21.5530576142
358PhosphorylationLKINGTVTENMSLTD
EEECCEEECCCCHHH		22.8330576142
373PhosphorylationARKLIEKSRGKLQLV
HHHHHHHCCCCEEEE		33.2124702127
385PhosphorylationQLVVLRDSQQTLINI
EEEEEECCCCEEEEC		20.1120873877
388PhosphorylationVLRDSQQTLINIPSL
EEECCCCEEEECCCC		23.2029116813
394PhosphorylationQTLINIPSLNDSDSE
CEEEECCCCCCCCCC		35.6926846344
398PhosphorylationNIPSLNDSDSEIEDI
ECCCCCCCCCCCCCH		41.8026846344
400PhosphorylationPSLNDSDSEIEDISE
CCCCCCCCCCCCHHH		44.4126846344
406PhosphorylationDSEIEDISEIESNRS
CCCCCCHHHHHHCCC		44.8628176443
410PhosphorylationEDISEIESNRSFSPE
CCHHHHHHCCCCCHH		43.1128176443
413PhosphorylationSEIESNRSFSPEERR
HHHHHCCCCCHHHHH		34.0330266825
415PhosphorylationIESNRSFSPEERRHQ
HHHCCCCCHHHHHHC		32.4229255136
423PhosphorylationPEERRHQYSDYDYHS
HHHHHHCCCCCCCCC		9.4421945579
424PhosphorylationEERRHQYSDYDYHSS
HHHHHCCCCCCCCCC		24.1121945579
426PhosphorylationRRHQYSDYDYHSSSE
HHHCCCCCCCCCCHH		16.6821945579
428PhosphorylationHQYSDYDYHSSSEKL
HCCCCCCCCCCHHHH		9.4321945579
429 (in isoform 7)Phosphorylation-20.5027251275
430PhosphorylationYSDYDYHSSSEKLKE
CCCCCCCCCHHHHHC		29.3621945579
431PhosphorylationSDYDYHSSSEKLKER
CCCCCCCCHHHHHCC		29.2421945579
431 (in isoform 7)Phosphorylation-29.2427251275
432PhosphorylationDYDYHSSSEKLKERP
CCCCCCCHHHHHCCC		41.5921945579
440PhosphorylationEKLKERPSSREDTPS
HHHHCCCCCCCCCHH		48.5325159151
441PhosphorylationKLKERPSSREDTPSR
HHHCCCCCCCCCHHH		42.2328355574
444 (in isoform 7)Phosphorylation-63.9127251275
445PhosphorylationRPSSREDTPSRLSRM
CCCCCCCCHHHHHHC		20.5725159151
446 (in isoform 7)Phosphorylation-29.7627251275
447PhosphorylationSSREDTPSRLSRMGA
CCCCCCHHHHHHCCC		48.2028176443
450PhosphorylationEDTPSRLSRMGATPT
CCCHHHHHHCCCCCC		21.0723312004
452 (in isoform 3)Ubiquitination-3.7321890473
452 (in isoform 4)Ubiquitination-3.7321906983
455PhosphorylationRLSRMGATPTPFKST
HHHHCCCCCCCCCCC		23.2023927012
455 (in isoform 7)Phosphorylation-23.2027251275
457PhosphorylationSRMGATPTPFKSTGD
HHCCCCCCCCCCCCC		36.6823927012
460MethylationGATPTPFKSTGDIAG
CCCCCCCCCCCCCCC		48.5954432169
460AcetylationGATPTPFKSTGDIAG
CCCCCCCCCCCCCCC		48.5926051181
461PhosphorylationATPTPFKSTGDIAGT
CCCCCCCCCCCCCCE		37.6923927012
461 (in isoform 7)Phosphorylation-37.6927251275
462PhosphorylationTPTPFKSTGDIAGTV
CCCCCCCCCCCCCEE		39.1925159151
462 (in isoform 7)Phosphorylation-39.1927251275
468PhosphorylationSTGDIAGTVVPETNK
CCCCCCCEECCCCCC		14.8723403867
472 (in isoform 7)Phosphorylation-54.1027251275
473PhosphorylationAGTVVPETNKEPRYQ
CCEECCCCCCCCCCC		45.5823403867
475UbiquitinationTVVPETNKEPRYQED
EECCCCCCCCCCCCC		76.2221906983
475 (in isoform 2)Ubiquitination-76.2221906983
475 (in isoform 5)Ubiquitination-76.2221906983
476 (in isoform 7)Phosphorylation-36.7627251275
479PhosphorylationETNKEPRYQEDPPAP
CCCCCCCCCCCCCCC		27.28-
481 (in isoform 7)Phosphorylation-64.6527251275
486 (in isoform 7)Phosphorylation-57.7027251275
492 (in isoform 7)Phosphorylation-40.4827251275
494PhosphorylationQPKAAPRTFLRPSPE
CCCCCCCCCCCCCCC		26.4321945579
499PhosphorylationPRTFLRPSPEDEAIY
CCCCCCCCCCCCCCC		34.1921945579
506PhosphorylationSPEDEAIYGPNTKMV
CCCCCCCCCCCCCEE		33.3121945579
506 (in isoform 1)Ubiquitination-33.3121890473
510PhosphorylationEAIYGPNTKMVRFKK
CCCCCCCCCEEEEEC		24.5321945579
520PhosphorylationVRFKKGDSVGLRLAG
EEEECCCCCCEEECC		27.1023312004
525 (in isoform 7)Phosphorylation-6.6327251275
530 (in isoform 7)Phosphorylation-43.2127251275
574PhosphorylationVREDAVLYLLEIPKG
CCCCEEEEEEECCCC		11.5719060867
585PhosphorylationIPKGEMVTILAQSRA
CCCCCCEEEEEHHHH		14.6822817900
590PhosphorylationMVTILAQSRADVYRD
CEEEEEHHHHHHHHH		24.6722817900
606PhosphorylationLACGRGDSFFIRSHF
HHCCCCCCEEEEECE		25.5323312004
637 (in isoform 7)Phosphorylation-2.9527251275
638PhosphorylationFRVVDTLYDGKLGNW
EEEEEEECCCCCCCE		25.41-
702PhosphorylationVKKNLRKSREDLTAV
HHHHHHHCHHHCEEE		34.1730266825
707PhosphorylationRKSREDLTAVVSVST
HHCHHHCEEEEEECC		29.7230266825
711PhosphorylationEDLTAVVSVSTKFPA
HHCEEEEEECCCCCH		12.0728176443
713PhosphorylationLTAVVSVSTKFPAYE
CEEEEEECCCCCHHH		20.5528176443
714PhosphorylationTAVVSVSTKFPAYER
EEEEEECCCCCHHHH		34.2528176443
730MethylationLLREAGFKRPVVLFG
HHHHCCCCCCEEEEC		55.67-
733 (in isoform 7)Phosphorylation-7.3027251275
738 (in isoform 7)Phosphorylation-15.9727251275
760PhosphorylationDWFQTAKTEPKDAGS
HHHHHCCCCCCCCCC		55.8722817900
767PhosphorylationTEPKDAGSEKSTGVV
CCCCCCCCCCCCCEE		43.5023403867
769UbiquitinationPKDAGSEKSTGVVRL
CCCCCCCCCCCEEEH		55.82-
770PhosphorylationKDAGSEKSTGVVRLN
CCCCCCCCCCEEEHH		26.7523403867
771PhosphorylationDAGSEKSTGVVRLNT
CCCCCCCCCEEEHHH		45.0923403867
778PhosphorylationTGVVRLNTVRQIIEQ
CCEEEHHHHHHHHHH		22.9722817900
831PhosphorylationMRQRLNPTSNKSSRK
HHHHCCCCCCHHHHH		43.8122817900
832PhosphorylationRQRLNPTSNKSSRKL
HHHCCCCCCHHHHHH		43.4422817900
836PhosphorylationNPTSNKSSRKLFDQA
CCCCCHHHHHHHHHH		34.7422817900
886PhosphorylationQGEAVWVSEGKMEGM
CCCEEEEECCCCCCC		25.5622817900
902PhosphorylationDDPEDRMSYLTAMGA
CCHHHHHHHHHHHCC		20.2021945579
903PhosphorylationDPEDRMSYLTAMGAD
CHHHHHHHHHHHCCC		9.9521945579
905PhosphorylationEDRMSYLTAMGADYL
HHHHHHHHHHCCCEE		13.3321945579
911PhosphorylationLTAMGADYLSCDSRL
HHHHCCCEEECCCCE		10.4421945579
913PhosphorylationAMGADYLSCDSRLIS
HHCCCEEECCCCEEC		15.0621945579
916PhosphorylationADYLSCDSRLISDFE
CCEEECCCCEECCCC		33.0621945579
920PhosphorylationSCDSRLISDFEDTDG
ECCCCEECCCCCCCC		40.6227273156
925PhosphorylationLISDFEDTDGEGGAY
EECCCCCCCCCCCCC		38.4127273156
932PhosphorylationTDGEGGAYTDNELDE
CCCCCCCCCCCCCCC		20.2123927012
933PhosphorylationDGEGGAYTDNELDEP
CCCCCCCCCCCCCCC		31.6427273156
933 (in isoform 7)Phosphorylation-31.6427251275
936 (in isoform 7)Phosphorylation-61.4827251275
944 (in isoform 7)Phosphorylation-29.5727251275
947PhosphorylationPAEEPLVSSITRSSE
CCCCCCCHHCCCCCC		24.5720873877
947 (in isoform 7)Phosphorylation-24.5727251275
948PhosphorylationAEEPLVSSITRSSEP
CCCCCCHHCCCCCCC		22.0926657352
950PhosphorylationEPLVSSITRSSEPVQ
CCCCHHCCCCCCCCC		26.8420873877
952PhosphorylationLVSSITRSSEPVQHE
CCHHCCCCCCCCCCH		30.3323927012
953PhosphorylationVSSITRSSEPVQHEE
CHHCCCCCCCCCCHH		42.5023927012
956 (in isoform 7)Phosphorylation-8.7827251275
961PhosphorylationEPVQHEESIRKPSPE
CCCCCHHHCCCCCCC		25.3925159151
964 (in isoform 7)Phosphorylation-48.4527251275
966PhosphorylationEESIRKPSPEPRAQM
HHHCCCCCCCHHHHH		44.9520201521
978PhosphorylationAQMRRAASSDQLRDN
HHHHHHHCHHHHHCC		33.2029255136
978 (in isoform 7)Phosphorylation-33.2027251275
979PhosphorylationQMRRAASSDQLRDNS
HHHHHHCHHHHHCCC		25.3429255136
982 (in isoform 5)Phosphorylation-9.9722210691
983 (in isoform 7)Phosphorylation-35.1227251275
986PhosphorylationSDQLRDNSPPPAFKP
HHHHHCCCCCCCCCC		42.9719664994
992 (in isoform 7)Phosphorylation-51.0527251275
993 (in isoform 3)Ubiquitination-53.5321890473
997 (in isoform 7)Phosphorylation-73.5527251275
1000PhosphorylationPEPPKAKTQNKEESY
CCCCCCCCCCCHHHC		42.0826074081
1006PhosphorylationKTQNKEESYDFSKSY
CCCCCHHHCCCCHHC		30.9721945579
1007PhosphorylationTQNKEESYDFSKSYE
CCCCHHHCCCCHHCC		25.0421945579
1009 (in isoform 7)Phosphorylation-8.2327251275
1010PhosphorylationKEESYDFSKSYEYKS
CHHHCCCCHHCCCCC		20.1421945579
1012PhosphorylationESYDFSKSYEYKSNP
HHCCCCHHCCCCCCC		23.2319664994
1013PhosphorylationSYDFSKSYEYKSNPS
HCCCCHHCCCCCCCC		27.3227259358
1015PhosphorylationDFSKSYEYKSNPSAV
CCCHHCCCCCCCCCC		16.1023312004
1016UbiquitinationFSKSYEYKSNPSAVA
CCHHCCCCCCCCCCC		31.6421890473
1017 (in isoform 7)Phosphorylation-53.7427251275
1017PhosphorylationSKSYEYKSNPSAVAG
CHHCCCCCCCCCCCC		53.7423403867
1020PhosphorylationYEYKSNPSAVAGNET
CCCCCCCCCCCCCCC		39.3623403867
1027PhosphorylationSAVAGNETPGASTKG
CCCCCCCCCCCCCCC		30.9019664994
1031PhosphorylationGNETPGASTKGYPPP
CCCCCCCCCCCCCCC		36.2525849741
1032PhosphorylationNETPGASTKGYPPPV
CCCCCCCCCCCCCCC		28.1423403867
1032O-linked_GlycosylationNETPGASTKGYPPPV
CCCCCCCCCCCCCCC		28.1428510447
1035PhosphorylationPGASTKGYPPPVAAK
CCCCCCCCCCCCCCC		17.7022210691
1037 (in isoform 7)Phosphorylation-27.7527642862
1038 (in isoform 7)Phosphorylation-24.7127642862
1042AcetylationYPPPVAAKPTFGRSI
CCCCCCCCCCCCCCC		34.5526051181
1043 (in isoform 7)Phosphorylation-28.3827642862
1044 (in isoform 7)Phosphorylation-37.7127642862
1047UbiquitinationAAKPTFGRSILKPST
CCCCCCCCCCCCCCC		19.1421890473
1047UbiquitinationAAKPTFGRSILKPST
CCCCCCCCCCCCCCC		19.1421890473
1047 (in isoform 1)Ubiquitination-19.1421890473
1048PhosphorylationAKPTFGRSILKPSTP
CCCCCCCCCCCCCCC		32.4323927012
1053PhosphorylationGRSILKPSTPIPPQE
CCCCCCCCCCCCCCC		45.2725159151
1054PhosphorylationRSILKPSTPIPPQEG
CCCCCCCCCCCCCCC		33.4923927012
1058 (in isoform 7)Phosphorylation-45.6427251275
1062 (in isoform 7)Phosphorylation-49.0827251275
1067PhosphorylationEGEEVGESSEEQDNA
CCCCCCCCHHHCCCC		36.8022167270
1068PhosphorylationGEEVGESSEEQDNAP
CCCCCCCHHHCCCCC		40.6322167270
1084 (in isoform 7)Phosphorylation-6.3727251275
1097SulfoxidationHKARLQRMQELQEAQ
HHHHHHHHHHHHHHH		2.0421406390
1098 (in isoform 7)Phosphorylation-50.8927251275
1099 (in isoform 7)Phosphorylation-42.9827251275
1113AcetylationARIEIAQKHPDIYAV
HHHHHHHHCCCEEEE		48.3525953088
1118PhosphorylationAQKHPDIYAVPIKTH
HHHCCCEEEEECCCC		14.6625159151
1124PhosphorylationIYAVPIKTHKPDPGT
EEEEECCCCCCCCCC		35.5323927012
1131PhosphorylationTHKPDPGTPQHTSSR
CCCCCCCCCCCCCCC		25.7620201521
1135PhosphorylationDPGTPQHTSSRPPEP
CCCCCCCCCCCCCCC		24.1320201521
1136PhosphorylationPGTPQHTSSRPPEPQ
CCCCCCCCCCCCCCC		23.4023927012
1137PhosphorylationGTPQHTSSRPPEPQK
CCCCCCCCCCCCCCC		50.3823927012
1147PhosphorylationPEPQKAPSRPYQDTR
CCCCCCCCCCCCCCC		51.2320363803
1149 (in isoform 7)Phosphorylation-35.1627642862
1150PhosphorylationQKAPSRPYQDTRGSY
CCCCCCCCCCCCCCC		20.2226657352
1153PhosphorylationPSRPYQDTRGSYGSD
CCCCCCCCCCCCCCC		22.7720363803
1156PhosphorylationPYQDTRGSYGSDAEE
CCCCCCCCCCCCHHH		24.0323927012
1157PhosphorylationYQDTRGSYGSDAEEE
CCCCCCCCCCCHHHH		24.3923927012
1159PhosphorylationDTRGSYGSDAEEEEY
CCCCCCCCCHHHHHH		25.9719664994
1162 (in isoform 7)Phosphorylation-71.5727251275
1166PhosphorylationSDAEEEEYRQQLSEH
CCHHHHHHHHHHHHH		19.5923927012
1171PhosphorylationEEYRQQLSEHSKRGY
HHHHHHHHHHHHCCC		29.0023927012
1174PhosphorylationRQQLSEHSKRGYYGQ
HHHHHHHHHCCCCCC		21.7223927012
1176MethylationQLSEHSKRGYYGQSA
HHHHHHHCCCCCCCC		41.1681441455
1178PhosphorylationSEHSKRGYYGQSARY
HHHHHCCCCCCCCCC		14.4121609022
1179PhosphorylationEHSKRGYYGQSARYR
HHHHCCCCCCCCCCC		16.1225884760
1182PhosphorylationKRGYYGQSARYRDTE
HCCCCCCCCCCCCCC		15.4528857561
1187 (in isoform 7)Phosphorylation-35.2827251275
1190 (in isoform 7)Phosphorylation-10.3827251275
1202 (in isoform 7)Phosphorylation-27251275
1205 (in isoform 7)Phosphorylation-27251275
1213 (in isoform 7)Phosphorylation-27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZO2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZO2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZO2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OCLN_HUMANOCLNphysical
14512431
CTNA1_HUMANCTNNA1physical
10026224
OCLN_HUMANOCLNphysical
10026224
ZO1_HUMANTJP1physical
10026224
ZO1_HUMANTJP1physical
10575001
41_HUMANEPB41physical
10874042
K1671_HUMANKIAA1671physical
24255178
KIF14_HUMANKIF14physical
24255178
PGAM5_HUMANPGAM5physical
24255178
PLOD1_HUMANPLOD1physical
24255178
ZO1_HUMANTJP1physical
24255178
LRC47_HUMANLRRC47physical
26344197
1433T_HUMANYWHAQphysical
26344197
Drug and Disease Associations
Kegg Disease
OMIM Disease
607748Familial hypercholanemia (FHCA)
615878Cholestasis, progressive familial intrahepatic, 4 (PFIC4)
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZO2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-1159, ANDMASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1027; SER-1067; SER-1068AND SER-1159, AND MASS SPECTROMETRY.
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1159, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-170; SER-174;SER-244; SER-266; SER-398; SER-400; THR-455; SER-920; THR-925;THR-933; SER-978; SER-986; SER-1067; SER-1068; THR-1131 AND SER-1159,AND MASS SPECTROMETRY.
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-170; SER-174;SER-244; SER-266; SER-415; SER-702; SER-966; SER-978; SER-986 ANDSER-1159, AND MASS SPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-170; SER-192;SER-244; SER-394; SER-398; SER-400; SER-440; SER-441; THR-445 ANDSER-986, AND MASS SPECTROMETRY.
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-174; SER-244AND SER-415, AND MASS SPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266; SER-296 ANDSER-1159, AND MASS SPECTROMETRY.
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1131, AND MASSSPECTROMETRY.
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-426 AND TYR-1118, ANDMASS SPECTROMETRY.
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-261 AND TYR-1118, ANDMASS SPECTROMETRY.
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-574, AND MASSSPECTROMETRY.

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