PLOD1_HUMAN - dbPTM
PLOD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLOD1_HUMAN
UniProt AC Q02809
Protein Name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Gene Name PLOD1
Organism Homo sapiens (Human).
Sequence Length 727
Subcellular Localization Rough endoplasmic reticulum membrane
Peripheral membrane protein
Lumenal side.
Protein Description Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. [PubMed: 8621606]
Protein Sequence MRPLLLLALLGWLLLAEAKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGLGEDWNVEKGTSAGGGQKVRLLKKALEKHADKEDLVILFADSYDVLFASGPRELLKKFRQARSQVVFSAEELIYPDRRLETKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQLFYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEVVLKFEMGHVRARNLAYDTLPVLIHGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLRSLKGIGDEALPTVLVGVFIEQPTPFVSLFFQRLLRLHYPQKHMRLFIHNHEQHHKAQVEEFLAQHGSEYQSVKLVGPEVRMANADARNMGADLCRQDRSCTYYFSVDADVALTEPNSLRLLIQQNKNVIAPLMTRHGRLWSNFWGALSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRGELQSSDLFHHSKLDPDMAFCANIRQQDVFMFLTNRHTLGHLLSLDSYRTTHLHNDLWEVFSNPEDWKEKYIHQNYTKALAGKLVETPCPDVYWFPIFTEVACDELVEEMEHFGQWSLGNNKDNRIQGGYENVPTIDIHMNQIGFEREWHKFLLEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLMPHHDASTFTINIALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTRGTRYIAVSFVDP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35PhosphorylationLLVLTVATKETEGFR
EEEEEEEECCCCCHH		25.6920068231
48 (in isoform 2)Phosphorylation-17.7720068231
53PhosphorylationRSAQFFNYKIQALGL
HHHHHHCCEEHCCCC		12.33-
56 (in isoform 2)Phosphorylation-26.7820068231
58 (in isoform 2)Phosphorylation-3.1420068231
60 (in isoform 2)Phosphorylation-7.6420068231
62 (in isoform 2)Phosphorylation-65.9720068231
63 (in isoform 2)Phosphorylation-40.2120068231
68UbiquitinationGEDWNVEKGTSAGGG
CCCCCCCCCCCCCCH		64.3129967540
72 (in isoform 2)Phosphorylation-22.0820068231
79 (in isoform 2)Phosphorylation-41.1420068231
82 (in isoform 2)Phosphorylation-40.3620068231
115UbiquitinationSGPRELLKKFRQARS
CCHHHHHHHHHHHHH		63.5929967540
141UbiquitinationPDRRLETKYPVVSDG
CCCCCCCCCCEEECC		37.8827667366
146PhosphorylationETKYPVVSDGKRFLG
CCCCCEEECCCEEEC		40.66-
154PhosphorylationDGKRFLGSGGFIGYA
CCCEEECCCCCCEEC		37.5820068231
160PhosphorylationGSGGFIGYAPNLSKL
CCCCCCEECCCHHHH		17.6728152594
163N-linked_GlycosylationGFIGYAPNLSKLVAE
CCCEECCCHHHHHHE		49.10UniProtKB CARBOHYD
165PhosphorylationIGYAPNLSKLVAEWE
CEECCCHHHHHHEEC		30.5020068231
188UbiquitinationLFYTKIFLDPEKREQ
EEEEEEEECHHHHHH		14.1327667366
197N-linked_GlycosylationPEKREQINITLDHRC
HHHHHHEEEEHHHHC		22.38UniProtKB CARBOHYD
197N-linked_GlycosylationPEKREQINITLDHRC
HHHHHHEEEEHHHHC		22.3820068230
344PhosphorylationLAQHGSEYQSVKLVG
HHHCCCCCEEEEECC		14.05-
392PhosphorylationVALTEPNSLRLLIQQ
EECCCCCHHHHHHHC		26.11-
401UbiquitinationRLLIQQNKNVIAPLM
HHHHHCCCCCHHHHH		48.53-
409PhosphorylationNVIAPLMTRHGRLWS
CCHHHHHCCCCCCHH		27.4820068231
431PhosphorylationADGYYARSEDYVDIV
CCCEEECCHHCEEEE		27.0121712546
434PhosphorylationYYARSEDYVDIVQGR
EEECCHHCEEEECCC		8.93-
448UbiquitinationRRVGVWNVPYISNIY
CCEEEEECCEEEEEE		1.92-
525PhosphorylationNDLWEVFSNPEDWKE
CCHHHHHCCHHHHHH		57.56-
534PhosphorylationPEDWKEKYIHQNYTK
HHHHHHHHHCHHHHH		12.5326657352
538N-linked_GlycosylationKEKYIHQNYTKALAG
HHHHHCHHHHHHHCC		32.07UniProtKB CARBOHYD
539PhosphorylationEKYIHQNYTKALAGK
HHHHCHHHHHHHCCC		11.7526657352
541UbiquitinationYIHQNYTKALAGKLV
HHCHHHHHHHCCCCC		30.9229967540
588UbiquitinationLGNNKDNRIQGGYEN
CCCCCCCCCCCCCCC		32.5129967540
619PhosphorylationWHKFLLEYIAPMTEK
HHHHHHHHHHHHHCC		11.44-
675PhosphorylationLNRVGVDYEGGGCRF
ECCCCCCCCCCCEEE		17.67-
686N-linked_GlycosylationGCRFLRYNCSIRAPR
CEEEEEEEEEEECCC		13.46UniProtKB CARBOHYD
715MethylationHEGLPTTRGTRYIAV
CCCCCCCCCCEEEEE		47.14115487895
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PLOD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLOD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLOD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLOD1_HUMANPLOD1physical
11956192
NCDN_HUMANNCDNphysical
22863883
HNRH2_HUMANHNRNPH2physical
26344197
NCPR_HUMANPORphysical
26344197
CO4A6_HUMANCOL4A6physical
28514442
CO4A5_HUMANCOL4A5physical
28514442
CO4A1_HUMANCOL4A1physical
28514442
CO5A1_HUMANCOL5A1physical
28514442
MEX3D_HUMANMEX3Dphysical
28514442
CO4A2_HUMANCOL4A2physical
28514442
FOXA1_HUMANFOXA1physical
28514442
ODFP2_HUMANODF2physical
28514442
F122B_HUMANFAM122Bphysical
28514442
COIA1_HUMANCOL18A1physical
28514442
ZN106_HUMANZNF106physical
28514442
HNRH1_HUMANHNRNPH1physical
28514442
CI040_HUMANC9orf40physical
28514442
COEA1_HUMANCOL14A1physical
28514442
CHERP_HUMANCHERPphysical
28514442
KI18B_HUMANKIF18Bphysical
28514442
KDM3B_HUMANKDM3Bphysical
28514442
CO6A2_HUMANCOL6A2physical
28514442
COPA1_HUMANCOL25A1physical
28514442
SC65_HUMANP3H4physical
28514442
CO1A1_HUMANCOL1A1physical
28514442
CO6A1_HUMANCOL6A1physical
28514442
RBM7_HUMANRBM7physical
28514442
PLK4_HUMANPLK4physical
28514442
ALG13_HUMANALG13physical
28514442
DUS11_HUMANDUSP11physical
28514442
PLOD2_HUMANPLOD2physical
28514442
Drug and Disease Associations
Kegg Disease
H00802 Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3);
H00980 Nevo syndrome
OMIM Disease
225400Ehlers-Danlos syndrome 6 (EDS6)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00139Succinic acid
DB00126Vitamin C
Regulatory Network of PLOD1_HUMAN

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Related Literatures of Post-Translational Modification

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