CO5A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO5A1_HUMAN
• UniProt AC: P20908
• Protein Name: Collagen alpha-1(V) chain
• Gene Name: COL5A1
• Organism: Homo sapiens (Human).
• Sequence Length: 1838
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin..
• Protein Sequence: MDVHTRWKARSALRPGAPLLPPLLLLLLWAPPPSRAAQPADLLKVLDFHNLPDGITKTTGFCATRRSSKGPDVAYRVTKDAQLSAPTKQLYPASAFPEDFSILTTVKAKKGSQAFLVSIYNEQGIQQIGLELGRSPVFLYEDHTGKPGPEDYPLFRGINLSDGKWHRIALSVHKKNVTLILDCKKKTTKFLDRSDHPMIDINGIIVFGTRILDEEVFEGDIQQLLFVSDHRAAYDYCEHYSPDCDTAVPDTPQSQDPNPDEYYTEGDGEGETYYYEYPYYEDPEDLGKEPTPSKKPVEAAKETTEVPEELTPTPTEAAPMPETSEGAGKEEDVGIGDYDYVPSEDYYTPSPYDDLTYGEGEENPDQPTDPGAGAEIPTSTADTSNSSNPAPPPGEGADDLEGEFTEETIRNLDENYYDPYYDPTSSPSEIGPGMPANQDTIYEGIGGPRGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLPGPPGTMGPTGQVGDPGERGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAILQQARLALRGPAGPMGLTGRPGPVGPPGSGGLKGEPGDVGPQGPRGVQGPPGPAGKPGRRGRAGSDGARGMPGQTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGPPGDDGERGDDGEVGPRGLPGEPGPRGLLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGPIGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGPPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGNGENYVDYADGMEEIFGSLNSLKLEIEQMKRPLGTQQNPARTCKDLQLCHPDFPDGEYWVDPNQGCSRDSFKVYCNFTAGGSTCVFPDKKSEGARITSWPKENPGSWFSEFKRGKLLSYVDAEGNPVGVVQMTFLRLLSASAHQNVTYHCYQSVAWQDAATGSYDKALRFLGSNDEEMSYDNNPYIRALVDGCATKKGYQKTVLEIDTPKVEQVPIVDIMFNDFGEASQKFGFEVGPACFMG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Phosphorylation	KTTGFCATRRSSKGP CCCCCCCCCCCCCCC	28.00	-
67	Phosphorylation	GFCATRRSSKGPDVA CCCCCCCCCCCCCCE	32.86	24719451
75	Phosphorylation	SKGPDVAYRVTKDAQ CCCCCCEEEECCCCC	12.88	24719451
79	Ubiquitination	DVAYRVTKDAQLSAP CCEEEECCCCCCCCC	48.48	-
91	Phosphorylation	SAPTKQLYPASAFPE CCCCCCCCCCCCCCC	8.34	24043423
94	Phosphorylation	TKQLYPASAFPEDFS CCCCCCCCCCCCCCE	26.41	24043423
101	Phosphorylation	SAFPEDFSILTTVKA CCCCCCCEEEEEEEE	29.07	24043423
104	Phosphorylation	PEDFSILTTVKAKKG CCCCEEEEEEEECCC	28.07	24043423
105	Phosphorylation	EDFSILTTVKAKKGS CCCEEEEEEEECCCC	19.30	24043423
234	Sulfation	VSDHRAAYDYCEHYS CCCHHHHHHHHHHHC	13.37	-
234	Sulfation	VSDHRAAYDYCEHYS CCCHHHHHHHHHHHC	13.37	-
236	Sulfation	DHRAAYDYCEHYSPD CHHHHHHHHHHHCCC	6.25	-
236	Sulfation	DHRAAYDYCEHYSPD CHHHHHHHHHHHCCC	6.25	-
240	Sulfation	AYDYCEHYSPDCDTA HHHHHHHHCCCCCCC	10.29	-
240	Sulfation	AYDYCEHYSPDCDTA HHHHHHHHCCCCCCC	10.29	-
262	Sulfation	QDPNPDEYYTEGDGE CCCCCHHCCCCCCCC	24.06	-
262	Sulfation	QDPNPDEYYTEGDGE CCCCCHHCCCCCCCC	24.06	-
263	Sulfation	DPNPDEYYTEGDGEG CCCCHHCCCCCCCCC	9.03	-
263	Sulfation	DPNPDEYYTEGDGEG CCCCHHCCCCCCCCC	9.03	-
313	O-linked_Glycosylation	VPEELTPTPTEAAPM CCHHHCCCCCCCCCC	37.29	OGP
315	O-linked_Glycosylation	EELTPTPTEAAPMPE HHHCCCCCCCCCCCC	40.51	OGP
338	Sulfation	EDVGIGDYDYVPSED CCCCCCCCCCCCCHH	12.17	-
338	Sulfation	EDVGIGDYDYVPSED CCCCCCCCCCCCCHH	12.17	-
340	Sulfation	VGIGDYDYVPSEDYY CCCCCCCCCCCHHCC	14.18	-
340	Sulfation	VGIGDYDYVPSEDYY CCCCCCCCCCCHHCC	14.18	-
346	Sulfation	DYVPSEDYYTPSPYD CCCCCHHCCCCCCCC	12.75	-
346	Sulfation	DYVPSEDYYTPSPYD CCCCCHHCCCCCCCC	12.75	-
347	Sulfation	YVPSEDYYTPSPYDD CCCCHHCCCCCCCCC	25.21	-
347	Sulfation	YVPSEDYYTPSPYDD CCCCHHCCCCCCCCC	25.21	-
387	O-linked_Glycosylation	TADTSNSSNPAPPPG CCCCCCCCCCCCCCC	51.59	OGP
416	Sulfation	IRNLDENYYDPYYDP HHHCCCCCCCCCCCC	13.75	-
416	Sulfation	IRNLDENYYDPYYDP HHHCCCCCCCCCCCC	13.75	-
417	Sulfation	RNLDENYYDPYYDPT HHCCCCCCCCCCCCC	23.25	-
417	Sulfation	RNLDENYYDPYYDPT HHCCCCCCCCCCCCC	23.25	-
420	Sulfation	DENYYDPYYDPTSSP CCCCCCCCCCCCCCH	20.01	-
420	Sulfation	DENYYDPYYDPTSSP CCCCCCCCCCCCCCH	20.01	-
421	Sulfation	ENYYDPYYDPTSSPS CCCCCCCCCCCCCHH	22.34	-
421	Sulfation	ENYYDPYYDPTSSPS CCCCCCCCCCCCCHH	22.34	-
424	O-linked_Glycosylation	YDPYYDPTSSPSEIG CCCCCCCCCCHHHCC	38.65	OGP
426	O-linked_Glycosylation	PYYDPTSSPSEIGPG CCCCCCCCHHHCCCC	34.62	OGP
442	Phosphorylation	PANQDTIYEGIGGPR CCCCCCCCCCCCCCC	15.36	-
540	O-linked_Glycosylation	GSKGPMVSAQESQAQ CCCCCCCCHHHHHHH	20.27	OGP
540	Phosphorylation	GSKGPMVSAQESQAQ CCCCCCCCHHHHHHH	20.27	24043423
544	Phosphorylation	PMVSAQESQAQAILQ CCCCHHHHHHHHHHH	20.80	24043423
567	Phosphorylation	PAGPMGLTGRPGPVG CCCCCCCCCCCCCCC	25.97	20068231
570	Hydroxylation	PMGLTGRPGPVGPPG CCCCCCCCCCCCCCC	53.43	2496661
576	Hydroxylation	RPGPVGPPGSGGLKG CCCCCCCCCCCCCCC	43.59	2496661
578	Phosphorylation	GPVGPPGSGGLKGEP CCCCCCCCCCCCCCC	35.15	30175587
614	Phosphorylation	GRRGRAGSDGARGMP CCCCCCCCCCCCCCC	31.70	27251275
621	Hydroxylation	SDGARGMPGQTGPKG CCCCCCCCCCCCCCC	34.27	2496661
624	Phosphorylation	ARGMPGQTGPKGDRG CCCCCCCCCCCCCCC	62.46	25247763
627	Hydroxylation	MPGQTGPKGDRGFDG CCCCCCCCCCCCCCC	74.84	2496661
639	Hydroxylation	FDGLAGLPGEKGHRG CCCCCCCCCCCCCCC	48.24	2496661
642	Hydroxylation	LAGLPGEKGHRGDPG CCCCCCCCCCCCCCC	66.97	2496661
648	Hydroxylation	EKGHRGDPGPSGPPG CCCCCCCCCCCCCCC	60.46	2496661
651	Phosphorylation	HRGDPGPSGPPGPPG CCCCCCCCCCCCCCC	70.60	29691806
654	Hydroxylation	DPGPSGPPGPPGDDG CCCCCCCCCCCCCCC	72.02	2496661
657	Hydroxylation	PSGPPGPPGDDGERG CCCCCCCCCCCCCCC	65.83	2496661
675	Hydroxylation	EVGPRGLPGEPGPRG CCCCCCCCCCCCCCC	48.18	2496661
678	Hydroxylation	PRGLPGEPGPRGLLG CCCCCCCCCCCCCCC	65.09	2496661
680	Hydroxylation	GLPGEPGPRGLLGPK CCCCCCCCCCCCCCC	37.57	2496661
686	Hydroxylation	GPRGLLGPKGPPGPP CCCCCCCCCCCCCCC	38.10	2496661
687	Hydroxylation	PRGLLGPKGPPGPPG CCCCCCCCCCCCCCC	80.43	2496661
690	Hydroxylation	LLGPKGPPGPPGPPG CCCCCCCCCCCCCCC	76.28	2496661
696	Hydroxylation	PPGPPGPPGVTGMDG CCCCCCCCCCCCCCC	56.66	2496661
705	Hydroxylation	VTGMDGQPGPKGNVG CCCCCCCCCCCCCCC	67.59	2496661
708	Hydroxylation	MDGQPGPKGNVGPQG CCCCCCCCCCCCCCC	69.87	2496661
717	Hydroxylation	NVGPQGEPGPPGQQG CCCCCCCCCCCCCCC	68.37	2496661
720	Hydroxylation	PQGEPGPPGQQGNPG CCCCCCCCCCCCCCC	60.17	2496661
726	Hydroxylation	PPGQQGNPGAQGLPG CCCCCCCCCCCCCCC	46.45	2496661
732	Hydroxylation	NPGAQGLPGPQGAIG CCCCCCCCCCCCCCC	60.28	2496661
744	Hydroxylation	AIGPPGEKGPLGKPG CCCCCCCCCCCCCCC	72.28	2496661
750	Hydroxylation	EKGPLGKPGLPGMPG CCCCCCCCCCCCCCC	47.99	2496661
756	Hydroxylation	KPGLPGMPGADGPPG CCCCCCCCCCCCCCC	40.51	2496661
762	Hydroxylation	MPGADGPPGHPGKEG CCCCCCCCCCCCCCC	60.29	2496661
765	Hydroxylation	ADGPPGHPGKEGPPG CCCCCCCCCCCCCCC	62.56	2496661
771	Hydroxylation	HPGKEGPPGEKGGQG CCCCCCCCCCCCCCC	74.55	2496661
774	Acetylation	KEGPPGEKGGQGPPG CCCCCCCCCCCCCCC	74.40	155951
774	Hydroxylation	KEGPPGEKGGQGPPG CCCCCCCCCCCCCCC	74.40	2496661
780	Hydroxylation	EKGGQGPPGPQGPIG CCCCCCCCCCCCCCC	74.13	2496661
789	Hydroxylation	PQGPIGYPGPRGVKG CCCCCCCCCCCCCCC	40.89	2496661
795	Acetylation	YPGPRGVKGADGIRG CCCCCCCCCCCCCCC	51.73	7966075
795	Hydroxylation	YPGPRGVKGADGIRG CCCCCCCCCCCCCCC	51.73	2496661
804	Hydroxylation	ADGIRGLKGTKGEKG CCCCCCCCCCCCCCC	68.32	2496661
807	Hydroxylation	IRGLKGTKGEKGEDG CCCCCCCCCCCCCCC	73.98	2496661
810	Hydroxylation	LKGTKGEKGEDGFPG CCCCCCCCCCCCCCC	76.03	2496661
816	Hydroxylation	EKGEDGFPGFKGDMG CCCCCCCCCCCCCCC	53.49	2496661
819	Hydroxylation	EDGFPGFKGDMGIKG CCCCCCCCCCCCCCC	60.97	2496661
834	Hydroxylation	DRGEIGPPGPRGEDG CCCCCCCCCCCCCCC	61.27	2496661
846	Hydroxylation	EDGPEGPKGRGGPNG CCCCCCCCCCCCCCC	72.58	2496661
861	Hydroxylation	DPGPLGPPGEKGKLG CCCCCCCCCCCCCCC	62.87	2496661
864	Hydroxylation	PLGPPGEKGKLGVPG CCCCCCCCCCCCCCC	68.23	2496661
870	Hydroxylation	EKGKLGVPGLPGYPG CCCCCCCCCCCCCCC	36.48	2496661
873	Hydroxylation	KLGVPGLPGYPGRQG CCCCCCCCCCCCCCC	46.30	2496661
876	Hydroxylation	VPGLPGYPGRQGPKG CCCCCCCCCCCCCCC	37.09	2496661
882	Hydroxylation	YPGRQGPKGSIGFPG CCCCCCCCCCCCCCC	72.60	2496661
884	Phosphorylation	GRQGPKGSIGFPGFP CCCCCCCCCCCCCCC	26.18	-
888	Hydroxylation	PKGSIGFPGFPGANG CCCCCCCCCCCCCCC	38.00	2496661
891	Hydroxylation	SIGFPGFPGANGEKG CCCCCCCCCCCCCCC	47.07	2496661
897	Hydroxylation	FPGANGEKGGRGTPG CCCCCCCCCCCCCCC	68.98	2496661
903	Hydroxylation	EKGGRGTPGKPGPRG CCCCCCCCCCCCCCC	52.19	2496661
906	Hydroxylation	GRGTPGKPGPRGQRG CCCCCCCCCCCCCCC	65.03	2496661
930	Hydroxylation	PRGITGKPGPKGNSG CCCCCCCCCCCCCCC	66.71	2496661
945	Hydroxylation	GDGPAGPPGERGPNG CCCCCCCCCCCCCCC	57.25	2496661
957	Phosphorylation	PNGPQGPTGFPGPKG CCCCCCCCCCCCCCC	59.27	20068231
1005	Phosphorylation	VVGPQGPTGETGPMG CCCCCCCCCCCCCCC	55.25	25332170
1008	Phosphorylation	PQGPTGETGPMGERG CCCCCCCCCCCCCCC	48.18	25332170
1017	Hydroxylation	PMGERGHPGPPGPPG CCCCCCCCCCCCCCC	60.86	2496661
1020	Hydroxylation	ERGHPGPPGPPGEQG CCCCCCCCCCCCCCC	74.06	2496661
1023	Hydroxylation	HPGPPGPPGEQGLPG CCCCCCCCCCCCCCC	65.94	2496661
1029	Hydroxylation	PPGEQGLPGLAGKEG CCCCCCCCCCCCCCC	42.44	2496661
1088	Phosphorylation	GPPGPAGSPGERGPA CCCCCCCCCCCCCCC	31.66	29083192
1221	Hydroxylation	DEGPRGFPGPPGPVG CCCCCCCCCCCCCCC	58.15	2496661
1224	Hydroxylation	PRGFPGPPGPVGLQG CCCCCCCCCCCCCCC	66.68	2496661
1314	Phosphorylation	ERGEKGESGPSGAAG CCCCCCCCCCCCCCC	65.75	28387310
1317	Phosphorylation	EKGESGPSGAAGPPG CCCCCCCCCCCCCCC	44.59	-
1391	Ubiquitination	GPSGPPGKRGPPGPA CCCCCCCCCCCCCCC	61.01	21906983
1467	Hydroxylation	PPGPMGPPGLPGLKG CCCCCCCCCCCCCCC	51.75	2496661
1470	Hydroxylation	PMGPPGLPGLKGDSG CCCCCCCCCCCCCCC	52.57	2496661
1547	Phosphorylation	GPKGAKGSSGPTGPK CCCCCCCCCCCCCCC	31.26	22985185
1548	Phosphorylation	PKGAKGSSGPTGPKG CCCCCCCCCCCCCCC	58.42	23532336
1601	Sulfation	DDGNGENYVDYADGM CCCCCCCCEEHHHHH	7.15	-
1601	Sulfation	DDGNGENYVDYADGM CCCCCCCCEEHHHHH	7.15	-
1604	Sulfation	NGENYVDYADGMEEI CCCCCEEHHHHHHHH	9.13	-
1604	Sulfation	NGENYVDYADGMEEI CCCCCEEHHHHHHHH	9.13	-
1686	Acetylation	TCVFPDKKSEGARIT EEECCCCCCCCCCCC	62.21	20167786
1693	Phosphorylation	KSEGARITSWPKENP CCCCCCCCCCCCCCC	21.13	23403867
1694	Phosphorylation	SEGARITSWPKENPG CCCCCCCCCCCCCCC	38.72	23403867
1697	Acetylation	ARITSWPKENPGSWF CCCCCCCCCCCCCHH	64.96	20167786
1702	Phosphorylation	WPKENPGSWFSEFKR CCCCCCCCHHHHHHC	26.63	-
1769	Phosphorylation	KALRFLGSNDEEMSY HHHHHHCCCCCHHCC	43.16	28787133
1775	Phosphorylation	GSNDEEMSYDNNPYI CCCCCHHCCCCCHHH	32.39	28787133
1792	2-Hydroxyisobutyrylation	LVDGCATKKGYQKTV HHHHHCCCCCCCCEE	26.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO5A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO5A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO5A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPRC_HUMAN	SPARC	physical	2745554
PDGFA_HUMAN	PDGFA	physical	8900172
PDGFB_HUMAN	PDGFB	physical	8900172

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 130000: Ehlers-Danlos syndrome, classic type (EDS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.