PDGFB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDGFB_HUMAN
• UniProt AC: P01127
• Protein Name: Platelet-derived growth factor subunit B
• Gene Name: PDGFB
• Organism: Homo sapiens (Human).
• Sequence Length: 241
• Subcellular Localization: Secreted. Released by platelets upon wounding.
• Protein Description: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. [PubMed: 26599395 Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity]
• Protein Sequence: MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	N-linked_Glycosylation	DGAELDLNMTRSHSG CCCEECCEEECCCCC	29.46	UniProtKB CARBOHYD
67	Phosphorylation	LDLNMTRSHSGGELE ECCEEECCCCCHHHH	16.91	28348404
69	Phosphorylation	LNMTRSHSGGELESL CEEECCCCCHHHHHH	50.14	28348404
99	Phosphorylation	AMIAECKTRTEVFEI HHEEECCCHHHHHHH	55.25	28509920
190	Phosphorylation	VAAARPVTRSPGGSQ EEECCCCCCCCCCCH	28.28	-
190	O-linked_Glycosylation	VAAARPVTRSPGGSQ EEECCCCCCCCCCCH	28.28	37009957
196	Phosphorylation	VTRSPGGSQEQRAKT CCCCCCCCHHHHCCC	36.14	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDGFB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDGFB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDGFB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDGFB_HUMAN	PDGFB	physical	1396586
MDFI_HUMAN	MDFI	physical	19060904
LYVE1_HUMAN	LYVE1	physical	7829517
FAT3_HUMAN	FAT3	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442
CK057_HUMAN	C11orf57	physical	28514442
ZC3H4_HUMAN	ZC3H4	physical	28514442
RT18C_HUMAN	MRPS18C	physical	28514442
GPR98_HUMAN	GPR98	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
PTCD3_HUMAN	PTCD3	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
RT33_HUMAN	MRPS33	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
RM30_HUMAN	MRPL30	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
UTP23_HUMAN	UTP23	physical	28514442
FAT1_HUMAN	FAT1	physical	28514442
C1QBP_HUMAN	C1QBP	physical	28514442
NOC2L_HUMAN	NOC2L	physical	28514442
BMS1_HUMAN	BMS1	physical	28514442
NOC3L_HUMAN	NOC3L	physical	28514442
MDM2_HUMAN	MDM2	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
RM47_HUMAN	MRPL47	physical	28514442
MYCB2_HUMAN	MYCBP2	physical	28514442
RT05_HUMAN	MRPS5	physical	28514442
FREM2_HUMAN	FREM2	physical	28514442
RT31_HUMAN	MRPS31	physical	28514442
NOC4L_HUMAN	NOC4L	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
RS3_HUMAN	RPS3	physical	28514442
MASU1_HUMAN	MALSU1	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
SAS10_HUMAN	UTP3	physical	28514442
RM27_HUMAN	MRPL27	physical	28514442
RL15_HUMAN	RPL15	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
RRP12_HUMAN	RRP12	physical	28514442
NOP53_HUMAN	GLTSCR2	physical	28514442
BUD13_HUMAN	BUD13	physical	28514442
RBM28_HUMAN	RBM28	physical	28514442
FAT4_HUMAN	FAT4	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442
RS15_HUMAN	RPS15	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
RM51_HUMAN	MRPL51	physical	28514442
CEBPZ_HUMAN	CEBPZ	physical	28514442
TEX10_HUMAN	TEX10	physical	28514442
EBP2_HUMAN	EBNA1BP2	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
SRRM1_HUMAN	SRRM1	physical	28514442
KRI1_HUMAN	KRI1	physical	28514442
RM13_HUMAN	MRPL13	physical	28514442
RT24_HUMAN	MRPS24	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.